LOCUS       NM_004956               6459 bp    mRNA    linear   PRI 03-OCT-2024
DEFINITION  Homo sapiens ETS variant transcription factor 1 (ETV1), transcript
            variant 1, mRNA.
ACCESSION   NM_004956
VERSION     NM_004956.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6459)
  AUTHORS   Qiu,X., Zhang,S., Zhang,Y., Cai,L., Li,D. and Lu,Y.
  TITLE     Reduction of ETV1 is Identified as a Prominent Feature of
            Age-Related Cataract
  JOURNAL   Curr Eye Res 49 (5), 496-504 (2024)
   PUBMED   38200696
  REMARK    GeneRIF: Reduction of ETV1 is Identified as a Prominent Feature of
            Age-Related Cataract.
REFERENCE   2  (bases 1 to 6459)
  AUTHORS   Weng,H., Feng,W., Li,F., Huang,D., Lin,L. and Wang,Z.
  TITLE     Transcription factor ETV1-induced lncRNA MAFG-AS1 promotes
            migration, invasion, and epithelial-mesenchymal transition of
            pancreatic cancer cells by recruiting IGF2BP2 to stabilize ETV1
            expression
  JOURNAL   Growth Factors 41 (3), 152-164 (2023)
   PUBMED   37428861
  REMARK    GeneRIF: Transcription factor ETV1-induced lncRNA MAFG-AS1 promotes
            migration, invasion, and epithelial-mesenchymal transition of
            pancreatic cancer cells by recruiting IGF2BP2 to stabilize ETV1
            expression.
REFERENCE   3  (bases 1 to 6459)
  AUTHORS   Zhang,T., Wang,Y., Xie,M., Ji,X., Luo,X., Chen,X., Zhang,B.,
            Liu,D., Feng,Y., Sun,M., Huang,W. and Xia,L.
  TITLE     HGF-mediated elevation of ETV1 facilitates hepatocellular carcinoma
            metastasis through upregulating PTK2 and c-MET
  JOURNAL   J Exp Clin Cancer Res 41 (1), 275 (2022)
   PUBMED   36109787
  REMARK    GeneRIF: HGF-mediated elevation of ETV1 facilitates hepatocellular
            carcinoma metastasis through upregulating PTK2 and c-MET.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6459)
  AUTHORS   Shen,X., Zhou,C., Feng,H., Li,J., Xia,T., Cheng,X., Zhao,R. and
            Zou,D.
  TITLE     ETV1 Positively Correlated With Immune Infiltration and Poor
            Clinical Prognosis in Colorectal Cancer
  JOURNAL   Front Immunol 13, 939806 (2022)
   PUBMED   35860243
  REMARK    GeneRIF: ETV1 Positively Correlated With Immune Infiltration and
            Poor Clinical Prognosis in Colorectal Cancer.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6459)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   6  (bases 1 to 6459)
  AUTHORS   Coutte,L., Monte,D., Imai,K., Pouilly,L., Dewitte,F., Vidaud,M.,
            Adamski,J., Baert,J.L. and de Launoit,Y.
  TITLE     Characterization of the human and mouse ETV1/ER81 transcription
            factor genes: role of the two alternatively spliced isoforms in the
            human
  JOURNAL   Oncogene 18 (46), 6278-6286 (1999)
   PUBMED   10597226
REFERENCE   7  (bases 1 to 6459)
  AUTHORS   Carrere,S., Verger,A., Flourens,A., Stehelin,D. and
            Duterque-Coquillaud,M.
  TITLE     Erg proteins, transcription factors of the Ets family, form homo,
            heterodimers and ternary complexes via two distinct domains
  JOURNAL   Oncogene 16 (25), 3261-3268 (1998)
   PUBMED   9681824
REFERENCE   8  (bases 1 to 6459)
  AUTHORS   Monte,D., Coutte,L., Baert,J.L., Angeli,I., Stehelin,D. and de
            Launoit,Y.
  TITLE     Molecular characterization of the ets-related human transcription
            factor ER81
  JOURNAL   Oncogene 11 (4), 771-779 (1995)
   PUBMED   7651741
REFERENCE   9  (bases 1 to 6459)
  AUTHORS   Jeon,I.S., Davis,J.N., Braun,B.S., Sublett,J.E., Roussel,M.F.,
            Denny,C.T. and Shapiro,D.N.
  TITLE     A variant Ewing's sarcoma translocation (7;22) fuses the EWS gene
            to the ETS gene ETV1
  JOURNAL   Oncogene 10 (6), 1229-1234 (1995)
   PUBMED   7700648
REFERENCE   10 (bases 1 to 6459)
  AUTHORS   Brown,T.A. and McKnight,S.L.
  TITLE     Specificities of protein-protein and protein-DNA interaction of
            GABP alpha and two newly defined ets-related proteins
  JOURNAL   Genes Dev 6 (12B), 2502-2512 (1992)
   PUBMED   1340465
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC098403.1, AC004857.1 and
            BU737178.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_004956.4.
            
            Summary: This gene encodes a member of the ETS (E twenty-six)
            family of transcription factors. The ETS proteins regulate many
            target genes that modulate biological processes like cell growth,
            angiogenesis, migration, proliferation and differentiation. All ETS
            proteins contain an ETS DNA-binding domain that binds to DNA
            sequences containing the consensus 5'-CGGA[AT]-3'. The protein
            encoded by this gene contains a conserved short acidic
            transactivation domain (TAD) in the N-terminal region, in addition
            to the ETS DNA-binding domain in the C-terminal region. This gene
            is involved in chromosomal translocations, which result in multiple
            fusion proteins including EWS-ETV1 in Ewing sarcoma and at least 10
            ETV1 partners (see PMID: 19657377, Table 1) in prostate cancer. In
            addition to chromosomal rearrangement, this gene is overexpressed
            in prostate cancer, melanoma and gastrointestinal stromal tumor.
            Multiple alternatively spliced transcript variants encoding
            different isoforms have been identified. [provided by RefSeq, Jul
            2016].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (a). This isoform
            contains the N-terminal TAD.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803611.176093.1, BC098403.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed/partial sample support
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000430479.6/ ENSP00000405327.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3533              BC098403.1         26-3558
            3534-6075           AC004857.1         96118-98659
            6076-6459           BU737178.1         15-398              c
FEATURES             Location/Qualifiers
     source          1..6459
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7p21.2"
     gene            1..6459
                     /gene="ETV1"
                     /gene_synonym="ER81"
                     /note="ETS variant transcription factor 1"
                     /db_xref="GeneID:2115"
                     /db_xref="HGNC:HGNC:3490"
                     /db_xref="MIM:600541"
     exon            1..104
                     /gene="ETV1"
                     /gene_synonym="ER81"
                     /inference="alignment:Splign:2.1.0"
     exon            105..301
                     /gene="ETV1"
                     /gene_synonym="ER81"
                     /inference="alignment:Splign:2.1.0"
     exon            302..433
                     /gene="ETV1"
                     /gene_synonym="ER81"
                     /inference="alignment:Splign:2.1.0"
     CDS             389..1822
                     /gene="ETV1"
                     /gene_synonym="ER81"
                     /note="isoform a is encoded by transcript variant 1; ets
                     variant gene 1; ets-related protein 81"
                     /codon_start=1
                     /product="ETS translocation variant 1 isoform a"
                     /protein_id="NP_004947.2"
                     /db_xref="CCDS:CCDS55088.1"
                     /db_xref="GeneID:2115"
                     /db_xref="HGNC:HGNC:3490"
                     /db_xref="MIM:600541"
                     /translation="MDGFYDQQVPYMVTNSQRGRNCNEKPTNVRKRKFINRDLAHDSE
                     ELFQDLSQLQETWLAEAQVPDNDEQFVPDYQAESLAFHGLPLKIKKEPHSPCSEISSA
                     CSQEQPFKFSYGEKCLYNVSAYDQKPQVGMRPSNPPTPSSTPVSPLHHASPNSTHTPK
                     PDRAFPAHLPPSQSIPDSSYPMDHRFRRQLSEPCNSFPPLPTMPREGRPMYQRQMSEP
                     NIPFPPQGFKQEYHDPVYEHNTMVGSAASQSFPPPLMIKQEPRDFAYDSEVPSCHSIY
                     MRQEGFLAHPSRTEGCMFEKGPRQFYDDTCVVPEKFDGDIKQEPGMYREGPTYQRRGS
                     LQLWQFLVALLDDPSNSHFIAWTGRGMEFKLIEPEEVARRWGIQKNRPAMNYDKLSRS
                     LRYYYEKGIMQKVAGERYVYKFVCDPEALFSMAFPDNQRPLLKTDMERHINEEDTVPL
                     SHFDESMAYMPEGGCCNPHPYNEGYVY"
     exon            434..521
                     /gene="ETV1"
                     /gene_synonym="ER81"
                     /inference="alignment:Splign:2.1.0"
     exon            522..569
                     /gene="ETV1"
                     /gene_synonym="ER81"
                     /inference="alignment:Splign:2.1.0"
     exon            570..623
                     /gene="ETV1"
                     /gene_synonym="ER81"
                     /inference="alignment:Splign:2.1.0"
     exon            624..753
                     /gene="ETV1"
                     /gene_synonym="ER81"
                     /inference="alignment:Splign:2.1.0"
     exon            754..942
                     /gene="ETV1"
                     /gene_synonym="ER81"
                     /inference="alignment:Splign:2.1.0"
     exon            943..1190
                     /gene="ETV1"
                     /gene_synonym="ER81"
                     /inference="alignment:Splign:2.1.0"
     exon            1191..1259
                     /gene="ETV1"
                     /gene_synonym="ER81"
                     /inference="alignment:Splign:2.1.0"
     exon            1260..1328
                     /gene="ETV1"
                     /gene_synonym="ER81"
                     /inference="alignment:Splign:2.1.0"
     exon            1329..1498
                     /gene="ETV1"
                     /gene_synonym="ER81"
                     /inference="alignment:Splign:2.1.0"
     exon            1499..1600
                     /gene="ETV1"
                     /gene_synonym="ER81"
                     /inference="alignment:Splign:2.1.0"
     exon            1601..6459
                     /gene="ETV1"
                     /gene_synonym="ER81"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4392..4397
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ETV1"
                     /gene_synonym="ER81"
                     /note="hexamer: AATAAA"
     polyA_site      4418
                     /gene="ETV1"
                     /gene_synonym="ER81"
                     /note="major polyA site"
     regulatory      6437..6442
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ETV1"
                     /gene_synonym="ER81"
                     /note="hexamer: AATAAA"
     polyA_site      6459
                     /gene="ETV1"
                     /gene_synonym="ER81"
ORIGIN      
        1 agaggcgctt tcggcttcca agggggaagt gctgggctat aattaatgtt tttattaaat
       61 ttggagggaa gtttttgcag cctttcgcct agcgtggcct tcagtcccgt taggtgcaaa
      121 gcaagtctcg ttgatcgcca ttgctagttt tgcacacgtt tgcgaatcag agctgcccgg
      181 ggtacaccga ccgcgcaggg aaacatcgag agtgtaaata aatacatcgc ctcttgttcg
      241 gatttttgct actaccgaaa atatgtaaat tgtgaactct gttggctctc tttggatcca
      301 ggttgataga agtccagatc ctgaggaaat ctccagctaa atgctcaaaa tataaaatac
      361 tgagctgaga tttgcgaaga gcagcagcat ggatggattt tatgaccagc aagtgcctta
      421 catggtcacc aatagtcagc gtgggagaaa ttgtaacgag aaaccaacaa atgtcaggaa
      481 aagaaaattc attaacagag atctggctca tgattcagaa gaactctttc aagatctaag
      541 tcaattacag gaaacatggc ttgcagaagc tcaggtacct gacaatgatg agcagtttgt
      601 accagactat caggctgaaa gtttggcttt tcatggcctg ccactgaaaa tcaagaaaga
      661 accccacagt ccatgttcag aaatcagctc tgcctgcagt caagaacagc cctttaaatt
      721 cagctatgga gaaaagtgcc tgtacaatgt cagtgcctat gatcagaagc cacaagtggg
      781 aatgaggccc tccaaccccc ccacaccatc cagcacgcca gtgtccccac tgcatcatgc
      841 atctccaaac tcaactcata caccgaaacc tgaccgggcc ttcccagctc acctccctcc
      901 atcgcagtcc ataccagata gcagctaccc catggaccac agatttcgcc gccagctttc
      961 tgaaccctgt aactcctttc ctcctttgcc gacgatgcca agggaaggac gtcctatgta
     1021 ccaacgccag atgtctgagc caaacatccc cttcccacca caaggcttta agcaggagta
     1081 ccacgaccca gtgtatgaac acaacaccat ggttggcagt gcggccagcc aaagctttcc
     1141 ccctcctctg atgattaaac aggaacccag agattttgca tatgactcag aagtgcctag
     1201 ctgccactcc atttatatga ggcaagaagg cttcctggct catcccagca gaacagaagg
     1261 ctgtatgttt gaaaagggcc ccaggcagtt ttatgatgac acctgtgttg tcccagaaaa
     1321 attcgatgga gacatcaaac aagagccagg aatgtatcgg gaaggaccca cataccaacg
     1381 gcgaggatca cttcagctct ggcagttttt ggtagctctt ctggatgacc cttcaaattc
     1441 tcattttatt gcctggactg gtcgaggcat ggaatttaaa ctgattgagc ctgaagaggt
     1501 ggcccgacgt tggggcattc agaaaaacag gccagctatg aactatgata aacttagccg
     1561 ttcactccgc tattactatg agaaaggaat tatgcaaaag gtggctggag agagatatgt
     1621 ctacaagttt gtgtgtgatc cagaagccct tttctccatg gcctttccag ataatcagcg
     1681 tccactgctg aagacagaca tggaacgtca catcaacgag gaggacacag tgcctctttc
     1741 tcactttgat gagagcatgg cctacatgcc ggaagggggc tgctgcaacc cccaccccta
     1801 caacgaaggc tacgtgtatt aacacaagtg acagtcaagc agggcgtttt tgcgcttttc
     1861 cttttttctg caagatacag agaattgctg aatctttgtt ttatttctgt tgtttgtatt
     1921 ttatttttaa ataataatac acaaaaaggg gcttttcctg ttgcattatt ctatggtctg
     1981 ccatggactg tgcactttat ttgagggtgg gtgggagtaa tctaaacatt tattctgtgt
     2041 aacaggaagc taatgggtga atgggcagag ggatttgggg attacttttt acttaggctt
     2101 gggatggggt cctacaagtt ttgagtatga tgaaactata tcatgtctgt ttgatttcat
     2161 aacaacataa gataatgttt attttatcgg ggtatctatg gtacagttaa tttcacgttg
     2221 tgtaaatatc cacttggaga ctatttgcct tgggcatttt cccctgtcat ttatgagtct
     2281 ctgcaggtgt acaaaaaaac cccaatctac tgtaaatggc agtttaattg ttagaaatga
     2341 ctgtttttgc accacttgta aaaaggtatt tagcgattgc atttgctgtt tgttgtttta
     2401 ttttgcttta tatatgactt gcagaggata accataaaat gggtaattct ctctgaagtt
     2461 gaataatcac catgactgta aatgaggggc acaattttgg actctggcgc caaactgagt
     2521 cataggccag tagcattacg tgtatctggt gccaccttgc tgtttagata caaatcatac
     2581 cgtcttttaa atattttgaa gcccatttca gttaaataat gacatgtcat ggtcctttgg
     2641 aatcttcatt taaatgttaa atctggaatc aaaatgaagc aaaaaatatc tgtctccttt
     2701 tcactttctt cagtacataa atacattatt taatcaataa gaattaactg tactaaatca
     2761 tgtattatgc tgttctagtt acagcaaaca ctctttaaga aaaatatcca atacactaaa
     2821 taggtactat agtaattttt agacatggta cccattgata tgcatttaaa ccttttactg
     2881 ctgtgttatg ttgataacat atataaatat tagataatgc taatgcttct gctgctgtct
     2941 tttctgtaat attctctttc atgctgaatt tactatgacc atttataagc agtgcagtta
     3001 actacagata gcatttcagg acaaaataga tgactcaaac catttattgc ttaaaaaata
     3061 gcttacgcca tgctatgcta taagcagctt ttatgcacat tgacaaatga agagtaagct
     3121 tcagcttgct aaaggaaact gtggaacctt ttgtaacttt tggtgatatg gaaaattatt
     3181 tacaaaccgt caaagaatat gaggaagttg ctgtatgaca tagtgctggc actgatatta
     3241 tccatcatct ctttttggac acttctgtaa atgtgattgg attgtttgaa agaagattta
     3301 aagtttcaaa gttttttgtt ctgtttttgc tttgcatttg gagaaaatat tgaaagcagg
     3361 gtatgttgtt tcattcacct tgaaaaaacc atgagtaaat ggggatatag aatctctgaa
     3421 tagctcgcta aaagattcaa gcaagggaca tgaattttgt tccatctatc aataatatcc
     3481 agaagaacaa cttttttaaa gagtctatag caaaaagcaa aaaaaaaaaa aaattctaaa
     3541 cacaaagtca aaataaacct attgtaaaag catttcgtga tgagcatgaa aaagattgtt
     3601 taaagatgat ccccccagct acccattttc caaaactaca cagatcacag ctcatttctc
     3661 taagtggagc agttatcaag aaacccaaac accaaaattg ctactcttca catttaatcc
     3721 tacaaaaagt actccaattt caaaatatgt atgtaacctg cgatttcaat gattgttgtt
     3781 catatacatc atgtattatt ttggcccatt ttgggcctaa aaaagaaaac tatgccttaa
     3841 aaatcagaac cttttctccc cactatgctt atgtggccat ctacagcact tagaataaaa
     3901 acagatgtta aaatattcag tgaaagtttt attggaaaaa ggaattgaga tatataattg
     3961 agatttggtg aaattgaagg agaaaattta agtgagtctt taaaatatat tctgaatgaa
     4021 aactgtattg aggattcatt tttgttcctt ttttttcttt ttctcttttc tcctttttct
     4081 tctttttaat agtctagttt tagtcagtca gtgaggaaga attgggccat gctaacgtta
     4141 tcacaagaga acaatggcag aaatggtatt agttatataa tatttaagga caaactatat
     4201 gttttgctgt tttaacgtag tgactcactg aactaaatac ataattgacc aacattaagt
     4261 gtatttccaa tacagaaggg ttgaaaatat tacattataa actcttttga aaaatgtatc
     4321 taaaattttt taagttctgt tttgattcca ctttttggtt gagtttttat gtttttgttt
     4381 tcaggtagat taataaatct ggcagctgat ttctgcaaga ttcttgtgtt ttgaatttct
     4441 cattgaattg gctactcaaa catagaaatc atttgttaat gatgtaatgt cttctctcag
     4501 cttttatctt cactgctgtt tgctgtctct tgatgatgac atgttaatac ccaatagatt
     4561 aattgcaaca aacacttata ctcaaataac taagtaaaaa taatttttct tgttatgtcc
     4621 atgaaaagtg cttcagaata aaaatccaca agactgacag tgcagaacat ttttctcaaa
     4681 tcatgggcgg atcttggagg tctagtttcc cgtagatgct gtaaccaatt accacaactt
     4741 cagtaattta cacaaattta tcttatagtt ctggaggcag aagttcaaaa gaagccttaa
     4801 gagactaaaa ccaagatgtc cttaggtctg gttccttctg gaggctccag gggagattct
     4861 tccagctttc acttctagag tctgctgaca ttccttggct cctggctaca tcacttcaat
     4921 ctctgcttcc atggtcacat actcttctac tatagtcaaa tttccttcct gcctcttata
     4981 aggatgcttg tgattacatt taggggatgc tcagataatc caggacaatc tctccatctc
     5041 aagatcctta acttaatgac gtgtgccaag tccctttggc tagataatta ttcataggtc
     5101 ccagggatta ggacatggat gtaaggggtg agggcagggc tgttattcag aacaccgcac
     5161 ggaggaggaa gactgtgtag caaagactct aattgattta ctcaggaaca gtggagttct
     5221 gctgagggat ctaggatttg aaagtactag agtttgcttt tatttaccac tgagatattt
     5281 tccccttatt ctgcataaat aattttgaaa actttctata ttaaatttca actattccac
     5341 taaaatgtct ggtaatcaca tcaagccttt agattattca aatccttccc cagcccccag
     5401 gaaaacacta agtcatgaaa cagaaaaaca gaaggtatga taataatagt aataacagtt
     5461 aaatcagtgg tctaatccag attttatttt ttaatacatt tcttttggtg ttaatatggg
     5521 ttactatgtg atcttatcat ttgctagtga ttattactta ttaggtaaga acaatgtgta
     5581 aaatatgtct attactcaaa agaacaattg caaaatgagt caacttatct ttatataacc
     5641 aggaaagaaa tatattgcca gaagctacag aattttgcca gatgataggg atttctaaaa
     5701 tgagccactt tgtctatcat gcagcctttt cagagcttgt aatgagaaaa cattacagag
     5761 gagaaggtca tttggatgtt tgttacttgg aatcctagaa aacaaaaact aaaatttaaa
     5821 aataagaagt gagtaagcta ttttccattt gcgatttggt atggagaaga gaggaaatag
     5881 aattattaaa aaaatacaaa ttgggtaaaa gtgatggtgg aaaaaatata aagaaggcaa
     5941 atgtacatat taagcaattc tactaagaat tggaaaaatc aagtttcaaa aagatggtaa
     6001 tagttgggca tgatactaga aaatttcacc cagtttattc agagctcaac tagtactttt
     6061 aggacttctt tttttatata catgagactc actttgacat acttaaaaaa aaaacagttt
     6121 atggaaagta cagtttaaga ggagaatttg attagactaa gtggatatct ttatagaaat
     6181 attaatgatt tcagaatttt cagttacaag tgtatatacc gtggctattg tttatggatt
     6241 catatgtaag gtagggtctt ttttgcatat agactccagt attagttact ttcattctaa
     6301 aattatattt atgcttctat ggggaagaaa atttttaatt cacttggttg tattaaaatt
     6361 atacttacgg tttgagaaaa catgctatga aaatcatgat tatagcaaat taaatatgct
     6421 caaaatttaa atctaaaata aaagcccaga aactgaaaa
//
