LOCUS       NM_001365265            3263 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens epithelial splicing regulatory protein 2 (ESRP2),
            transcript variant 3, mRNA.
ACCESSION   NM_001365265
VERSION     NM_001365265.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3263)
  AUTHORS   Yan,Q., Fang,X., Liu,X., Guo,S., Chen,S., Luo,M., Lan,P. and
            Guan,X.Y.
  TITLE     Loss of ESRP2 Activates TAK1-MAPK Signaling through the Fetal
            RNA-Splicing Program to Promote Hepatocellular Carcinoma
            Progression
  JOURNAL   Adv Sci (Weinh) 11 (1), e2305653 (2024)
   PUBMED   37985644
  REMARK    GeneRIF: Loss of ESRP2 Activates TAK1-MAPK Signaling through the
            Fetal RNA-Splicing Program to Promote Hepatocellular Carcinoma
            Progression.
REFERENCE   2  (bases 1 to 3263)
  AUTHORS   Yang,Y., Lee,G.C., Nakagaki-Silva,E., Huang,Y., Peacey,M.,
            Partridge,R., Gooding,C. and Smith,C.W.J.
  TITLE     Cell-type specific regulator RBPMS switches alternative splicing
            via higher-order oligomerization and heterotypic interactions with
            other splicing regulators
  JOURNAL   Nucleic Acids Res 51 (18), 9961-9982 (2023)
   PUBMED   37548402
REFERENCE   3  (bases 1 to 3263)
  AUTHORS   Legge,D., Li,L., Moriarty,W., Lee,D., Szemes,M., Zahed,A.,
            Panousopoulos,L., Chung,W.Y., Aghabi,Y., Barratt,J., Williams,R.,
            Pritchard-Jones,K., Malik,K.T.A., Oltean,S. and Brown,K.W.
  TITLE     The epithelial splicing regulator ESRP2 is epigenetically repressed
            by DNA hypermethylation in Wilms tumour and acts as a tumour
            suppressor
  JOURNAL   Mol Oncol 16 (3), 630-647 (2022)
   PUBMED   34520622
  REMARK    GeneRIF: The epithelial splicing regulator ESRP2 is epigenetically
            repressed by DNA hypermethylation in Wilms tumour and acts as a
            tumour suppressor.
REFERENCE   4  (bases 1 to 3263)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 3263)
  AUTHORS   Becker,T., Pich,A., Tamm,S., Hedtfeld,S., Ibrahim,M., Altmuller,J.,
            Dalibor,N., Toliat,M.R., Janciauskiene,S., Tummler,B. and Stanke,F.
  TITLE     Genetic information from discordant sibling pairs points to ESRP2
            as a candidate trans-acting regulator of the CF modifier gene
            SCNN1B
  JOURNAL   Sci Rep 10 (1), 22447 (2020)
   PUBMED   33384439
  REMARK    GeneRIF: Genetic information from discordant sibling pairs points
            to ESRP2 as a candidate trans-acting regulator of the CF modifier
            gene SCNN1B.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3263)
  AUTHORS   Warzecha,C.C., Jiang,P., Amirikian,K., Dittmar,K.A., Lu,H.,
            Shen,S., Guo,W., Xing,Y. and Carstens,R.P.
  TITLE     An ESRP-regulated splicing programme is abrogated during the
            epithelial-mesenchymal transition
  JOURNAL   EMBO J 29 (19), 3286-3300 (2010)
   PUBMED   20711167
  REMARK    GeneRIF: ESRP2 coordinates a complex alternative splicing network
            that adds an important post-transcriptional layer to the changes in
            gene expression that underlie epithelial-mesenchymal transitions
            during development and disease.
REFERENCE   7  (bases 1 to 3263)
  AUTHORS   Warzecha,C.C., Shen,S., Xing,Y. and Carstens,R.P.
  TITLE     The epithelial splicing factors ESRP1 and ESRP2 positively and
            negatively regulate diverse types of alternative splicing events
  JOURNAL   RNA Biol 6 (5), 546-562 (2009)
   PUBMED   19829082
  REMARK    GeneRIF: results further establish ESRP1 and ESRP2 as global
            regulators of an epithelial splicing regulatory network.
REFERENCE   8  (bases 1 to 3263)
  AUTHORS   Warzecha,C.C., Sato,T.K., Nabet,B., Hogenesch,J.B. and
            Carstens,R.P.
  TITLE     ESRP1 and ESRP2 are epithelial cell-type-specific regulators of
            FGFR2 splicing
  JOURNAL   Mol Cell 33 (5), 591-601 (2009)
   PUBMED   19285943
  REMARK    GeneRIF: ESRP1 and ESRP2 are epithelial cell-type-specific
            regulators of FGFR2 splicing.
REFERENCE   9  (bases 1 to 3263)
  AUTHORS   Wan,D., Gong,Y., Qin,W., Zhang,P., Li,J., Wei,L., Zhou,X., Li,H.,
            Qiu,X., Zhong,F., He,L., Yu,J., Yao,G., Jiang,H., Qian,L., Yu,Y.,
            Shu,H., Chen,X., Xu,H., Guo,M., Pan,Z., Chen,Y., Ge,C., Yang,S. and
            Gu,J.
  TITLE     Large-scale cDNA transfection screening for genes related to cancer
            development and progression
  JOURNAL   Proc Natl Acad Sci U S A 101 (44), 15724-15729 (2004)
   PUBMED   15498874
  REMARK    Erratum:[Proc Natl Acad Sci U S A. 2004 Dec 14:101(50):17565]
REFERENCE   10 (bases 1 to 3263)
  AUTHORS   Adams,M.D., Kerlavage,A.R., Fleischmann,R.D., Fuldner,R.A.,
            Bult,C.J., Lee,N.H., Kirkness,E.F., Weinstock,K.G., Gocayne,J.D.,
            White,O. et al.
  TITLE     Initial assessment of human gene diversity and expression patterns
            based upon 83 million nucleotides of cDNA sequence
  JOURNAL   Nature 377 (6547 Suppl), 3-174 (1995)
   PUBMED   7566098
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BG721782.1, LN680438.1, BC030146.2 and T36047.1.
            
            Summary: ESPR2 is an epithelial cell-type-specific splicing
            regulator (Warzecha et al., 2009 [PubMed 19285943]).[supplied by
            OMIM, Aug 2009].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: LN680438.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-82                BG721782.1         112-193
            83-2071             LN680438.1         1-1989
            2072-3176           BC030146.2         2166-3270
            3177-3263           T36047.1           140-226
FEATURES             Location/Qualifiers
     source          1..3263
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16q22.1"
     gene            1..3263
                     /gene="ESRP2"
                     /gene_synonym="RBM35B"
                     /note="epithelial splicing regulatory protein 2"
                     /db_xref="GeneID:80004"
                     /db_xref="HGNC:HGNC:26152"
                     /db_xref="MIM:612960"
     exon            1..280
                     /gene="ESRP2"
                     /gene_synonym="RBM35B"
                     /inference="alignment:Splign:2.1.0"
     CDS             83..2008
                     /gene="ESRP2"
                     /gene_synonym="RBM35B"
                     /note="isoform 3 is encoded by transcript variant 3; RNA
                     binding motif protein 35A; RNA-binding protein 35B;
                     RNA-binding motif protein 35B"
                     /codon_start=1
                     /product="epithelial splicing regulatory protein 2 isoform
                     3"
                     /protein_id="NP_001352194.1"
                     /db_xref="GeneID:80004"
                     /db_xref="HGNC:HGNC:26152"
                     /db_xref="MIM:612960"
                     /translation="MTPPPPPPPPPGPDPAADPAADPCPWPGSLVVLFGATAGALGRD
                     LGSDETDLILLVWQVVEPRSRQVGTLHKSLVRAEAAALSTQCREASGLSADSLARAEP
                     LDKVLQQFSQLVNGDVALLGGGPYMLCTDGQQLLRQVLHPEASRKNLVLPDMFFSFYD
                     LRREFHMQHPSTCPARDLTVATMAQGLGLETDATEDDFGVWEVKTMVAVILHLLKEPS
                     SQLFSKPEVIKQKYETGPCSKADVVDSETVVRARGLPWQSSDQDVARFFKGLNVARGG
                     VALCLNAQGRRNGEALIRFVDSEQRDLALQRHKHHMGVRYIEVYKATGEEFVKIAGGT
                     SLEVARFLSREDQVILRLRGLPFSAGPTDVLGFLGPECPVTGGTEGLLFVRHPDGRPT
                     GDAFALFACEELAQAALRRHKGMLGKRYIELFRSTAAEVQQVLNRYASGPLLPTLTAP
                     LLPIPFPLAPGTGRDCVRLRGLPYTATIEDILSFLGEAAADIRPHGVHMVLNQQGRPS
                     GDAFIQMTSAERALAAAQRCHKKVMKERYVEVVPCSTEEMSRVLMGGTLGRSGMSPPP
                     CKLPCLSPPTYTTFQATPTLIPTETAALYPSSALLPAARVPAAPTPVAYYPGPATQLY
                     LNYTAYYPSYPLMTTPV"
     exon            281..409
                     /gene="ESRP2"
                     /gene_synonym="RBM35B"
                     /inference="alignment:Splign:2.1.0"
     exon            410..523
                     /gene="ESRP2"
                     /gene_synonym="RBM35B"
                     /inference="alignment:Splign:2.1.0"
     exon            524..638
                     /gene="ESRP2"
                     /gene_synonym="RBM35B"
                     /inference="alignment:Splign:2.1.0"
     exon            639..737
                     /gene="ESRP2"
                     /gene_synonym="RBM35B"
                     /inference="alignment:Splign:2.1.0"
     exon            738..792
                     /gene="ESRP2"
                     /gene_synonym="RBM35B"
                     /inference="alignment:Splign:2.1.0"
     exon            793..903
                     /gene="ESRP2"
                     /gene_synonym="RBM35B"
                     /inference="alignment:Splign:2.1.0"
     exon            904..1036
                     /gene="ESRP2"
                     /gene_synonym="RBM35B"
                     /inference="alignment:Splign:2.1.0"
     exon            1037..1079
                     /gene="ESRP2"
                     /gene_synonym="RBM35B"
                     /inference="alignment:Splign:2.1.0"
     exon            1080..1381
                     /gene="ESRP2"
                     /gene_synonym="RBM35B"
                     /inference="alignment:Splign:2.1.0"
     exon            1382..1594
                     /gene="ESRP2"
                     /gene_synonym="RBM35B"
                     /inference="alignment:Splign:2.1.0"
     exon            1595..1793
                     /gene="ESRP2"
                     /gene_synonym="RBM35B"
                     /inference="alignment:Splign:2.1.0"
     exon            1794..1980
                     /gene="ESRP2"
                     /gene_synonym="RBM35B"
                     /inference="alignment:Splign:2.1.0"
     exon            1981..3263
                     /gene="ESRP2"
                     /gene_synonym="RBM35B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2861..2866
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ESRP2"
                     /gene_synonym="RBM35B"
                     /note="hexamer: ATTAAA"
     polyA_site      2881
                     /gene="ESRP2"
                     /gene_synonym="RBM35B"
                     /note="major polyA site"
     regulatory      3154..3159
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ESRP2"
                     /gene_synonym="RBM35B"
                     /note="hexamer: AATACA"
     polyA_site      3179
                     /gene="ESRP2"
                     /gene_synonym="RBM35B"
                     /note="major polyA site"
     regulatory      3219..3224
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ESRP2"
                     /gene_synonym="RBM35B"
                     /note="hexamer: ACTAAA"
     regulatory      3234..3239
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ESRP2"
                     /gene_synonym="RBM35B"
                     /note="hexamer: TATAAA"
     polyA_site      3240
                     /gene="ESRP2"
                     /gene_synonym="RBM35B"
     polyA_site      3263
                     /gene="ESRP2"
                     /gene_synonym="RBM35B"
ORIGIN      
        1 gatccgcgtc tgcggtcggt cggtgcgtgc gtgcgcctcg tcggtccgcg tgtctggccg
       61 agagccccct tcctctgcgg ccatgactcc gccgccgccg ccgccccctc ccccgggccc
      121 tgaccccgcg gccgaccccg ccgcggaccc ctgcccctgg cccggatcac tggtcgtcct
      181 cttcggggct acggcgggtg cgctgggacg ggacctgggc tcggacgaga ccgacttaat
      241 cctcctagtt tggcaagtgg ttgagccgcg gagccgccag gtggggacgc tgcacaaatc
      301 gctggttcgt gccgaggcgg ccgcactgag tacgcagtgc cgcgaggcga gcggcctgag
      361 cgccgacagc ctggcgcggg cagagccgct ggacaaggtg ctgcagcagt tctcacagct
      421 ggtgaacggg gatgtggctt tgctgggcgg gggcccctac atgctctgca ctgatgggca
      481 gcagctattg cgacaggtcc tgcaccccga ggcctccagg aagaacctgg tgctccccga
      541 catgttcttc tccttctatg acctccgaag agaattccat atgcagcatc caagcacctg
      601 ccctgccagg gacctcactg tggccaccat ggcacagggt ttaggactgg agacagatgc
      661 cacagaggat gactttgggg tctgggaagt caagacaatg gtagctgtta tcctccatct
      721 actcaaagag cccagcagtc aattgttttc gaagcccgag gtgataaagc agaaatacga
      781 gacggggcct tgcagcaagg ctgatgtggt ggacagtgag actgtggtac gggctcgtgg
      841 gttgccgtgg cagtcatcag accaggacgt ggctcgcttc ttcaaagggc tcaacgtggc
      901 caggggtggt gtagcactct gcctcaacgc ccagggccgc agaaatggcg aggccctcat
      961 ccgctttgtg gacagcgagc agcgggacct agcgctgcag agacacaagc accacatggg
     1021 cgtccgctat attgaggtgt ataaagcgac aggggaggag tttgtaaaga ttgcaggggg
     1081 cacatcacta gaggtggctc gtttcttgtc acgggaagac caagtgatcc tgcggctgcg
     1141 gggactgccc ttctcggctg ggccaacgga cgtgcttggc ttcctggggc cagagtgccc
     1201 agtgactggg ggtaccgagg ggctgctctt tgtgcgccat cctgatggcc ggccgactgg
     1261 tgatgccttc gccctctttg cttgtgagga gctggcacag gctgcactgc gcaggcacaa
     1321 gggcatgctg ggtaagcgat acattgaact cttccggagc actgcagccg aagtgcagca
     1381 ggtcttgaac cgctatgcat ccggcccact ccttcctaca ctgactgccc cactgctgcc
     1441 catccccttc ccactggcac ctgggactgg gagggactgt gtacgcctcc gaggcctgcc
     1501 ctacacggcc accattgaag acatcctgag ctttctgggg gaggcagcag ctgacattcg
     1561 gccccacggt gtacacatgg tgctcaacca gcagggccgg ccatcgggcg atgccttcat
     1621 tcagatgaca tcagcagagc gagccctagc tgctgctcag cgttgccata agaaggtgat
     1681 gaaggagcgc tacgtggagg tggtcccctg ttccacagag gagatgagcc gagtgctgat
     1741 ggggggcacc ttgggccgca gtggcatgtc ccctccaccc tgcaagctgc cctgcctctc
     1801 accacctacc tacaccacct tccaagccac cccaacgctc attcccacgg agacggcagc
     1861 tctatacccc tcttcagcac tgctcccagc tgccagggtg cctgctgccc ccacccctgt
     1921 tgcctactat ccagggccag ccactcaact ctacctgaac tacacagcct actacccaag
     1981 ctacccgctg atgactacac cagtctgatg cctgttggtg acccacctcg cactgtgtta
     2041 caagccccca aggaatgggt gtgtttgtag gagagaaagc caggaggtaa gagccagctg
     2101 atatcctcgg cgaacatgtc tctcctgagt ccagaagacc agcaccctca acctggtagc
     2161 ttctttctgg cttgtcaaag ctctcagaag gtacctagag gagcccaagc cccagctcca
     2221 tcctccactt attctgcctg tttcccccaa agacaatggc tggaccctgc atgcagggct
     2281 gggggtggaa tggggctaac cagctcctga tggcctgagc caggcatctt gactggcacc
     2341 tggagagccc ttaagtctgt cctggctgtg gcccatgccg acagatatcg tggggctgac
     2401 aggtccacgg caggcttgct ttcttttata aaatggaagc tctggtacct tcaatgtatg
     2461 actcctggga gaatcaaggg tccatctgag cctctgagta aagatcccaa tgttctacct
     2521 ctccctgtcc ctcttgtagg ggatagggag gcagagagag ccagccccta ccctcagagt
     2581 atctggacct cagagaccat gttgtgccag gggtggtccc acctaaagat gctagcccct
     2641 ctccaggtgg gcataaggag taacagatgg caaaaccaca aactattttg atggactgtg
     2701 ctgcagtatc accagaagac attagggggc agtaggcccc cacacaaaac cttcaggctt
     2761 gaattttaaa ggggaggact ttctgccaac ttttcttgta tgccttggga aagccagttg
     2821 ccctgaaccc agcagacacc atggaatgtc ctttgcacgc attaaatggt acagaactga
     2881 agcctcggaa gcaatttgga actcgatctt ctcttcctta aatgaaaagt tattgaccaa
     2941 atggactttt taaaagacac aggaccctta actttgcccc aaagtgaggg gctccacacc
     3001 aaccccaggc ggaggaacac tcagacagat taaggatact gttgacctgt cactgtttat
     3061 tatttcagca ctaaaactga ggagcctcaa ctgctggctc ttcttccctt tgtatttgtg
     3121 taaggagcac tgcactccca taaaaggttt taaaatacaa aatgtacaag aacacacaat
     3181 tccaagtgct gtaaacataa ctgagaacca gttcctttac taaacatcca ttttataaaa
     3241 cacaaggttt caatttgagc cca
//
