LOCUS       NM_001261437            2224 bp    mRNA    linear   PRI 11-SEP-2024
DEFINITION  Homo sapiens ETS variant transcription factor 4 (ETV4), transcript
            variant 3, mRNA.
ACCESSION   NM_001261437
VERSION     NM_001261437.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2224)
  AUTHORS   Zhang,J., Wang,Q., Qi,S., Duan,Y., Liu,Z., Liu,J., Zhang,Z. and
            Li,C.
  TITLE     An oncogenic enhancer promotes melanoma progression via regulating
            ETV4 expression
  JOURNAL   J Transl Med 22 (1), 547 (2024)
   PUBMED   38849954
  REMARK    GeneRIF: An oncogenic enhancer promotes melanoma progression via
            regulating ETV4 expression.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2224)
  AUTHORS   Yang,S., Golkaram,M., Oh,S., Oh,Y., Cho,Y., Yoe,J., Ju,S.,
            Lalli,M.A., Park,S.Y., Lee,Y. and Jang,J.
  TITLE     ETV4 is a mechanical transducer linking cell crowding dynamics to
            lineage specification
  JOURNAL   Nat Cell Biol 26 (6), 903-916 (2024)
   PUBMED   38702503
  REMARK    GeneRIF: ETV4 is a mechanical transducer linking cell crowding
            dynamics to lineage specification.
REFERENCE   3  (bases 1 to 2224)
  AUTHORS   Neri,P., Barwick,B.G., Jung,D., Patton,J.C., Maity,R., Tagoug,I.,
            Stein,C.K., Tilmont,R., Leblay,N., Ahn,S., Lee,H., Welsh,S.J.,
            Riggs,D.L., Stong,N., Flynt,E., Thakurta,A., Keats,J.J., Lonial,S.,
            Bergsagel,P.L., Boise,L.H. and Bahlis,N.J.
  TITLE     ETV4-Dependent Transcriptional Plasticity Maintains MYC Expression
            and Results in IMiD Resistance in Multiple Myeloma
  JOURNAL   Blood Cancer Discov 5 (1), 56-73 (2024)
   PUBMED   37934799
  REMARK    GeneRIF: ETV4-Dependent Transcriptional Plasticity Maintains MYC
            Expression and Results in IMiD Resistance in Multiple Myeloma.
REFERENCE   4  (bases 1 to 2224)
  AUTHORS   Yang,P., He,S., Ye,L. and Weng,H.
  TITLE     Transcription Factor ETV4 Activates AURKA to Promote PD-L1
            Expression and Mediate Immune Escape in Lung Adenocarcinoma
  JOURNAL   Int Arch Allergy Immunol 185 (9), 910-920 (2024)
   PUBMED   38781935
  REMARK    GeneRIF: Transcription Factor ETV4 Activates AURKA to Promote PD-L1
            Expression and Mediate Immune Escape in Lung Adenocarcinoma.
REFERENCE   5  (bases 1 to 2224)
  AUTHORS   Tun,K.M., Kitkumthorn,N., Bumalee,D., Arayapisit,T. and
            Lapthanasupkul,P.
  TITLE     Differential expression of PEA3 in odontogenic cysts and tumors
  JOURNAL   J Oral Pathol Med 52 (8), 777-785 (2023)
   PUBMED   37549030
  REMARK    GeneRIF: Differential expression of PEA3 in odontogenic cysts and
            tumors.
REFERENCE   6  (bases 1 to 2224)
  AUTHORS   Friedman,L.S., Ostermeyer,E.A., Lynch,E.D., Welcsh,P., Szabo,C.I.,
            Meza,J.E., Anderson,L.A., Dowd,P., Lee,M.K., Rowell,S.E. et al.
  TITLE     22 genes from chromosome 17q21: cloning, sequencing, and
            characterization of mutations in breast cancer families and tumors
  JOURNAL   Genomics 25 (1), 256-263 (1995)
   PUBMED   7774926
REFERENCE   7  (bases 1 to 2224)
  AUTHORS   Liu,S.H., Peng,B.H., Ma,J.T., Liu,Y.C. and Ng,S.Y.
  TITLE     Serum response element associated transcription factors in mouse
            embryos: serum response factor, YY1, and PEA3 factor
  JOURNAL   Dev Genet 16 (3), 229-240 (1995)
   PUBMED   7796532
REFERENCE   8  (bases 1 to 2224)
  AUTHORS   Friedman,L.S., Ostermeyer,E.A., Lynch,E.D., Szabo,C.I.,
            Anderson,L.A., Dowd,P., Lee,M.K., Rowell,S.E., Boyd,J. and
            King,M.C.
  TITLE     The search for BRCA1
  JOURNAL   Cancer Res 54 (24), 6374-6382 (1994)
   PUBMED   7987831
REFERENCE   9  (bases 1 to 2224)
  AUTHORS   Higashino,F., Yoshida,K., Fujinaga,Y., Kamio,K. and Fujinaga,K.
  TITLE     Isolation of a cDNA encoding the adenovirus E1A enhancer binding
            protein: a new human member of the ets oncogene family
  JOURNAL   Nucleic Acids Res 21 (3), 547-553 (1993)
   PUBMED   8441666
REFERENCE   10 (bases 1 to 2224)
  AUTHORS   Xin,J.H., Cowie,A., Lachance,P. and Hassell,J.A.
  TITLE     Molecular cloning and characterization of PEA3, a new member of the
            Ets oncogene family that is differentially expressed in mouse
            embryonic cells
  JOURNAL   Genes Dev 6 (3), 481-496 (1992)
   PUBMED   1547944
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC068675.17.
            
            On Apr 16, 2019 this sequence version replaced NM_001261437.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK315961.1, SRR18074967.1604758.1
                                           [ECO:0000332]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-156               AC068675.17        112342-112497
            157-250             AC068675.17        113315-113408
            251-298             AC068675.17        113660-113707
            299-352             AC068675.17        122203-122256
            353-479             AC068675.17        124697-124823
            480-641             AC068675.17        125334-125495
            642-907             AC068675.17        125743-126008
            908-982             AC068675.17        128501-128575
            983-1051            AC068675.17        128730-128798
            1052-1224           AC068675.17        129006-129178
            1225-1326           AC068675.17        129446-129547
            1327-2224           AC068675.17        129939-130836
FEATURES             Location/Qualifiers
     source          1..2224
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q21.31"
     gene            1..2224
                     /gene="ETV4"
                     /gene_synonym="E1A-F; E1AF; PEA3; PEAS3"
                     /note="ETS variant transcription factor 4"
                     /db_xref="GeneID:2118"
                     /db_xref="HGNC:HGNC:3493"
                     /db_xref="MIM:600711"
     exon            1..156
                     /gene="ETV4"
                     /gene_synonym="E1A-F; E1AF; PEA3; PEAS3"
                     /inference="alignment:Splign:2.1.0"
     exon            157..250
                     /gene="ETV4"
                     /gene_synonym="E1A-F; E1AF; PEA3; PEAS3"
                     /inference="alignment:Splign:2.1.0"
     CDS             214..1551
                     /gene="ETV4"
                     /gene_synonym="E1A-F; E1AF; PEA3; PEAS3"
                     /note="isoform 2 is encoded by transcript variant 3; ets
                     variant gene 4 (E1A enhancer-binding protein, E1AF); EWS
                     protein/E1A enhancer binding protein chimera; adenovirus
                     E1A enhancer-binding protein; polyomavirus enhancer
                     activator 3 homolog"
                     /codon_start=1
                     /product="ETS translocation variant 4 isoform 2"
                     /protein_id="NP_001248366.1"
                     /db_xref="CCDS:CCDS58553.1"
                     /db_xref="GeneID:2118"
                     /db_xref="HGNC:HGNC:3493"
                     /db_xref="MIM:600711"
                     /translation="MDPGSLPPLDSEDLFQDLSHFQETWLAEAQVPDSDEQFVPDFHS
                     ENLAFHSPTTRIKKEPQSPRTDPALSCSRKPPLPYHHGEQCLYSSAYDPPRQIAIKSP
                     APGALGQSPLQPFPRAEQRNFLRSSGTSQPHPGHGYLGEHSSVFQQPLDICHSFTSQG
                     GGREPLPAPYQHQLSEPCPPYPQQSFKQEYHDPLYEQAGQPAVDQGGVNGHRYPGAGV
                     VIKQEQTDFAYDSDVTGCASMYLHTEGFSGPSPGDGAMGYGYEKPLRPFPDDVCVVPE
                     KFEGDIKQEGVGAFREGPPYQRRGALQLWQFLVALLDDPTNAHFIAWTGRGMEFKLIE
                     PEEVARLWGIQKNRPAMNYDKLSRSLRYYYEKGIMQKVAGERYVYKFVCEPEALFSLA
                     FPDNQRPALKAEFDRPVSEEDTVPLSHLDESPAYLPELAGPAQPFGPKGGYSY"
     exon            251..298
                     /gene="ETV4"
                     /gene_synonym="E1A-F; E1AF; PEA3; PEAS3"
                     /inference="alignment:Splign:2.1.0"
     exon            299..352
                     /gene="ETV4"
                     /gene_synonym="E1A-F; E1AF; PEA3; PEAS3"
                     /inference="alignment:Splign:2.1.0"
     exon            353..479
                     /gene="ETV4"
                     /gene_synonym="E1A-F; E1AF; PEA3; PEAS3"
                     /inference="alignment:Splign:2.1.0"
     exon            480..641
                     /gene="ETV4"
                     /gene_synonym="E1A-F; E1AF; PEA3; PEAS3"
                     /inference="alignment:Splign:2.1.0"
     exon            642..907
                     /gene="ETV4"
                     /gene_synonym="E1A-F; E1AF; PEA3; PEAS3"
                     /inference="alignment:Splign:2.1.0"
     exon            908..982
                     /gene="ETV4"
                     /gene_synonym="E1A-F; E1AF; PEA3; PEAS3"
                     /inference="alignment:Splign:2.1.0"
     exon            983..1051
                     /gene="ETV4"
                     /gene_synonym="E1A-F; E1AF; PEA3; PEAS3"
                     /inference="alignment:Splign:2.1.0"
     exon            1052..1224
                     /gene="ETV4"
                     /gene_synonym="E1A-F; E1AF; PEA3; PEAS3"
                     /inference="alignment:Splign:2.1.0"
     exon            1225..1326
                     /gene="ETV4"
                     /gene_synonym="E1A-F; E1AF; PEA3; PEAS3"
                     /inference="alignment:Splign:2.1.0"
     exon            1327..2224
                     /gene="ETV4"
                     /gene_synonym="E1A-F; E1AF; PEA3; PEAS3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2202..2207
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ETV4"
                     /gene_synonym="E1A-F; E1AF; PEA3; PEAS3"
                     /note="hexamer: AATAAA"
     polyA_site      2224
                     /gene="ETV4"
                     /gene_synonym="E1A-F; E1AF; PEA3; PEAS3"
                     /note="major polyA site"
ORIGIN      
        1 gctcacaact gtctgctgcg cccgaaaaac aagtcggtgc gctggggacc cggggccggg
       61 gccgccttac tccggcctag ccccgcggcc ctcggtgcgg gctccagggc atgctcggga
      121 ccccccgcgg ctccagccca gacgccccgg cctcagaaat cgcccggaaa tgggagcttg
      181 cgcgaagcgc tgatcggccc gctggggaag ctcatggacc cgggctccct gccgcccctc
      241 gactctgaag atctcttcca ggatctaagt cacttccagg agacgtggct cgctgaagct
      301 caggtaccag acagtgatga gcagtttgtt cctgatttcc attcagaaaa cctagctttc
      361 cacagcccca ccaccaggat caagaaggag ccccagagtc cccgcacaga cccggccctg
      421 tcctgcagca ggaagccgcc actcccctac caccatggcg agcagtgcct ttactccagt
      481 gcctatgacc cccccagaca aatcgccatc aagtcccctg cccctggtgc ccttggacag
      541 tcgcccctac agccctttcc ccgggcagag caacggaatt tcctgagatc ctctggcacc
      601 tcccagcccc accctggcca tgggtacctc ggggaacata gctccgtctt ccagcagccc
      661 ctggacattt gccactcctt cacatctcag ggagggggcc gggaacccct cccagccccc
      721 taccaacacc agctgtcgga gccctgccca ccctatcccc agcagagctt taagcaagaa
      781 taccatgatc ccctgtatga acaggcgggc cagccagccg tggaccaggg tggggtcaat
      841 gggcacaggt acccaggggc gggggtggtg atcaaacagg aacagacgga cttcgcctac
      901 gactcagatg tcaccgggtg cgcatcaatg tacctccaca cagagggctt ctctgggccc
      961 tctccaggtg acggggccat gggctatggc tatgagaaac ctctgcgacc attcccagat
     1021 gatgtctgcg ttgtccctga gaaatttgaa ggagacatca agcaggaagg ggtcggtgca
     1081 tttcgagagg ggccgcccta ccagcgccgg ggtgccctgc agctgtggca atttctggtg
     1141 gccttgctgg atgacccaac aaatgcccat ttcattgcct ggacgggccg gggaatggag
     1201 ttcaagctca ttgagcctga ggaggtcgcc aggctctggg gcatccagaa gaaccggcca
     1261 gccatgaatt acgacaagct gagccgctcg ctccgatact attatgagaa aggcatcatg
     1321 cagaaggtgg ctggtgagcg ttacgtgtac aagtttgtgt gtgagcccga ggccctcttc
     1381 tctttggcct tcccggacaa tcagcgtcca gctctcaagg ctgagtttga ccggcctgtc
     1441 agtgaggagg acacagtccc tttgtcccac ttggatgaga gccccgccta cctcccagag
     1501 ctggctggcc ccgcccagcc atttggcccc aagggtggct actcttacta gcccccagcg
     1561 gctgttcccc ctgccgcagg tgggtgctgc cctgtgtaca tataaatgaa tctggtgttg
     1621 gggaaacctt catctgaaac ccacagatgt ctctggggca gatccccact gtcctaccag
     1681 ttgccctagc ccagactctg agctgctcac cggagtcatt gggaaggaaa agtggagaaa
     1741 tggcaagtct agagtctcag aaactcccct gggggtttca cctgggccct ggaggaattc
     1801 agctcagctt cttcctaggt ccaagccccc cacacctttt ccccaaccac agagaacaag
     1861 agtttgttct gttctggggg acagagaagg cgcttcccaa cttcatactg gcaggagggt
     1921 gaggaggttc actgagctcc ccagatctcc cactgcgggg agacagaagc ctggactctg
     1981 ccccacgctg tggccctgga gggtcccggt ttgtcagttc ttggtgctct gtgttcccag
     2041 aggcaggcgg aggttgaaga aaggaacctg ggatgagggg tgctgggtat aagcagagag
     2101 ggatgggttc ctgctccaag ggaccctttg cctttcttct gccctttcct aggcccaggc
     2161 ctgggtttgt acttccacct ccaccacatc tgccagacct taataaaggc ccccacttct
     2221 ccca
//
