LOCUS       NM_018208               2475 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens ethanolamine kinase 2 (ETNK2), transcript variant 1,
            mRNA.
ACCESSION   NM_018208
VERSION     NM_018208.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2475)
  AUTHORS   Miwa,T., Kanda,M., Shimizu,D., Umeda,S., Sawaki,K., Tanaka,H.,
            Tanaka,C., Hattori,N., Hayashi,M., Yamada,S., Nakayama,G., Koike,M.
            and Kodera,Y.
  TITLE     Hepatic metastasis of gastric cancer is associated with enhanced
            expression of ethanolamine kinase 2 via the p53-Bcl-2 intrinsic
            apoptosis pathway
  JOURNAL   Br J Cancer 124 (8), 1449-1460 (2021)
   PUBMED   33531692
  REMARK    GeneRIF: Hepatic metastasis of gastric cancer is associated with
            enhanced expression of ethanolamine kinase 2 via the p53-Bcl-2
            intrinsic apoptosis pathway.
REFERENCE   2  (bases 1 to 2475)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 2475)
  AUTHORS   Tian,Y., Jackson,P., Gunter,C., Wang,J., Rock,C.O. and Jackowski,S.
  TITLE     Placental thrombosis and spontaneous fetal death in mice deficient
            in ethanolamine kinase 2
  JOURNAL   J Biol Chem 281 (38), 28438-28449 (2006)
   PUBMED   16861741
REFERENCE   4  (bases 1 to 2475)
  AUTHORS   Hurley,T.M., McClive,P.J., Sarraj,M.A. and Sinclair,A.H.
  TITLE     Eki2 is upregulated specifically in the testis during mouse sex
            determination
  JOURNAL   Gene Expr Patterns 4 (2), 135-140 (2004)
   PUBMED   15161093
REFERENCE   5  (bases 1 to 2475)
  AUTHORS   Lykidis,A., Wang,J., Karim,M.A. and Jackowski,S.
  TITLE     Overexpression of a mammalian ethanolamine-specific kinase
            accelerates the CDP-ethanolamine pathway
  JOURNAL   J Biol Chem 276 (3), 2174-2179 (2001)
   PUBMED   11044454
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB454429.1 and BC010082.2.
            
            On Nov 22, 2018 this sequence version replaced NM_018208.3.
            
            Summary: The protein encoded by this gene is a member of
            choline/ethanolamine kinase family which catalyzes the first step
            of phosphatidylethanolamine (PtdEtn) biosynthesis via the cytidine
            diphosphate (CDP) ethanolamine pathway. Alternative splicing
            results in multiple transcript variants. [provided by RefSeq, Jul
            2014].
            
            Transcript Variant: This variant (1) encodes isoform 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC010082.2, SRR1660809.29667.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000367202.9/ ENSP00000356170.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-41                DB454429.1         136-176
            42-2475             BC010082.2         1-2434
FEATURES             Location/Qualifiers
     source          1..2475
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q32.1"
     gene            1..2475
                     /gene="ETNK2"
                     /gene_synonym="EKI2; HMFT1716"
                     /note="ethanolamine kinase 2"
                     /db_xref="GeneID:55224"
                     /db_xref="HGNC:HGNC:25575"
                     /db_xref="MIM:609859"
     exon            1..450
                     /gene="ETNK2"
                     /gene_synonym="EKI2; HMFT1716"
                     /inference="alignment:Splign:2.1.0"
     CDS             193..1353
                     /gene="ETNK2"
                     /gene_synonym="EKI2; HMFT1716"
                     /EC_number="2.7.1.82"
                     /note="isoform 1 is encoded by transcript variant 1;
                     ethanolamine kinase-like protein"
                     /codon_start=1
                     /product="ethanolamine kinase 2 isoform 1"
                     /protein_id="NP_060678.2"
                     /db_xref="CCDS:CCDS1442.2"
                     /db_xref="GeneID:55224"
                     /db_xref="HGNC:HGNC:25575"
                     /db_xref="MIM:609859"
                     /translation="MAVPPSAPQPRASFHLRRHTPCPQCSWGMEEKAAASASCREPPG
                     PPRAAAVAYFGISVDPDDILPGALRLIQELRPHWKPEQVRTKRFTDGITNKLVACYVE
                     EDMQDCVLVRVYGERTELLVDRENEVRNFQLLRAHSCAPKLYCTFQNGLCYEYMQGVA
                     LEPEHIREPRLFRLIALEMAKIHTIHANGSLPKPILWHKMHNYFTLVKNEINPSLSAD
                     VPKVEVLERELAWLKEHLSQLESPVVFCHNDLLCKNIIYDSIKGHVRFIDYEYAGYNY
                     QAFDIGNHFNEFAGVNEVDYCLYPARETQLQWLHYYLQAQKGMAVTPREVQRLYVQVN
                     KFALASHFFWALWALIQNQYSTIDFDFLRYAVIRFNQYFKVKPQASALEMPK"
     exon            451..710
                     /gene="ETNK2"
                     /gene_synonym="EKI2; HMFT1716"
                     /inference="alignment:Splign:2.1.0"
     exon            711..833
                     /gene="ETNK2"
                     /gene_synonym="EKI2; HMFT1716"
                     /inference="alignment:Splign:2.1.0"
     exon            834..976
                     /gene="ETNK2"
                     /gene_synonym="EKI2; HMFT1716"
                     /inference="alignment:Splign:2.1.0"
     exon            977..1060
                     /gene="ETNK2"
                     /gene_synonym="EKI2; HMFT1716"
                     /inference="alignment:Splign:2.1.0"
     exon            1061..1206
                     /gene="ETNK2"
                     /gene_synonym="EKI2; HMFT1716"
                     /inference="alignment:Splign:2.1.0"
     exon            1207..1280
                     /gene="ETNK2"
                     /gene_synonym="EKI2; HMFT1716"
                     /inference="alignment:Splign:2.1.0"
     exon            1281..2475
                     /gene="ETNK2"
                     /gene_synonym="EKI2; HMFT1716"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2455..2460
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ETNK2"
                     /gene_synonym="EKI2; HMFT1716"
                     /note="hexamer: ATTAAA"
     polyA_site      2475
                     /gene="ETNK2"
                     /gene_synonym="EKI2; HMFT1716"
                     /note="major polyA site"
ORIGIN      
        1 acaatcgcgg cgggccgcgg cgctccgggg tcggcggtgg gcggcgggcc gcgagccggc
       61 gatcgaagcg ggcagctcgc gcctgagtca tggacttccc ctggcccctc ctctaccact
      121 cccactccct cgccggaccc ccccgccggg gctagcgtct gccgcggctc cgagggggtg
      181 gggctgctgg gaatggctgt gcccccttcg gcccctcagc cgcgcgcgtc ctttcacctg
      241 aggaggcaca cgccttgccc gcagtgctca tggggcatgg aggagaaggc ggcggccagc
      301 gccagctgcc gggagccgcc gggccccccg agggccgccg ccgtcgcgta cttcggcatt
      361 tccgtggacc cggacgacat ccttcccggg gccctgcgcc tcatccagga gctgcggccg
      421 cattggaaac ccgagcaagt tcggaccaag cgcttcacgg atggcatcac caacaagctg
      481 gtggcctgct atgtggagga ggacatgcag gactgcgtgc tggtccgggt gtatggggag
      541 cggacggagc tgctggtgga ccgggagaat gaggtcagaa acttccagct gctgcgagca
      601 cacagctgtg cccccaaact ctactgcacc ttccagaatg ggctgtgcta tgagtacatg
      661 cagggtgtgg ccctggagcc tgagcacatc cgtgagcccc ggcttttcag gttaatcgcc
      721 ttagaaatgg caaagattca tactatccac gccaacggca gcctgcccaa gcccatcctc
      781 tggcacaaga tgcacaatta tttcacgctt gtgaagaacg agatcaaccc cagcctttct
      841 gcagatgtcc ctaaggtaga ggtgttggaa cgggagctgg cctggctgaa ggagcatctg
      901 tcccagctgg agtcccctgt ggtgttttgt cacaatgacc tgctctgcaa gaatatcatc
      961 tatgacagca tcaaaggtca cgtgcggttc attgactatg aatatgctgg ctacaactac
     1021 caagcttttg acattggcaa ccatttcaat gagtttgcag gcgtgaatga ggtggattac
     1081 tgcctgtacc cggcgcggga gacccagctg cagtggctgc actactacct gcaggcacaa
     1141 aaggggatgg ccgtgacccc cagggaggtg caaaggctct acgtgcaagt caacaagttt
     1201 gccctggcgt ctcacttctt ctgggctctc tgggccctca tccagaacca gtactccacc
     1261 atcgactttg atttcctcag gtacgcagtg atccgattca accagtactt caaggtgaag
     1321 cctcaagcgt cagccttgga gatgccaaag tgaccagcca ccccatccct cccctaccca
     1381 tctgtctggc cagacctgtt ctccagagct caattctgca ctctgggatc cacacccttg
     1441 gacagggtgg gagaggggac acatgggtgt ccagggagaa ggctctgtcc ctgccgccag
     1501 accccagtgg ttgccactga agacctcatt ctcctgtctg gaggggctga taggaccccc
     1561 ttccgggggt ccccttcacc ccaccaggct tgggaggaag tgcctgcagc caggtcctga
     1621 accataacca cccctgggaa acacatcatt cccagcctca ggccctgctg gaattggggc
     1681 tgccttatat gtgtgtttac cccttcctgg cctggggaag gaggcgggga gggctccttt
     1741 ctacctccag tgccctgagc ctccagtccg tctccccctg catgccccat gtgggaggtg
     1801 ctgagctcca aaccagcatc acaccaactc tgacacatgg atgtacctat cttggtgatg
     1861 ggtgggggcc aagaattgag catgacatct tccccagcag ccacctcctc tgagatccct
     1921 caccttctcc aaaccagatc caatcaaacc tcagcccgag gaaacatgct ccccaacgtg
     1981 ctctcctgtg cttctgtttt gtccccctgc tggggggaca ggagagggag tggtgaggcc
     2041 ctgggcctcc agagcctggc tctgctttgt gctgtggctt agccggaggg gacgtggcca
     2101 agggtgaggt ggccaaaacc agaaccagca gtctcctgcc ttgttccctc cctggccctc
     2161 aggccctcct tccagggatg tctctccagc tctactttat gtcctgaagc tgacccgagg
     2221 tcttcctatc tggaatgact agagggagcc aagaggatgg ggtgggggcc agggcccccc
     2281 agggcctatc gtgggagagc ctgggcagga tcccatcaga aaggtgctga ctaaactggt
     2341 tgcccggaca ctcaacagcc tccacctccc tttctaccct cacagctcct ggggccttcc
     2401 tggctctggc ccagaaagtg attcatttgt aaattatcat ggttttcttt ctgcattaaa
     2461 atgctcattt ccgga
//
