LOCUS       NM_005239               3668 bp    mRNA    linear   PRI 03-SEP-2024
DEFINITION  Homo sapiens ETS proto-oncogene 2, transcription factor (ETS2),
            transcript variant 1, mRNA.
ACCESSION   NM_005239
VERSION     NM_005239.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3668)
  AUTHORS   Wang,X., Zhao,H., Luo,X., Chen,Y., Shi,C., Wang,Y., Bai,J., Shao,Z.
            and Shang,Z.
  TITLE     NNMT switches the proangiogenic phenotype of cancer-associated
            fibroblasts via epigenetically regulating ETS2/VEGFA axis
  JOURNAL   Oncogene 43 (35), 2647-2660 (2024)
   PUBMED   39069579
  REMARK    GeneRIF: NNMT switches the proangiogenic phenotype of
            cancer-associated fibroblasts via epigenetically regulating
            ETS2/VEGFA axis.
REFERENCE   2  (bases 1 to 3668)
  AUTHORS   Vazquez-Cabrera,G., Skandik,M., Roncier,N., Real Oualit,F., Cruz De
            Los Santos,M., Baleviciute,A., Cheray,M. and Joseph,B.
  TITLE     ID2-ETS2 axis regulates the transcriptional acquisition of
            pro-tumoral microglia phenotype in glioma
  JOURNAL   Cell Death Dis 15 (7), 512 (2024)
   PUBMED   39019900
  REMARK    GeneRIF: ID2-ETS2 axis regulates the transcriptional acquisition of
            pro-tumoral microglia phenotype in glioma.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3668)
  AUTHORS   Stankey,C.T., Bourges,C., Haag,L.M., Turner-Stokes,T.,
            Piedade,A.P., Palmer-Jones,C., Papa,I., Silva Dos Santos,M.,
            Zhang,Q., Cameron,A.J., Legrini,A., Zhang,T., Wood,C.S., New,F.N.,
            Randzavola,L.O., Speidel,L., Brown,A.C., Hall,A., Saffioti,F.,
            Parkes,E.C., Edwards,W., Direskeneli,H., Grayson,P.C., Jiang,L.,
            Merkel,P.A., Saruhan-Direskeneli,G., Sawalha,A.H., Tombetti,E.,
            Quaglia,A., Thorburn,D., Knight,J.C., Rochford,A.P., Murray,C.D.,
            Divakar,P., Green,M., Nye,E., MacRae,J.I., Jamieson,N.B.,
            Skoglund,P., Cader,M.Z., Wallace,C., Thomas,D.C. and Lee,J.C.
  TITLE     A disease-associated gene desert directs macrophage inflammation
            through ETS2
  JOURNAL   Nature 630 (8016), 447-456 (2024)
   PUBMED   38839969
  REMARK    GeneRIF: A disease-associated gene desert directs macrophage
            inflammation through ETS2.
REFERENCE   4  (bases 1 to 3668)
  AUTHORS   Choi,Y., Lee,Y., Kim,J.S., Zhang,P. and Kim,J.
  TITLE     USP39-Mediated Non-Proteolytic Control of ETS2 Suppresses Nuclear
            Localization and Activity
  JOURNAL   Biomolecules 13 (10), 1475 (2023)
   PUBMED   37892157
  REMARK    GeneRIF: USP39-Mediated Non-Proteolytic Control of ETS2 Suppresses
            Nuclear Localization and Activity.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3668)
  AUTHORS   Tan,L., Xiong,D., Zhang,H., Xiao,S., Yi,R. and Wu,J.
  TITLE     ETS2 promotes cardiomyocyte apoptosis and autophagy in heart
            failure by regulating lncRNA TUG1/miR-129-5p/ATG7 axis
  JOURNAL   FASEB J 37 (6), e22937 (2023)
   PUBMED   37171262
  REMARK    GeneRIF: ETS2 promotes cardiomyocyte apoptosis and autophagy in
            heart failure by regulating lncRNA TUG1/miR-129-5p/ATG7 axis.
REFERENCE   6  (bases 1 to 3668)
  AUTHORS   Watson,D.K., Mavrothalassitis,G.J., Jorcyk,C.L., Smyth,F.E. and
            Papas,T.S.
  TITLE     Molecular organization and differential polyadenylation sites of
            the human ETS2 gene
  JOURNAL   Oncogene 5 (10), 1521-1527 (1990)
   PUBMED   2250910
REFERENCE   7  (bases 1 to 3668)
  AUTHORS   Boulukos,K.E., Pognonec,P., Sariban,E., Bailly,M., Lagrou,C. and
            Ghysdael,J.
  TITLE     Rapid and transient expression of Ets2 in mature macrophages
            following stimulation with cMGF, LPS, and PKC activators
  JOURNAL   Genes Dev 4 (3), 401-409 (1990)
   PUBMED   2186967
REFERENCE   8  (bases 1 to 3668)
  AUTHORS   Watson,D.K., McWilliams,M.J., Lapis,P., Lautenberger,J.A.,
            Schweinfest,C.W. and Papas,T.S.
  TITLE     Mammalian ets-1 and ets-2 genes encode highly conserved proteins
  JOURNAL   Proc Natl Acad Sci U S A 85 (21), 7862-7866 (1988)
   PUBMED   2847145
REFERENCE   9  (bases 1 to 3668)
  AUTHORS   Le Beau,M.M., Rowley,J.D., Sacchi,N., Watson,D.K., Papas,T.S. and
            Diaz,M.O.
  TITLE     Hu-ets-2 is translocated to chromosome 8 in the t(8;21) in acute
            myelogenous leukemia
  JOURNAL   Cancer Genet Cytogenet 23 (3), 269-274 (1986)
   PUBMED   3021321
REFERENCE   10 (bases 1 to 3668)
  AUTHORS   Watson,D.K., McWilliams-Smith,M.J., Nunn,M.F., Duesberg,P.H.,
            O'Brien,S.J. and Papas,T.S.
  TITLE     The ets sequence from the transforming gene of avian
            erythroblastosis virus, E26, has unique domains on human
            chromosomes 11 and 21: both loci are transcriptionally active
  JOURNAL   Proc Natl Acad Sci U S A 82 (21), 7294-7298 (1985)
   PUBMED   2997781
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from J04102.1, BC042954.2,
            AA452482.1 and AK000535.1.
            
            On Nov 23, 2018 this sequence version replaced NM_005239.5.
            
            Summary: This gene encodes a transcription factor which regulates
            genes involved in development and apoptosis. The encoded protein is
            also a protooncogene and shown to be involved in regulation of
            telomerase. A pseudogene of this gene is located on the X
            chromosome. Alternative splicing results in multiple transcript
            variants. [provided by RefSeq, Jan 2012].
            
            Transcript Variant: This variant (1) represents the shorter
            transcript and encodes the shorter protein (isoform 1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803613.34960.1,
                                           SRR1660805.50855.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000360938.8/ ENSP00000354194.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1672              J04102.1           100-1771
            1673-2510           BC042954.2         1673-2510
            2511-2775           AA452482.1         56-320
            2776-3668           AK000535.1         1-893
FEATURES             Location/Qualifiers
     source          1..3668
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="21"
                     /map="21q22.2"
     gene            1..3668
                     /gene="ETS2"
                     /gene_synonym="ETS2IT1"
                     /note="ETS proto-oncogene 2, transcription factor"
                     /db_xref="GeneID:2114"
                     /db_xref="HGNC:HGNC:3489"
                     /db_xref="MIM:164740"
     exon            1..192
                     /gene="ETS2"
                     /gene_synonym="ETS2IT1"
                     /inference="alignment:Splign:2.1.0"
     CDS             193..1602
                     /gene="ETS2"
                     /gene_synonym="ETS2IT1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     oncogene ETS-2; protein C-ets-2; v-ets avian
                     erythroblastosis virus E2 oncogene homolog 2; v-ets
                     erythroblastosis virus E26 oncogene homolog 2; v-ets avian
                     erythroblastosis virus E26 oncogene homolog 2"
                     /codon_start=1
                     /product="protein C-ets-2 isoform 1"
                     /protein_id="NP_005230.1"
                     /db_xref="CCDS:CCDS13659.1"
                     /db_xref="GeneID:2114"
                     /db_xref="HGNC:HGNC:3489"
                     /db_xref="MIM:164740"
                     /translation="MNDFGIKNMDQVAPVANSYRGTLKRQPAFDTFDGSLFAVFPSLN
                     EEQTLQEVPTGLDSISHDSANCELPLLTPCSKAVMSQALKATFSGFKKEQRRLGIPKN
                     PWLWSEQQVCQWLLWATNEFSLVNVNLQRFGMNGQMLCNLGKERFLELAPDFVGDILW
                     EHLEQMIKENQEKTEDQYEENSHLTSVPHWINSNTLGFGTEQAPYGMQTQNYPKGGLL
                     DSMCPASTPSVLSSEQEFQMFPKSRLSSVSVTYCSVSQDFPGSNLNLLTNNSGTPKDH
                     DSPENGADSFESSDSLLQSWNSQSSLLDVQRVPSFESFEDDCSQSLCLNKPTMSFKDY
                     IQERSDPVEQGKPVIPAAVLAGFTGSGPIQLWQFLLELLSDKSCQSFISWTGDGWEFK
                     LADPDEVARRWGKRKNKPKMNYEKLSRGLRYYYDKNIIHKTSGKRYVYRFVCDLQNLL
                     GFTPEELHAILGVQPDTED"
     exon            193..264
                     /gene="ETS2"
                     /gene_synonym="ETS2IT1"
                     /inference="alignment:Splign:2.1.0"
     exon            265..376
                     /gene="ETS2"
                     /gene_synonym="ETS2IT1"
                     /inference="alignment:Splign:2.1.0"
     exon            377..496
                     /gene="ETS2"
                     /gene_synonym="ETS2IT1"
                     /inference="alignment:Splign:2.1.0"
     exon            497..697
                     /gene="ETS2"
                     /gene_synonym="ETS2IT1"
                     /inference="alignment:Splign:2.1.0"
     exon            698..781
                     /gene="ETS2"
                     /gene_synonym="ETS2IT1"
                     /inference="alignment:Splign:2.1.0"
     exon            782..1003
                     /gene="ETS2"
                     /gene_synonym="ETS2IT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1004..1267
                     /gene="ETS2"
                     /gene_synonym="ETS2IT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1268..1386
                     /gene="ETS2"
                     /gene_synonym="ETS2IT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1387..3668
                     /gene="ETS2"
                     /gene_synonym="ETS2IT1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3645..3650
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ETS2"
                     /gene_synonym="ETS2IT1"
                     /note="hexamer: AATAAA"
     polyA_site      3668
                     /gene="ETS2"
                     /gene_synonym="ETS2IT1"
                     /note="major polyA site"
ORIGIN      
        1 ggttacttcc tccagagact gacgagtgcg gtgtcgctcc agctcagagc tcccggagcc
       61 gcccggccag cgtccggcct ccctgatcgt ctctggccgg cgccctcgcc ctcgcccggc
      121 gcgcaccgag cagccgcggg cgccgagcag ccaccgtccc gaccaagcgc cggccctgcc
      181 cgcagcggca ggatgaatga tttcggaatc aagaatatgg accaggtagc ccctgtggct
      241 aacagttaca gagggacact caagcgccag ccagcctttg acacctttga tgggtccctg
      301 tttgctgttt ttccttctct aaatgaagag caaacactgc aagaagtgcc aacaggcttg
      361 gattccattt ctcatgactc cgccaactgt gaattgcctt tgttaacccc gtgcagcaag
      421 gctgtgatga gtcaagcctt aaaagctacc ttcagtggct tcaaaaagga acagcggcgc
      481 ctgggcattc caaagaaccc ctggctgtgg agtgagcaac aggtatgcca gtggcttctc
      541 tgggccacca atgagttcag tctggtgaac gtgaatctgc agaggttcgg catgaatggc
      601 cagatgctgt gtaaccttgg caaggaacgc tttctggagc tggcacctga ctttgtgggt
      661 gacattctct gggaacatct ggagcaaatg atcaaagaaa accaagaaaa gacagaagat
      721 caatatgaag aaaattcaca cctcacctcc gttcctcatt ggattaacag caatacatta
      781 ggttttggca cagagcaggc gccctatgga atgcagacac agaattaccc caaaggcggc
      841 ctcctggaca gcatgtgtcc ggcctccaca cccagcgtac tcagctctga gcaggagttt
      901 cagatgttcc ccaagtctcg gctcagctcc gtcagcgtca cctactgctc tgtcagtcag
      961 gacttcccag gcagcaactt gaatttgctc accaacaatt ctgggactcc caaagaccac
     1021 gactcccctg agaacggtgc ggacagcttc gagagctcag actccctcct ccagtcctgg
     1081 aacagccagt cgtccttgct ggatgtgcaa cgggttcctt ccttcgagag cttcgaagat
     1141 gactgcagcc agtctctctg cctcaataag ccaaccatgt ctttcaagga ttacatccaa
     1201 gagaggagtg acccagtgga gcaaggcaaa ccagttatac ctgcagctgt gctggccggc
     1261 ttcacaggaa gtggacctat tcagctgtgg cagtttctcc tggagctgct atcagacaaa
     1321 tcctgccagt cattcatcag ctggactgga gacggatggg agtttaagct cgccgacccc
     1381 gatgaggtgg cccgccggtg gggaaagagg aaaaataagc ccaagatgaa ctacgagaag
     1441 ctgagccggg gcttacgcta ctattacgac aagaacatca tccacaagac gtcggggaag
     1501 cgctacgtgt accgcttcgt gtgcgacctc cagaacttgc tggggttcac gcccgaggaa
     1561 ctgcacgcca tcctgggcgt ccagcccgac acggaggact gaggtcgccg ggaccaccct
     1621 gagccggccc caggctcgtg gactgagtgg gaagcccatc ctgaccagct gctccgagga
     1681 cccaggaaag gcaggattga aaatgtccag gaaagtggcc aagaagcagt ggccttattg
     1741 catcccaaac cacgcctctt gaccaggctg cctcccttgt ggcagcaacg gcacagctaa
     1801 ttctactcac agtgctttta agtgaaaatg gtcgagaaag aggcaccagg aagccgtcct
     1861 ggcgcctggc agtccgtggg acgggatggt tctggctgtt tgagattctc aaaggagcga
     1921 gcatgtcgtg gacacacaca gactattttt agattttctt ttgccttttg caaccaggaa
     1981 cagcaaatgc aaaaactctt tgagagggta ggagggtggg aaggaaacaa ccatgtcatt
     2041 tcagaagtta gtttgtatat attattataa tcttataatt gttctcagaa tcccttaaca
     2101 gttgtattta acagaaattg tatattgtaa tttaaaataa ttatataact gtatttgaaa
     2161 taagaattca gacatctgag gttttatttc atttttcaat agcacatatg gaattttgca
     2221 aagatttaat ctgccaaggg ccgactaaga gaagttgtaa agtatgtatt atttacattt
     2281 aatagactta cagggataag gcctgtgggg ggtaatccct gctttttgtg tttttttgtt
     2341 tgtttgtttg tttgtttttg gggggttttc ttgccttggt tgtctggcaa ggactttgta
     2401 catttgggag tttttatgag aaacttaaat gttattatct gggcttatat ctggcctctg
     2461 ctttctcctt taattgtaaa gtaaaagcta taaagcagta tttttcttga caaatggcat
     2521 atgttttcca cttctttgca tgcgtttaag tcagtttata cacaaaatgg attttatttt
     2581 ttagtttaac tgtgtttctc cgacagctca cctctctctg accacccagc catttccttc
     2641 ctgtgctcca cgttcttctg tgtgattaaa ataagaatat tatttttgga aatatgcaac
     2701 tccttttcag agatcaggag ggatttatgt agcagctatt tttactgcaa aagtaattca
     2761 ctggaaaaaa aatgtaattt gtaagaaagc tttattttta tctcagctct atgtaaagtt
     2821 aaagttactg tacagagctg aaggacgggg ggcggtaggg gtcttgatga aacctcttga
     2881 acgaagcaca gtttgtccca tctttgttca ctcgtgtgtc tcaaccatct taatagcatg
     2941 ctgctccttt ttgctcagtg tccacagcaa gatgacgtga ttcttatttt cttggacaca
     3001 gactattctg aggcacagag cggggactta agatgggaaa gagaaagcat cggagccatt
     3061 cattcggaga aaacgttttg atcaaaatgg agacttttgt agtcgtttca aaagagcacc
     3121 tgagtcatgt gtattcccgg cctttataaa tgacccggtc aagttggttt caaagtccga
     3181 caggcttgtc tgtttactag ctgcgtggcc ttggacgggt ggctgacatc tgtaaagaat
     3241 cctcctgtga tgaaactgag gaatcgggtg gccgggcaag ctgggaagag caaagccaga
     3301 gctgcgctgc ctcaataccc acaaaagacc attcccagta tacataagca caggatgttt
     3361 ttctcaagag ggatgtattt atcacttgga catctgttta taatataaac agacatgtga
     3421 ctgggaacat cttgctgcca aaagaatcct aggcagtggc tcattgtatg tgaggttgaa
     3481 ccacgtgaaa ttgccaatat taggctggct tttatctaca aagaaggagt ttcatggggt
     3541 tcagcctaac agttatggaa actacagtcc ttataaacca ttggcatggt aataaacaga
     3601 tcttaagtat aaaaattttg taattgggcc tttactctct caataataaa gtattttgtt
     3661 tatataaa
//
