LOCUS       NM_001367773            5902 bp    mRNA    linear   PRI 24-SEP-2024
DEFINITION  Homo sapiens extended synaptotagmin 2 (ESYT2), transcript variant
            1, mRNA.
ACCESSION   NM_001367773 XM_024446845
VERSION     NM_001367773.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5902)
  AUTHORS   Du,W., Li,Y., Wang,X., Xie,S., Ci,H., Zhou,J., Zhu,N., Chen,Z.,
            Zheng,Y. and Jia,H.
  TITLE     Circular RNA circESYT2 serves as a microRNA-665 sponge to promote
            the progression of hepatocellular carcinoma through ENO2
  JOURNAL   Cancer Sci 115 (8), 2659-2672 (2024)
   PUBMED   38710213
  REMARK    GeneRIF: Circular RNA circESYT2 serves as a microRNA-665 sponge to
            promote the progression of hepatocellular carcinoma through ENO2.
REFERENCE   2  (bases 1 to 5902)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   3  (bases 1 to 5902)
  AUTHORS   Woo,J.S., Sun,Z., Srikanth,S. and Gwack,Y.
  TITLE     The short isoform of extended synaptotagmin-2 controls Ca2+
            dynamics in T cells via interaction with STIM1
  JOURNAL   Sci Rep 10 (1), 14433 (2020)
   PUBMED   32879390
  REMARK    GeneRIF: The short isoform of extended synaptotagmin-2 controls
            Ca(2+) dynamics in T cells via interaction with STIM1.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5902)
  AUTHORS   Sandhu,J., Li,S., Fairall,L., Pfisterer,S.G., Gurnett,J.E.,
            Xiao,X., Weston,T.A., Vashi,D., Ferrari,A., Orozco,J.L.,
            Hartman,C.L., Strugatsky,D., Lee,S.D., He,C., Hong,C., Jiang,H.,
            Bentolila,L.A., Gatta,A.T., Levine,T.P., Ferng,A., Lee,R.,
            Ford,D.A., Young,S.G., Ikonen,E., Schwabe,J.W.R. and Tontonoz,P.
  TITLE     Aster Proteins Facilitate Nonvesicular Plasma Membrane to ER
            Cholesterol Transport in Mammalian Cells
  JOURNAL   Cell 175 (2), 514-529 (2018)
   PUBMED   30220461
REFERENCE   5  (bases 1 to 5902)
  AUTHORS   Saheki,Y., Bian,X., Schauder,C.M., Sawaki,Y., Surma,M.A., Klose,C.,
            Pincet,F., Reinisch,K.M. and De Camilli,P.
  TITLE     Control of plasma membrane lipid homeostasis by the extended
            synaptotagmins
  JOURNAL   Nat Cell Biol 18 (5), 504-515 (2016)
   PUBMED   27065097
REFERENCE   6  (bases 1 to 5902)
  AUTHORS   Craxton,M.
  TITLE     Evolutionary genomics of plant genes encoding N-terminal-TM-C2
            domain proteins and the similar FAM62 genes and synaptotagmin genes
            of metazoans
  JOURNAL   BMC Genomics 8, 259 (2007)
   PUBMED   17672888
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 5902)
  AUTHORS   Min,S.W., Chang,W.P. and Sudhof,T.C.
  TITLE     E-Syts, a family of membranous Ca2+-sensor proteins with multiple
            C2 domains
  JOURNAL   Proc Natl Acad Sci U S A 104 (10), 3823-3828 (2007)
   PUBMED   17360437
REFERENCE   8  (bases 1 to 5902)
  AUTHORS   Foster,L.J., Rudich,A., Talior,I., Patel,N., Huang,X.,
            Furtado,L.M., Bilan,P.J., Mann,M. and Klip,A.
  TITLE     Insulin-dependent interactions of proteins with GLUT4 revealed
            through stable isotope labeling by amino acids in cell culture
            (SILAC)
  JOURNAL   J Proteome Res 5 (1), 64-75 (2006)
   PUBMED   16396496
REFERENCE   9  (bases 1 to 5902)
  AUTHORS   Beausoleil,S.A., Jedrychowski,M., Schwartz,D., Elias,J.E.,
            Villen,J., Li,J., Cohn,M.A., Cantley,L.C. and Gygi,S.P.
  TITLE     Large-scale characterization of HeLa cell nuclear phosphoproteins
  JOURNAL   Proc Natl Acad Sci U S A 101 (33), 12130-12135 (2004)
   PUBMED   15302935
REFERENCE   10 (bases 1 to 5902)
  AUTHORS   Craxton,M.
  TITLE     Genomic analysis of synaptotagmin genes
  JOURNAL   Genomics 77 (1-2), 43-49 (2001)
   PUBMED   11543631
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC019084.9.
            
            On Dec 15, 2018 this sequence version replaced XM_024446845.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038194.3499912.1,
                                           SRR14038197.370567.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000275418.13/ ENSP00000275418.8
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-421               AC019084.9         196574-196994       c
            422-463             AC019084.9         166516-166557       c
            464-598             AC019084.9         165427-165561       c
            599-675             AC019084.9         161135-161211       c
            676-748             AC019084.9         155830-155902       c
            749-838             AC019084.9         155489-155578       c
            839-894             AC019084.9         140826-140881       c
            895-1015            AC019084.9         135139-135259       c
            1016-1192           AC019084.9         132162-132338       c
            1193-1275           AC019084.9         130568-130650       c
            1276-1324           AC019084.9         128981-129029       c
            1325-1414           AC019084.9         127543-127632       c
            1415-1510           AC019084.9         126971-127066       c
            1511-1573           AC019084.9         120266-120328       c
            1574-1648           AC019084.9         117134-117208       c
            1649-1735           AC019084.9         115679-115765       c
            1736-1885           AC019084.9         111014-111163       c
            1886-2259           AC019084.9         109008-109381       c
            2260-2358           AC019084.9         106508-106606       c
            2359-2490           AC019084.9         104533-104664       c
            2491-2596           AC019084.9         102988-103093       c
            2597-2646           AC019084.9         101907-101956       c
            2647-5902           AC019084.9         98482-101737        c
FEATURES             Location/Qualifiers
     source          1..5902
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q36.3"
     gene            1..5902
                     /gene="ESYT2"
                     /gene_synonym="CHR2SYT; E-Syt2; FAM62B"
                     /note="extended synaptotagmin 2"
                     /db_xref="GeneID:57488"
                     /db_xref="HGNC:HGNC:22211"
                     /db_xref="MIM:616691"
     exon            1..421
                     /gene="ESYT2"
                     /gene_synonym="CHR2SYT; E-Syt2; FAM62B"
                     /inference="alignment:Splign:2.1.0"
     CDS             92..2692
                     /gene="ESYT2"
                     /gene_synonym="CHR2SYT; E-Syt2; FAM62B"
                     /note="isoform 1 is encoded by transcript variant 1;
                     family with sequence similarity 62 (C2 domain containing),
                     member B; chr2 synaptotagmin; extended synaptotagmin
                     protein 2; extended synaptotagmin like protein 2"
                     /codon_start=1
                     /product="extended synaptotagmin-2 isoform 1"
                     /protein_id="NP_001354702.1"
                     /db_xref="CCDS:CCDS94243.1"
                     /db_xref="GeneID:57488"
                     /db_xref="HGNC:HGNC:22211"
                     /db_xref="MIM:616691"
                     /translation="MSGARGEGPEAGAGGAGGRAAPENPGGVLSVELPGLLAQLARSF
                     ALLLPVYALGYLGLSFSWVLLALALLAWCRRSRGLKALRLCRALALLEDEERVVRLGV
                     RACDLPAWVHFPDTERAEWLNKTVKHMWPFICQFIEKLFRETIEPAVRGANTHLSTFS
                     FTKVDVGQQPLRINGVKVYTENVDKRQIILDLQISFVGNCEIDLEIKRYFCRAGVKSI
                     QIHGTMRVILEPLIGDMPLVGALSIFFLRKPLLEINWTGLTNLLDVPGLNGLSDTIIL
                     DIISNYLVLPNRITVPLVSEVQIAQLRFPVPKGVLRIHFIEAQDLQGKDTYLKGLVKG
                     KSDPYGIIRVGNQIFQSRVIKENLSPKWNEVYEALVYEHPGQELEIELFDEDPDKDDF
                     LGSLMIDLIEVEKERLLDEWFTLDEVPKGKLHLRLEWLTLMPNASNLDKVLTDIKADK
                     DQANDGLSSALLILYLDSARNLPSNPLEFNPDVLKKTAVQRALKSGKKISSNPNPVVQ
                     MSVGHKAQESKIRYKTNEPVWEENFTFFIHNPKRQDLEVEVRDEQHQCSLGNLKVPLS
                     QLLTSEDMTVSQRFQLSNSGPNSTIKMKIALRVLHLEKRERPPDHQHSAQVKRPSVSK
                     EGRKTSIKSHMSGSPGPGGSNTAPSTPVIGGSDKPGMEEKAQPPEAGPQGLHDLGRSS
                     SSLLASPGHISVKEPTPSIASDISLPIATQELRQRLRQLENGTTLGQSPLGQIQLTIR
                     HSSQRNKLIVVVHACRNLIAFSEDGSDPYVRMYLLPDKRRSGRRKTHVSKKTLNPVFD
                     QSFDFSVSLPEVQRRTLDVAVKNSGGFLSKDKGLLGKVLVALASEELAKGWTQWYDLT
                     EDGTRPQAMT"
     exon            422..463
                     /gene="ESYT2"
                     /gene_synonym="CHR2SYT; E-Syt2; FAM62B"
                     /inference="alignment:Splign:2.1.0"
     exon            464..598
                     /gene="ESYT2"
                     /gene_synonym="CHR2SYT; E-Syt2; FAM62B"
                     /inference="alignment:Splign:2.1.0"
     exon            599..675
                     /gene="ESYT2"
                     /gene_synonym="CHR2SYT; E-Syt2; FAM62B"
                     /inference="alignment:Splign:2.1.0"
     exon            676..748
                     /gene="ESYT2"
                     /gene_synonym="CHR2SYT; E-Syt2; FAM62B"
                     /inference="alignment:Splign:2.1.0"
     exon            749..838
                     /gene="ESYT2"
                     /gene_synonym="CHR2SYT; E-Syt2; FAM62B"
                     /inference="alignment:Splign:2.1.0"
     exon            839..894
                     /gene="ESYT2"
                     /gene_synonym="CHR2SYT; E-Syt2; FAM62B"
                     /inference="alignment:Splign:2.1.0"
     exon            895..1015
                     /gene="ESYT2"
                     /gene_synonym="CHR2SYT; E-Syt2; FAM62B"
                     /inference="alignment:Splign:2.1.0"
     exon            1016..1192
                     /gene="ESYT2"
                     /gene_synonym="CHR2SYT; E-Syt2; FAM62B"
                     /inference="alignment:Splign:2.1.0"
     exon            1193..1275
                     /gene="ESYT2"
                     /gene_synonym="CHR2SYT; E-Syt2; FAM62B"
                     /inference="alignment:Splign:2.1.0"
     exon            1276..1324
                     /gene="ESYT2"
                     /gene_synonym="CHR2SYT; E-Syt2; FAM62B"
                     /inference="alignment:Splign:2.1.0"
     exon            1325..1414
                     /gene="ESYT2"
                     /gene_synonym="CHR2SYT; E-Syt2; FAM62B"
                     /inference="alignment:Splign:2.1.0"
     exon            1415..1510
                     /gene="ESYT2"
                     /gene_synonym="CHR2SYT; E-Syt2; FAM62B"
                     /inference="alignment:Splign:2.1.0"
     exon            1511..1573
                     /gene="ESYT2"
                     /gene_synonym="CHR2SYT; E-Syt2; FAM62B"
                     /inference="alignment:Splign:2.1.0"
     exon            1574..1648
                     /gene="ESYT2"
                     /gene_synonym="CHR2SYT; E-Syt2; FAM62B"
                     /inference="alignment:Splign:2.1.0"
     exon            1649..1735
                     /gene="ESYT2"
                     /gene_synonym="CHR2SYT; E-Syt2; FAM62B"
                     /inference="alignment:Splign:2.1.0"
     exon            1736..1885
                     /gene="ESYT2"
                     /gene_synonym="CHR2SYT; E-Syt2; FAM62B"
                     /inference="alignment:Splign:2.1.0"
     exon            1886..2259
                     /gene="ESYT2"
                     /gene_synonym="CHR2SYT; E-Syt2; FAM62B"
                     /inference="alignment:Splign:2.1.0"
     exon            2260..2358
                     /gene="ESYT2"
                     /gene_synonym="CHR2SYT; E-Syt2; FAM62B"
                     /inference="alignment:Splign:2.1.0"
     exon            2359..2490
                     /gene="ESYT2"
                     /gene_synonym="CHR2SYT; E-Syt2; FAM62B"
                     /inference="alignment:Splign:2.1.0"
     exon            2491..2596
                     /gene="ESYT2"
                     /gene_synonym="CHR2SYT; E-Syt2; FAM62B"
                     /inference="alignment:Splign:2.1.0"
     exon            2597..2646
                     /gene="ESYT2"
                     /gene_synonym="CHR2SYT; E-Syt2; FAM62B"
                     /inference="alignment:Splign:2.1.0"
     exon            2647..5902
                     /gene="ESYT2"
                     /gene_synonym="CHR2SYT; E-Syt2; FAM62B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3267..3272
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ESYT2"
                     /gene_synonym="CHR2SYT; E-Syt2; FAM62B"
                     /note="hexamer: AATAAA"
     polyA_site      3288
                     /gene="ESYT2"
                     /gene_synonym="CHR2SYT; E-Syt2; FAM62B"
                     /note="major polyA site"
     regulatory      5880..5885
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ESYT2"
                     /gene_synonym="CHR2SYT; E-Syt2; FAM62B"
                     /note="hexamer: AATAAA"
     polyA_site      5902
                     /gene="ESYT2"
                     /gene_synonym="CHR2SYT; E-Syt2; FAM62B"
                     /note="major polyA site"
ORIGIN      
        1 agaggggcgc tggcgcgggg ctgagccgcc cgggatcagc gcgagcaccc agcccgcctc
       61 ggccgggagg gcagcgcggc actgcggggc gatgagcggc gcccggggcg agggcccgga
      121 ggcgggcgcc ggcggggctg ggggccgcgc ggcgcctgag aaccccgggg gcgtgctgag
      181 cgtggagctg cccgggctgc tggcgcagct ggcgcggagc ttcgcgctgc tgctgcccgt
      241 gtacgcgctg ggctacctgg ggctcagctt cagctgggtt ctcctcgcgc tcgcgctgct
      301 cgcctggtgt cgccgcagcc gcggcctcaa ggccctgcgc ctgtgccgcg cgctggcgct
      361 gctggaagac gaggagcgcg tcgtgcgcct gggggtgcgc gcctgcgacc tgcccgcctg
      421 ggttcatttt ccagacactg aaagagcaga atggctaaat aagactgtaa aacacatgtg
      481 gcctttcatt tgccaattta tagagaagtt gtttcgagaa actatagaac cagccgtgcg
      541 gggagcaaac acccacctta gcacctttag tttcacgaag gtcgacgtgg gccagcagcc
      601 cctcaggatc aatggtgtta aggtatacac tgaaaatgta gacaaaaggc aaattatttt
      661 ggaccttcag attagttttg taggaaattg tgagattgat ttggagatca aacgatattt
      721 ttgtagagct ggtgtgaaaa gtatccagat tcatggtacc atgcgggtga tcctggaacc
      781 gttgattgga gatatgccct tagttggagc tttgtctatc ttcttcctta ggaaaccact
      841 tttagaaatt aactggacag gactgacgaa tcttctggat gtccctggat tgaatggttt
      901 atcagatact atcattttgg atataatatc aaactatctg gtgcttccca atcgaatcac
      961 cgttccactt gtcagtgaag ttcaaatagc tcagttgcgg tttcctgtac caaagggtgt
     1021 tctaaggata cattttattg aagctcagga tcttcagggg aaagacactt accttaaggg
     1081 acttgtcaag ggaaagtcag acccctatgg aatcattaga gttggcaacc aaatcttcca
     1141 aagcagagtc atcaaggaga acctcagtcc aaagtggaat gaagtctatg aggctttagt
     1201 gtatgaacat cctggacaag aattagagat tgagctcttt gatgaagacc cagacaagga
     1261 tgacttttta ggaagtctta tgattgacct cattgaagtt gaaaaggagc gccttttaga
     1321 tgaatggttc actctggacg aggttcccaa ggggaagcta cacttgagac tggagtggct
     1381 cacgttaatg ccaaatgcgt caaacctcga caaggtgcta acagacatca aagctgacaa
     1441 agaccaagcc aacgatggtc tttcctctgc attgctgatc ttgtacttgg attcagcaag
     1501 gaaccttccg agtaacccat tagaatttaa ccccgatgtc ttgaagaaga ctgcagttca
     1561 gagagcttta aagtcaggga agaaaataag cagcaaccca aatcctgttg tccagatgtc
     1621 agttgggcac aaggcccagg agagcaagat tcgatacaaa accaatgaac ctgtgtggga
     1681 ggaaaacttc actttcttca ttcacaatcc caagcgccag gaccttgaag ttgaggtcag
     1741 agacgagcag caccagtgtt ccctggggaa cctgaaggtc cccctcagcc agctgctcac
     1801 cagtgaggac atgactgtga gccagcgctt ccagctcagt aactcgggtc caaacagcac
     1861 catcaagatg aagattgccc tgcgggtgct ccatctcgaa aagcgagaaa ggcctccaga
     1921 ccaccaacac tcagctcaag tcaaacgtcc ctctgtgtcc aaagagggga ggaaaacatc
     1981 catcaaatct catatgtctg ggtctccagg ccctggtggc agcaacacag ctccatccac
     2041 accagtcatt gggggcagtg ataagcctgg tatggaagaa aaggcccagc cccctgaggc
     2101 cggccctcag gggctgcacg acctgggcag aagctcctcc agcctcctgg cctccccagg
     2161 ccacatctca gtcaaggagc cgacccccag catcgcctcg gacatctcgc tgcccatcgc
     2221 cacccaggag ctgcggcaaa ggctgaggca gctggaaaac gggacgaccc tgggacagtc
     2281 tccactgggg cagatccagc tgaccatccg gcacagctcg cagagaaaca agcttatcgt
     2341 ggtcgtgcat gcctgcagaa acctcattgc cttctctgaa gacggctctg acccctatgt
     2401 ccgcatgtat ttattaccag acaagaggcg gtcaggaagg aggaaaacac acgtgtcaaa
     2461 gaaaacatta aatccagtgt ttgatcaaag ctttgatttc agtgtttcgt taccagaagt
     2521 gcagaggaga acgctcgacg ttgccgtgaa gaacagtggc ggcttcctgt ccaaagacaa
     2581 agggctcctt ggcaaagtat tggttgctct ggcatctgaa gaacttgcca aaggctggac
     2641 ccagtggtat gacctcacgg aagatgggac gaggcctcag gcgatgacat agccgcagca
     2701 ggcaggaggc gtcctcttca gcgtagctct ccacctctac ccggaacaca ccctctcaca
     2761 gacgtaccaa tgttattttt ataatttcat ggatttagtt atacatacct taatagtttt
     2821 ataaaattgt tgacatttca ggcaaatttg gccaatatta tcattgaatt ttctgtgttg
     2881 gatttcctct aggatttcgc cagttcctac aacgtgcagt agggcggcgg tagctcttgt
     2941 gtctgtggac tctgctcagc tgtgtccgta ggagtcggat gtgtctgtgc tttattatgg
     3001 ccttgtttat atatcactga ggtatactat gccatgtaaa tagactattt tttataatct
     3061 ttacatgctg gtttaaattc agaaggaaat agatcaagga aatatatata ttttcttcta
     3121 aaacttatta aattcgtgtg acaaataatc attttcatct tggcagcaaa aagttctcag
     3181 tgacctattt tgtggtgttt ctttttgaaa agaaaagctg aaatattatt aaatgctagt
     3241 atgtttctgc ccattatgaa agatgaaata aagtattcaa aatattaaca ttttcataaa
     3301 tataaggatg tattattgag aagtaagttg aagggcttat aaggaaaaat gttttataac
     3361 tgagtaatat attaagagaa ttgtcatggt tcataaatca cattatgcta atctgaaatt
     3421 tcttacataa aaatgaagtg tcttatgttt attttaattg ctgttgtaac ttactcatga
     3481 aacagtatac agacaccttg tacttttcct caactgtaag agcagacttt caatgttagc
     3541 aattaagctg ttgtcaaaca atcagtcatg agctttgtta attttcaatg ttttcccagc
     3601 ctataaaaaa aggaaggtac acgttgtcct tttaaaggtt gtgaggtaga ttggagtgag
     3661 tagacaggat attgcattaa aaattgaaag ctcgatctca ttattgtcag gaacccccag
     3721 tgtgacctca cacataggat gtgggacctt tgagccgatg tgcactggcc accaccaggg
     3781 ttgggggcgc cacagctgcg agcccggccc ctgctgttct cagcagccac ttcccaggct
     3841 gcctcacttt atgccatgac tgaccttaat attgggatat tgttatgcaa tttttatcct
     3901 gtttagactg ttaaaagcag gtttctgtac ttaagagtcc cccagacctc ctgtgaggtg
     3961 aggctctgtt gcagtgtcgt aggctgtgtg tgtctgtaaa gaaagaatgc acatatgtag
     4021 acgattaagt gtatattata agctatatgc tgaaaatggc ttccatagcc atgagaacat
     4081 cttaaaacta tgtgtaaata tattaaggaa agtatagctt tgtaatttaa attggagctt
     4141 ttagcttgtt tcatggaact atacaacttg tgggtaactc acatgaccaa acaaaccaaa
     4201 gtgcctgtga cggggcgggt ggcgtctacc caccctccct tctagcagat tcttattttg
     4261 tttgaattta taaacaaggc tggtggctgt ctacccaccc tcccttctag cagattttga
     4321 ttttgtttca atttataact tacactttga accatgggtt tacttataat ggagtctgta
     4381 gcttcacagc atatttcatg taatcataaa gaccagtata ttccctcctg ctgaatgaca
     4441 tgcgactgta aagcctcttt ataaaccatt tccaatgtta gtatatagga ttatttggga
     4501 agcgtatcaa tacctttata gacaaatacg aacatgtatg cacacaaaac atttaactat
     4561 ggtatttatg gaagacaggt aacaacatta aatctagttg ctttccctta gtattagatt
     4621 tgttgagggt tttttaaaaa tcaggtctgt tgaaagtctt ctgtcataat ctataaagca
     4681 gcagcactca tggaaattgt agcatgccag taatttttac caacatccca tacatctgag
     4741 ttctgcagtc cagtgtgtaa tccgctccat gtgtattttg cttaatggaa tgctttattt
     4801 aagcacttag gcagagtaga cacaattaaa ggtacaaagc ccagaggaag tggtagagca
     4861 gcaccgtgcc tgccctgagg cagtggagtc agtagcgctg tccccagggc cttgagtgcc
     4921 tggaggtgct tggcctccag tagctgcctc cattctcttt taaaaaaagg gggtgattct
     4981 gaggcactga agtgcctccc agatgtggag gagtgaagcc accatcgagg ccacactcag
     5041 cactccagga tcccagcgat gtcagacact cttgagttgt caaaacgtta attttcagtt
     5101 ttaaataatc agtttatcta agaaaaggga attttaactt ttctaccttg agccaagcca
     5161 atgaagggaa aattaattaa cttagtaaat ttgaagtgca gctctgttag ctcgtacatg
     5221 tgggttctta tcctgatcct gtgccttaaa gtaggaaggt gtttccaagt tcagattaaa
     5281 atagaagcag ctggccgggt gcggtggctc acgcctgtaa tcccagcact ttgggaggcc
     5341 gaggcgggcg gatgacctga ggtcaggagt tcaagaccag cctggccaac atggagaaac
     5401 cccatcttta ctaaaaatac aaaaattagc cgggcgtggt ggtggagcgc acgcctgtag
     5461 tcccagctac tcgggaggct gaggcaggag aattgcttga acccaggagg cggaggttgc
     5521 agtgagccaa gatcgcacca ctgcactcca gcctgggcaa cagagtgaga ctccgtctca
     5581 aaaaataaat aaaatagaag cagccttgta actgtattta ccatgataat atattctgca
     5641 cggtaagaat tccttttaca gacattcttt atcaagaggt cggcccttct ttttcaggca
     5701 cataagccaa atgcaggcct gtgtgtagct gtgtgttttt tctgtggttg ccgcatttat
     5761 tccacctcca gctggacccc ccactgcaaa tagagaacag cggtggggga tgggggttaa
     5821 aaagtagaga acctcctttc tgttcaacta atttcacgtg acagtgcatg tatttattca
     5881 ataaaacctt tatgttagct ca
//
