LOCUS       NM_001001660            1242 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens electron transfer flavoprotein regulatory factor 1
            (ETFRF1), mRNA.
ACCESSION   NM_001001660 XM_370685
VERSION     NM_001001660.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1242)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 1242)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 1242)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   4  (bases 1 to 1242)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 1242)
  AUTHORS   Floyd,B.J., Wilkerson,E.M., Veling,M.T., Minogue,C.E., Xia,C.,
            Beebe,E.T., Wrobel,R.L., Cho,H., Kremer,L.S., Alston,C.L.,
            Gromek,K.A., Dolan,B.K., Ulbrich,A., Stefely,J.A., Bohl,S.L.,
            Werner,K.M., Jochem,A., Westphall,M.S., Rensvold,J.W., Taylor,R.W.,
            Prokisch,H., Kim,J.P., Coon,J.J. and Pagliarini,D.J.
  TITLE     Mitochondrial Protein Interaction Mapping Identifies Regulators of
            Respiratory Chain Function
  JOURNAL   Mol Cell 63 (4), 621-632 (2016)
   PUBMED   27499296
REFERENCE   6  (bases 1 to 1242)
  AUTHORS   Hendrickson,S.L., Lautenberger,J.A., Chinn,L.W., Malasky,M.,
            Sezgin,E., Kingsley,L.A., Goedert,J.J., Kirk,G.D., Gomperts,E.D.,
            Buchbinder,S.P., Troyer,J.L. and O'Brien,S.J.
  TITLE     Genetic variants in nuclear-encoded mitochondrial genes influence
            AIDS progression
  JOURNAL   PLoS One 5 (9), e12862 (2010)
   PUBMED   20877624
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
            Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BG771497.1, BC071769.1, AC092794.10, BC100276.1 and DA502833.1.
            
            On Jul 1, 2019 this sequence version replaced NM_001001660.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BQ435595.1, BG496484.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000381356.9/ ENSP00000370761.4
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-45                BG771497.1         27-71
            46-739              BC071769.1         1-694
            740-794             AC092794.10        22953-23007         c
            795-1114            BC100276.1         764-1083
            1115-1242           DA502833.1         309-436
FEATURES             Location/Qualifiers
     source          1..1242
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12p12.1"
     gene            1..1242
                     /gene="ETFRF1"
                     /gene_synonym="LYRM5"
                     /note="electron transfer flavoprotein regulatory factor 1"
                     /db_xref="GeneID:144363"
                     /db_xref="HGNC:HGNC:27052"
     exon            1..101
                     /gene="ETFRF1"
                     /gene_synonym="LYRM5"
                     /inference="alignment:Splign:2.1.0"
     exon            102..189
                     /gene="ETFRF1"
                     /gene_synonym="LYRM5"
                     /inference="alignment:Splign:2.1.0"
     CDS             139..411
                     /gene="ETFRF1"
                     /gene_synonym="LYRM5"
                     /note="LYR motif-containing protein 5; LYR motif
                     containing 5"
                     /codon_start=1
                     /product="electron transfer flavoprotein regulatory factor
                     1"
                     /protein_id="NP_001001660.2"
                     /db_xref="CCDS:CCDS53764.1"
                     /db_xref="GeneID:144363"
                     /db_xref="HGNC:HGNC:27052"
                     /translation="MKMANSLRGEVLKLYKNLLYLGRDYPKGADYFKKRLKNIFLKNK
                     DVKNPEKIKELIAQGEFVMKELEALYFLRKYRAMKQRYYSDTNKTN"
     exon            190..1242
                     /gene="ETFRF1"
                     /gene_synonym="LYRM5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1092..1097
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ETFRF1"
                     /gene_synonym="LYRM5"
                     /note="hexamer: AATAAA"
     regulatory      1100..1105
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ETFRF1"
                     /gene_synonym="LYRM5"
                     /note="hexamer: AATAAT"
     polyA_site      1114
                     /gene="ETFRF1"
                     /gene_synonym="LYRM5"
                     /note="major polyA site"
     polyA_site      1129
                     /gene="ETFRF1"
                     /gene_synonym="LYRM5"
     regulatory      1216..1221
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ETFRF1"
                     /gene_synonym="LYRM5"
                     /note="hexamer: AATAAA"
     polyA_site      1242
                     /gene="ETFRF1"
                     /gene_synonym="LYRM5"
ORIGIN      
        1 actgacaggt tgcccacctc ccccaacgcc accccgcttc gcagtagacg gacagaggag
       61 tcgtagcggt cgaggctttt gcggctccgg cgtgccggaa agtatgttat gcataaaagt
      121 ggataattta catgataaat gaaaatggcc aattctttaa gaggagaagt actaaaactt
      181 tataaaaatc tgctgtatct tggacgagac tatccaaaag gagcagacta ttttaaaaag
      241 cgtttgaaga acattttcct taaaaacaaa gatgtgaaga atccagagaa gatcaaagaa
      301 cttattgcac agggcgaatt tgtaatgaaa gagctagaag ctttgtactt ccttaggaaa
      361 tacagagcta tgaaacaacg ctattattca gataccaaca aaactaattg atcattacta
      421 ctttaattta gctatcagtg ccagctgttt atgtatacca gatgttgtaa aataattcta
      481 acttaaaatg ggaagatata catgttgtgt aaaaaatccc tgagctgccc tactgaacta
      541 aataggtttc aacttctgtt catacggaga aagtatcagc aactttatgc tcaattttga
      601 tacaaacata gcaatttagc tatactaccg atcataaatt aatgagcacc caattttgaa
      661 tgaaaatata atacacttaa tcctctaact taataggact tagccaatta tttttagctt
      721 atttctccat tttactgaca agagaatgcc atttaccgaa catttaataa gcaaaataat
      781 ttcttacaca cttacttctc ttaacttttg aaaggaatcc cttatttttt cacccaattt
      841 ggtatattaa cagcacatac tcaaggttca ctacaaaaca aacagttcct ggtaatgatt
      901 taaatgtagt tatagaaata aataatatgt atggagtcat tacttctgac cttgaaatag
      961 cctgctggtg actggcatta acatacataa ctaactattc aattatttcc attattaatg
     1021 ttgctgctgc tacctttggg cctaaaacca agtcacctgt tgtgtatcaa ttaccttctt
     1081 tgataaaagg aaataaataa ataatgttat cctatttttt tgtcataaag gcagatttgt
     1141 tttgcatcta cttctaaata tggttttaag tttaagcaaa cacgccttta cataatatcc
     1201 acagcacctt ttagaaataa aggatacttc taacaagctg ca
//
