LOCUS       NM_005240               1460 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens ETS variant transcription factor 3 (ETV3), transcript
            variant 2, mRNA.
ACCESSION   NM_005240
VERSION     NM_005240.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1460)
  AUTHORS   Villar,J., Cros,A., De Juan,A., Alaoui,L., Bonte,P.E., Lau,C.M.,
            Tiniakou,I., Reizis,B. and Segura,E.
  TITLE     ETV3 and ETV6 enable monocyte differentiation into dendritic cells
            by repressing macrophage fate commitment
  JOURNAL   Nat Immunol 24 (1), 84-95 (2023)
   PUBMED   36543959
  REMARK    GeneRIF: ETV3 and ETV6 enable monocyte differentiation into
            dendritic cells by repressing macrophage fate commitment.
REFERENCE   2  (bases 1 to 1460)
  AUTHORS   Davick,J.J., Kim,J., Wick,M.R. and Gru,A.A.
  TITLE     Indeterminate Dendritic Cell Tumor: A Report of Two New Cases
            Lacking the ETV3-NCOA2 Translocation and a Literature Review
  JOURNAL   Am J Dermatopathol 40 (10), 736-748 (2018)
   PUBMED   29877893
  REMARK    GeneRIF: Case Reports/Review: indeterminate dendritic cell tumor
            lacking the ETV3-NCOA2 translocation.
            Review article
REFERENCE   3  (bases 1 to 1460)
  AUTHORS   Yin,Y., Morgunova,E., Jolma,A., Kaasinen,E., Sahu,B.,
            Khund-Sayeed,S., Das,P.K., Kivioja,T., Dave,K., Zhong,F.,
            Nitta,K.R., Taipale,M., Popov,A., Ginno,P.A., Domcke,S., Yan,J.,
            Schubeler,D., Vinson,C. and Taipale,J.
  TITLE     Impact of cytosine methylation on DNA binding specificities of
            human transcription factors
  JOURNAL   Science 356 (6337) (2017)
   PUBMED   28473536
REFERENCE   4  (bases 1 to 1460)
  AUTHORS   Mesquita,B., Lopes,P., Rodrigues,A., Pereira,D., Afonso,M.,
            Leal,C., Henrique,R., Lind,G.E., Jeronimo,C., Lothe,R.A. and
            Teixeira,M.R.
  TITLE     Frequent copy number gains at 1q21 and 1q32 are associated with
            overexpression of the ETS transcription factors ETV3 and ELF3 in
            breast cancer irrespective of molecular subtypes
  JOURNAL   Breast Cancer Res Treat 138 (1), 37-45 (2013)
   PUBMED   23329352
  REMARK    GeneRIF: Frequent copy number gains at 1q21 and 1q32 are associated
            with overexpression of the ETS transcription factors ETV3 and ELF3
            in breast cancer irrespective of molecular subtypes.
REFERENCE   5  (bases 1 to 1460)
  AUTHORS   Vaquerizas,J.M., Kummerfeld,S.K., Teichmann,S.A. and Luscombe,N.M.
  TITLE     A census of human transcription factors: function, expression and
            evolution
  JOURNAL   Nat Rev Genet 10 (4), 252-263 (2009)
   PUBMED   19274049
  REMARK    Review article
REFERENCE   6  (bases 1 to 1460)
  AUTHORS   El Kasmi,K.C., Smith,A.M., Williams,L., Neale,G., Panopoulos,A.D.,
            Watowich,S.S., Hacker,H., Foxwell,B.M. and Murray,P.J.
  TITLE     Cutting edge: A transcriptional repressor and corepressor induced
            by the STAT3-regulated anti-inflammatory signaling pathway
  JOURNAL   J Immunol 179 (11), 7215-7219 (2007)
   PUBMED   18025162
  REMARK    GeneRIF: The ETV3 expression was strongly induced by the STAT3
            pathway regulated by IL-10 but not by STAT3 signaling activated by
            IL-6, which cannot activate the anti-inflammatory signaling
            pathway.
            Erratum:[J Immunol. 2008 Mar 1;180(5):3612. Panopolous, Athanasia
            [corrected to Panopoulos, Athanasia D]]
REFERENCE   7  (bases 1 to 1460)
  AUTHORS   Hester,K.D., Verhelle,D., Escoubet-Lozach,L., Luna,R., Rose,D.W.
            and Glass,C.K.
  TITLE     Differential repression of c-myc and cdc2 gene expression by ERF
            and PE-1/METS
  JOURNAL   Cell Cycle 6 (13), 1594-1604 (2007)
   PUBMED   17525531
  REMARK    GeneRIF: Differential repression of c-myc and cdc2 gene expression
            by ERF and PE-1/METS.
REFERENCE   8  (bases 1 to 1460)
  AUTHORS   Sawka-Verhelle,D., Escoubet-Lozach,L., Fong,A.L., Hester,K.D.,
            Herzig,S., Lebrun,P. and Glass,C.K.
  TITLE     PE-1/METS, an antiproliferative Ets repressor factor, is induced by
            CREB-1/CREM-1 during macrophage differentiation
  JOURNAL   J Biol Chem 279 (17), 17772-17784 (2004)
   PUBMED   14754893
  REMARK    GeneRIF: PE-1/METS is an antiproliferative Ets repressor factor
            induced by CREB-1/CREM-1 during macrophage differentiation
REFERENCE   9  (bases 1 to 1460)
  AUTHORS   Klappacher,G.W., Lunyak,V.V., Sykes,D.B., Sawka-Verhelle,D.,
            Sage,J., Brard,G., Ngo,S.D., Gangadharan,D., Jacks,T., Kamps,M.P.,
            Rose,D.W., Rosenfeld,M.G. and Glass,C.K.
  TITLE     An induced Ets repressor complex regulates growth arrest during
            terminal macrophage differentiation
  JOURNAL   Cell 109 (2), 169-180 (2002)
   PUBMED   12007404
REFERENCE   10 (bases 1 to 1460)
  AUTHORS   Klemsz,M., Hromas,R., Raskind,W., Bruno,E. and Hoffman,R.
  TITLE     PE-1, a novel ETS oncogene family member, localizes to chromosome
            1q21-q23
  JOURNAL   Genomics 20 (2), 291-294 (1994)
   PUBMED   8020980
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL157713.10 and BC022868.1.
            
            On Aug 13, 2020 this sequence version replaced NM_005240.2.
            
            Transcript Variant: This variant (2) represents a shorter
            transcript, compared to transcript variant 1. The predicted protein
            (isoform 2) is shorter and has a distinct C-terminus compared to
            isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC022868.1, SRR5189661.174354.1
                                           [ECO:0000332]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-10                AL157713.10        135919-135928       c
            11-1421             BC022868.1         5-1415
            1422-1460           AL157713.10        130678-130716       c
FEATURES             Location/Qualifiers
     source          1..1460
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q23.1"
     gene            1..1460
                     /gene="ETV3"
                     /gene_synonym="METS; PE-1; PE1"
                     /note="ETS variant transcription factor 3"
                     /db_xref="GeneID:2117"
                     /db_xref="HGNC:HGNC:3492"
                     /db_xref="MIM:164873"
     exon            1..80
                     /gene="ETV3"
                     /gene_synonym="METS; PE-1; PE1"
                     /inference="alignment:Splign:2.1.0"
     exon            81..139
                     /gene="ETV3"
                     /gene_synonym="METS; PE-1; PE1"
                     /inference="alignment:Splign:2.1.0"
     CDS             94..525
                     /gene="ETV3"
                     /gene_synonym="METS; PE-1; PE1"
                     /note="isoform 2 is encoded by transcript variant 2; ets
                     variant gene 3, ETS family transcriptional repressor; ETS
                     domain transcriptional repressor PE1; mitogenic Ets
                     transcriptional suppressor"
                     /codon_start=1
                     /product="ETS translocation variant 3 isoform 2"
                     /protein_id="NP_005231.1"
                     /db_xref="CCDS:CCDS1164.1"
                     /db_xref="GeneID:2117"
                     /db_xref="HGNC:HGNC:3492"
                     /db_xref="MIM:164873"
                     /translation="MKAGCSIVEKPEGGGGYQFPDWAYKTESSPGSRQIQLWHFILEL
                     LQKEEFRHVIAWQQGEYGEFVIKDPDEVARLWGRRKCKPQMNYDKLSRALRYYYNKRI
                     LHKTKGKRFTYKFNFNKLVMPNYPFINIRSSGKIQTLLVGN"
     exon            140..377
                     /gene="ETV3"
                     /gene_synonym="METS; PE-1; PE1"
                     /inference="alignment:Splign:2.1.0"
     exon            378..1460
                     /gene="ETV3"
                     /gene_synonym="METS; PE-1; PE1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1406..1411
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ETV3"
                     /gene_synonym="METS; PE-1; PE1"
                     /note="hexamer: AATAGA"
     polyA_site      1424
                     /gene="ETV3"
                     /gene_synonym="METS; PE-1; PE1"
                     /note="major polyA site"
     regulatory      1433..1438
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ETV3"
                     /gene_synonym="METS; PE-1; PE1"
                     /note="hexamer: AATAAA"
     polyA_site      1460
                     /gene="ETV3"
                     /gene_synonym="METS; PE-1; PE1"
                     /note="major polyA site"
ORIGIN      
        1 acttcctgct ggggtggatg aggaggagcc ggagacgccg cggaggagac cggaccgaag
       61 acggaccgtg ccgggaagag caggcgggtg aaaatgaaag ccggctgtag catcgtggaa
      121 aagccagaag gaggtggagg gtatcagttt cctgactggg cctacaaaac agagtcatcc
      181 ccaggctccc ggcagatcca gctgtggcac ttcatcctgg agctgctgca gaaggaagag
      241 ttccgccatg tcatcgcctg gcagcaggga gagtacgggg aatttgtcat caaggatcca
      301 gatgaggtgg cccgcctctg gggccgcagg aaatgcaaac cacagatgaa ttatgacaag
      361 ctgagccggg ccctcagata ctattacaac aagaggatcc ttcataaaac aaaagggaaa
      421 agatttacct ataaatttaa cttcaacaag ctggtgatgc ccaactaccc attcatcaac
      481 attcggtcaa gtggtaagat acaaactctt ttggtaggga attaattttg aattgaaaag
      541 aatttttaaa aatccaaatc taagacatgg catgtttagg aagattttag aaacactaaa
      601 ataatgtgat cctttggatt gcctcaatgt tcttactcaa gtcatctcac ttataaggag
      661 agttataggc tattcagtat caagatagat ttctttggtt tatttggttg gttccctttt
      721 ctgcatattg tttgtaatct cctagatact attacgctat cttgtttggg aatgatgttt
      781 cataggtttg tgatgatctt tacgttcagg actcagtttt aacacccagc ccagtggttc
      841 tttcatagat gggaacctgt ttctacaaac acttccgatt ttctgtgaaa ctaccaagct
      901 ctcccttatc aagtgaatat catcaaaacc acagcatcct tgatcagaga agggggaggt
      961 tcacatgttt gcagtgaaaa gcagtgtctt tgatctgcaa cagcaaatcc tcagagaaaa
     1021 agattctggg gttacttgac cttctctcct gttaagtgca gtagggcttc ccctcttgac
     1081 tttcctggtt atagctttcc atcacagctc cccacattct ctcttgatgt tgaaagcagt
     1141 ctctcaaaag actttgttgt tgtgtggttt tttgtttgtg atttttttcc ttatgcaaat
     1201 catactcctg cccaagaaaa tacagtagtt ccccttatct gagcagtata tgttctaaga
     1261 cccctagtag attcgcaaac cacagatagt accaaactcc attcatatat atgatgtttt
     1321 ttcttccctt aaccccactc atatgtatct gtgataacgt ttaatttata aattaggcac
     1381 agtaagagat taatgacaat aataaaatag aaaaattata acaatatgct gtaataaact
     1441 taatgtggtc tttctcaaaa
//
