LOCUS       NM_014209               1487 bp    mRNA    linear   PRI 11-SEP-2024
DEFINITION  Homo sapiens ETS variant transcription factor 2 (ETV2), transcript
            variant 1, mRNA.
ACCESSION   NM_014209 XM_290831
VERSION     NM_014209.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1487)
  AUTHORS   Li,Z., Wu,W., Li,Q., Heng,X., Zhang,W., Zhu,Y., Chen,L., Chen,Z.,
            Shen,M., Ma,N., Xiao,Q. and Yan,Y.
  TITLE     BCL6B-dependent suppression of ETV2 hampers endothelial cell
            differentiation
  JOURNAL   Stem Cell Res Ther 15 (1), 226 (2024)
   PUBMED   39075623
  REMARK    GeneRIF: BCL6B-dependent suppression of ETV2 hampers endothelial
            cell differentiation.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1487)
  AUTHORS   Grath,A. and Dai,G.
  TITLE     SOX17/ETV2 improves the direct reprogramming of adult fibroblasts
            to endothelial cells
  JOURNAL   Cell Rep Methods 4 (3), 100732 (2024)
   PUBMED   38503291
  REMARK    GeneRIF: SOX17/ETV2 improves the direct reprogramming of adult
            fibroblasts to endothelial cells.
REFERENCE   3  (bases 1 to 1487)
  AUTHORS   Steimle,J.D., Kim,C., Rowton,M., Nadadur,R.D., Wang,Z., Stocker,M.,
            Hoffmann,A.D., Hanson,E., Kweon,J., Sinha,T., Choi,K., Black,B.L.,
            Cunningham,J.M., Moskowitz,I.P. and Ikegami,K.
  TITLE     ETV2 primes hematoendothelial gene enhancers prior to
            hematoendothelial fate commitment
  JOURNAL   Cell Rep 42 (6), 112665 (2023)
   PUBMED   37330911
  REMARK    GeneRIF: ETV2 primes hematoendothelial gene enhancers prior to
            hematoendothelial fate commitment.
REFERENCE   4  (bases 1 to 1487)
  AUTHORS   Kim,T.M., Lee,R.H., Kim,M.S., Lewis,C.A. and Park,C.
  TITLE     ETV2/ER71, the key factor leading the paths to vascular
            regeneration and angiogenic reprogramming
  JOURNAL   Stem Cell Res Ther 14 (1), 41 (2023)
   PUBMED   36927793
  REMARK    GeneRIF: ETV2/ER71, the key factor leading the paths to vascular
            regeneration and angiogenic reprogramming.
            Review article
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1487)
  AUTHORS   Li,J., Du,H., Ji,X., Chen,Y., Li,Y., Heng,B.C. and Xu,J.
  TITLE     ETV2 promotes osteogenic differentiation of human dental pulp stem
            cells through the ERK/MAPK and PI3K-Akt signaling pathways
  JOURNAL   Stem Cell Res Ther 13 (1), 495 (2022)
   PUBMED   36195958
  REMARK    GeneRIF: ETV2 promotes osteogenic differentiation of human dental
            pulp stem cells through the ERK/MAPK and PI3K-Akt signaling
            pathways.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1487)
  AUTHORS   Vaquerizas,J.M., Kummerfeld,S.K., Teichmann,S.A. and Luscombe,N.M.
  TITLE     A census of human transcription factors: function, expression and
            evolution
  JOURNAL   Nat Rev Genet 10 (4), 252-263 (2009)
   PUBMED   19274049
  REMARK    Review article
REFERENCE   7  (bases 1 to 1487)
  AUTHORS   Sumanas,S., Gomez,G., Zhao,Y., Park,C., Choi,K. and Lin,S.
  TITLE     Interplay among Etsrp/ER71, Scl, and Alk8 signaling controls
            endothelial and myeloid cell formation
  JOURNAL   Blood 111 (9), 4500-4510 (2008)
   PUBMED   18270322
  REMARK    GeneRIF: identify human Etv2/ER71 and mouse ER71 proteins as
            functional orthologs of Etsrp
REFERENCE   8  (bases 1 to 1487)
  AUTHORS   Grimwood,J., Gordon,L.A., Olsen,A., Terry,A., Schmutz,J.,
            Lamerdin,J., Hellsten,U., Goodstein,D., Couronne,O.,
            Tran-Gyamfi,M., Aerts,A., Altherr,M., Ashworth,L., Bajorek,E.,
            Black,S., Branscomb,E., Caenepeel,S., Carrano,A., Caoile,C.,
            Chan,Y.M., Christensen,M., Cleland,C.A., Copeland,A., Dalin,E.,
            Dehal,P., Denys,M., Detter,J.C., Escobar,J., Flowers,D.,
            Fotopulos,D., Garcia,C., Georgescu,A.M., Glavina,T., Gomez,M.,
            Gonzales,E., Groza,M., Hammon,N., Hawkins,T., Haydu,L., Ho,I.,
            Huang,W., Israni,S., Jett,J., Kadner,K., Kimball,H., Kobayashi,A.,
            Larionov,V., Leem,S.H., Lopez,F., Lou,Y., Lowry,S., Malfatti,S.,
            Martinez,D., McCready,P., Medina,C., Morgan,J., Nelson,K.,
            Nolan,M., Ovcharenko,I., Pitluck,S., Pollard,M., Popkie,A.P.,
            Predki,P., Quan,G., Ramirez,L., Rash,S., Retterer,J., Rodriguez,A.,
            Rogers,S., Salamov,A., Salazar,A., She,X., Smith,D., Slezak,T.,
            Solovyev,V., Thayer,N., Tice,H., Tsai,M., Ustaszewska,A., Vo,N.,
            Wagner,M., Wheeler,J., Wu,K., Xie,G., Yang,J., Dubchak,I.,
            Furey,T.S., DeJong,P., Dickson,M., Gordon,D., Eichler,E.E.,
            Pennacchio,L.A., Richardson,P., Stubbs,L., Rokhsar,D.S.,
            Myers,R.M., Rubin,E.M. and Lucas,S.M.
  TITLE     The DNA sequence and biology of human chromosome 19
  JOURNAL   Nature 428 (6982), 529-535 (2004)
   PUBMED   15057824
REFERENCE   9  (bases 1 to 1487)
  AUTHORS   De Haro,L. and Janknecht,R.
  TITLE     Functional analysis of the transcription factor ER71 and its
            activation of the matrix metalloproteinase-1 promoter
  JOURNAL   Nucleic Acids Res 30 (13), 2972-2979 (2002)
   PUBMED   12087183
REFERENCE   10 (bases 1 to 1487)
  AUTHORS   Brown,T.A. and McKnight,S.L.
  TITLE     Specificities of protein-protein and protein-DNA interaction of
            GABP alpha and two newly defined ets-related proteins
  JOURNAL   Genes Dev 6 (12B), 2502-2512 (1992)
   PUBMED   1340465
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            HY053182.1, BC040908.1 and BC140746.1.
            
            On Nov 24, 2018 this sequence version replaced NM_014209.3.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: ERR279829.1365.1, BC140746.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2148093
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000402764.6/ ENSP00000384524.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-48                HY053182.1         9-56
            49-302              BC040908.1         1-254
            303-1477            BC140746.1         1-1175
            1478-1487           BC040908.1         1333-1342
FEATURES             Location/Qualifiers
     source          1..1487
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.12"
     gene            1..1487
                     /gene="ETV2"
                     /gene_synonym="ER71; ETSRP71"
                     /note="ETS variant transcription factor 2"
                     /db_xref="GeneID:2116"
                     /db_xref="HGNC:HGNC:3491"
                     /db_xref="MIM:609358"
     exon            1..412
                     /gene="ETV2"
                     /gene_synonym="ER71; ETSRP71"
                     /inference="alignment:Splign:2.1.0"
     exon            413..509
                     /gene="ETV2"
                     /gene_synonym="ER71; ETSRP71"
                     /inference="alignment:Splign:2.1.0"
     CDS             440..1468
                     /gene="ETV2"
                     /gene_synonym="ER71; ETSRP71"
                     /note="isoform 1 is encoded by transcript variant 1; ets
                     variant gene 2; ets-related protein 71"
                     /codon_start=1
                     /product="ETS translocation variant 2 isoform 1"
                     /protein_id="NP_055024.2"
                     /db_xref="CCDS:CCDS32995.2"
                     /db_xref="GeneID:2116"
                     /db_xref="HGNC:HGNC:3491"
                     /db_xref="MIM:609358"
                     /translation="MDLWNWDEASPQEVPPGNKLAGLEGAKLGFCFPDLALQGDTPTA
                     TAETCWKGTSSSLASFPQLDWGSALLHPEVPWGAEPDSQALPWSGDWTDMACTAWDSW
                     SGASQTLGPAPLGPGPIPAAGSEGAAGQNCVPVAGEATSWSRAQAAGSNTSWDCSVGP
                     DGDTYWGSGLGGEPRTDCTISWGGPAGPDCTTSWNPGLHAGGTTSLKRYQSSALTVCS
                     EPSPQSDRASLARCPKTNHRGPIQLWQFLLELLHDGARSSCIRWTGNSREFQLCDPKE
                     VARLWGERKRKPGMNYEKLSRGLRYYYRRDIVRKSGGRKYTYRFGGRVPSLAYPDCAG
                     GGRGAETQ"
     exon            510..593
                     /gene="ETV2"
                     /gene_synonym="ER71; ETSRP71"
                     /inference="alignment:Splign:2.1.0"
     exon            594..674
                     /gene="ETV2"
                     /gene_synonym="ER71; ETSRP71"
                     /inference="alignment:Splign:2.1.0"
     exon            675..1154
                     /gene="ETV2"
                     /gene_synonym="ER71; ETSRP71"
                     /inference="alignment:Splign:2.1.0"
     exon            1155..1267
                     /gene="ETV2"
                     /gene_synonym="ER71; ETSRP71"
                     /inference="alignment:Splign:2.1.0"
     exon            1268..1487
                     /gene="ETV2"
                     /gene_synonym="ER71; ETSRP71"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1464..1469
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ETV2"
                     /gene_synonym="ER71; ETSRP71"
                     /note="hexamer: AATAAA"
     polyA_site      1487
                     /gene="ETV2"
                     /gene_synonym="ER71; ETSRP71"
                     /note="major polyA site"
ORIGIN      
        1 gcagataagc ccagcttagc ccagctgacc ccagaccctc tcccctcact ccccccatgt
       61 cgcaggatcg agaccctgag gcagacagcc cgttcaccaa gccccccgcc ccgcccccat
      121 caccccgtaa acttctccca gcctccgccc tgccctcacc cagcccgctg ttccccaagc
      181 ctcgctccaa gcccacgcca cccctgcagc agggcagccc cagaggccag cacctatccc
      241 cgaggctggg gtcgaggctc ggccccgccc ctgcctctgc aacttgagcc tggctgcgac
      301 ccctgctctg acgtctcgga aaattccccc ttgcccaggc ccttggggga gggggtgcat
      361 ggtatgaaat ggggctgaga cccccggctg ggggcagagg aacccgccag agaacattca
      421 gaaggccttc atcgcatcca tggacctgtg gaactgggat gaggcatccc cacaggaagt
      481 gcctccaggg aacaagctgg cagggcttga aggagccaaa ttaggcttct gtttccctga
      541 tctggcactc caaggggaca cgccgacagc gacagcagag acatgctgga aaggtacaag
      601 ctcatccctg gcaagcttcc cacagctgga ctggggctcc gcgttactgc acccagaagt
      661 tccatggggg gcggagcccg actctcaggc tcttccgtgg tccggggact ggacagacat
      721 ggcgtgcaca gcctgggact cttggagcgg cgcctcgcag accctgggcc ccgcccctct
      781 cggcccgggc cccatccccg ccgccggctc cgaaggcgcc gcgggccaga actgcgtccc
      841 cgtggcggga gaggccacct cgtggtcgcg cgcccaggcc gccgggagca acaccagctg
      901 ggactgttct gtggggcccg acggcgatac ctactggggc agtggcctgg gcggggagcc
      961 gcgcacggac tgtaccattt cgtggggcgg gcccgcgggc ccggactgta ccacctcctg
     1021 gaacccgggg ctgcatgcgg gtggcaccac ctctttgaag cggtaccaga gctcagctct
     1081 caccgtttgc tccgaaccga gcccgcagtc ggaccgtgcc agtttggctc gatgccccaa
     1141 aactaaccac cgaggtccca ttcagctgtg gcagttcctc ctggagctgc tccacgacgg
     1201 ggcgcgtagc agctgcatcc gttggactgg caacagccgc gagttccagc tgtgcgaccc
     1261 caaagaggtg gctcggctgt ggggcgagcg caagagaaag ccgggcatga attacgagaa
     1321 gctgagccgg ggccttcgct actactatcg ccgcgacatc gtgcgcaaga gcggggggcg
     1381 aaagtacacg taccgcttcg ggggccgcgt gcccagccta gcctatccgg actgtgcggg
     1441 aggcggacgg ggagcagaga cacaataaaa attcccggtc aaacctc
//
