LOCUS       NM_022719               5359 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens ess-2 splicing factor homolog (ESS2), transcript
            variant 1, mRNA.
ACCESSION   NM_022719
VERSION     NM_022719.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5359)
  AUTHORS   Takada,I., Hidano,S., Takahashi,S., Yanaka,K., Ogawa,H.,
            Tsuchiya,M., Yokoyama,A., Sato,S., Ochi,H., Nakagawa,T.,
            Kobayashi,T., Nakagawa,S. and Makishima,M.
  TITLE     Transcriptional coregulator Ess2 controls survival of post-thymic
            CD4+ T cells through the Myc and IL-7 signaling pathways
  JOURNAL   J Biol Chem 298 (9), 102342 (2022)
   PUBMED   35933014
  REMARK    GeneRIF: Transcriptional coregulator Ess2 controls survival of
            post-thymic CD4(+) T cells through the Myc and IL-7 signaling
            pathways.
REFERENCE   2  (bases 1 to 5359)
  AUTHORS   von Elsner,L., Chai,G., Schneeberger,P.E., Harms,F.L., Casar,C.,
            Qi,M., Alawi,M., Abdel-Salam,G.M.H., Zaki,M.S., Arndt,F., Yang,X.,
            Stanley,V., Hempel,M., Gleeson,J.G. and Kutsche,K.
  TITLE     Biallelic FRA10AC1 variants cause a neurodevelopmental disorder
            with growth retardation
  JOURNAL   Brain 145 (4), 1551-1563 (2022)
   PUBMED   34694367
REFERENCE   3  (bases 1 to 5359)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 5359)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   5  (bases 1 to 5359)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 5359)
  AUTHORS   Botta,A., Lindsay,E.A., Jurecic,V. and Baldini,A.
  TITLE     Comparative mapping of the DiGeorge syndrome region in mouse shows
            inconsistent gene order and differential degree of gene
            conservation
  JOURNAL   Mamm Genome 8 (12), 890-895 (1997)
   PUBMED   9383280
  REMARK    Erratum:[Mamm Genome 1998 Apr;9(4):344]
REFERENCE   7  (bases 1 to 5359)
  AUTHORS   Gong,W., Emanuel,B.S., Galili,N., Kim,D.H., Roe,B., Driscoll,D.A.
            and Budarf,M.L.
  TITLE     Structural and mutational analysis of a conserved gene (DGSI) from
            the minimal DiGeorge syndrome critical region
  JOURNAL   Hum Mol Genet 6 (2), 267-276 (1997)
   PUBMED   9063747
REFERENCE   8  (bases 1 to 5359)
  AUTHORS   Rizzu,P., Lindsay,E.A., Taylor,C., O'Donnell,H., Levy,A.,
            Scambler,P. and Baldini,A.
  TITLE     Cloning and comparative mapping of a gene from the commonly deleted
            region of DiGeorge and Velocardiofacial syndromes conserved in C.
            elegans
  JOURNAL   Mamm Genome 7 (9), 639-643 (1996)
   PUBMED   8703114
REFERENCE   9  (bases 1 to 5359)
  AUTHORS   Gong,W., Emanuel,B.S., Collins,J., Kim,D.H., Wang,Z., Chen,F.,
            Zhang,G., Roe,B. and Budarf,M.L.
  TITLE     A transcription map of the DiGeorge and velo-cardio-facial syndrome
            minimal critical region on 22q11
  JOURNAL   Hum Mol Genet 5 (6), 789-800 (1996)
   PUBMED   8776594
REFERENCE   10 (bases 1 to 5359)
  AUTHORS   Lindsay,E.A., Rizzu,P., Antonacci,R., Jurecic,V., Delmas-Mata,J.,
            Lee,C.C., Kim,U.J., Scambler,P.J. and Baldini,A.
  TITLE     A transcription map in the CATCH22 critical region: identification,
            mapping, and ordering of four novel transcripts expressed in heart
  JOURNAL   Genomics 32 (1), 104-112 (1996)
   PUBMED   8786095
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BM545545.1, BC003015.1,
            DB090071.1, L77565.1 and BC069275.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_022719.2.
            
            Summary: This gene is located within the minimal DGS critical
            region (MDGCR) thought to contain the gene(s) responsible for a
            group of developmental disorders. These disorders include DiGeorge
            syndrome, velocardiofacial syndrome, conotruncal anomaly face
            syndrome, and some familial or sporadic conotruncal cardiac defects
            which have been associated with microdeletion of 22q11.2. The
            encoded protein may be a component of C complex spliceosomes, and
            the orthologous protein in the mouse localizes to the nucleus.
            Alternatively spliced transcript variants have been found for this
            gene. [provided by RefSeq, Dec 2015].
            
            Transcript Variant: This variant (1) represents the protein-coding
            transcript.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803616.245313.1,
                                           SRR3476690.1104187.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000252137.11/ ENSP00000252137.6
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-12                BM545545.1         53-64
            13-1703             BC003015.1         1-1691
            1704-2239           DB090071.1         29-564
            2240-3041           L77565.1           301-1102
            3042-5359           BC069275.1         705-3022
FEATURES             Location/Qualifiers
     source          1..5359
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q11.21"
     gene            1..5359
                     /gene="ESS2"
                     /gene_synonym="bis1; DGCR13; DGCR14; DGS-H; DGS-I; DGSH;
                     DGSI; ES2; Es2el; ESS-2"
                     /note="ess-2 splicing factor homolog"
                     /db_xref="GeneID:8220"
                     /db_xref="HGNC:HGNC:16817"
                     /db_xref="MIM:601755"
     exon            1..146
                     /gene="ESS2"
                     /gene_synonym="bis1; DGCR13; DGCR14; DGS-H; DGS-I; DGSH;
                     DGSI; ES2; Es2el; ESS-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             12..1442
                     /gene="ESS2"
                     /gene_synonym="bis1; DGCR13; DGCR14; DGS-H; DGS-I; DGSH;
                     DGSI; ES2; Es2el; ESS-2"
                     /note="DiGeorge syndrome gene H; DiGeorge syndrome
                     critical region gene 13; protein DGCR14; DiGeorge syndrome
                     critical region gene DGSI; DiGeorge syndrome gene I;
                     Protein DGCR13; DiGeorge syndrome critical region gene 14;
                     diGeorge syndrome protein H"
                     /codon_start=1
                     /product="splicing factor ESS-2 homolog"
                     /protein_id="NP_073210.1"
                     /db_xref="CCDS:CCDS13756.1"
                     /db_xref="GeneID:8220"
                     /db_xref="HGNC:HGNC:16817"
                     /db_xref="MIM:601755"
                     /translation="METPGASASSLLLPAASRPPRKREAGEAGAATSKQRVLDEEEYI
                     EGLQTVIQRDFFPDVEKLQAQKEYLEAEENGDLERMRQIAIKFGSALGKMSREPPPPY
                     VTPATFETPEVHAGTGVVGNKPRPRGRGLEDGEAGEEEEKEPLPSLDVFLSRYTSEDN
                     ASFQEIMEVAKERSRARHAWLYQAEEEFEKRQKDNLELPSAEHQAIESSQASVETWKY
                     KAKNSLMYYPEGVPDEEQLFKKPRQVVHKNTRFLRDPFSQALSRCQLQQAAALNAQHK
                     QGKVGPDGKELIPQESPRVGGFGFVATPSPAPGVNESPMMTWGEVENTPLRVEGSETP
                     YVDRTPGPAFKILEPGRRERLGLKMANEAAAKNRAKKQEALRRVTENLASLTPKGLSP
                     AMSPALQRLVSRTASKYTDRALRASYTPSPARSTHLKTPASGLQTPTSTPAPGSATRT
                     PLTQDPASITDNLLQLPARRKASDFF"
     exon            147..315
                     /gene="ESS2"
                     /gene_synonym="bis1; DGCR13; DGCR14; DGS-H; DGS-I; DGSH;
                     DGSI; ES2; Es2el; ESS-2"
                     /inference="alignment:Splign:2.1.0"
     exon            316..411
                     /gene="ESS2"
                     /gene_synonym="bis1; DGCR13; DGCR14; DGS-H; DGS-I; DGSH;
                     DGSI; ES2; Es2el; ESS-2"
                     /inference="alignment:Splign:2.1.0"
     exon            412..581
                     /gene="ESS2"
                     /gene_synonym="bis1; DGCR13; DGCR14; DGS-H; DGS-I; DGSH;
                     DGSI; ES2; Es2el; ESS-2"
                     /inference="alignment:Splign:2.1.0"
     exon            582..699
                     /gene="ESS2"
                     /gene_synonym="bis1; DGCR13; DGCR14; DGS-H; DGS-I; DGSH;
                     DGSI; ES2; Es2el; ESS-2"
                     /inference="alignment:Splign:2.1.0"
     exon            700..833
                     /gene="ESS2"
                     /gene_synonym="bis1; DGCR13; DGCR14; DGS-H; DGS-I; DGSH;
                     DGSI; ES2; Es2el; ESS-2"
                     /inference="alignment:Splign:2.1.0"
     exon            834..936
                     /gene="ESS2"
                     /gene_synonym="bis1; DGCR13; DGCR14; DGS-H; DGS-I; DGSH;
                     DGSI; ES2; Es2el; ESS-2"
                     /inference="alignment:Splign:2.1.0"
     exon            937..1046
                     /gene="ESS2"
                     /gene_synonym="bis1; DGCR13; DGCR14; DGS-H; DGS-I; DGSH;
                     DGSI; ES2; Es2el; ESS-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1047..1162
                     /gene="ESS2"
                     /gene_synonym="bis1; DGCR13; DGCR14; DGS-H; DGS-I; DGSH;
                     DGSI; ES2; Es2el; ESS-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1163..5359
                     /gene="ESS2"
                     /gene_synonym="bis1; DGCR13; DGCR14; DGS-H; DGS-I; DGSH;
                     DGSI; ES2; Es2el; ESS-2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1680..1685
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ESS2"
                     /gene_synonym="bis1; DGCR13; DGCR14; DGS-H; DGS-I; DGSH;
                     DGSI; ES2; Es2el; ESS-2"
                     /note="hexamer: ATTAAA"
     polyA_site      1703
                     /gene="ESS2"
                     /gene_synonym="bis1; DGCR13; DGCR14; DGS-H; DGS-I; DGSH;
                     DGSI; ES2; Es2el; ESS-2"
                     /note="major polyA site"
     regulatory      5339..5344
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ESS2"
                     /gene_synonym="bis1; DGCR13; DGCR14; DGS-H; DGS-I; DGSH;
                     DGSI; ES2; Es2el; ESS-2"
                     /note="hexamer: GATAAA"
     polyA_site      5359
                     /gene="ESS2"
                     /gene_synonym="bis1; DGCR13; DGCR14; DGS-H; DGS-I; DGSH;
                     DGSI; ES2; Es2el; ESS-2"
ORIGIN      
        1 ctgggatagc gatggagacg ccgggcgcat cagcgtcgtc cttgttgctt cccgccgcgt
       61 ccaggccccc gaggaagcgc gaggcgggag aggctggggc tgcgacgagc aagcagcggg
      121 tcctggacga ggaagagtat atcgagggcc tccagacggt catccaaagg gatttctttc
      181 ctgatgtgga gaagctccag gcacagaagg agtacctgga agccgaggag aatggagact
      241 tggaacggat gcgccagatt gccatcaagt ttggctctgc cttgggcaag atgtcccggg
      301 agcccccgcc accctatgtg actccagcca catttgaaac ccctgaggtg catgcaggca
      361 ctggagtggt gggcaacaag cccaggcccc gcggccgagg cctggaggat ggagaggctg
      421 gagaggagga ggagaaggag ccgctgccca gcctagatgt cttcctgagc cgctacacga
      481 gtgaggacaa tgcctccttc caggagatca tggaggtggc caaggagaga agccgggcac
      541 gccacgcttg gctctaccag gctgaggaag agtttgagaa gaggcagaaa gataatctcg
      601 aactcccgtc agcagagcac caggccatcg agagcagcca ggccagtgtg gagacctgga
      661 agtacaaggc caagaattcc ctcatgtact atccagaggg tgtccctgac gaggagcagc
      721 tgtttaagaa gccccggcag gtggtacata agaacacgcg cttccttagg gaccccttca
      781 gccaagccct gagcaggtgc cagctccagc aggcagccgc cctcaatgcc cagcacaaac
      841 agggcaaggt gggccccgat ggcaaggagc tgatccccca ggagtcccct cgagtgggtg
      901 gatttggatt tgttgccact ccttcccctg cccctggtgt gaacgagtcc ccgatgatga
      961 cctgggggga ggttgagaac acacccttga gagttgaagg gtcggaaacg ccctacgtgg
     1021 acaggacacc cggcccagct tttaagatcc tggagccagg ccgcagggag cggctgggtc
     1081 tgaagatggc caacgaggcc gctgccaaga accgggccaa gaagcaggaa gccttgcgga
     1141 gagtgacgga gaatctggcc agcctcaccc ccaaaggcct gagcccagcc atgtcgccag
     1201 ccctacagcg ccttgtgagc aggacggcca gcaagtacac agaccgggcc ctgcgggcca
     1261 gctacacacc atccccagca cgctccaccc acctcaagac cccggccagt gggctgcaga
     1321 cccccacaag cacaccggcg cctggctctg ccacacgcac ccctctcaca caggacccgg
     1381 cctccatcac ggacaacctg ctgcagctcc ctgcccggcg caaagcttcg gacttctttt
     1441 agagccaggc ctgggctggg ctcatagacg cttcacagag cctgcagggc agctgtacac
     1501 ccagcagagg actccagcct tctcggggcc caggcctggg ccagaagctg ttgaccatac
     1561 caggagtcac tggagaaagg ggctgtgctg gggccagact ggcacaaggc actcgtgccc
     1621 acaccacacc ccagggcctt gccaagctgt ttgctgttta attggcccct tgaactgtca
     1681 ttaaagaaca cctaggtaca gtctgggggg ttgcctctcc atcttgctcc ccacacgagc
     1741 cctagccttg ccctggggcc tgcatcacgt ctcaggactg cggggcttga agcgaggggc
     1801 cccccaggtg aggaagctgc aggtggggcg gctgtgggag caccgggtga ctggcgttgc
     1861 tttctgcggc actcggaacc tgtgttctga gttgagctca catcctgcag tgctttctgc
     1921 ttctctgggg ggatatgaag gagaaacgga gcccttggaa gttgtaccct taggttcccc
     1981 tgcggttctg ggcccaggtc tgcagcctcc actctgggct tgccggctgt gaggtgcgct
     2041 ggttatagga ctgtgtgggg gctgcatatc aggtgatctc agctatcacc ttctcccagc
     2101 acctggcttc cagctcatgg ggtgggacta tcccactcac ccctctgcta taggcactgc
     2161 ccatcttatg ctgctggccc tggcctcacc tggtcacttc caccaacagg agctcccaga
     2221 taacagtggg ttgctggaca gatcaggctg ggactcttaa ggggtggggg acgtggggcc
     2281 ttcagtgctt tatcccctag gaaagggtgc acgttatccc aagggagccc ccaggaagtg
     2341 gggagggagg ggggaggagc atgtctaggt gctgaccacc tggagcactt ggccagcaag
     2401 tgggccgcat gctttgggag caatgggtga cccagcagga agcacaaaag accggccagt
     2461 gtgccatcat caagggctgc tgagcagctt gaagagccac tgggtgggga gggcacacgg
     2521 ggaggtctca gctggggctg cccctggagg acagggcagg gaacttgagg gctgaggaca
     2581 gaaatctcac atgactccag gaaatagagg aagaggagga tgctgagcga gggattgtga
     2641 gggagtgggg gtaggtcaga gggggctgaa ctgcaggaag ccagggggag tcgtggacca
     2701 ctggagctgg ccagccccag ggcattgggg acaaggccag gtcagaggga gacagtgtgg
     2761 gcctggtggg tggaccctgg cagaggccct cttgtccccc acaaggccag gccacactgt
     2821 gattctgcct gtacctgagc atctgtcctg tgctcctagg ccggagacca ctgtgtgtca
     2881 ggtggggcgg ttggctgagt cccagagaaa aacactcctc actgggcact cttgatgctt
     2941 gcacacaccc tgtggtttat ttggtggtca gtaaggaacg tctttgctgc taagtggaag
     3001 aaagctaatg gaacgtaatc aaaatagtgg tttaattgac gaattttact tgcacctgtg
     3061 ccttcttcag atcctacctg cctacttagt ttacgtgaag gccgactgca ccatgccccc
     3121 caaccccgac ccccaccaca cacaacgggg ccattgtcat gctaggtgct tgctttcccc
     3181 acctcagctc cggagatgtg atggtctttg gccctggagg tctcggccag cctgtcctcc
     3241 atcctgttct cgttctcggg caccaccagc agccggtgct gggttttggc tccaagcttg
     3301 tggtcgggcc ggtggtcggg cctcaagcct gtcttggtgt ccagtttgca ctcagcgcgg
     3361 tacttgccct ccccctccct cttgaaggag gcagaagacg tggctttggg cttggggggc
     3421 tgcagccacg agtggctgag gatctcatcg atgtggagcc gctggctgac gtcgggctgc
     3481 agcatgcggt agatgaggtc cttgcactcg caggtcaggt tcttggagcg cgggaagtcc
     3541 acacggtgct ccttctggat acgcagcatc ttcctgatgt cggagtcgtc atagggcatg
     3601 gagccgcaga ccatgatgta caggatcacg cccaggctcc agatgtcata caccttgggc
     3661 tggtagggga tgctctgcag cacctcgggg gctgcatatg ctgccgaccc gcagaaggtc
     3721 ttgctgagga tgatgcgccc attgctgtcc cgcaggcagc gcttggagaa gccaaagtca
     3781 gacagcttga tgttgaagtc cttgtcgagg agaaggttct cgcacttgag gtcccggtgg
     3841 acgatgtcca ggtcgtggca gtacttgacg gcggaggaga gctgtcggaa catcttgcgt
     3901 gccacgtcct catgcagggc tccctggcac ttgatgaact cgaggaggtc gccctggacg
     3961 ccaagctcca tgatgatgta gatccgtccg tcagaggtct caaagatctc gtaagtcttg
     4021 atgatggagc cgtggttgac agttgccagg atgtccatct cccgaggaag gaatctctcc
     4081 acaaagtcag taggtgtttt cttgcggtcg atgatcttga cagccacatt gaacttgagg
     4141 cgctcagagt aggcagattt gacttttgcg taggaaccct tgccaagatt gatgcctacg
     4201 atgtaaccct tcttccttag gactgtggca tcgtccatgg tgccaggagc gactggcgcc
     4261 gctgccgtct acatcccccc gtcatgtggg ccagcaggca ttgtcctcat ttacactacc
     4321 ggaggcgtct ggctgggctg ccctgggctg ggcttcgact caggggtgga acactcagca
     4381 ttgtctccgg gtgacttcag ccaatgaact cataaagcca aggagtgggg gcggggactg
     4441 ggctgaggga gaacagggtc tctggaaccg tggaagccag gctggtctgg caggagcacc
     4501 cactccccgc ccgctggaag gaagcctgtc cccaggacag gactctggtg gccctgctgc
     4561 tgctgcattg gtttccctgt cacaagtcaa gctggagggg aggcggccca cgtccagcct
     4621 gtttgcatca cctggctgtg gggactgacc ctgcattggt ctttgtccca ctagggtggg
     4681 tttcctgcag cttctttggc tatgaagaaa agcaccccca gggctgtgtc cttggtgtgg
     4741 taggacagtt gtccctgaca gtcacccaga caggcctgca tagcacccca gttacacaga
     4801 cagatttcca cagcactgcc ttaccattga gcacatagtt aaatctaggg aaatcagtgc
     4861 ccagacatca aagctagaaa tgaaacatgg tcagcaggag ccttgcatgg gcttctcttt
     4921 tgctggagca agccaaaata ataggaacgg ttttacattc ctagtgccag gacccatctc
     4981 gggtcgacaa aatctgaaga caagttaagg gaacaggcag ctgtttgaat agatcaattg
     5041 gatagtctaa ggcagctctc tggaccaagc tgtaaaggag atacaatcga aataatcact
     5101 ccggtaccac agtagacagg ccttgaaggc actgggcccc ttttaatcgg acttagcaag
     5161 catttttttt gcctctgacc ttctccttgg aacaaaatta gttaccagta gacttaggtg
     5221 attgctgtac tgcatgtagg cacataaccc caacctatat aaacagtaag aaaattgtag
     5281 cactttgagt tggtctgctg gaattatctc cagccttctc cctgtatcca gttacagtga
     5341 taaactccct tctttccta
//
