LOCUS       NP_001138784             512 aa            linear   PRI 05-APR-2024
DEFINITION  ETS translocation variant 3 isoform 1 [Homo sapiens].
ACCESSION   NP_001138784
VERSION     NP_001138784.1
DBSOURCE    REFSEQ: accession NM_001145312.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 512)
  AUTHORS   Villar,J., Cros,A., De Juan,A., Alaoui,L., Bonte,P.E., Lau,C.M.,
            Tiniakou,I., Reizis,B. and Segura,E.
  TITLE     ETV3 and ETV6 enable monocyte differentiation into dendritic cells
            by repressing macrophage fate commitment
  JOURNAL   Nat Immunol 24 (1), 84-95 (2023)
   PUBMED   36543959
  REMARK    GeneRIF: ETV3 and ETV6 enable monocyte differentiation into
            dendritic cells by repressing macrophage fate commitment.
REFERENCE   2  (residues 1 to 512)
  AUTHORS   Davick,J.J., Kim,J., Wick,M.R. and Gru,A.A.
  TITLE     Indeterminate Dendritic Cell Tumor: A Report of Two New Cases
            Lacking the ETV3-NCOA2 Translocation and a Literature Review
  JOURNAL   Am J Dermatopathol 40 (10), 736-748 (2018)
   PUBMED   29877893
  REMARK    GeneRIF: Case Reports/Review: indeterminate dendritic cell tumor
            lacking the ETV3-NCOA2 translocation.
            Review article
REFERENCE   3  (residues 1 to 512)
  AUTHORS   Yin,Y., Morgunova,E., Jolma,A., Kaasinen,E., Sahu,B.,
            Khund-Sayeed,S., Das,P.K., Kivioja,T., Dave,K., Zhong,F.,
            Nitta,K.R., Taipale,M., Popov,A., Ginno,P.A., Domcke,S., Yan,J.,
            Schubeler,D., Vinson,C. and Taipale,J.
  TITLE     Impact of cytosine methylation on DNA binding specificities of
            human transcription factors
  JOURNAL   Science 356 (6337) (2017)
   PUBMED   28473536
REFERENCE   4  (residues 1 to 512)
  AUTHORS   Mesquita,B., Lopes,P., Rodrigues,A., Pereira,D., Afonso,M.,
            Leal,C., Henrique,R., Lind,G.E., Jeronimo,C., Lothe,R.A. and
            Teixeira,M.R.
  TITLE     Frequent copy number gains at 1q21 and 1q32 are associated with
            overexpression of the ETS transcription factors ETV3 and ELF3 in
            breast cancer irrespective of molecular subtypes
  JOURNAL   Breast Cancer Res Treat 138 (1), 37-45 (2013)
   PUBMED   23329352
  REMARK    GeneRIF: Frequent copy number gains at 1q21 and 1q32 are associated
            with overexpression of the ETS transcription factors ETV3 and ELF3
            in breast cancer irrespective of molecular subtypes.
REFERENCE   5  (residues 1 to 512)
  AUTHORS   Vaquerizas,J.M., Kummerfeld,S.K., Teichmann,S.A. and Luscombe,N.M.
  TITLE     A census of human transcription factors: function, expression and
            evolution
  JOURNAL   Nat Rev Genet 10 (4), 252-263 (2009)
   PUBMED   19274049
  REMARK    Review article
REFERENCE   6  (residues 1 to 512)
  AUTHORS   El Kasmi,K.C., Smith,A.M., Williams,L., Neale,G., Panopoulos,A.D.,
            Watowich,S.S., Hacker,H., Foxwell,B.M. and Murray,P.J.
  TITLE     Cutting edge: A transcriptional repressor and corepressor induced
            by the STAT3-regulated anti-inflammatory signaling pathway
  JOURNAL   J Immunol 179 (11), 7215-7219 (2007)
   PUBMED   18025162
  REMARK    GeneRIF: The ETV3 expression was strongly induced by the STAT3
            pathway regulated by IL-10 but not by STAT3 signaling activated by
            IL-6, which cannot activate the anti-inflammatory signaling
            pathway.
            Erratum:[J Immunol. 2008 Mar 1;180(5):3612. Panopolous, Athanasia
            [corrected to Panopoulos, Athanasia D]]
REFERENCE   7  (residues 1 to 512)
  AUTHORS   Hester,K.D., Verhelle,D., Escoubet-Lozach,L., Luna,R., Rose,D.W.
            and Glass,C.K.
  TITLE     Differential repression of c-myc and cdc2 gene expression by ERF
            and PE-1/METS
  JOURNAL   Cell Cycle 6 (13), 1594-1604 (2007)
   PUBMED   17525531
  REMARK    GeneRIF: Differential repression of c-myc and cdc2 gene expression
            by ERF and PE-1/METS.
REFERENCE   8  (residues 1 to 512)
  AUTHORS   Sawka-Verhelle,D., Escoubet-Lozach,L., Fong,A.L., Hester,K.D.,
            Herzig,S., Lebrun,P. and Glass,C.K.
  TITLE     PE-1/METS, an antiproliferative Ets repressor factor, is induced by
            CREB-1/CREM-1 during macrophage differentiation
  JOURNAL   J Biol Chem 279 (17), 17772-17784 (2004)
   PUBMED   14754893
  REMARK    GeneRIF: PE-1/METS is an antiproliferative Ets repressor factor
            induced by CREB-1/CREM-1 during macrophage differentiation
REFERENCE   9  (residues 1 to 512)
  AUTHORS   Klappacher,G.W., Lunyak,V.V., Sykes,D.B., Sawka-Verhelle,D.,
            Sage,J., Brard,G., Ngo,S.D., Gangadharan,D., Jacks,T., Kamps,M.P.,
            Rose,D.W., Rosenfeld,M.G. and Glass,C.K.
  TITLE     An induced Ets repressor complex regulates growth arrest during
            terminal macrophage differentiation
  JOURNAL   Cell 109 (2), 169-180 (2002)
   PUBMED   12007404
REFERENCE   10 (residues 1 to 512)
  AUTHORS   Klemsz,M., Hromas,R., Raskind,W., Bruno,E. and Hoffman,R.
  TITLE     PE-1, a novel ETS oncogene family member, localizes to chromosome
            1q21-q23
  JOURNAL   Genomics 20 (2), 291-294 (1994)
   PUBMED   8020980
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK316274.1, AL157713.10 and BU690105.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and predicted protein isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK304789.1, AK316274.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000368192.9/ ENSP00000357175.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..512
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q23.1"
     Protein         1..512
                     /product="ETS translocation variant 3 isoform 1"
                     /note="ets variant gene 3, ETS family transcriptional
                     repressor; ETS domain transcriptional repressor PE1;
                     mitogenic Ets transcriptional suppressor"
                     /calculated_mol_wt=56870
     Region          34..120
                     /region_name="ETS"
                     /note="erythroblast transformation specific domain;
                     smart00413"
                     /db_xref="CDD:197710"
     Region          136..222
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P41162.2)"
     Site            139
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:19690332,
                     ECO:0007744|PubMed:23186163; propagated from
                     UniProtKB/Swiss-Prot (P41162.2)"
     Site            159
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:23186163; propagated from
                     UniProtKB/Swiss-Prot (P41162.2)"
     Site            315
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q8R4Z4; propagated from
                     UniProtKB/Swiss-Prot (P41162.2)"
     Region          336..512
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P41162.2)"
     Site            388
                     /site_type="acetylation"
                     /note="N6-acetyllysine, alternate.
                     /evidence=ECO:0007744|PubMed:19608861; propagated from
                     UniProtKB/Swiss-Prot (P41162.2)"
     CDS             1..512
                     /gene="ETV3"
                     /gene_synonym="METS; PE-1; PE1"
                     /coded_by="NM_001145312.3:94..1632"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS44250.1"
                     /db_xref="GeneID:2117"
                     /db_xref="HGNC:HGNC:3492"
                     /db_xref="MIM:164873"
ORIGIN      
        1 mkagcsivek peggggyqfp dwayktessp gsrqiqlwhf ilellqkeef rhviawqqge
       61 ygefvikdpd evarlwgrrk ckpqmnydkl sralryyynk rilhktkgkr ftykfnfnkl
      121 vmpnypfini rssgvvpqsa ppvptassrf hfppldthsp tndvqpgrfs assltasgqe
      181 ssngtdrkte lseledgsaa dwrrgvdpvs srnaiggggi ghqkrkpdim lplfarpgmy
      241 pdphspfavs pipgrggvln vpispalslt ptifsyspsp glspftsssc fsfnpeemkh
      301 ylhsqacsvf nyhlsprtfp rypglmvppl qcqmhpeest qfsiklqppp vgrknrerve
      361 sseesapvtt ptmasippri kvepasekdp eslrqsarek eehtqeegtv psrtieeekg
      421 tifarpaapp iwpsvpistp sgeplevted sedrpgkeps apekkedalm ppklrlkrrw
      481 nddpearels ksgkflwngs gpqglataaa da
//
