LOCUS       NM_031913               5915 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens extended synaptotagmin 3 (ESYT3), transcript variant
            1, mRNA.
ACCESSION   NM_031913 XM_291067
VERSION     NM_031913.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5915)
  AUTHORS   Li,X., Chen,J. and Meng,J.
  TITLE     Comprehensive analysis of the prognostic values and immune
            implication of ESYT3 in lung adenocarcinoma
  JOURNAL   Medicine (Baltimore) 102 (35), e34557 (2023)
   PUBMED   37657044
  REMARK    GeneRIF: Comprehensive analysis of the prognostic values and immune
            implication of ESYT3 in lung adenocarcinoma.
REFERENCE   2  (bases 1 to 5915)
  AUTHORS   Li,Q., Chen,W., Wang,C., Liu,Z., Gu,Y., Xu,X., Xu,J., Jiang,T.,
            Xu,M., Wang,Y., Chen,C., Zhong,Y., Zhang,Y., Yao,L., Jin,G., Hu,Z.
            and Zhou,P.
  TITLE     Whole-exome sequencing reveals common and rare variants in
            immunologic and neurological genes implicated in achalasia
  JOURNAL   Am J Hum Genet 108 (8), 1478-1487 (2021)
   PUBMED   34197731
  REMARK    GeneRIF: Whole-exome sequencing reveals common and rare variants in
            immunologic and neurological genes implicated in achalasia.
REFERENCE   3  (bases 1 to 5915)
  AUTHORS   Sandhu,J., Li,S., Fairall,L., Pfisterer,S.G., Gurnett,J.E.,
            Xiao,X., Weston,T.A., Vashi,D., Ferrari,A., Orozco,J.L.,
            Hartman,C.L., Strugatsky,D., Lee,S.D., He,C., Hong,C., Jiang,H.,
            Bentolila,L.A., Gatta,A.T., Levine,T.P., Ferng,A., Lee,R.,
            Ford,D.A., Young,S.G., Ikonen,E., Schwabe,J.W.R. and Tontonoz,P.
  TITLE     Aster Proteins Facilitate Nonvesicular Plasma Membrane to ER
            Cholesterol Transport in Mammalian Cells
  JOURNAL   Cell 175 (2), 514-529 (2018)
   PUBMED   30220461
REFERENCE   4  (bases 1 to 5915)
  AUTHORS   Saheki,Y., Bian,X., Schauder,C.M., Sawaki,Y., Surma,M.A., Klose,C.,
            Pincet,F., Reinisch,K.M. and De Camilli,P.
  TITLE     Control of plasma membrane lipid homeostasis by the extended
            synaptotagmins
  JOURNAL   Nat Cell Biol 18 (5), 504-515 (2016)
   PUBMED   27065097
REFERENCE   5  (bases 1 to 5915)
  AUTHORS   Tremblay,M.G., Herdman,C., Guillou,F., Mishra,P.K., Baril,J.,
            Bellenfant,S. and Moss,T.
  TITLE     Extended Synaptotagmin Interaction with the Fibroblast Growth
            Factor Receptor Depends on Receptor Conformation, Not Catalytic
            Activity
  JOURNAL   J Biol Chem 290 (26), 16142-16156 (2015)
   PUBMED   25922075
  REMARK    GeneRIF: ESyt2 and ESyt3, but not ESyt1, interact with activated
            FGFR1.
            Erratum:[J Biol Chem. 2016 Feb 12;291(7):3173. doi:
            10.1074/jbc.A115.656918.. PMID: 26873909]
REFERENCE   6  (bases 1 to 5915)
  AUTHORS   Jiang,F., Dong,Y., Wu,C., Yang,X., Zhao,L., Guo,J., Li,Y., Dong,J.,
            Zheng,G.Y., Cao,H., Jin,L., Ren,Y., Cheng,W., Li,W., Tian,X.L. and
            Li,X.
  TITLE     Fine mapping of chromosome 3q22.3 identifies two haplotype blocks
            in ESYT3 associated with coronary artery disease in female Han
            Chinese
  JOURNAL   Atherosclerosis 218 (2), 397-403 (2011)
   PUBMED   21733517
  REMARK    GeneRIF: two haplotype blocks of ESYT3 gene in 3q22.3 region that
            likely harbor functional variants and have a role in coronary
            artery disease in females
REFERENCE   7  (bases 1 to 5915)
  AUTHORS   Craxton,M.
  TITLE     Evolutionary genomics of plant genes encoding N-terminal-TM-C2
            domain proteins and the similar FAM62 genes and synaptotagmin genes
            of metazoans
  JOURNAL   BMC Genomics 8, 259 (2007)
   PUBMED   17672888
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 5915)
  AUTHORS   Min,S.W., Chang,W.P. and Sudhof,T.C.
  TITLE     E-Syts, a family of membranous Ca2+-sensor proteins with multiple
            C2 domains
  JOURNAL   Proc Natl Acad Sci U S A 104 (10), 3823-3828 (2007)
   PUBMED   17360437
REFERENCE   9  (bases 1 to 5915)
  AUTHORS   Craxton,M.
  TITLE     Synaptotagmin gene content of the sequenced genomes
  JOURNAL   BMC Genomics 5 (1), 43 (2004)
   PUBMED   15238157
  REMARK    Publication Status: Online-Only
REFERENCE   10 (bases 1 to 5915)
  AUTHORS   Craxton,M.
  TITLE     Genomic analysis of synaptotagmin genes
  JOURNAL   Genomics 77 (1-2), 43-49 (2001)
   PUBMED   11543631
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA726011.1, DQ993202.1, AC022497.18, AW513592.1, AJ697972.1 and
            BM668912.1.
            
            On Nov 22, 2018 this sequence version replaced NM_031913.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            transcript and genomic sequence to make the sequence consistent
            with the reference genome assembly. The genomic coordinates used
            for the transcript record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803611.39891.1,
                                           SRR1803616.220066.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189, SAMEA2142363
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000389567.9/ ENSP00000374218.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-183               DA726011.1         44-226
            184-2844            DQ993202.1         1-2661
            2845-3951           AC022497.18        129769-130875
            3952-4404           AW513592.1         3-455               c
            4405-5621           AJ697972.1         1349-2565
            5622-5915           BM668912.1         35-328              c
FEATURES             Location/Qualifiers
     source          1..5915
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q22.3"
     gene            1..5915
                     /gene="ESYT3"
                     /gene_synonym="CHR3SYT; E-Syt3; FAM62C"
                     /note="extended synaptotagmin 3"
                     /db_xref="GeneID:83850"
                     /db_xref="HGNC:HGNC:24295"
                     /db_xref="MIM:616692"
     exon            1..510
                     /gene="ESYT3"
                     /gene_synonym="CHR3SYT; E-Syt3; FAM62C"
                     /inference="alignment:Splign:2.1.0"
     CDS             184..2844
                     /gene="ESYT3"
                     /gene_synonym="CHR3SYT; E-Syt3; FAM62C"
                     /note="isoform a is encoded by transcript variant 1;
                     family with sequence similarity 62 (C2 domain containing),
                     member C; chr3 synaptotagmin; extended synaptotagmin
                     protein 3"
                     /codon_start=1
                     /product="extended synaptotagmin-3 isoform a"
                     /protein_id="NP_114119.2"
                     /db_xref="CCDS:CCDS3101.2"
                     /db_xref="GeneID:83850"
                     /db_xref="HGNC:HGNC:24295"
                     /db_xref="MIM:616692"
                     /translation="MRAEEPCAPGAPSALGAQRTPGPELRLSSQLLPELCTFVVRVLF
                     YLGPVYLAGYLGLSITWLLLGALLWMWWRRNRRGKLGRLAAAFEFLDNEREFISRELR
                     GQHLPAWIHFPDVERVEWANKIISQTWPYLSMIMESKFREKLEPKIREKSIHLRTFTF
                     TKLYFGQKCPRVNGVKAHTNTCNRRRVTVDLQICYIGDCEISVELQKIQAGVNGIQLQ
                     GTLRVILEPLLVDKPFVGAVTVFFLQKPHLQINWTGLTNLLDAPGINDVSDSLLEDLI
                     ATHLVLPNRVTVPVKKGLDLTNLRFPLPCGVIRVHLLEAEQLAQKDNFLGLRGKSDPY
                     AKVSIGLQHFRSRTIYRNLNPTWNEVFEFMVYEVPGQDLEVDLYDEDTDRDDFLGSLQ
                     ICLGDVMTNRVVDEWFVLNDTTSGRLHLRLEWLSLLTDQEVLTEDHGGLSTAILVVFL
                     ESACNLPRNPFDYLNGEYRAKKLSRFARNKVSKDPSSYVKLSVGKKTHTSKTCPHNKD
                     PVWSQVFSFFVHNVATERLHLKVLDDDQECALGMLEVPLCQILPYADLTLEQRFQLDH
                     SGLDSLISMRLVLRFLQVEERELGSPYTGPEALKKGPLLIKKVATNQGPKAQPQEEGP
                     TDLPCPPDPASDTKDVSRSTTTTTSATTVATEPTSQETGPEPKGKDSAKRFCEPIGEK
                     KSPATIFLTVPGPHSPGPIKSPRPMKCPASPFAWPPKRLAPSMSSLNSLASSCFDLAD
                     ISLNIEGGDLRRRQLGEIQLTVRYVCLRRCLSVLINGCRNLTPCTSSGADPYVRVYLL
                     PERKWACRKKTSVKRKTLEPLFDETFEFFVPMEEVKKRSLDVAVKNSRPLGSHRRKEL
                     GKVLIDLSKEDLIKGFSQWYELTPNGQPRS"
     exon            511..552
                     /gene="ESYT3"
                     /gene_synonym="CHR3SYT; E-Syt3; FAM62C"
                     /inference="alignment:Splign:2.1.0"
     exon            553..687
                     /gene="ESYT3"
                     /gene_synonym="CHR3SYT; E-Syt3; FAM62C"
                     /inference="alignment:Splign:2.1.0"
     exon            688..764
                     /gene="ESYT3"
                     /gene_synonym="CHR3SYT; E-Syt3; FAM62C"
                     /inference="alignment:Splign:2.1.0"
     exon            765..831
                     /gene="ESYT3"
                     /gene_synonym="CHR3SYT; E-Syt3; FAM62C"
                     /inference="alignment:Splign:2.1.0"
     exon            832..921
                     /gene="ESYT3"
                     /gene_synonym="CHR3SYT; E-Syt3; FAM62C"
                     /inference="alignment:Splign:2.1.0"
     exon            922..977
                     /gene="ESYT3"
                     /gene_synonym="CHR3SYT; E-Syt3; FAM62C"
                     /inference="alignment:Splign:2.1.0"
     exon            978..1098
                     /gene="ESYT3"
                     /gene_synonym="CHR3SYT; E-Syt3; FAM62C"
                     /inference="alignment:Splign:2.1.0"
     exon            1099..1269
                     /gene="ESYT3"
                     /gene_synonym="CHR3SYT; E-Syt3; FAM62C"
                     /inference="alignment:Splign:2.1.0"
     exon            1270..1352
                     /gene="ESYT3"
                     /gene_synonym="CHR3SYT; E-Syt3; FAM62C"
                     /inference="alignment:Splign:2.1.0"
     exon            1353..1401
                     /gene="ESYT3"
                     /gene_synonym="CHR3SYT; E-Syt3; FAM62C"
                     /inference="alignment:Splign:2.1.0"
     exon            1402..1491
                     /gene="ESYT3"
                     /gene_synonym="CHR3SYT; E-Syt3; FAM62C"
                     /inference="alignment:Splign:2.1.0"
     exon            1492..1554
                     /gene="ESYT3"
                     /gene_synonym="CHR3SYT; E-Syt3; FAM62C"
                     /inference="alignment:Splign:2.1.0"
     exon            1555..1617
                     /gene="ESYT3"
                     /gene_synonym="CHR3SYT; E-Syt3; FAM62C"
                     /inference="alignment:Splign:2.1.0"
     exon            1618..1686
                     /gene="ESYT3"
                     /gene_synonym="CHR3SYT; E-Syt3; FAM62C"
                     /inference="alignment:Splign:2.1.0"
     exon            1687..1773
                     /gene="ESYT3"
                     /gene_synonym="CHR3SYT; E-Syt3; FAM62C"
                     /inference="alignment:Splign:2.1.0"
     exon            1774..1923
                     /gene="ESYT3"
                     /gene_synonym="CHR3SYT; E-Syt3; FAM62C"
                     /inference="alignment:Splign:2.1.0"
     exon            1924..2420
                     /gene="ESYT3"
                     /gene_synonym="CHR3SYT; E-Syt3; FAM62C"
                     /inference="alignment:Splign:2.1.0"
     exon            2421..2519
                     /gene="ESYT3"
                     /gene_synonym="CHR3SYT; E-Syt3; FAM62C"
                     /inference="alignment:Splign:2.1.0"
     exon            2520..2651
                     /gene="ESYT3"
                     /gene_synonym="CHR3SYT; E-Syt3; FAM62C"
                     /inference="alignment:Splign:2.1.0"
     exon            2652..2757
                     /gene="ESYT3"
                     /gene_synonym="CHR3SYT; E-Syt3; FAM62C"
                     /inference="alignment:Splign:2.1.0"
     exon            2758..2807
                     /gene="ESYT3"
                     /gene_synonym="CHR3SYT; E-Syt3; FAM62C"
                     /inference="alignment:Splign:2.1.0"
     exon            2808..5915
                     /gene="ESYT3"
                     /gene_synonym="CHR3SYT; E-Syt3; FAM62C"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4381..4386
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ESYT3"
                     /gene_synonym="CHR3SYT; E-Syt3; FAM62C"
                     /note="hexamer: AATAAA"
     polyA_site      4404
                     /gene="ESYT3"
                     /gene_synonym="CHR3SYT; E-Syt3; FAM62C"
                     /note="major polyA site"
     regulatory      5890..5895
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ESYT3"
                     /gene_synonym="CHR3SYT; E-Syt3; FAM62C"
                     /note="hexamer: AATACA"
     polyA_site      5915
                     /gene="ESYT3"
                     /gene_synonym="CHR3SYT; E-Syt3; FAM62C"
ORIGIN      
        1 gcatttccag gcgctgctct ccgtcgcaga gaaccctgag ctcggcgcgc cgagagtccc
       61 agcagggcaa gggggcgcgg cgtcctggtc ctcgagcttg ggagacagat gcgcatgggc
      121 gtgggggcat gcggacctaa gctcgggtga agctctcggg aagggcaaga ctgcggcgac
      181 gagatgcgag cagaggagcc ctgcgccccc ggggccccca gcgccctggg agcccagcgc
      241 acgccgggcc ccgagctgcg cctgtccagc cagctgctgc ccgagctctg taccttcgtg
      301 gtgcgcgtgc tgttctacct ggggcctgtc tacctagctg gctacctggg gctcagcata
      361 acctggttgc tgctcggcgc cctgctgtgg atgtggtggc gcaggaaccg ccgcgggaag
      421 cttgggcgcc tggccgccgc cttcgaattc cttgacaatg aacgcgagtt catcagccgc
      481 gagctgcggg gccagcacct gccagcctgg atccacttcc cggacgtgga gcgggtcgag
      541 tgggccaaca agatcatctc tcagacctgg ccctacctaa gcatgatcat ggaaagcaag
      601 ttccgggaga aacttgagcc caagatccga gagaagagca tccacctgag gacctttacc
      661 tttaccaagc tctactttgg acagaagtgt cccagggtca acggtgtcaa ggcacacact
      721 aatacgtgca accgaagacg tgtgactgtg gacctgcaga tctgctacat cggggactgt
      781 gagatcagtg tggagctgca gaagattcag gctggtgtga acgggatcca gttgcagggc
      841 accctgcggg tcatcctgga gcccctccta gtggacaagc cctttgtggg agccgtgact
      901 gtgttcttcc ttcagaagcc gcacctacag atcaactgga ctggcctgac caacctgctg
      961 gatgcgccgg gaatcaatga tgtgtcagac agcttactgg aggacctcat tgccacccac
     1021 ctggtgctgc ccaaccgtgt gactgtgcct gtgaagaagg ggctggatct gaccaacctg
     1081 cgcttccctc tgccctgtgg ggtgatcaga gtgcacttgc tggaggcaga gcagctggcc
     1141 cagaaggaca actttctggg gctccgaggc aagtcagatc cctacgccaa ggtgagcatc
     1201 ggcctacagc atttccggag taggaccatc tacaggaacc tgaaccccac ctggaacgaa
     1261 gtgtttgagt tcatggtgta cgaagtccct ggacaggacc tggaggtaga cctgtatgat
     1321 gaggataccg acagggatga cttcctgggc agcctgcaga tctgccttgg agatgtcatg
     1381 accaacagag tggtggatga gtggtttgtc ctgaatgaca caaccagcgg gcggctgcac
     1441 ctgcggctgg agtggctttc attgcttact gaccaagaag ttctgactga ggaccatggt
     1501 ggcctttcca ctgccattct cgtggtcttc ttggagagtg cctgcaactt gccgagaaac
     1561 ccttttgact acctgaatgg tgaatatcga gccaaaaaac tctccaggtt tgccagaaac
     1621 aaggtcagca aagacccttc ttcctatgtc aaactatctg taggcaagaa gacacataca
     1681 agtaagacct gtccccacaa caaggaccct gtgtggagcc aggtgttctc cttctttgtg
     1741 cacaatgtgg ccactgagcg gctccatctg aaggtgcttg atgatgacca ggagtgtgct
     1801 ctgggaatgc tggaggtccc cctgtgccag atcctcccct atgctgacct cactcttgag
     1861 cagcgctttc agctggacca ctcaggcctg gacagcctca tctccatgag gctggtgctt
     1921 cggttcctgc aagtggagga acgagagctg gggagcccat acacaggacc tgaagcccta
     1981 aagaaaggcc ctctgctcat caagaaagtg gctaccaacc agggtcccaa agcccaacct
     2041 caggaagaag gccctacaga tttgccatgt cccccagacc ctgcttctga tactaaggac
     2101 gtatccagga gtaccacaac caccaccagt gctaccaccg ttgccactga gcccacatcc
     2161 caagagacag gcccagagcc taaaggcaag gacagtgcca aaaggttctg tgagcccatc
     2221 ggggagaaga agagtccagc caccatcttc ctgactgtcc caggtcccca ctctccaggg
     2281 cccatcaagt cacccagacc catgaaatgc cctgcctccc cattcgcatg gccgcccaag
     2341 aggctggctc ccagcatgtc ctcgctcaac tccttggcct cttcttgctt tgacctggca
     2401 gatatcagcc tcaacattga aggtggggac ctcaggcgac ggcagctggg tgagattcag
     2461 ctcacagtgc gctatgtgtg tctgcggcgc tgcctcagcg tgctaatcaa tggctgcaga
     2521 aacctaacac catgtaccag cagtggagct gatccctacg tccgtgtcta cttgttgcca
     2581 gaaaggaagt gggcatgtcg taagaagact tcagtgaagc ggaagacctt ggaacccctg
     2641 tttgatgaga catttgaatt ttttgttccc atggaagaag taaagaagag gtcactagat
     2701 gttgcagtga aaaatagtag gccacttggc tcacacagaa gaaaggagtt aggaaaagta
     2761 ctgattgact tatcaaaaga agatctgatt aagggctttt cacaatggta tgagctgact
     2821 ccaaatggac agcccagaag ctgatgatga gaattcttat cactcacctt tatattaaaa
     2881 tgtatatata tgtatatatt ttttcctttg gatcacttac atccaatata tgtatatttt
     2941 gtcatttaaa tcagaacaac cacttgaaat tatatacata caattcttgt gtggaattta
     3001 actccatgac tgaatagcat aaggaagagg ttatttaaaa gcaagaacta ctttttttgg
     3061 ttggattttt ttgttcaagt ccagaaagaa atgttatatt tgtgcctact aaattatcca
     3121 aacctcagtg tttatatact taaacaagtg ccacttttta gtaggtaatt atataccatc
     3181 tgatttagga cttacctgaa tgtatgtacc agaaagtgtc ctgcctctgg cataggggct
     3241 gggggaggtc tgtttctgga gccactacca gcattcctgg gcagtgactg gccaaaggga
     3301 agtcactttt ttatggaaat agaaagtgac ccaactcaaa actgccaaga gctaacactg
     3361 ccaaagccct tctggctgcc acctgtggta cttgtatgcc tggatatttg ttcttttatt
     3421 tgacctggag ctaaaaatgt atttccctac tggcaaaaat gttatactga tatacttaaa
     3481 taccttgagt taaatactct tgtgtagtct aagggccaaa ctccagcgtg tagcattatt
     3541 tccataggaa aatgcaaacc aagttccaag cccaggtcta tgtctgactc tcatagcaaa
     3601 gcactggaga ctgctgaaga gtgtcaccat cagagaaaag gaagctttca gataagttta
     3661 ggctattcaa cttttctaaa gagatggttg gttcacctaa ataacatgtt aaaagcaaag
     3721 tattaaatta tatgcttaaa caagcgcctc ttttacattt cagactttac aagaccaaat
     3781 atacttctca tcccctccaa cattcctgga cctcctcttc tctcttacca acaccaacac
     3841 tacctgccgt cagttttctg tctctgcctc tgccttcact gccacttttc tgaagcaggg
     3901 caacattcga gaacaaagtt ttgtcatgtt actcttattc cagtttcctg ccatctgatt
     3961 cacatgcaga tgttctattc cagagtagtc caaatactat gctctgctga ctcaagtcat
     4021 gtctcaaacc tatttcctct attaagtaag tcagtcaatc catagtgaaa tggactcttc
     4081 ctaccgcctg tagcatttac tgttgatact gagtattttc cattttaata gttcccagcc
     4141 tttataacac taagttttaa gaaatgttga ttaggcatct gctaaggtta catgctaagc
     4201 agctacttat attgtatttg gtatttaatt ttgtttattc tccagttgaa cagtagggaa
     4261 caattcaagc tacttgaatt gtttttcacc ctcaccatcc aagaccgtgt taagtacata
     4321 gaagatgcat ggtgaaattc gtttctgctg aggtttctat tttaaatggc aaattctcat
     4381 aataaaatgg agcattgatg cctaccctgt ctaccttatg atggcattct aattgccccc
     4441 taaatagaca agtgccttga aaatggagaa gcaccagaga aataagggaa tgtatcatat
     4501 gtacatcgaa acattagcaa ccctaaaaca gctaatcaaa atggcagata agtgaaaacc
     4561 tacccctctt cttccaaact taaaccacaa acatttattt taaacgtggt caattgaacc
     4621 gtttttacct gtgtcaggca acacaggtaa atacctggtg atggtctgaa gaggagttaa
     4681 aatgttgaag ggaaccagaa ttttagtaca cagcagacag gaggcaaggt tatataggcg
     4741 ctgtgtgagg ggcagggagc ctgaaaagtt gttaatacct tggctgccac tgaggacaag
     4801 aattggtttt cagcagtggg tggaaacaat cagctaatat gcaggagcat agggtctgaa
     4861 gttaacatca tcttggtaca gaaaccccca aacctaagac ggaatgtgaa tattggttta
     4921 gaacctggaa gcctgtgaag ccttgatgga ggcaaccata aaattggccc cacagggttg
     4981 ccactcccat ccagggcaca tatgcgacaa ctgcagcaga tggctgtcac taaagggaaa
     5041 ctcacgggca aaaataaatt atgaaacaaa acaaaaacag actttaaaaa aaatacaaag
     5101 tacacaggaa tatcaaactg aaaaatagcc atagataata tttcagccag aaggaaaatg
     5161 taccagtaag gcagaaatag catgtgagaa gcagtggaaa gcaaagaaat ccataaaata
     5221 cattggcaaa cctaagcaag ttttgatgat gattgttcac aagatataaa caaataacca
     5281 aagatttttg caagggttca gaaacatagt agaactaaaa tgttagtact aacaactaag
     5341 aaggggcagc taggctgatt aagaaagtaa gtattcaaga ccatatctta tttaggaagc
     5401 taaagatact catcttaaaa atataactgt gtcagtcact aattcattac ctctcagctt
     5461 caaattgacg tctgtctcct ttgctgcttt cccggcaggc tgatgtttgg ctttgccaat
     5521 agggggcgat ggaaggacac tctatagcag gaagaagggg cttttcttct gatgttttcc
     5581 atggctgcta gctaattggc atacagagct gttctcaatc aatcacctaa gtacccccac
     5641 agtttaccct tggctcatgg ccttcatgtt ttatcagcag gcaacacctt ttggcaagtt
     5701 tcttagccac aagtgggttg catggtccta tggctgccag cggaaatcta aatctcagcc
     5761 tggtagggag gcacttagtt tctaacttcc tttcttgttc actctccctt acccctgggg
     5821 gtaaggatct gcatcctgaa gttgatattc tgtatcccct agagtccact tctaccccgt
     5881 ttagtagtaa atacaagaat tgctaactag taaaa
//
