LOCUS       NM_004454               4082 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens ETS variant transcription factor 5 (ETV5), mRNA.
ACCESSION   NM_004454 XM_942483 XM_946034
VERSION     NM_004454.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4082)
  AUTHORS   Park,J., Lee,J., Hur,Y., Kim,C.J., Kim,H.B., Um,D., Kim,D.S.,
            Lee,J.Y., Park,S., Park,Y., Kim,T.K., Im,S.H., Kim,S.W., Kwok,S.K.
            and Lee,Y.
  TITLE     ETV5 promotes lupus pathogenesis and follicular helper T cell
            differentiation by inducing osteopontin expression
  JOURNAL   Proc Natl Acad Sci U S A 121 (24), e2322009121 (2024)
   PUBMED   38843187
  REMARK    GeneRIF: ETV5 promotes lupus pathogenesis and follicular helper T
            cell differentiation by inducing osteopontin expression.
REFERENCE   2  (bases 1 to 4082)
  AUTHORS   Yu,S., Ma,Z., Chen,T., Wang,H., Yao,Q., Li,J. and Cheng,J.
  TITLE     ETV5 facilitates tumor progression in head-neck squamous cell
            carcinoma
  JOURNAL   Oral Dis 30 (4), 2004-2017 (2024)
   PUBMED   37649213
  REMARK    GeneRIF: ETV5 facilitates tumor progression in head-neck squamous
            cell carcinoma.
REFERENCE   3  (bases 1 to 4082)
  AUTHORS   Wen,J., Xue,L., Wei,Y., Liang,J., Jia,W., Yong,T., Chu,L., Li,H.,
            Han,S., Liao,J., Chen,Z., Liu,Y., Liu,Q., Ding,Z., Liang,H.,
            Gan,L., Chen,X., Huang,Z. and Zhang,B.
  TITLE     YTHDF2 Is a Therapeutic Target for HCC by Suppressing Immune
            Evasion and Angiogenesis Through ETV5/PD-L1/VEGFA Axis
  JOURNAL   Adv Sci (Weinh) 11 (13), e2307242 (2024)
   PUBMED   38247171
  REMARK    GeneRIF: YTHDF2 Is a Therapeutic Target for HCC by Suppressing
            Immune Evasion and Angiogenesis Through ETV5/PD-L1/VEGFA Axis.
REFERENCE   4  (bases 1 to 4082)
  AUTHORS   Li,D., Shen,Y., Ren,H., Wang,L., Yang,J. and Wang,Y.
  TITLE     ETV5 transcriptionally activates TGFbeta1 and promotes cancer cell
            invasion and migration of NSCLC
  JOURNAL   J Mol Histol 54 (5), 419-426 (2023)
   PUBMED   37656259
  REMARK    GeneRIF: ETV5 transcriptionally activates TGFbeta1 and promotes
            cancer cell invasion and migration of NSCLC.
REFERENCE   5  (bases 1 to 4082)
  AUTHORS   Wei,Y., Han,S., Wen,J., Liao,J., Liang,J., Yu,J., Chen,X.,
            Xiang,S., Huang,Z. and Zhang,B.
  TITLE     E26 transformation-specific transcription variant 5 in development
            and cancer: modification, regulation and function
  JOURNAL   J Biomed Sci 30 (1), 17 (2023)
   PUBMED   36872348
  REMARK    GeneRIF: E26 transformation-specific transcription variant 5 in
            development and cancer: modification, regulation and function.
            Review article
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4082)
  AUTHORS   Wang,X., Yeh,S., Wu,G., Hsu,C.L., Wang,L., Chiang,T., Yang,Y.,
            Guo,Y. and Chang,C.
  TITLE     Identification and characterization of a novel androgen receptor
            coregulator ARA267-alpha in prostate cancer cells
  JOURNAL   J Biol Chem 276 (44), 40417-40423 (2001)
   PUBMED   11509567
REFERENCE   7  (bases 1 to 4082)
  AUTHORS   Monte,D., Coutte,L., Dewitte,F., Defossez,P.A., Le Coniat,M.,
            Stehelin,D., Berger,R. and de Launoit,Y.
  TITLE     Genomic organization of the human ERM (ETV5) gene, a PEA3 group
            member of ETS transcription factors
  JOURNAL   Genomics 35 (1), 236-240 (1996)
   PUBMED   8661127
REFERENCE   8  (bases 1 to 4082)
  AUTHORS   Protopopova,M.V., Vorobieva,N.V., Protopopov,A.I., Gizatullin,R.Z.,
            Kashuba,V.I., Klein,G., Zabarovsky,E.R. and Graphodatsky,A.S.
  TITLE     Assignment of the ERM gene (ETV5) coding for the ets-related
            protein to human chromosome band 3q28 by in situ hybridization
  JOURNAL   Cytogenet Cell Genet 74 (3), 220 (1996)
   PUBMED   8941378
REFERENCE   9  (bases 1 to 4082)
  AUTHORS   Nakae,K., Nakajima,K., Inazawa,J., Kitaoka,T. and Hirano,T.
  TITLE     ERM, a PEA3 subfamily of Ets transcription factors, can cooperate
            with c-Jun
  JOURNAL   J Biol Chem 270 (40), 23795-23800 (1995)
   PUBMED   7559555
REFERENCE   10 (bases 1 to 4082)
  AUTHORS   Monte,D., Baert,J.L., Defossez,P.A., de Launoit,Y. and Stehelin,D.
  TITLE     Molecular cloning and characterization of human ERM, a new member
            of the Ets family closely related to mouse PEA3 and ER81
            transcription factors
  JOURNAL   Oncogene 9 (5), 1397-1406 (1994)
   PUBMED   8152800
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC112649.9, AC131156.6 and AC108671.5.
            
            On Nov 23, 2018 this sequence version replaced NM_004454.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803612.49230.1,
                                           SRR1803614.284524.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000306376.10/ ENSP00000306894.5
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-150               AC112649.9         9833-9982           c
            151-269             AC112649.9         6717-6835           c
            270-357             AC112649.9         6518-6605           c
            358-405             AC112649.9         6342-6389           c
            406-456             AC112649.9         6198-6248           c
            457-586             AC131156.6         14058-14187         c
            587-874             AC131156.6         12829-13116         c
            875-1134            AC108671.5         170697-170956       c
            1135-1194           AC108671.5         169301-169360       c
            1195-1263           AC108671.5         162307-162375       c
            1264-1433           AC108671.5         161959-162128       c
            1434-1535           AC108671.5         156914-157015       c
            1536-4079           AC108671.5         151201-153744       c
            4080-4082           AC108671.5         151198-151200       c
FEATURES             Location/Qualifiers
     source          1..4082
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q27.2"
     gene            1..4082
                     /gene="ETV5"
                     /gene_synonym="ERM"
                     /note="ETS variant transcription factor 5"
                     /db_xref="GeneID:2119"
                     /db_xref="HGNC:HGNC:3494"
                     /db_xref="MIM:601600"
     exon            1..150
                     /gene="ETV5"
                     /gene_synonym="ERM"
                     /inference="alignment:Splign:2.1.0"
     exon            151..269
                     /gene="ETV5"
                     /gene_synonym="ERM"
                     /inference="alignment:Splign:2.1.0"
     CDS             225..1757
                     /gene="ETV5"
                     /gene_synonym="ERM"
                     /note="ets-related molecule; ets-related protein ERM"
                     /codon_start=1
                     /product="ETS translocation variant 5"
                     /protein_id="NP_004445.1"
                     /db_xref="CCDS:CCDS33906.1"
                     /db_xref="GeneID:2119"
                     /db_xref="HGNC:HGNC:3494"
                     /db_xref="MIM:601600"
                     /translation="MDGFYDQQVPFMVPGKSRSEECRGRPVIDRKRKFLDTDLAHDSE
                     ELFQDLSQLQEAWLAEAQVPDDEQFVPDFQSDNLVLHAPPPTKIKRELHSPSSELSSC
                     SHEQALGANYGEKCLYNYCAYDRKPPSGFKPLTPPTTPLSPTHQNPLFPPPQATLPTS
                     GHAPAAGPVQGVGPAPAPHSLPEPGPQQQTFAVPRPPHQPLQMPKMMPENQYPSEQRF
                     QRQLSEPCHPFPPQPGVPGDNRPSYHRQMSEPIVPAAPPPPQGFKQEYHDPLYEHGVP
                     GMPGPPAHGFQSPMGIKQEPRDYCVDSEVPNCQSSYMRGGYFSSSHEGFSYEKDPRLY
                     FDDTCVVPERLEGKVKQEPTMYREGPPYQRRGSLQLWQFLVTLLDDPANAHFIAWTGR
                     GMEFKLIEPEEVARRWGIQKNRPAMNYDKLSRSLRYYYEKGIMQKVAGERYVYKFVCD
                     PDALFSMAFPDNQRPFLKAESECHLSEEDTLPLTHFEDSPAYLLDMDRCSSLPYAEGF
                     AY"
     exon            270..357
                     /gene="ETV5"
                     /gene_synonym="ERM"
                     /inference="alignment:Splign:2.1.0"
     exon            358..405
                     /gene="ETV5"
                     /gene_synonym="ERM"
                     /inference="alignment:Splign:2.1.0"
     exon            406..456
                     /gene="ETV5"
                     /gene_synonym="ERM"
                     /inference="alignment:Splign:2.1.0"
     exon            457..586
                     /gene="ETV5"
                     /gene_synonym="ERM"
                     /inference="alignment:Splign:2.1.0"
     exon            587..874
                     /gene="ETV5"
                     /gene_synonym="ERM"
                     /inference="alignment:Splign:2.1.0"
     exon            875..1134
                     /gene="ETV5"
                     /gene_synonym="ERM"
                     /inference="alignment:Splign:2.1.0"
     exon            1135..1194
                     /gene="ETV5"
                     /gene_synonym="ERM"
                     /inference="alignment:Splign:2.1.0"
     exon            1195..1263
                     /gene="ETV5"
                     /gene_synonym="ERM"
                     /inference="alignment:Splign:2.1.0"
     exon            1264..1433
                     /gene="ETV5"
                     /gene_synonym="ERM"
                     /inference="alignment:Splign:2.1.0"
     exon            1434..1535
                     /gene="ETV5"
                     /gene_synonym="ERM"
                     /inference="alignment:Splign:2.1.0"
     exon            1536..4082
                     /gene="ETV5"
                     /gene_synonym="ERM"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4051..4056
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ETV5"
                     /gene_synonym="ERM"
                     /note="hexamer: AATAAA"
     polyA_site      4082
                     /gene="ETV5"
                     /gene_synonym="ERM"
                     /note="major polyA site"
ORIGIN      
        1 agagtccagc cgctggtgcg cggagcggtt caccgtcttc ggagcggttc ggcccagcct
       61 ttcgcccagg cgcccaggcc cgctgcgcgc gtgcgtgagc gcgcctgcgc cgccggggcc
      121 gctgcaaggg gaggagagag gccgcctcag gaggatccct tttcccccag aaattactca
      181 atgctgaaac ctctcaaagt ggtattagag acgctgaaag caccatggac gggttttatg
      241 atcagcaagt cccttttatg gtcccaggga aatctcgatc tgaggaatgc agagggcggc
      301 ctgtgattga cagaaagagg aagtttttgg acacagatct ggctcacgat tctgaagagc
      361 tatttcagga tctcagtcaa cttcaagagg cttggttagc tgaagcacaa gttcctgatg
      421 atgaacagtt tgtcccagat tttcagtctg ataacctggt gcttcatgcc ccacctccaa
      481 ccaagatcaa acgggagctg cacagcccct cctctgagct gtcgtcttgt agccatgagc
      541 aggctcttgg tgctaactat ggagaaaagt gcctctacaa ctattgtgcc tatgatagga
      601 agcctccctc tgggttcaag ccattaaccc ctcctacaac ccccctctca cccacccatc
      661 agaatcccct atttccccca cctcaggcaa ctctgcccac ctcagggcat gcccctgcag
      721 ctggcccagt tcaaggtgtg ggccccgccc ccgcccccca ttcgcttcca gagcctggac
      781 cacagcagca aacatttgcg gtcccccgac caccacatca gcccctgcag atgccaaaga
      841 tgatgcctga aaaccagtat ccatcagaac agagatttca gagacaactg tctgaaccct
      901 gccacccctt ccctcctcag ccaggagttc ctggagataa tcgccccagt taccatcggc
      961 aaatgtcaga acctattgtc cctgcagctc ccccgccccc tcagggattc aaacaagaat
     1021 accatgaccc actctatgaa catggggtcc cgggcatgcc agggccccca gcacacgggt
     1081 tccagtcacc aatgggaatc aagcaggagc ctcgggatta ctgcgtcgat tcagaagtgc
     1141 ctaactgcca gtcatcctac atgagagggg gttatttctc cagcagccat gaaggttttt
     1201 catatgaaaa agatccccga ttatactttg acgacacttg tgttgtgcct gagagactgg
     1261 aaggcaaagt caaacaggag cctaccatgt atcgagaggg gcccccttac cagaggcgag
     1321 gttcccttca gctgtggcag ttcctggtca cccttcttga tgacccagcc aatgcccact
     1381 tcattgcctg gacaggtcga ggcatggagt tcaagctgat agaaccggaa gaggttgctc
     1441 ggcgctgggg catccagaag aaccggccag ccatgaacta tgacaagctg agccgctctc
     1501 tccgctatta ctatgaaaag ggcatcatgc agaaggtggc tggagagcga tacgtctaca
     1561 aatttgtctg tgacccagat gccctcttct ccatggcttt cccggataac cagcgtccgt
     1621 tcctgaaggc agagtccgag tgccacctca gcgaggagga caccctgccg ctgacccact
     1681 ttgaagacag ccccgcttac ctcctggaca tggaccgctg cagcagcctc ccctatgccg
     1741 aaggctttgc ttactaagtt tctgagtggc ggagtggcca aaccctagag ctagcagttc
     1801 ccattcaggc aaacaagggc agtggttttg tttgtgtttt tggttgttcc taaagcttgc
     1861 cctttgagta ttatctggag aacccaagct gtctctggat tggcaccctt aaagacagat
     1921 acattggctg gggagtggga acagggaggg gcagaaaacc accaaaaggc cagtgcctca
     1981 actcttgatt ctgatgaggt ttctgggaag agatcaaaat ggagtctcct taccatggac
     2041 aatacatgca aagcaatatc ttgttcaggt tagtacccgc aaaacgggac atagtatgtg
     2101 acaatctgca tcgatcatgg actactaaat gcctttacat agaagggctc tgatttgcac
     2161 aatttgttga aaaatcacaa acccatagaa aagtaagtag gctaagttgg ggaggctcaa
     2221 accattaagg gttaaaaata catcttaaac attggaaagc tcttctagct gaatctgaaa
     2281 tattacccct tgtctagaaa aaggggggca gtcagaacag ctgttcccca ctccgtggtt
     2341 ctcaaaatca taaaccatgg ctactcttgg gaaccacccg gccatgtggt cgccaagtag
     2401 agcaagcccc ctttctcttc ccaatcacgt ggctgagtgt ggatgacttt tattttagga
     2461 gaagggcgat taacactttt gacagtattt tgttttgccc tgatttgggg gattgttttg
     2521 ttttggtggt tgttttggaa aaacagttta taaactgatt tttgtagttt tggtatttaa
     2581 agcaaaaaaa cgaaaaacaa aaaacaaaaa caaacctttt ggtaactgtg cactgtgtcc
     2641 tttagccagg gccgtgccaa cttatgaaga cactgcagct tgagaggggc tttgctgagg
     2701 cttccccttg gccatgtgaa agcccgcctt gttgcctgct ttgtgctttc tgcaccagac
     2761 aacctgatgg aacatttgca cctgagttgt acatttttga agtgtgcagg gcagcctgga
     2821 cacaagctta gattctctat gtatagttcc ccgtgttcac taacatgccc tctctggaaa
     2881 gcatatgtat ataacatgtg tcatgtcctt tggaaacctg gtcacctggt gaaaaccctt
     2941 gggattcttc cctgggcatg actgatgaca atttccattt catcagtttg ttttgttttc
     3001 ctttttcttt aaatcttgga ctttaaaccc tacctgtgtg attcagtagg gtttgagact
     3061 tacgtgtgat actgacaggt aagcaacagt gctagcattc tagattcctg ccttttttta
     3121 aaaagaaatt attctcattg ctgtattata ttggaaaagt tttaaacaac caagctaaag
     3181 ctatgtgaaa gttgagctca aagtagagga aaagttactg gtggtacctt gctgcctgct
     3241 ctgctggtag aattctgtgc tccccgtgac acttagtaca ttaagaatga ctacactgtt
     3301 cctcgtatgt gaaggaggca gtgctgactc cgtgagtgtg agacacgtgc tttgaactgc
     3361 ttttctattc atggagcact ccatagtctc aaactgtccc ccttatgacc aacagcacat
     3421 ttgtgaagag gttcgcaggg ataaggggtg cactttatag ctatggaaac atgagattct
     3481 cctctattgg aagctaatta gcccacaaag gtggtaaacc tgtagattgg gccttaatta
     3541 gcattgtact ctaatcaaag gactctttct aaaccatatt tatagctttc ttaacctaca
     3601 catagtctat acatagatgc atattttacc cccagctggc tagagattta tttgttgtaa
     3661 atgctgtata gatttggttt tcctttcttt acttaccctg gtttggattt tttttttttt
     3721 tcttttgaat ggatttatgc tgtcttagca atatgacaat aatcctctgt agcttgagct
     3781 acccctcccc tgctgtaact tacgtgacct gtgctgtcac tgggcatagg acagcggcat
     3841 cacggttgca ttcccattgg actcatgcac ctcccggatg gtttttgttt ttttcggggg
     3901 ttctttgggg tttgtttgtt tgcttctttt ccagagtgtg gaaagtctac agtgcagaaa
     3961 ggcttgaacc tgccagctga tttgaaatac tttcccctgc gcagggccgt atgcatcctg
     4021 ccaagctgcg ttatattctg tactgtgtac aataaagaag tttgcttttc gtttaccaag
     4081 ca
//
