LOCUS       NM_001438               5195 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens estrogen related receptor gamma (ESRRG), transcript
            variant 1, mRNA.
ACCESSION   NM_001438
VERSION     NM_001438.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5195)
  AUTHORS   Sato,K., Takayama,K.I., Saito,Y. and Inoue,S.
  TITLE     ERRalpha and ERRgamma coordinate expression of genes associated
            with Alzheimer's disease, inhibiting DKK1 to suppress tau
            phosphorylation
  JOURNAL   Proc Natl Acad Sci U S A 121 (37), e2406854121 (2024)
   PUBMED   39231208
  REMARK    GeneRIF: ERRalpha and ERRgamma coordinate expression of genes
            associated with Alzheimer's disease, inhibiting DKK1 to suppress
            tau phosphorylation.
REFERENCE   2  (bases 1 to 5195)
  AUTHORS   Adkins-Threats,M., Arimura,S., Huang,Y.Z., Divenko,M., To,S.,
            Mao,H., Zeng,Y., Hwang,J.Y., Burclaff,J.R., Jain,S. and Mills,J.C.
  TITLE     Metabolic regulator ERRgamma governs gastric stem cell
            differentiation into acid-secreting parietal cells
  JOURNAL   Cell Stem Cell 31 (6), 886-903 (2024)
   PUBMED   38733994
  REMARK    GeneRIF: Metabolic regulator ERRgamma governs gastric stem cell
            differentiation into acid-secreting parietal cells.
REFERENCE   3  (bases 1 to 5195)
  AUTHORS   Jung,Y.S., Radhakrishnan,K., Hammad,S., Muller,S., Muller,J.,
            Noh,J.R., Kim,J., Lee,I.K., Cho,S.J., Kim,D.K., Kim,Y.H., Lee,C.H.,
            Dooley,S. and Choi,H.S.
  TITLE     ERRgamma-inducible FGF23 promotes alcoholic liver injury through
            enhancing CYP2E1 mediated hepatic oxidative stress
  JOURNAL   Redox Biol 71, 103107 (2024)
   PUBMED   38479224
  REMARK    GeneRIF: ERRgamma-inducible FGF23 promotes alcoholic liver injury
            through enhancing CYP2E1 mediated hepatic oxidative stress.
REFERENCE   4  (bases 1 to 5195)
  AUTHORS   Lee,C.Y., Hubrich,D., Varga,J.K., Schafer,C., Welzel,M.,
            Schumbera,E., Djokic,M., Strom,J.M., Schonfeld,J., Geist,J.L.,
            Polat,F., Gibson,T.J., Keller Valsecchi,C.I., Kumar,M.,
            Schueler-Furman,O. and Luck,K.
  TITLE     Systematic discovery of protein interaction interfaces using
            AlphaFold and experimental validation
  JOURNAL   Mol Syst Biol 20 (2), 75-97 (2024)
   PUBMED   38225382
REFERENCE   5  (bases 1 to 5195)
  AUTHORS   Wang,X.X., Hua,T. and Wang,H.B.
  TITLE     Estrogen receptor-related receptor gamma uppresses hypoxia-induced
            angiogenesis by regulating VEGFA in endometrial cancer
  JOURNAL   Gynecol Endocrinol 39 (1), 2264411 (2023)
   PUBMED   37859604
  REMARK    GeneRIF: Estrogen receptor-related receptor gamma uppresses
            hypoxia-induced angiogenesis by regulating VEGFA in endometrial
            cancer.
REFERENCE   6  (bases 1 to 5195)
  AUTHORS   Greschik,H., Wurtz,J.M., Sanglier,S., Bourguet,W., van
            Dorsselaer,A., Moras,D. and Renaud,J.P.
  TITLE     Structural and functional evidence for ligand-independent
            transcriptional activation by the estrogen-related receptor 3
  JOURNAL   Mol Cell 9 (2), 303-313 (2002)
   PUBMED   11864604
  REMARK    GeneRIF: Transcriptional activation by ERR3 can be
            ligand-independent.
REFERENCE   7  (bases 1 to 5195)
  AUTHORS   Heard,D.J., Norby,P.L., Holloway,J. and Vissing,H.
  TITLE     Human ERRgamma, a third member of the estrogen receptor-related
            receptor (ERR) subfamily of orphan nuclear receptors:
            tissue-specific isoforms are expressed during development and in
            the adult
  JOURNAL   Mol Endocrinol 14 (3), 382-392 (2000)
   PUBMED   10707956
REFERENCE   8  (bases 1 to 5195)
  AUTHORS   Hong,H., Yang,L. and Stallcup,M.R.
  TITLE     Hormone-independent transcriptional activation and coactivator
            binding by novel orphan nuclear receptor ERR3
  JOURNAL   J Biol Chem 274 (32), 22618-22626 (1999)
   PUBMED   10428842
REFERENCE   9  (bases 1 to 5195)
  AUTHORS   Chen,F., Zhang,Q., McDonald,T., Davidoff,M.J., Bailey,W., Bai,C.,
            Liu,Q. and Caskey,C.T.
  TITLE     Identification of two hERR2-related novel nuclear receptors
            utilizing bioinformatics and inverse PCR
  JOURNAL   Gene 228 (1-2), 101-109 (1999)
   PUBMED   10072763
REFERENCE   10 (bases 1 to 5195)
  AUTHORS   Eudy,J.D., Yao,S., Weston,M.D., Ma-Edmonds,M., Talmadge,C.B.,
            Cheng,J.J., Kimberling,W.J. and Sumegi,J.
  TITLE     Isolation of a gene encoding a novel member of the nuclear receptor
            superfamily from the critical region of Usher syndrome type IIa at
            1q41
  JOURNAL   Genomics 50 (3), 382-384 (1998)
   PUBMED   9676434
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AB020639.1 and BU752915.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_001438.3.
            
            Summary: This gene encodes a member of the estrogen
            receptor-related receptor (ESRR) family, which belongs to the
            nuclear hormone receptor superfamily. All members of the ESRR
            family share an almost identical DNA binding domain, which is
            composed of two C4-type zinc finger motifs. The ESRR members are
            orphan nuclear receptors; they bind to the estrogen response
            element and steroidogenic factor 1 response element, and activate
            genes controlled by both response elements in the absence of any
            ligands. The ESRR family is closely related to the estrogen
            receptor (ER) family. They share target genes, co-regulators and
            promoters, and by targeting the same set of genes, the ESRRs seem
            to interfere with the ER-mediated estrogen response in various
            ways. It has been reported that the family member encoded by this
            gene functions as a transcriptional activator of DNA
            cytosine-5-methyltransferases 1 (Dnmt1) expression by direct
            binding to its response elements in the DNMT1 promoters, modulates
            cell proliferation and estrogen signaling in breast cancer, and
            negatively regulates bone morphogenetic protein 2-induced
            osteoblast differentiation and bone formation. Multiple
            alternatively spliced transcript variants have been identified,
            which mainly differ at the 5' end and some of which encode protein
            isoforms differing in the N-terminal region. [provided by RefSeq,
            Aug 2011].
            
            Transcript Variant: This variant (1) encodes isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY388456.1, AB020639.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000408911.8/ ENSP00000386171.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-5192              AB020639.1         25-5216
            5193-5195           BU752915.1         23-25               c
FEATURES             Location/Qualifiers
     source          1..5195
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q41"
     gene            1..5195
                     /gene="ESRRG"
                     /gene_synonym="ERR-gamma; ERR3; ERRg; ERRgamma; NR3B3"
                     /note="estrogen related receptor gamma"
                     /db_xref="GeneID:2104"
                     /db_xref="HGNC:HGNC:3474"
                     /db_xref="MIM:602969"
     exon            1..186
                     /gene="ESRRG"
                     /gene_synonym="ERR-gamma; ERR3; ERRg; ERRgamma; NR3B3"
                     /inference="alignment:Splign:2.1.0"
     CDS             131..1507
                     /gene="ESRRG"
                     /gene_synonym="ERR-gamma; ERR3; ERRg; ERRgamma; NR3B3"
                     /note="isoform 1 is encoded by transcript variant 1;
                     estrogen receptor-related protein 3; nuclear receptor
                     subfamily 3 group B member 3; ERR gamma-2"
                     /codon_start=1
                     /product="estrogen-related receptor gamma isoform 1"
                     /protein_id="NP_001429.2"
                     /db_xref="CCDS:CCDS41468.1"
                     /db_xref="GeneID:2104"
                     /db_xref="HGNC:HGNC:3474"
                     /db_xref="MIM:602969"
                     /translation="MDSVELCLPESFSLHYEEELLCRMSNKDRHIDSSCSSFIKTEPS
                     SPASLTDSVNHHSPGGSSDASGSYSSTMNGHQNGLDSPPLYPSAPILGGSGPVRKLYD
                     DCSSTIVEDPQTKCEYMLNSMPKRLCLVCGDIASGYHYGVASCEACKAFFKRTIQGNI
                     EYSCPATNECEITKRRRKSCQACRFMKCLKVGMLKEGVRLDRVRGGRQKYKRRIDAEN
                     SPYLNPQLVQPAKKPYNKIVSHLLVAEPEKIYAMPDPTVPDSDIKALTTLCDLADREL
                     VVIIGWAKHIPGFSTLSLADQMSLLQSAWMEILILGVVYRSLSFEDELVYADDYIMDE
                     DQSKLAGLLDLNNAILQLVKKYKSMKLEKEEFVTLKAIALANSDSMHIEDVEAVQKLQ
                     DVLHEALQDYEAGQHMEDPRRAGKMLMTLPLLRQTSTKAVQHFYNIKLEGKVPMHKLF
                     LEMLEAKV"
     exon            187..602
                     /gene="ESRRG"
                     /gene_synonym="ERR-gamma; ERR3; ERRg; ERRgamma; NR3B3"
                     /inference="alignment:Splign:2.1.0"
     exon            603..719
                     /gene="ESRRG"
                     /gene_synonym="ERR-gamma; ERR3; ERRg; ERRgamma; NR3B3"
                     /inference="alignment:Splign:2.1.0"
     exon            720..830
                     /gene="ESRRG"
                     /gene_synonym="ERR-gamma; ERR3; ERRg; ERRgamma; NR3B3"
                     /inference="alignment:Splign:2.1.0"
     exon            831..992
                     /gene="ESRRG"
                     /gene_synonym="ERR-gamma; ERR3; ERRg; ERRgamma; NR3B3"
                     /inference="alignment:Splign:2.1.0"
     exon            993..1262
                     /gene="ESRRG"
                     /gene_synonym="ERR-gamma; ERR3; ERRg; ERRgamma; NR3B3"
                     /inference="alignment:Splign:2.1.0"
     exon            1263..5195
                     /gene="ESRRG"
                     /gene_synonym="ERR-gamma; ERR3; ERRg; ERRgamma; NR3B3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5173..5178
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ESRRG"
                     /gene_synonym="ERR-gamma; ERR3; ERRg; ERRgamma; NR3B3"
                     /note="hexamer: ATTAAA"
     polyA_site      5195
                     /gene="ESRRG"
                     /gene_synonym="ERR-gamma; ERR3; ERRg; ERRgamma; NR3B3"
                     /note="major polyA site"
ORIGIN      
        1 gagctttggt cccaactggc tgtgcctata ggcttgtcac taggagaaca tttgtgttaa
       61 ttgcactgtg ctctgtcaag gaaactttga tttatagctg gggtgcacaa ataatggttg
      121 ccggtcgcac atggattcgg tagaactttg ccttcctgaa tctttttccc tgcactacga
      181 ggaagagctt ctctgcagaa tgtcaaacaa agatcgacac attgattcca gctgttcgtc
      241 cttcatcaag acggaacctt ccagcccagc ctccctgacg gacagcgtca accaccacag
      301 ccctggtggc tcttcagacg ccagtgggag ctacagttca accatgaatg gccatcagaa
      361 cggacttgac tcgccacctc tctacccttc tgctcctatc ctgggaggta gtgggcctgt
      421 caggaaactg tatgatgact gctccagcac cattgttgaa gatccccaga ccaagtgtga
      481 atacatgctc aactcgatgc ccaagagact gtgtttagtg tgtggtgaca tcgcttctgg
      541 gtaccactat ggggtagcat catgtgaagc ctgcaaggca ttcttcaaga ggacaattca
      601 aggcaatata gaatacagct gccctgccac gaatgaatgt gaaatcacaa agcgcagacg
      661 taaatcctgc caggcttgcc gcttcatgaa gtgtttaaaa gtgggcatgc tgaaagaagg
      721 ggtgcgtctt gacagagtac gtggaggtcg gcagaagtac aagcgcagga tagatgcgga
      781 gaacagccca tacctgaacc ctcagctggt tcagccagcc aaaaagccat ataacaagat
      841 tgtctcacat ttgttggtgg ctgaaccgga gaagatctat gccatgcctg accctactgt
      901 ccccgacagt gacatcaaag ccctcactac actgtgtgac ttggccgacc gagagttggt
      961 ggttatcatt ggatgggcga agcatattcc aggcttctcc acgctgtccc tggcggacca
     1021 gatgagcctt ctgcagagtg cttggatgga aattttgatc cttggtgtcg tataccggtc
     1081 tctttcgttt gaggatgaac ttgtctatgc agacgattat ataatggacg aagaccagtc
     1141 caaattagca ggccttcttg atctaaataa tgctatcctg cagctggtaa agaaatacaa
     1201 gagcatgaag ctggaaaaag aagaatttgt caccctcaaa gctatagctc ttgctaattc
     1261 agactccatg cacatagaag atgttgaagc cgttcagaag cttcaggatg tcttacatga
     1321 agcgctgcag gattatgaag ctggccagca catggaagac cctcgtcgag ctggcaagat
     1381 gctgatgaca ctgccactcc tgaggcagac ctctaccaag gccgtgcagc atttctacaa
     1441 catcaaacta gaaggcaaag tcccaatgca caaacttttt ttggaaatgt tggaggccaa
     1501 ggtctgacta aaagctccct gggccttccc atccttcatg ttgaaaaagg gaaaataaac
     1561 ccaagagtga tgtcgaagaa acttagagtt tagttaacaa catcaaaaat caacagactg
     1621 cactgataat ttagcagcaa gactatgaag cagctttcag attcctccat aggttcctga
     1681 tgagtttctt tctactttct ccatcatctt ctttcctctt tcttcccaca tttctctttc
     1741 tctttatttt ttctcctttt cttctttcac ctcccttatt tctttgcttc tttcattcct
     1801 agttcccatt ctcctttatt ttcttcccgt ctgcctgcct tctttctttt ctttacctac
     1861 tctcattcct ctcttttctc atccttcccc ttttttctaa atttgaaata gctttagttt
     1921 aaaaaaaaat cctcccttcc ccctttcctt tccctttctt tcctttttcc ctttcctttt
     1981 ccctttcctt tcctttcctc ttgaccttct ttccatcttt ctttttcttc cttctgctgc
     2041 tgaactttta aaagaggtct ctaactgaag agagatggaa gccagccctg ccaaaggatg
     2101 gagatccata atatggatgc cagtgaactt attgtgaacc atactgtccc caatgactaa
     2161 ggaatcaaag agagagaacc aacgttccta aaagtacagt gcaacatata caaattgact
     2221 gagtgcagta ttagatttca tgggagcagc ctctaattag acaacttaag caacgttgca
     2281 tcggctgctt cttatcattg cttttccatc tagatcagtt acagccattt gattccttaa
     2341 ttgttttttc aagtcttcca ggtatttgtt agtttagcta ctatgtaact ttttcaggga
     2401 atagtttaag ctttattcat tcatgcaata ctaaagagaa ataagaatac tgcaattttg
     2461 tgctggcttt gaacaattac gaacaataat gaaggacaaa tgaatcctga aggaagattt
     2521 ttaaaaatgt tttgtttctt cttacaaatg gagatttttt tgtaccagct ttaccacttt
     2581 tcagccattt attaatatgg gaatttaact tactcaagca atagttgaag ggaaggtgca
     2641 tattatcacg gatgcaattt atgttgtgtg ccagtctggt cccaaacatc aatttcttaa
     2701 catgagctcc agtttaccta aatgttcact gacacaaagg atgagattac acctacagtg
     2761 actctgagta gtcacatata taagcactgc acatgagata tagatccgta gaattgtcag
     2821 gagtgcacct ctctacttgg gaggtacaat tgccatatga tttctagctg ccatggtggt
     2881 taggaatgtg atactgcctg tttgcaaagt cacagacctt gcctcagaag gagctgtgag
     2941 ccagtattca tttaagaggc aataaggcaa atgccagaat taaaaaaaaa aatcatcaaa
     3001 gacagaaaat gcctgaccaa attctaaaac ctaatccata taagtttatt catttaggaa
     3061 tgttcgttta aattaatctg cagtttttac caagagctaa gccaatatat gtgcttttca
     3121 accagtattg tcacagcatg aaagtcaagt caggttccag actgttaaga ggtgtaatct
     3181 aatgaagaaa tcaattagat gccccgaaat ctacagtcgc tgaataacca ataaacagta
     3241 acctccatca aatgctatac caatggacca gtgttagtag ctgctccctg tattatgtga
     3301 acagtcttat tctatgtaca cagatgtaat taaaattgta atcctaacaa acaaaagaaa
     3361 tgtagttcag cttttcaatg tttcatgttt gctgtgcttt tctgaatttt atgttgcatt
     3421 caaagactgt tgtcttgttc ttgtggtgtt tggattcttg tggtgtgtgc ttttagacac
     3481 agggtagaat tagagacaat attggatgta caattcctca ggagactaca gtagtatatt
     3541 ctattcctta ccagtaataa ggttcttcct aataataatt aagagattga aactccaaac
     3601 aagtattcat tatgaacaga tacacatcaa aatcataata atattttcaa aacaaggaat
     3661 aatttctcta atggtttatt atagaatacc aatgtatagc ttagaaataa aactttgaat
     3721 atttcaagaa tatagataag tctaattttt aaatgctgta tatatggctt tcactcaatc
     3781 atctctcaga tgttgttatt aactcgctct gtgttgttgc aaaacttttt ggtgcagatt
     3841 cgtttccaaa actattgcta ctttgtgtgc tttaaacaaa ataccttggg ttgatgaaac
     3901 atcaacccag tgctaggaat actgtgtatc tatcattagc tatatgggac tatattgtag
     3961 attgtggttt ctcagtagag aagtgactgt agtgtgattc tagataaatc atcattagca
     4021 attcattcag atggtcaata acttgaaatt tatagctgtg ataggagttc agaaattggc
     4081 acatcccttt aaaaataaca acagaaaata caactcctgg gaaaaaaggt gctgattcta
     4141 taagattatt tatatatgta agtgtttaaa aagattattt tccagaaagt ttgtgcaggg
     4201 tttaagttgc tactattcaa ctacactata tataaataaa atatatacaa tatatacatt
     4261 gttttcactg tatcacatta aagtacttgg gcttcagaag taagagccaa ccaactgaaa
     4321 acctgagatg gagatatgtt caaagaatga gatacaattt tttagttttc agtttaagta
     4381 actctcagca ttacaaaaga gtaagtatct cacaaatagg aaataaaact aaaacgtgga
     4441 tttaaaaaga actgcacggg ctttagggta aatgctcatc ttaaacctca ctagagggaa
     4501 gtcttctcaa gtttcaagca agaccattta cttaatgtga agttttggaa agttataaag
     4561 gtgtatgttt tagccatatg attttaattt taattttgct tcttttaggt tcgttcttat
     4621 ttaaagcaat atgattgtgt gactccttgt agttacactt gtgtttcaat cagatcagat
     4681 tgttgtattt attccactat tttgcattta aatgataaca taaaagatat aaaaaattta
     4741 aaactgctat ttttcttata gaagagaaaa tgggtgttgg tgattgtatt ttaattattt
     4801 aagcgtctct gtttacctgc ctaggaaaac attttatggc agtcttatgt gcaaagatcg
     4861 taaaaggaca aaaaatttaa actgcttata ataatccagg agttgcatta tagccagtag
     4921 taaaaataat aataataata ataaaaccat gtctatagct gtagatgggc ttcacatctg
     4981 taaagcaatc aattgtatat ttttgtgatg tgtaccatac tgtgtgctcc agcaaatgtc
     5041 catttgtgta aatgtattta ttttatattg tatatattgt taaatgcaaa aaggagatat
     5101 gattctgtaa ctccaatcag ttcagatgtg taactcaaat tattatgcct ttcaggatga
     5161 tggtagagca atattaaaca agcttccact tttga
//
