LOCUS       NM_001079675            2335 bp    mRNA    linear   PRI 11-SEP-2024
DEFINITION  Homo sapiens ETS variant transcription factor 4 (ETV4), transcript
            variant 2, mRNA.
ACCESSION   NM_001079675
VERSION     NM_001079675.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2335)
  AUTHORS   Zhang,J., Wang,Q., Qi,S., Duan,Y., Liu,Z., Liu,J., Zhang,Z. and
            Li,C.
  TITLE     An oncogenic enhancer promotes melanoma progression via regulating
            ETV4 expression
  JOURNAL   J Transl Med 22 (1), 547 (2024)
   PUBMED   38849954
  REMARK    GeneRIF: An oncogenic enhancer promotes melanoma progression via
            regulating ETV4 expression.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2335)
  AUTHORS   Yang,S., Golkaram,M., Oh,S., Oh,Y., Cho,Y., Yoe,J., Ju,S.,
            Lalli,M.A., Park,S.Y., Lee,Y. and Jang,J.
  TITLE     ETV4 is a mechanical transducer linking cell crowding dynamics to
            lineage specification
  JOURNAL   Nat Cell Biol 26 (6), 903-916 (2024)
   PUBMED   38702503
  REMARK    GeneRIF: ETV4 is a mechanical transducer linking cell crowding
            dynamics to lineage specification.
REFERENCE   3  (bases 1 to 2335)
  AUTHORS   Neri,P., Barwick,B.G., Jung,D., Patton,J.C., Maity,R., Tagoug,I.,
            Stein,C.K., Tilmont,R., Leblay,N., Ahn,S., Lee,H., Welsh,S.J.,
            Riggs,D.L., Stong,N., Flynt,E., Thakurta,A., Keats,J.J., Lonial,S.,
            Bergsagel,P.L., Boise,L.H. and Bahlis,N.J.
  TITLE     ETV4-Dependent Transcriptional Plasticity Maintains MYC Expression
            and Results in IMiD Resistance in Multiple Myeloma
  JOURNAL   Blood Cancer Discov 5 (1), 56-73 (2024)
   PUBMED   37934799
  REMARK    GeneRIF: ETV4-Dependent Transcriptional Plasticity Maintains MYC
            Expression and Results in IMiD Resistance in Multiple Myeloma.
REFERENCE   4  (bases 1 to 2335)
  AUTHORS   Yang,P., He,S., Ye,L. and Weng,H.
  TITLE     Transcription Factor ETV4 Activates AURKA to Promote PD-L1
            Expression and Mediate Immune Escape in Lung Adenocarcinoma
  JOURNAL   Int Arch Allergy Immunol 185 (9), 910-920 (2024)
   PUBMED   38781935
  REMARK    GeneRIF: Transcription Factor ETV4 Activates AURKA to Promote PD-L1
            Expression and Mediate Immune Escape in Lung Adenocarcinoma.
REFERENCE   5  (bases 1 to 2335)
  AUTHORS   Tun,K.M., Kitkumthorn,N., Bumalee,D., Arayapisit,T. and
            Lapthanasupkul,P.
  TITLE     Differential expression of PEA3 in odontogenic cysts and tumors
  JOURNAL   J Oral Pathol Med 52 (8), 777-785 (2023)
   PUBMED   37549030
  REMARK    GeneRIF: Differential expression of PEA3 in odontogenic cysts and
            tumors.
REFERENCE   6  (bases 1 to 2335)
  AUTHORS   Friedman,L.S., Ostermeyer,E.A., Lynch,E.D., Welcsh,P., Szabo,C.I.,
            Meza,J.E., Anderson,L.A., Dowd,P., Lee,M.K., Rowell,S.E. et al.
  TITLE     22 genes from chromosome 17q21: cloning, sequencing, and
            characterization of mutations in breast cancer families and tumors
  JOURNAL   Genomics 25 (1), 256-263 (1995)
   PUBMED   7774926
REFERENCE   7  (bases 1 to 2335)
  AUTHORS   Liu,S.H., Peng,B.H., Ma,J.T., Liu,Y.C. and Ng,S.Y.
  TITLE     Serum response element associated transcription factors in mouse
            embryos: serum response factor, YY1, and PEA3 factor
  JOURNAL   Dev Genet 16 (3), 229-240 (1995)
   PUBMED   7796532
REFERENCE   8  (bases 1 to 2335)
  AUTHORS   Friedman,L.S., Ostermeyer,E.A., Lynch,E.D., Szabo,C.I.,
            Anderson,L.A., Dowd,P., Lee,M.K., Rowell,S.E., Boyd,J. and
            King,M.C.
  TITLE     The search for BRCA1
  JOURNAL   Cancer Res 54 (24), 6374-6382 (1994)
   PUBMED   7987831
REFERENCE   9  (bases 1 to 2335)
  AUTHORS   Higashino,F., Yoshida,K., Fujinaga,Y., Kamio,K. and Fujinaga,K.
  TITLE     Isolation of a cDNA encoding the adenovirus E1A enhancer binding
            protein: a new human member of the ets oncogene family
  JOURNAL   Nucleic Acids Res 21 (3), 547-553 (1993)
   PUBMED   8441666
REFERENCE   10 (bases 1 to 2335)
  AUTHORS   Xin,J.H., Cowie,A., Lachance,P. and Hassell,J.A.
  TITLE     Molecular cloning and characterization of PEA3, a new member of the
            Ets oncogene family that is differentially expressed in mouse
            embryonic cells
  JOURNAL   Genes Dev 6 (3), 481-496 (1992)
   PUBMED   1547944
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC068675.17.
            
            On Apr 16, 2019 this sequence version replaced NM_001079675.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U18018.1, SRR14372080.4614419.1
                                           [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000319349.10/ ENSP00000321835.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-156               AC068675.17        112342-112497
            157-267             AC068675.17        113014-113124
            268-361             AC068675.17        113315-113408
            362-409             AC068675.17        113660-113707
            410-463             AC068675.17        122203-122256
            464-590             AC068675.17        124697-124823
            591-752             AC068675.17        125334-125495
            753-1018            AC068675.17        125743-126008
            1019-1093           AC068675.17        128501-128575
            1094-1162           AC068675.17        128730-128798
            1163-1335           AC068675.17        129006-129178
            1336-1437           AC068675.17        129446-129547
            1438-2335           AC068675.17        129939-130836
FEATURES             Location/Qualifiers
     source          1..2335
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q21.31"
     gene            1..2335
                     /gene="ETV4"
                     /gene_synonym="E1A-F; E1AF; PEA3; PEAS3"
                     /note="ETS variant transcription factor 4"
                     /db_xref="GeneID:2118"
                     /db_xref="HGNC:HGNC:3493"
                     /db_xref="MIM:600711"
     exon            1..156
                     /gene="ETV4"
                     /gene_synonym="E1A-F; E1AF; PEA3; PEAS3"
                     /inference="alignment:Splign:2.1.0"
     exon            157..267
                     /gene="ETV4"
                     /gene_synonym="E1A-F; E1AF; PEA3; PEAS3"
                     /inference="alignment:Splign:2.1.0"
     CDS             208..1662
                     /gene="ETV4"
                     /gene_synonym="E1A-F; E1AF; PEA3; PEAS3"
                     /note="isoform 1 is encoded by transcript variant 2; ets
                     variant gene 4 (E1A enhancer-binding protein, E1AF); EWS
                     protein/E1A enhancer binding protein chimera; adenovirus
                     E1A enhancer-binding protein; polyomavirus enhancer
                     activator 3 homolog"
                     /codon_start=1
                     /product="ETS translocation variant 4 isoform 1"
                     /protein_id="NP_001073143.1"
                     /db_xref="CCDS:CCDS11465.1"
                     /db_xref="GeneID:2118"
                     /db_xref="HGNC:HGNC:3493"
                     /db_xref="MIM:600711"
                     /translation="MERRMKAGYLDQQVPYTFSSKSPGNGSLREALIGPLGKLMDPGS
                     LPPLDSEDLFQDLSHFQETWLAEAQVPDSDEQFVPDFHSENLAFHSPTTRIKKEPQSP
                     RTDPALSCSRKPPLPYHHGEQCLYSSAYDPPRQIAIKSPAPGALGQSPLQPFPRAEQR
                     NFLRSSGTSQPHPGHGYLGEHSSVFQQPLDICHSFTSQGGGREPLPAPYQHQLSEPCP
                     PYPQQSFKQEYHDPLYEQAGQPAVDQGGVNGHRYPGAGVVIKQEQTDFAYDSDVTGCA
                     SMYLHTEGFSGPSPGDGAMGYGYEKPLRPFPDDVCVVPEKFEGDIKQEGVGAFREGPP
                     YQRRGALQLWQFLVALLDDPTNAHFIAWTGRGMEFKLIEPEEVARLWGIQKNRPAMNY
                     DKLSRSLRYYYEKGIMQKVAGERYVYKFVCEPEALFSLAFPDNQRPALKAEFDRPVSE
                     EDTVPLSHLDESPAYLPELAGPAQPFGPKGGYSY"
     exon            268..361
                     /gene="ETV4"
                     /gene_synonym="E1A-F; E1AF; PEA3; PEAS3"
                     /inference="alignment:Splign:2.1.0"
     exon            362..409
                     /gene="ETV4"
                     /gene_synonym="E1A-F; E1AF; PEA3; PEAS3"
                     /inference="alignment:Splign:2.1.0"
     exon            410..463
                     /gene="ETV4"
                     /gene_synonym="E1A-F; E1AF; PEA3; PEAS3"
                     /inference="alignment:Splign:2.1.0"
     exon            464..590
                     /gene="ETV4"
                     /gene_synonym="E1A-F; E1AF; PEA3; PEAS3"
                     /inference="alignment:Splign:2.1.0"
     exon            591..752
                     /gene="ETV4"
                     /gene_synonym="E1A-F; E1AF; PEA3; PEAS3"
                     /inference="alignment:Splign:2.1.0"
     exon            753..1018
                     /gene="ETV4"
                     /gene_synonym="E1A-F; E1AF; PEA3; PEAS3"
                     /inference="alignment:Splign:2.1.0"
     exon            1019..1093
                     /gene="ETV4"
                     /gene_synonym="E1A-F; E1AF; PEA3; PEAS3"
                     /inference="alignment:Splign:2.1.0"
     exon            1094..1162
                     /gene="ETV4"
                     /gene_synonym="E1A-F; E1AF; PEA3; PEAS3"
                     /inference="alignment:Splign:2.1.0"
     exon            1163..1335
                     /gene="ETV4"
                     /gene_synonym="E1A-F; E1AF; PEA3; PEAS3"
                     /inference="alignment:Splign:2.1.0"
     exon            1336..1437
                     /gene="ETV4"
                     /gene_synonym="E1A-F; E1AF; PEA3; PEAS3"
                     /inference="alignment:Splign:2.1.0"
     exon            1438..2335
                     /gene="ETV4"
                     /gene_synonym="E1A-F; E1AF; PEA3; PEAS3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2313..2318
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ETV4"
                     /gene_synonym="E1A-F; E1AF; PEA3; PEAS3"
                     /note="hexamer: AATAAA"
     polyA_site      2335
                     /gene="ETV4"
                     /gene_synonym="E1A-F; E1AF; PEA3; PEAS3"
                     /note="major polyA site"
ORIGIN      
        1 gctcacaact gtctgctgcg cccgaaaaac aagtcggtgc gctggggacc cggggccggg
       61 gccgccttac tccggcctag ccccgcggcc ctcggtgcgg gctccagggc atgctcggga
      121 ccccccgcgg ctccagccca gacgccccgg cctcaggtct cggcccccgc ttggggcccc
      181 ggccgtgcgg ccggagggag cggccggatg gagcggagga tgaaagccgg atacttggac
      241 cagcaagtgc cctacacctt cagcagcaaa tcgcccggaa atgggagctt gcgcgaagcg
      301 ctgatcggcc cgctggggaa gctcatggac ccgggctccc tgccgcccct cgactctgaa
      361 gatctcttcc aggatctaag tcacttccag gagacgtggc tcgctgaagc tcaggtacca
      421 gacagtgatg agcagtttgt tcctgatttc cattcagaaa acctagcttt ccacagcccc
      481 accaccagga tcaagaagga gccccagagt ccccgcacag acccggccct gtcctgcagc
      541 aggaagccgc cactccccta ccaccatggc gagcagtgcc tttactccag tgcctatgac
      601 ccccccagac aaatcgccat caagtcccct gcccctggtg cccttggaca gtcgccccta
      661 cagccctttc cccgggcaga gcaacggaat ttcctgagat cctctggcac ctcccagccc
      721 caccctggcc atgggtacct cggggaacat agctccgtct tccagcagcc cctggacatt
      781 tgccactcct tcacatctca gggagggggc cgggaacccc tcccagcccc ctaccaacac
      841 cagctgtcgg agccctgccc accctatccc cagcagagct ttaagcaaga ataccatgat
      901 cccctgtatg aacaggcggg ccagccagcc gtggaccagg gtggggtcaa tgggcacagg
      961 tacccagggg cgggggtggt gatcaaacag gaacagacgg acttcgccta cgactcagat
     1021 gtcaccgggt gcgcatcaat gtacctccac acagagggct tctctgggcc ctctccaggt
     1081 gacggggcca tgggctatgg ctatgagaaa cctctgcgac cattcccaga tgatgtctgc
     1141 gttgtccctg agaaatttga aggagacatc aagcaggaag gggtcggtgc atttcgagag
     1201 gggccgccct accagcgccg gggtgccctg cagctgtggc aatttctggt ggccttgctg
     1261 gatgacccaa caaatgccca tttcattgcc tggacgggcc ggggaatgga gttcaagctc
     1321 attgagcctg aggaggtcgc caggctctgg ggcatccaga agaaccggcc agccatgaat
     1381 tacgacaagc tgagccgctc gctccgatac tattatgaga aaggcatcat gcagaaggtg
     1441 gctggtgagc gttacgtgta caagtttgtg tgtgagcccg aggccctctt ctctttggcc
     1501 ttcccggaca atcagcgtcc agctctcaag gctgagtttg accggcctgt cagtgaggag
     1561 gacacagtcc ctttgtccca cttggatgag agccccgcct acctcccaga gctggctggc
     1621 cccgcccagc catttggccc caagggtggc tactcttact agcccccagc ggctgttccc
     1681 cctgccgcag gtgggtgctg ccctgtgtac atataaatga atctggtgtt ggggaaacct
     1741 tcatctgaaa cccacagatg tctctggggc agatccccac tgtcctacca gttgccctag
     1801 cccagactct gagctgctca ccggagtcat tgggaaggaa aagtggagaa atggcaagtc
     1861 tagagtctca gaaactcccc tgggggtttc acctgggccc tggaggaatt cagctcagct
     1921 tcttcctagg tccaagcccc ccacaccttt tccccaacca cagagaacaa gagtttgttc
     1981 tgttctgggg gacagagaag gcgcttccca acttcatact ggcaggaggg tgaggaggtt
     2041 cactgagctc cccagatctc ccactgcggg gagacagaag cctggactct gccccacgct
     2101 gtggccctgg agggtcccgg tttgtcagtt cttggtgctc tgtgttccca gaggcaggcg
     2161 gaggttgaag aaaggaacct gggatgaggg gtgctgggta taagcagaga gggatgggtt
     2221 cctgctccaa gggacccttt gcctttcttc tgccctttcc taggcccagg cctgggtttg
     2281 tacttccacc tccaccacat ctgccagacc ttaataaagg cccccacttc tccca
//
