LOCUS       NM_001163147            6193 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens ETS variant transcription factor 1 (ETV1), transcript
            variant 2, mRNA.
ACCESSION   NM_001163147
VERSION     NM_001163147.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6193)
  AUTHORS   Qiu,X., Zhang,S., Zhang,Y., Cai,L., Li,D. and Lu,Y.
  TITLE     Reduction of ETV1 is Identified as a Prominent Feature of
            Age-Related Cataract
  JOURNAL   Curr Eye Res 49 (5), 496-504 (2024)
   PUBMED   38200696
  REMARK    GeneRIF: Reduction of ETV1 is Identified as a Prominent Feature of
            Age-Related Cataract.
REFERENCE   2  (bases 1 to 6193)
  AUTHORS   Weng,H., Feng,W., Li,F., Huang,D., Lin,L. and Wang,Z.
  TITLE     Transcription factor ETV1-induced lncRNA MAFG-AS1 promotes
            migration, invasion, and epithelial-mesenchymal transition of
            pancreatic cancer cells by recruiting IGF2BP2 to stabilize ETV1
            expression
  JOURNAL   Growth Factors 41 (3), 152-164 (2023)
   PUBMED   37428861
  REMARK    GeneRIF: Transcription factor ETV1-induced lncRNA MAFG-AS1 promotes
            migration, invasion, and epithelial-mesenchymal transition of
            pancreatic cancer cells by recruiting IGF2BP2 to stabilize ETV1
            expression.
REFERENCE   3  (bases 1 to 6193)
  AUTHORS   Zhang,T., Wang,Y., Xie,M., Ji,X., Luo,X., Chen,X., Zhang,B.,
            Liu,D., Feng,Y., Sun,M., Huang,W. and Xia,L.
  TITLE     HGF-mediated elevation of ETV1 facilitates hepatocellular carcinoma
            metastasis through upregulating PTK2 and c-MET
  JOURNAL   J Exp Clin Cancer Res 41 (1), 275 (2022)
   PUBMED   36109787
  REMARK    GeneRIF: HGF-mediated elevation of ETV1 facilitates hepatocellular
            carcinoma metastasis through upregulating PTK2 and c-MET.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6193)
  AUTHORS   Shen,X., Zhou,C., Feng,H., Li,J., Xia,T., Cheng,X., Zhao,R. and
            Zou,D.
  TITLE     ETV1 Positively Correlated With Immune Infiltration and Poor
            Clinical Prognosis in Colorectal Cancer
  JOURNAL   Front Immunol 13, 939806 (2022)
   PUBMED   35860243
  REMARK    GeneRIF: ETV1 Positively Correlated With Immune Infiltration and
            Poor Clinical Prognosis in Colorectal Cancer.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6193)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   6  (bases 1 to 6193)
  AUTHORS   Coutte,L., Monte,D., Imai,K., Pouilly,L., Dewitte,F., Vidaud,M.,
            Adamski,J., Baert,J.L. and de Launoit,Y.
  TITLE     Characterization of the human and mouse ETV1/ER81 transcription
            factor genes: role of the two alternatively spliced isoforms in the
            human
  JOURNAL   Oncogene 18 (46), 6278-6286 (1999)
   PUBMED   10597226
REFERENCE   7  (bases 1 to 6193)
  AUTHORS   Carrere,S., Verger,A., Flourens,A., Stehelin,D. and
            Duterque-Coquillaud,M.
  TITLE     Erg proteins, transcription factors of the Ets family, form homo,
            heterodimers and ternary complexes via two distinct domains
  JOURNAL   Oncogene 16 (25), 3261-3268 (1998)
   PUBMED   9681824
REFERENCE   8  (bases 1 to 6193)
  AUTHORS   Monte,D., Coutte,L., Baert,J.L., Angeli,I., Stehelin,D. and de
            Launoit,Y.
  TITLE     Molecular characterization of the ets-related human transcription
            factor ER81
  JOURNAL   Oncogene 11 (4), 771-779 (1995)
   PUBMED   7651741
REFERENCE   9  (bases 1 to 6193)
  AUTHORS   Jeon,I.S., Davis,J.N., Braun,B.S., Sublett,J.E., Roussel,M.F.,
            Denny,C.T. and Shapiro,D.N.
  TITLE     A variant Ewing's sarcoma translocation (7;22) fuses the EWS gene
            to the ETS gene ETV1
  JOURNAL   Oncogene 10 (6), 1229-1234 (1995)
   PUBMED   7700648
REFERENCE   10 (bases 1 to 6193)
  AUTHORS   Brown,T.A. and McKnight,S.L.
  TITLE     Specificities of protein-protein and protein-DNA interaction of
            GABP alpha and two newly defined ets-related proteins
  JOURNAL   Genes Dev 6 (12B), 2502-2512 (1992)
   PUBMED   1340465
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA114165.1, AB209202.1,
            BC098403.1, AC004857.1 and BU737178.1.
            
            On Aug 13, 2020 this sequence version replaced NM_001163147.1.
            
            Summary: This gene encodes a member of the ETS (E twenty-six)
            family of transcription factors. The ETS proteins regulate many
            target genes that modulate biological processes like cell growth,
            angiogenesis, migration, proliferation and differentiation. All ETS
            proteins contain an ETS DNA-binding domain that binds to DNA
            sequences containing the consensus 5'-CGGA[AT]-3'. The protein
            encoded by this gene contains a conserved short acidic
            transactivation domain (TAD) in the N-terminal region, in addition
            to the ETS DNA-binding domain in the C-terminal region. This gene
            is involved in chromosomal translocations, which result in multiple
            fusion proteins including EWS-ETV1 in Ewing sarcoma and at least 10
            ETV1 partners (see PMID: 19657377, Table 1) in prostate cancer. In
            addition to chromosomal rearrangement, this gene is overexpressed
            in prostate cancer, melanoma and gastrointestinal stromal tumor.
            Multiple alternatively spliced transcript variants encoding
            different isoforms have been identified. [provided by RefSeq, Jul
            2016].
            
            Transcript Variant: This variant (2) lacks an alternate exon in the
            5' UTR and an alternate in-frame exon in the 3' coding region,
            compared to variant 1. The resulting isoform (b) lacks an internal
            segment, compared to isoform a. This isoform contains the
            N-terminal TAD.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB209202.1, SRR14372080.364736.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2                 DA114165.1         352-353
            3-488               AB209202.1         1-486
            489-489             BC098403.1         711-711
            490-2358            AB209202.1         488-2356
            2359-5809           AC004857.1         95209-98659
            5810-6193           BU737178.1         15-398              c
FEATURES             Location/Qualifiers
     source          1..6193
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7p21.2"
     gene            1..6193
                     /gene="ETV1"
                     /gene_synonym="ER81"
                     /note="ETS variant transcription factor 1"
                     /db_xref="GeneID:2115"
                     /db_xref="HGNC:HGNC:3490"
                     /db_xref="MIM:600541"
     exon            1..104
                     /gene="ETV1"
                     /gene_synonym="ER81"
                     /inference="alignment:Splign:2.1.0"
     exon            105..236
                     /gene="ETV1"
                     /gene_synonym="ER81"
                     /inference="alignment:Splign:2.1.0"
     CDS             192..1556
                     /gene="ETV1"
                     /gene_synonym="ER81"
                     /note="isoform b is encoded by transcript variant 2; ets
                     variant gene 1; ets-related protein 81"
                     /codon_start=1
                     /product="ETS translocation variant 1 isoform b"
                     /protein_id="NP_001156619.1"
                     /db_xref="CCDS:CCDS55087.1"
                     /db_xref="GeneID:2115"
                     /db_xref="HGNC:HGNC:3490"
                     /db_xref="MIM:600541"
                     /translation="MDGFYDQQVPYMVTNSQRGRNCNEKPTNVRKRKFINRDLAHDSE
                     ELFQDLSQLQETWLAEAQVPDNDEQFVPDYQAESLAFHGLPLKIKKEPHSPCSEISSA
                     CSQEQPFKFSYGEKCLYNVSAYDQKPQVGMRPSNPPTPSSTPVSPLHHASPNSTHTPK
                     PDRAFPAHLPPSQSIPDSSYPMDHRFRRQLSEPCNSFPPLPTMPREGRPMYQRQMSEP
                     NIPFPPQGFKQEYHDPVYEHNTMVGSAASQSFPPPLMIKQEPRDFAYDSGCMFEKGPR
                     QFYDDTCVVPEKFDGDIKQEPGMYREGPTYQRRGSLQLWQFLVALLDDPSNSHFIAWT
                     GRGMEFKLIEPEEVARRWGIQKNRPAMNYDKLSRSLRYYYEKGIMQKVAGERYVYKFV
                     CDPEALFSMAFPDNQRPLLKTDMERHINEEDTVPLSHFDESMAYMPEGGCCNPHPYNE
                     GYVY"
     exon            237..324
                     /gene="ETV1"
                     /gene_synonym="ER81"
                     /inference="alignment:Splign:2.1.0"
     exon            325..372
                     /gene="ETV1"
                     /gene_synonym="ER81"
                     /inference="alignment:Splign:2.1.0"
     exon            373..426
                     /gene="ETV1"
                     /gene_synonym="ER81"
                     /inference="alignment:Splign:2.1.0"
     exon            427..556
                     /gene="ETV1"
                     /gene_synonym="ER81"
                     /inference="alignment:Splign:2.1.0"
     exon            557..745
                     /gene="ETV1"
                     /gene_synonym="ER81"
                     /inference="alignment:Splign:2.1.0"
     exon            746..993
                     /gene="ETV1"
                     /gene_synonym="ER81"
                     /inference="alignment:Splign:2.1.0"
     exon            994..1062
                     /gene="ETV1"
                     /gene_synonym="ER81"
                     /inference="alignment:Splign:2.1.0"
     exon            1063..1232
                     /gene="ETV1"
                     /gene_synonym="ER81"
                     /inference="alignment:Splign:2.1.0"
     exon            1233..1334
                     /gene="ETV1"
                     /gene_synonym="ER81"
                     /inference="alignment:Splign:2.1.0"
     exon            1335..6193
                     /gene="ETV1"
                     /gene_synonym="ER81"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4126..4131
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ETV1"
                     /gene_synonym="ER81"
                     /note="hexamer: AATAAA"
     polyA_site      4152
                     /gene="ETV1"
                     /gene_synonym="ER81"
                     /note="major polyA site"
     regulatory      6171..6176
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ETV1"
                     /gene_synonym="ER81"
                     /note="hexamer: AATAAA"
     polyA_site      6193
                     /gene="ETV1"
                     /gene_synonym="ER81"
ORIGIN      
        1 agaggcgctt tcggcttcca agggggaagt gctgggctat aattaatgtt tttattaaat
       61 ttggagggaa gtttttgcag cctttcgcct agcgtggcct tcaggttgat agaagtccag
      121 atcctgagga aatctccagc taaatgctca aaatataaaa tactgagctg agatttgcga
      181 agagcagcag catggatgga ttttatgacc agcaagtgcc ttacatggtc accaatagtc
      241 agcgtgggag aaattgtaac gagaaaccaa caaatgtcag gaaaagaaaa ttcattaaca
      301 gagatctggc tcatgattca gaagaactct ttcaagatct aagtcaatta caggaaacat
      361 ggcttgcaga agctcaggta cctgacaatg atgagcagtt tgtaccagac tatcaggctg
      421 aaagtttggc ttttcatggc ctgccactga aaatcaagaa agaaccccac agtccatgtt
      481 cagaaatcag ctctgcctgc agtcaagaac agccctttaa attcagctat ggagaaaagt
      541 gcctgtacaa tgtcagtgcc tatgatcaga agccacaagt gggaatgagg ccctccaacc
      601 cccccacacc atccagcacg ccagtgtccc cactgcatca tgcatctcca aactcaactc
      661 atacaccgaa acctgaccgg gccttcccag ctcacctccc tccatcgcag tccataccag
      721 atagcagcta ccccatggac cacagatttc gccgccagct ttctgaaccc tgtaactcct
      781 ttcctccttt gccgacgatg ccaagggaag gacgtcctat gtaccaacgc cagatgtctg
      841 agccaaacat ccccttccca ccacaaggct ttaagcagga gtaccacgac ccagtgtatg
      901 aacacaacac catggttggc agtgcggcca gccaaagctt tccccctcct ctgatgatta
      961 aacaggaacc cagagatttt gcatatgact caggctgtat gtttgaaaag ggccccaggc
     1021 agttttatga tgacacctgt gttgtcccag aaaaattcga tggagacatc aaacaagagc
     1081 caggaatgta tcgggaagga cccacatacc aacggcgagg atcacttcag ctctggcagt
     1141 ttttggtagc tcttctggat gacccttcaa attctcattt tattgcctgg actggtcgag
     1201 gcatggaatt taaactgatt gagcctgaag aggtggcccg acgttggggc attcagaaaa
     1261 acaggccagc tatgaactat gataaactta gccgttcact ccgctattac tatgagaaag
     1321 gaattatgca aaaggtggct ggagagagat atgtctacaa gtttgtgtgt gatccagaag
     1381 cccttttctc catggccttt ccagataatc agcgtccact gctgaagaca gacatggaac
     1441 gtcacatcaa cgaggaggac acagtgcctc tttctcactt tgatgagagc atggcctaca
     1501 tgccggaagg gggctgctgc aacccccacc cctacaacga aggctacgtg tattaacaca
     1561 agtgacagtc aagcagggcg tttttgcgct tttccttttt tctgcaagat acagagaatt
     1621 gctgaatctt tgttttattt ctgttgtttg tattttattt ttaaataata atacacaaaa
     1681 aggggctttt cctgttgcat tattctatgg tctgccatgg actgtgcact ttatttgagg
     1741 gtgggtggga gtaatctaaa catttattct gtgtaacagg aagctaatgg gtgaatgggc
     1801 agagggattt ggggattact ttttacttag gcttgggatg gggtcctaca agttttgagt
     1861 atgatgaaac tatatcatgt ctgtttgatt tcataacaac ataagataat gtttatttta
     1921 tcggggtatc tatggtacag ttaatttcac gttgtgtaaa tatccacttg gagactattt
     1981 gccttgggca ttttcccctg tcatttatga gtctctgcag gtgtacaaaa aaaccccaat
     2041 ctactgtaaa tggcagttta attgttagaa atgactgttt ttgcaccact tgtaaaaagg
     2101 tatttagcga ttgcatttgc tgtttgttgt tttattttgc tttatatatg acttgcagag
     2161 gataaccata aaatgggtaa ttctctctga agttgaataa tcaccatgac tgtaaatgag
     2221 gggcacaatt ttggactctg gcgccaaact gagtcatagg ccagtagcat tacgtgtatc
     2281 tggtgccacc ttgctgttta gatacaaatc ataccgtctt ttaaatattt tgaagcccat
     2341 ttcagttaaa taatgacatg tcatggtcct ttggaatctt catttaaatg ttaaatctgg
     2401 aatcaaaatg aagcaaaaaa tatctgtctc cttttcactt tcttcagtac ataaatacat
     2461 tatttaatca ataagaatta actgtactaa atcatgtatt atgctgttct agttacagca
     2521 aacactcttt aagaaaaata tccaatacac taaataggta ctatagtaat ttttagacat
     2581 ggtacccatt gatatgcatt taaacctttt actgctgtgt tatgttgata acatatataa
     2641 atattagata atgctaatgc ttctgctgct gtcttttctg taatattctc tttcatgctg
     2701 aatttactat gaccatttat aagcagtgca gttaactaca gatagcattt caggacaaaa
     2761 tagatgactc aaaccattta ttgcttaaaa aatagcttac gccatgctat gctataagca
     2821 gcttttatgc acattgacaa atgaagagta agcttcagct tgctaaagga aactgtggaa
     2881 ccttttgtaa cttttggtga tatggaaaat tatttacaaa ccgtcaaaga atatgaggaa
     2941 gttgctgtat gacatagtgc tggcactgat attatccatc atctcttttt ggacacttct
     3001 gtaaatgtga ttggattgtt tgaaagaaga tttaaagttt caaagttttt tgttctgttt
     3061 ttgctttgca tttggagaaa atattgaaag cagggtatgt tgtttcattc accttgaaaa
     3121 aaccatgagt aaatggggat atagaatctc tgaatagctc gctaaaagat tcaagcaagg
     3181 gacatgaatt ttgttccatc tatcaataat atccagaaga acaacttttt taaagagtct
     3241 atagcaaaaa gcaaaaaaaa aaaaaaattc taaacacaaa gtcaaaataa acctattgta
     3301 aaagcatttc gtgatgagca tgaaaaagat tgtttaaaga tgatcccccc agctacccat
     3361 tttccaaaac tacacagatc acagctcatt tctctaagtg gagcagttat caagaaaccc
     3421 aaacaccaaa attgctactc ttcacattta atcctacaaa aagtactcca atttcaaaat
     3481 atgtatgtaa cctgcgattt caatgattgt tgttcatata catcatgtat tattttggcc
     3541 cattttgggc ctaaaaaaga aaactatgcc ttaaaaatca gaaccttttc tccccactat
     3601 gcttatgtgg ccatctacag cacttagaat aaaaacagat gttaaaatat tcagtgaaag
     3661 ttttattgga aaaaggaatt gagatatata attgagattt ggtgaaattg aaggagaaaa
     3721 tttaagtgag tctttaaaat atattctgaa tgaaaactgt attgaggatt catttttgtt
     3781 cctttttttt ctttttctct tttctccttt ttcttctttt taatagtcta gttttagtca
     3841 gtcagtgagg aagaattggg ccatgctaac gttatcacaa gagaacaatg gcagaaatgg
     3901 tattagttat ataatattta aggacaaact atatgttttg ctgttttaac gtagtgactc
     3961 actgaactaa atacataatt gaccaacatt aagtgtattt ccaatacaga agggttgaaa
     4021 atattacatt ataaactctt ttgaaaaatg tatctaaaat tttttaagtt ctgttttgat
     4081 tccacttttt ggttgagttt ttatgttttt gttttcaggt agattaataa atctggcagc
     4141 tgatttctgc aagattcttg tgttttgaat ttctcattga attggctact caaacataga
     4201 aatcatttgt taatgatgta atgtcttctc tcagctttta tcttcactgc tgtttgctgt
     4261 ctcttgatga tgacatgtta atacccaata gattaattgc aacaaacact tatactcaaa
     4321 taactaagta aaaataattt ttcttgttat gtccatgaaa agtgcttcag aataaaaatc
     4381 cacaagactg acagtgcaga acatttttct caaatcatgg gcggatcttg gaggtctagt
     4441 ttcccgtaga tgctgtaacc aattaccaca acttcagtaa tttacacaaa tttatcttat
     4501 agttctggag gcagaagttc aaaagaagcc ttaagagact aaaaccaaga tgtccttagg
     4561 tctggttcct tctggaggct ccaggggaga ttcttccagc tttcacttct agagtctgct
     4621 gacattcctt ggctcctggc tacatcactt caatctctgc ttccatggtc acatactctt
     4681 ctactatagt caaatttcct tcctgcctct tataaggatg cttgtgatta catttagggg
     4741 atgctcagat aatccaggac aatctctcca tctcaagatc cttaacttaa tgacgtgtgc
     4801 caagtccctt tggctagata attattcata ggtcccaggg attaggacat ggatgtaagg
     4861 ggtgagggca gggctgttat tcagaacacc gcacggagga ggaagactgt gtagcaaaga
     4921 ctctaattga tttactcagg aacagtggag ttctgctgag ggatctagga tttgaaagta
     4981 ctagagtttg cttttattta ccactgagat attttcccct tattctgcat aaataatttt
     5041 gaaaactttc tatattaaat ttcaactatt ccactaaaat gtctggtaat cacatcaagc
     5101 ctttagatta ttcaaatcct tccccagccc ccaggaaaac actaagtcat gaaacagaaa
     5161 aacagaaggt atgataataa tagtaataac agttaaatca gtggtctaat ccagatttta
     5221 ttttttaata catttctttt ggtgttaata tgggttacta tgtgatctta tcatttgcta
     5281 gtgattatta cttattaggt aagaacaatg tgtaaaatat gtctattact caaaagaaca
     5341 attgcaaaat gagtcaactt atctttatat aaccaggaaa gaaatatatt gccagaagct
     5401 acagaatttt gccagatgat agggatttct aaaatgagcc actttgtcta tcatgcagcc
     5461 ttttcagagc ttgtaatgag aaaacattac agaggagaag gtcatttgga tgtttgttac
     5521 ttggaatcct agaaaacaaa aactaaaatt taaaaataag aagtgagtaa gctattttcc
     5581 atttgcgatt tggtatggag aagagaggaa atagaattat taaaaaaata caaattgggt
     5641 aaaagtgatg gtggaaaaaa tataaagaag gcaaatgtac atattaagca attctactaa
     5701 gaattggaaa aatcaagttt caaaaagatg gtaatagttg ggcatgatac tagaaaattt
     5761 cacccagttt attcagagct caactagtac ttttaggact tcttttttta tatacatgag
     5821 actcactttg acatacttaa aaaaaaaaca gtttatggaa agtacagttt aagaggagaa
     5881 tttgattaga ctaagtggat atctttatag aaatattaat gatttcagaa ttttcagtta
     5941 caagtgtata taccgtggct attgtttatg gattcatatg taaggtaggg tcttttttgc
     6001 atatagactc cagtattagt tactttcatt ctaaaattat atttatgctt ctatggggaa
     6061 gaaaattttt aattcacttg gttgtattaa aattatactt acggtttgag aaaacatgct
     6121 atgaaaatca tgattatagc aaattaaata tgctcaaaat ttaaatctaa aataaaagcc
     6181 cagaaactga aaa
//
