LOCUS       NM_001143820            5139 bp    mRNA    linear   PRI 29-OCT-2024
DEFINITION  Homo sapiens ETS proto-oncogene 1, transcription factor (ETS1),
            transcript variant 1, mRNA.
ACCESSION   NM_001143820
VERSION     NM_001143820.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5139)
  AUTHORS   Chatterjee,P., Ghosh,D., Chowdhury,S.R. and Roy,S.S.
  TITLE     ETS1 drives EGF-induced glycolytic shift and metastasis of
            epithelial ovarian cancer cells
  JOURNAL   Biochim Biophys Acta Mol Cell Res 1871 (8), 119805 (2024)
   PUBMED   39159682
  REMARK    GeneRIF: ETS1 drives EGF-induced glycolytic shift and metastasis of
            epithelial ovarian cancer cells.
REFERENCE   2  (bases 1 to 5139)
  AUTHORS   Chen,J.H., Li,J.J., Yuan,Y., Tian,Q., Feng,D.D., Zhuang,L.L.,
            Cao,Q., Zhou,G.P. and Jin,R.
  TITLE     ETS1 and RBPJ transcriptionally regulate METTL14 to suppress
            TGF-beta1-induced epithelial-mesenchymal transition in human
            bronchial epithelial cells
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1870 (7), 167349 (2024)
   PUBMED   39002703
  REMARK    GeneRIF: ETS1 and RBPJ transcriptionally regulate METTL14 to
            suppress TGF-beta1-induced epithelial-mesenchymal transition in
            human bronchial epithelial cells.
REFERENCE   3  (bases 1 to 5139)
  AUTHORS   Guo,Y., Pan,J., Gao,X. and Zheng,Y.
  TITLE     Circ-PITX1 promotes non-small-cell lung cancer progression through
            regulating ETS1 expression via miR-615-5p
  JOURNAL   Thorac Cancer 15 (27), 1946-1957 (2024)
   PUBMED   39138880
  REMARK    GeneRIF: Circ-PITX1 promotes non-small-cell lung cancer progression
            through regulating ETS1 expression via miR-615-5p.
REFERENCE   4  (bases 1 to 5139)
  AUTHORS   Sreelakshmi,B.J., Karthika,C.L., Ahalya,S., Kalpana,S.R.,
            Kartha,C.C. and Sumi,S.
  TITLE     Mechanoresponsive ETS1 causes endothelial dysfunction and
            arterialization in varicose veins via NOTCH4/DLL4 signaling
  JOURNAL   Eur J Cell Biol 103 (2), 151420 (2024)
   PUBMED   38759515
  REMARK    GeneRIF: Mechanoresponsive ETS1 causes endothelial dysfunction and
            arterialization in varicose veins via NOTCH4/DLL4 signaling.
REFERENCE   5  (bases 1 to 5139)
  AUTHORS   Guo,J.R., He,K.Y., Yuan,J.L., An,W., Yin,W.T., Li,Q.T., Lu,L.Y.,
            Yang,J.Y., Liu,M.J., Li,Y.J., Zhao,Y., Yang,Q., Lei,X.Y., Gao,F.,
            Zhang,L., Wu,D.H., Li,J.Q., Zhao,Z.L., Liu,H., Zhu,L.J.,
            Xiang,X.Y., Sun,Q.H., Jian,Y.P. and Xu,Z.X.
  TITLE     HMGA1 sensitizes esophageal squamous cell carcinoma to mTOR
            inhibitors through the ETS1-FKBP12 axis
  JOURNAL   Int J Biol Sci 20 (7), 2640-2657 (2024)
   PUBMED   38725843
  REMARK    GeneRIF: HMGA1 sensitizes esophageal squamous cell carcinoma to
            mTOR inhibitors through the ETS1-FKBP12 axis.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5139)
  AUTHORS   Delattre,O., Zucman,J., Plougastel,B., Desmaze,C., Melot,T.,
            Peter,M., Kovar,H., Joubert,I., de Jong,P., Rouleau,G. et al.
  TITLE     Gene fusion with an ETS DNA-binding domain caused by chromosome
            translocation in human tumours
  JOURNAL   Nature 359 (6391), 162-165 (1992)
   PUBMED   1522903
REFERENCE   7  (bases 1 to 5139)
  AUTHORS   Majerus,M.A., Bibollet-Ruche,F., Telliez,J.B., Wasylyk,B. and
            Bailleul,B.
  TITLE     Serum, AP-1 and Ets-1 stimulate the human ets-1 promoter
  JOURNAL   Nucleic Acids Res 20 (11), 2699-2703 (1992)
   PUBMED   1614856
REFERENCE   8  (bases 1 to 5139)
  AUTHORS   Nye,J.A., Petersen,J.M., Gunther,C.V., Jonsen,M.D. and Graves,B.J.
  TITLE     Interaction of murine ets-1 with GGA-binding sites establishes the
            ETS domain as a new DNA-binding motif
  JOURNAL   Genes Dev 6 (6), 975-990 (1992)
   PUBMED   1592264
REFERENCE   9  (bases 1 to 5139)
  AUTHORS   Cocquerelle,C., Daubersies,P., Majerus,M.A., Kerckaert,J.P. and
            Bailleul,B.
  TITLE     Splicing with inverted order of exons occurs proximal to large
            introns
  JOURNAL   EMBO J 11 (3), 1095-1098 (1992)
   PUBMED   1339341
REFERENCE   10 (bases 1 to 5139)
  AUTHORS   Bhat,N.K., Thompson,C.B., Lindsten,T., June,C.H., Fujiwara,S.,
            Koizumi,S., Fisher,R.J. and Papas,T.S.
  TITLE     Reciprocal expression of human ETS1 and ETS2 genes during T-cell
            activation: regulatory role for the protooncogene ETS1
  JOURNAL   Proc Natl Acad Sci U S A 87 (10), 3723-3727 (1990)
   PUBMED   2187191
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BX640634.1, AP003397.2 and
            AK001630.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_001143820.1.
            
            Summary: This gene encodes a member of the ETS family of
            transcription factors, which are defined by the presence of a
            conserved ETS DNA-binding domain that recognizes the core consensus
            DNA sequence GGAA/T in target genes. These proteins function either
            as transcriptional activators or repressors of numerous genes, and
            are involved in stem cell development, cell senescence and death,
            and tumorigenesis. Alternatively spliced transcript variants
            encoding different isoforms have been described for this
            gene.[provided by RefSeq, Jul 2011].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BX640634.1, SRR18074969.275850.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000392668.8/ ENSP00000376436.3
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1924              BX640634.1         1-1924
            1925-3832           AP003397.2         68320-70227         c
            3833-5139           AK001630.1         1523-2829
FEATURES             Location/Qualifiers
     source          1..5139
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q24.3"
     gene            1..5139
                     /gene="ETS1"
                     /gene_synonym="c-ets-1; ETS-1; EWSR2; p54"
                     /note="ETS proto-oncogene 1, transcription factor"
                     /db_xref="GeneID:2113"
                     /db_xref="HGNC:HGNC:3488"
                     /db_xref="MIM:164720"
     exon            1..71
                     /gene="ETS1"
                     /gene_synonym="c-ets-1; ETS-1; EWSR2; p54"
                     /inference="alignment:Splign:2.1.0"
     exon            72..154
                     /gene="ETS1"
                     /gene_synonym="c-ets-1; ETS-1; EWSR2; p54"
                     /inference="alignment:Splign:2.1.0"
     CDS             86..1543
                     /gene="ETS1"
                     /gene_synonym="c-ets-1; ETS-1; EWSR2; p54"
                     /note="isoform 1 is encoded by transcript variant 1; Avian
                     erythroblastosis virus E26 (v-ets) oncogene homolog-1;
                     protein C-ets-1; v-ets avian erythroblastosis virus E26
                     oncogene homolog 1; v-ets avian erythroblastosis virus E2
                     oncogene homolog 1"
                     /codon_start=1
                     /product="protein C-ets-1 isoform 1"
                     /protein_id="NP_001137292.1"
                     /db_xref="CCDS:CCDS44767.1"
                     /db_xref="GeneID:2113"
                     /db_xref="HGNC:HGNC:3488"
                     /db_xref="MIM:164720"
                     /translation="MSYFVDSAGSSPVPYSAPRPAVVRQGPSNTYEDPRMNCGFQSNY
                     HQQRPCYPFWDEMATQEVPTGLEHCVSDMECADVPLLTPSSKEMMSQALKATFSGFTK
                     EQQRLGIPKDPRQWTETHVRDWVMWAVNEFSLKGVDFQKFCMNGAALCALGKDCFLEL
                     APDFVGDILWEHLEILQKEDVKPYQVNGVNPAYPESRYTSDYFISYGIEHAQCVPPSE
                     FSEPSFITESYQTLHPISSEELLSLKYENDYPSVILRDPLQTDTLQNDYFAIKQEVVT
                     PDNMCMGRTSRGKLGGQDSFESIESYDSCDRLTQSWSSQSSFNSLQRVPSYDSFDSED
                     YPAALPNHKPKGTFKDYVRDRADLNKDKPVIPAAALAGYTGSGPIQLWQFLLELLTDK
                     SCQSFISWTGDGWEFKLSDPDEVARRWGKRKNKPKMNYEKLSRGLRYYYDKNIIHKTA
                     GKRYVYRFVCDLQSLLGYTPEELHAMLDVKPDADE"
     exon            155..299
                     /gene="ETS1"
                     /gene_synonym="c-ets-1; ETS-1; EWSR2; p54"
                     /inference="alignment:Splign:2.1.0"
     exon            300..419
                     /gene="ETS1"
                     /gene_synonym="c-ets-1; ETS-1; EWSR2; p54"
                     /inference="alignment:Splign:2.1.0"
     exon            420..620
                     /gene="ETS1"
                     /gene_synonym="c-ets-1; ETS-1; EWSR2; p54"
                     /inference="alignment:Splign:2.1.0"
     exon            621..698
                     /gene="ETS1"
                     /gene_synonym="c-ets-1; ETS-1; EWSR2; p54"
                     /inference="alignment:Splign:2.1.0"
     exon            699..947
                     /gene="ETS1"
                     /gene_synonym="c-ets-1; ETS-1; EWSR2; p54"
                     /inference="alignment:Splign:2.1.0"
     exon            948..1208
                     /gene="ETS1"
                     /gene_synonym="c-ets-1; ETS-1; EWSR2; p54"
                     /inference="alignment:Splign:2.1.0"
     exon            1209..1327
                     /gene="ETS1"
                     /gene_synonym="c-ets-1; ETS-1; EWSR2; p54"
                     /inference="alignment:Splign:2.1.0"
     exon            1328..5139
                     /gene="ETS1"
                     /gene_synonym="c-ets-1; ETS-1; EWSR2; p54"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5113..5118
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ETS1"
                     /gene_synonym="c-ets-1; ETS-1; EWSR2; p54"
                     /note="hexamer: ATTAAA"
     regulatory      5119..5124
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ETS1"
                     /gene_synonym="c-ets-1; ETS-1; EWSR2; p54"
                     /note="hexamer: AACAAA"
     polyA_site      5136
                     /gene="ETS1"
                     /gene_synonym="c-ets-1; ETS-1; EWSR2; p54"
     polyA_site      5139
                     /gene="ETS1"
                     /gene_synonym="c-ets-1; ETS-1; EWSR2; p54"
                     /note="major polyA site"
ORIGIN      
        1 agttggaaag agaccacaga ctttgaggga agctcactca ggatctgctc tccggcaaag
       61 tagtaagtga ggtgctgaga gcagaatgag ctactttgtg gattctgctg ggagcagccc
      121 cgtcccttac tcagcgcctc gtcctgcagt ggtgaggcaa ggacctagca acacttatga
      181 agatcctcga atgaactgtg gtttccagtc caattatcac cagcaaagac cttgctaccc
      241 cttttgggat gagatggcaa ctcaggaagt tcctactggt cttgaacact gtgtctcaga
      301 tatggaatgt gcagatgtcc cactattaac tccaagcagc aaagaaatga tgtctcaagc
      361 attaaaagct actttcagtg gtttcactaa agaacagcaa cgactgggga tcccaaaaga
      421 cccccggcag tggacagaaa cccatgttcg ggactgggtg atgtgggctg tgaatgaatt
      481 cagcctgaaa ggtgtagact tccagaagtt ctgtatgaat ggagcagccc tctgcgccct
      541 gggtaaagac tgctttctcg agctggcccc agactttgtt ggggacatct tatgggaaca
      601 tctagagatc ctgcagaaag aggatgtgaa accatatcaa gttaatggag tcaacccagc
      661 ctatccagaa tcccgctata cctcggatta cttcattagc tatggtattg agcatgccca
      721 gtgtgttcca ccatcggagt tctcagagcc cagcttcatc acagagtcct atcagacgct
      781 ccatcccatc agctcggaag agctcctctc cctcaagtat gagaatgact acccctcggt
      841 cattctccga gaccctctcc agacagacac cttgcagaat gactactttg ctatcaaaca
      901 agaagtcgtc accccagaca acatgtgcat ggggaggacc agtcgtggta aactcggggg
      961 ccaggactct tttgaaagca tagagagcta cgatagttgt gatcgcctca cccagtcctg
     1021 gagcagccag tcatctttca acagcctgca gcgtgttccc tcctatgaca gcttcgactc
     1081 agaggactat ccggctgccc tgcccaacca caagcccaag ggcaccttca aggactatgt
     1141 gcgggaccgt gctgacctca ataaggacaa gcctgtcatt cctgctgctg ccctagctgg
     1201 ctacacaggc agtggaccaa tccagctatg gcagtttctt ctggaattac tcactgataa
     1261 atcctgtcag tcttttatca gctggacagg agatggctgg gaattcaaac tttctgaccc
     1321 agatgaggtg gccaggagat ggggaaagag gaaaaacaaa cctaagatga attatgagaa
     1381 actgagccgt ggcctacgct actattacga caaaaacatc atccacaaga cagcggggaa
     1441 acgctacgtg taccgctttg tgtgtgacct gcagagcctg ctggggtaca cccctgagga
     1501 gctgcacgcc atgctggacg tcaagccaga tgccgacgag tgatggcact gaaggggctg
     1561 gggaaaccct gctgagacct tccaaggaca gccgtgttgg ttggactctg aattttgaat
     1621 tgttattcta ttttttattt tccagaactc attttttacc ttcaggggtg ggagctaagt
     1681 cagttgcagc tgtaatcaat tgtgcgcagt tgggaaagga aagccaggac ttgtggggtg
     1741 ggtgggacca gaaattcttg agcaaatttt caggagaggg agaagggcct tctcagaagc
     1801 ttgaaggctc tggcttaaca gagaaagaga ctaatgtgtc caatcatttt taaaaatcat
     1861 ccatgaaaaa gtgtcttgag ttgtggaccc attagcaagt gacattgtca catcagaact
     1921 catgaaactg atgtaaggca attaatttgc ttctgttttt aggtctggga gggcaaaaaa
     1981 gaggtgggtg ggatgaaaca tgttttgggg ggggatgcac tgaaaatctg agaactattt
     2041 acctatcact ctagttttga agcaaagatg gacttcagtg gggaggggcc aaaaccgttg
     2101 ttgtgttaaa atttatttta ttaaattttg tgccagtatt ttttttctta aaaatcgtct
     2161 taagctctaa ggtggtctca gtattgcaat atcatgtaag tttgttttta tttgccggct
     2221 gaggattctg tcacaatgaa agaaaactgt ttatatagac cccattggaa aagcaaaacg
     2281 ctctcactga gatcagggat cccaaattca tgggacttat ataagaagga caattaatgc
     2341 tgatttgggt acaggggaat tatgtgtgtg aatgtcatct acaattaaaa aaaattagca
     2401 catcccttta cttacttgtt atcagtggat tctcggggtt tggacttaat gttgagctaa
     2461 gaagcattaa gtctttgaac tgaatgtatt ttgcatccct ggttttggac gacagtaaac
     2521 gtaggagcac tgttgaagtc ctggaaggga gatcgaagga ggaagattga cttggttctt
     2581 tcttagtcct atatctgtag catagatgac ttggaataaa agctgtatgc atgggcatta
     2641 cccctcaggt cctaagaaat aagtcctgaa tgcatgtcgt tccaaactaa cactctgtaa
     2701 tttttctttt atgtcttatt ttccaagagt cctccatttt ttgcaccccc tcaccgccaa
     2761 ctctgttatt cagtagagag aagtgtacgg ctttctgatt ggtgagtgaa aaagtaactt
     2821 gagacacgac ctaagttgaa gagtttagac ttgctgagtt ttagaagtga tggaaattaa
     2881 gagagcattt caataaaatg tgacttggct gtctttggaa gagaagtgca aggctttcct
     2941 ttgaagaatt taaattagtc cggtaggatg tcaggtgaga ctgtgtatgc aaaatgaatg
     3001 gcacaggtga tgccagggcc tcttgcttgg gtctgatgtc ttggcacagg gtaagtgaag
     3061 gttaattcca gaagagagga atgacttgaa ggcaaaggaa actaaggaag gaggttcagt
     3121 gaggaaaata aggttgtcca tgagatttga atagattttt agttccccca aggtttaaat
     3181 acaaacatag tcaagcaagg tagtcatctt tctgctggtt gtgaggggga atctgaaaat
     3241 ggagttttag aggaaaagtc aacatctaac tagtgaggaa aagtgcctaa tacaattaga
     3301 atctccctca ctctatagtt gcccagttga aaggataagg aggaggggtg gcttttatgg
     3361 acttccatga gagaaggaaa gaaatatttc aggtaagctt ctcagggctg gccctttttg
     3421 ggatttggat gagaaattgg aagtactaac tactttctag catatcttta agaaaattga
     3481 ttgttattta ctcccagatc ctcttgcaga cccagaatta tcaggaacat agctctgtga
     3541 ttcatgagtg tccccatact gatgaattgg agcatccata tggaaagcaa aggcagaatt
     3601 atcccagctg tattattttg atcttttgga tgcaggtgcc ttaatgaagc tctcaaaata
     3661 ttttaggagc tgctcaggga gtgttgggtg gaactgtttg gactacattg ttttctctta
     3721 gattatgtga tttttgttgg gcactggcaa aaggtgtgtg tgtgaatgtg tgcatgtgtg
     3781 tgaatgttgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtttgcagac
     3841 atgcaaaact gcagctgaaa taatacctta gatttctagg taagtctttc cacatttcaa
     3901 taatgggtaa gagtagaacc agggccgggt atcaattatt gcttgctgtt tgcaaccagg
     3961 cataaaatca ctttctcaaa tcatccaccg ttcctattaa atttatgccg gaaactctcc
     4021 ttctgtgagt ataactcctg cagttcctat agcagataag atataagaaa gtgcctccta
     4081 gtgctcctcc gcccgcttgt ttgctaaaat tccctttctc tctaagtcca ccattttcaa
     4141 gatttgtaga tagtgtatta gttaagacag ctttgtcgat ctggccagat gttttttctc
     4201 ctttgtccaa aggccagaga ccatcccagg aagagtggtg ggtggtttat acactggaaa
     4261 tgttgcgttt atgcttttta aaaacacacg ttaacttcag aggaaggatg ggcaaatctg
     4321 gtctagctgg gtgaaaccct tattttccca gagatgcctt aacctttgtt ggttttggct
     4381 ttagggttca gagtcacttt tgttcccttc tccattctgg agagggactt cccctacata
     4441 gagccctgat ttttgtggct gtggggattg gaggtagcat tcaaagatca gatgtgcttt
     4501 tcctcacttt ggagatgaac actctgggtt ttacagcatt aacctgccta accttcatgg
     4561 tgagaaatac accatctctc ttctagtcat gctgtgcatg ccgcttactc tgttggggtc
     4621 tatataaatt tgttgaactc ttacctacat tccaaagaag tttcaaggaa ccataaatat
     4681 atgtatacat atacatatat aaaatatata tattaaaata aaattatcag gaatactgcc
     4741 tcagttattg aacttttttt tttaagaata cttttttttt aagctgagaa gtatagggat
     4801 gaaaaagatg ttatattgtg tttgactatt ttccaacttg tattttcata taatttatat
     4861 tttttaaaag ctgaaaattt agaagcaaga tgaaaaaaag gaaaagcagg tgctttttaa
     4921 aaatcagaac tgaggtagct tagagatgta gcgatgtaag tgtcgatgtt tttttaaaaa
     4981 aaaatgcaaa aaaattctta tggcggagtt ttttgtttgt ttattttagt agctgatgct
     5041 ggcacatcat tttgctggag agttttttat atactgtagc ctgatttcat attgtatttt
     5101 aaactgtgtg aaattaaaaa caaagaattt cattcataa
//
