LOCUS       NM_017697               3768 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens epithelial splicing regulatory protein 1 (ESRP1),
            transcript variant 1, mRNA.
ACCESSION   NM_017697
VERSION     NM_017697.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3768)
  AUTHORS   Wang,P., Gao,X., Zheng,W. and Zhang,J.
  TITLE     Potential impact of epithelial splicing regulatory protein 1
            (ESRP1) associated with tumor immunity in pancreatic adenocarcinoma
  JOURNAL   J Proteomics 308, 105277 (2024)
   PUBMED   39127164
  REMARK    GeneRIF: Potential impact of epithelial splicing regulatory protein
            1 (ESRP1) associated with tumor immunity in pancreatic
            adenocarcinoma.
REFERENCE   2  (bases 1 to 3768)
  AUTHORS   Chen,S., Zong,Y., Hou,Z., Deng,Z. and Xia,Z.
  TITLE     Splicing factor ESRP1 derived circ_0068162 promotes the progression
            of oral squamous cell carcinoma via the miR-186/JAG axis
  JOURNAL   Carcinogenesis 45 (3), 107-118 (2024)
   PUBMED   37966490
  REMARK    GeneRIF: Splicing factor ESRP1 derived circ_0068162 promotes the
            progression of oral squamous cell carcinoma via the miR-186/JAG
            axis.
REFERENCE   3  (bases 1 to 3768)
  AUTHORS   Liu,D., Dredge,B.K., Bert,A.G., Pillman,K.A., Toubia,J., Guo,W.,
            Dyakov,B.J.A., Migault,M.M., Conn,V.M., Conn,S.J., Gregory,P.A.,
            Gingras,A.C., Patel,D., Wu,B. and Goodall,G.J.
  TITLE     ESRP1 controls biogenesis and function of a large abundant
            multiexon circRNA
  JOURNAL   Nucleic Acids Res 52 (3), 1387-1403 (2024)
   PUBMED   38015468
  REMARK    GeneRIF: ESRP1 controls biogenesis and function of a large abundant
            multiexon circRNA.
REFERENCE   4  (bases 1 to 3768)
  AUTHORS   Wang,W., Taufalele,P.V., Millet,M., Homsy,K., Smart,K.,
            Berestesky,E.D., Schunk,C.T., Rowe,M.M., Bordeleau,F. and
            Reinhart-King,C.A.
  TITLE     Matrix stiffness regulates tumor cell intravasation through
            expression and ESRP1-mediated alternative splicing of MENA
  JOURNAL   Cell Rep 42 (4), 112338 (2023)
   PUBMED   37027295
  REMARK    GeneRIF: Matrix stiffness regulates tumor cell intravasation
            through expression and ESRP1-mediated alternative splicing of MENA.
REFERENCE   5  (bases 1 to 3768)
  AUTHORS   Gokmen-Polar,Y., Gu,Y., Polar,A., Gu,X. and Badve,S.S.
  TITLE     The Role of ESRP1 in the Regulation of PHGDH in Estrogen
            Receptor-Positive Breast Cancer
  JOURNAL   Lab Invest 103 (3), 100002 (2023)
   PUBMED   36925195
  REMARK    GeneRIF: The Role of ESRP1 in the Regulation of PHGDH in Estrogen
            Receptor-Positive Breast Cancer.
REFERENCE   6  (bases 1 to 3768)
  AUTHORS   Warzecha,C.C., Shen,S., Xing,Y. and Carstens,R.P.
  TITLE     The epithelial splicing factors ESRP1 and ESRP2 positively and
            negatively regulate diverse types of alternative splicing events
  JOURNAL   RNA Biol 6 (5), 546-562 (2009)
   PUBMED   19829082
  REMARK    GeneRIF: results further establish ESRP1 and ESRP2 as global
            regulators of an epithelial splicing regulatory network.
REFERENCE   7  (bases 1 to 3768)
  AUTHORS   Warzecha,C.C., Sato,T.K., Nabet,B., Hogenesch,J.B. and
            Carstens,R.P.
  TITLE     ESRP1 and ESRP2 are epithelial cell-type-specific regulators of
            FGFR2 splicing
  JOURNAL   Mol Cell 33 (5), 591-601 (2009)
   PUBMED   19285943
  REMARK    GeneRIF: ESRP1 and ESRP2 are epithelial cell-type-specific
            regulators of FGFR2 splicing.
REFERENCE   8  (bases 1 to 3768)
  AUTHORS   Leontieva,O.V. and Ionov,Y.
  TITLE     RNA-binding motif protein 35A is a novel tumor suppressor for
            colorectal cancer
  JOURNAL   Cell Cycle 8 (3), 490-497 (2009)
   PUBMED   19177006
  REMARK    GeneRIF: Results demonstrate that RBM35A functions as a tumor
            suppressor in colon cancer cells, and suggest that RBM35A is
            involved in posttranscriptional regulation of a number of genes by
            exerting a differential effect on protein translation via 5'UTRs of
            mRNAs.
REFERENCE   9  (bases 1 to 3768)
  AUTHORS   Rohan,S., Tu,J.J., Kao,J., Mukherjee,P., Campagne,F., Zhou,X.K.,
            Hyjek,E., Alonso,M.A. and Chen,Y.T.
  TITLE     Gene expression profiling separates chromophobe renal cell
            carcinoma from oncocytoma and identifies vesicular transport and
            cell junction proteins as differentially expressed genes
  JOURNAL   Clin Cancer Res 12 (23), 6937-6945 (2006)
   PUBMED   17145811
  REMARK    GeneRIF: The FLJ20171 gene was shown to effectively separate these
            two chromophobe renal cell carcinoma (RCC) and benign oncocytoma
            groups by quantitative reverse transcription-PCR using fresh tissue
            samples, with similar trends seen on formalin-fixed tissues.
REFERENCE   10 (bases 1 to 3768)
  AUTHORS   Harrington,J.J., Sherf,B., Rundlett,S., Jackson,P.D., Perry,R.,
            Cain,S., Leventhal,C., Thornton,M., Ramachandran,R.,
            Whittington,J., Lerner,L., Costanzo,D., McElligott,K., Boozer,S.,
            Mays,R., Smith,E., Veloso,N., Klika,A., Hess,J., Cothren,K., Lo,K.,
            Offenbacher,J., Danzig,J. and Ducar,M.
  TITLE     Creation of genome-wide protein expression libraries using random
            activation of gene expression
  JOURNAL   Nat Biotechnol 19 (5), 440-445 (2001)
   PUBMED   11329013
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BX647570.1, BC067098.1, BG182742.1, BC052574.1 and AI990751.1.
            
            On Nov 23, 2018 this sequence version replaced NM_017697.3.
            
            Summary: ESPR1 is an epithelial cell-type-specific splicing
            regulator (Warzecha et al., 2009 [PubMed 19285943]).[supplied by
            OMIM, Aug 2009].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC067098.1, SRR18074967.354466.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968832
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000433389.8/ ENSP00000405738.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-20                BX647570.1         101-120
            21-1128             BC067098.1         13-1120
            1129-1658           BX647570.1         1229-1758
            1659-1944           BC067098.1         1651-1936
            1945-1965           BX647570.1         2033-2053
            1966-2742           BC067098.1         1958-2734
            2743-3000           BG182742.1         520-777
            3001-3400           BC052574.1         2699-3098
            3401-3768           AI990751.1         1-368               c
FEATURES             Location/Qualifiers
     source          1..3768
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q22.1"
     gene            1..3768
                     /gene="ESRP1"
                     /gene_synonym="DFNB109; RBM35A; RMB35A"
                     /note="epithelial splicing regulatory protein 1"
                     /db_xref="GeneID:54845"
                     /db_xref="HGNC:HGNC:25966"
                     /db_xref="MIM:612959"
     exon            1..277
                     /gene="ESRP1"
                     /gene_synonym="DFNB109; RBM35A; RMB35A"
                     /inference="alignment:Splign:2.1.0"
     CDS             146..2191
                     /gene="ESRP1"
                     /gene_synonym="DFNB109; RBM35A; RMB35A"
                     /note="isoform 1 is encoded by transcript variant 1;
                     RNA-binding protein 35A; RNA-binding motif protein 35A"
                     /codon_start=1
                     /product="epithelial splicing regulatory protein 1 isoform
                     1"
                     /protein_id="NP_060167.2"
                     /db_xref="CCDS:CCDS47897.1"
                     /db_xref="GeneID:54845"
                     /db_xref="HGNC:HGNC:25966"
                     /db_xref="MIM:612959"
                     /translation="MTASPDYLVVLFGITAGATGAKLGSDEKELILLFWKVVDLANKK
                     VGQLHEVLVRPDQLELTEDCKEETKIDVESLSSASQLDQALRQFNQSVSNELNIGVGT
                     SFCLCTDGQLHVRQILHPEASKKNVLLPECFYSFFDLRKEFKKCCPGSPDIDKLDVAT
                     MTEYLNFEKSSSVSRYGASQVEDMGNIILAMISEPYNHRFSDPERVNYKFESGTCSKM
                     ELIDDNTVVRARGLPWQSSDQDIARFFKGLNIAKGGAALCLNAQGRRNGEALVRFVSE
                     EHRDLALQRHKHHMGTRYIEVYKATGEDFLKIAGGTSNEVAQFLSKENQVIVRMRGLP
                     FTATAEEVVAFFGQHCPITGGKEGILFVTYPDGRPTGDAFVLFACEEYAQNALRKHKD
                     LLGKRYIELFRSTAAEVQQVLNRFSSAPLIPLPTPPIIPVLPQQFVPPTNVRDCIRLR
                     GLPYAATIEDILDFLGEFATDIRTHGVHMVLNHQGRPSGDAFIQMKSADRAFMAAQKC
                     HKKNMKDRYVEVFQCSAEEMNFVLMGGTLNRNGLSPPPCKLPCLSPPSYTFPAPAAVI
                     PTEAAIYQPSVILNPRALQPSTAYYPAGTQLFMNYTAYYPSPPGSPNSLGYFPTAANL
                     SGVPPQPGTVVRMQGLAYNTGVKEILNFFQGYQYATEDGLIHTNDQARTLPKEWVCI"
     exon            278..406
                     /gene="ESRP1"
                     /gene_synonym="DFNB109; RBM35A; RMB35A"
                     /inference="alignment:Splign:2.1.0"
     exon            407..520
                     /gene="ESRP1"
                     /gene_synonym="DFNB109; RBM35A; RMB35A"
                     /inference="alignment:Splign:2.1.0"
     exon            521..635
                     /gene="ESRP1"
                     /gene_synonym="DFNB109; RBM35A; RMB35A"
                     /inference="alignment:Splign:2.1.0"
     exon            636..734
                     /gene="ESRP1"
                     /gene_synonym="DFNB109; RBM35A; RMB35A"
                     /inference="alignment:Splign:2.1.0"
     exon            735..789
                     /gene="ESRP1"
                     /gene_synonym="DFNB109; RBM35A; RMB35A"
                     /inference="alignment:Splign:2.1.0"
     exon            790..900
                     /gene="ESRP1"
                     /gene_synonym="DFNB109; RBM35A; RMB35A"
                     /inference="alignment:Splign:2.1.0"
     exon            901..1033
                     /gene="ESRP1"
                     /gene_synonym="DFNB109; RBM35A; RMB35A"
                     /inference="alignment:Splign:2.1.0"
     exon            1034..1076
                     /gene="ESRP1"
                     /gene_synonym="DFNB109; RBM35A; RMB35A"
                     /inference="alignment:Splign:2.1.0"
     exon            1077..1378
                     /gene="ESRP1"
                     /gene_synonym="DFNB109; RBM35A; RMB35A"
                     /inference="alignment:Splign:2.1.0"
     exon            1379..1597
                     /gene="ESRP1"
                     /gene_synonym="DFNB109; RBM35A; RMB35A"
                     /inference="alignment:Splign:2.1.0"
     exon            1598..1796
                     /gene="ESRP1"
                     /gene_synonym="DFNB109; RBM35A; RMB35A"
                     /inference="alignment:Splign:2.1.0"
     exon            1797..1965
                     /gene="ESRP1"
                     /gene_synonym="DFNB109; RBM35A; RMB35A"
                     /inference="alignment:Splign:2.1.0"
     exon            1966..2116
                     /gene="ESRP1"
                     /gene_synonym="DFNB109; RBM35A; RMB35A"
                     /inference="alignment:Splign:2.1.0"
     exon            2117..2226
                     /gene="ESRP1"
                     /gene_synonym="DFNB109; RBM35A; RMB35A"
                     /inference="alignment:Splign:2.1.0"
     exon            2227..3768
                     /gene="ESRP1"
                     /gene_synonym="DFNB109; RBM35A; RMB35A"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3743..3748
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ESRP1"
                     /gene_synonym="DFNB109; RBM35A; RMB35A"
                     /note="hexamer: AATAAA"
     polyA_site      3768
                     /gene="ESRP1"
                     /gene_synonym="DFNB109; RBM35A; RMB35A"
                     /note="major polyA site"
ORIGIN      
        1 cttttgcact agcagtagca aggaaggggg gtgggcgctc tttctttttc tcttagaaga
       61 gggtttagca caggtttttt cgttctcact tccacaccac cttaccgcct cccgaccccc
      121 cctctccccc tccccaccta tcgtcatgac ggcctctccg gattacttgg tggtgctttt
      181 tgggatcact gctggggcca ccggggccaa gctaggctcg gatgagaagg agttgatcct
      241 gctgttctgg aaagtcgtgg atctggccaa caagaaggtg ggacagttgc acgaagtgct
      301 agttagaccg gatcagttgg aactgacgga ggactgcaaa gaagaaacta aaatagacgt
      361 cgaaagcctg tcctcggcgt cgcagctgga ccaagccctc cgacagttta accagtcagt
      421 gagcaatgaa ctgaatattg gagtagggac ttccttctgt ctctgtactg atgggcagct
      481 tcatgtcagg caaatcctgc atcctgaggc ttccaagaag aatgtactat tacctgaatg
      541 cttctattcc ttttttgatc ttcgaaaaga attcaagaaa tgttgccctg gttcacctga
      601 tattgacaaa ctggacgttg ccacaatgac agagtattta aattttgaga agagtagttc
      661 agtctctcga tatggagcct ctcaagttga agatatgggg aatataattt tagcaatgat
      721 ttcagagcct tataatcaca ggttttcaga tccagagaga gtgaattaca agtttgaaag
      781 tggaacttgc agcaagatgg aacttattga tgataacacc gtagtcaggg cacgaggttt
      841 accatggcag tcttcagatc aagatattgc aagattcttc aaaggactca atattgccaa
      901 gggaggtgca gcactttgtc tgaatgctca gggtcgaagg aacggagaag ctctggttag
      961 gtttgtaagt gaggagcacc gagacctagc actacagagg cacaaacatc acatggggac
     1021 ccggtatatt gaggtttaca aagcaacagg tgaagatttc cttaaaattg ctggtggtac
     1081 ttccaatgag gtagcccagt ttctctccaa ggaaaatcaa gtcattgtcc gcatgcgggg
     1141 gctccctttc acggccacag ctgaagaagt ggtggccttc tttggacagc attgccctat
     1201 tactggggga aaggaaggca tcctctttgt cacctaccca gatggtaggc caacagggga
     1261 cgcttttgtc ctctttgcct gtgaggaata tgcacagaat gcgttgagga agcataaaga
     1321 cttgttgggt aaaagataca ttgaactctt caggagcaca gcagctgaag ttcagcaggt
     1381 gctgaatcga ttctcctcgg cccctctcat tccacttcca acccctccca ttattccagt
     1441 actacctcag caatttgtgc cccctacaaa tgttagagac tgtatacgcc ttcgaggtct
     1501 tccctatgca gccacaattg aggacatcct ggatttcctg ggggagttcg ccacagatat
     1561 tcgtactcat ggggttcaca tggttttgaa tcaccagggc cgcccatcag gagatgcctt
     1621 tatccagatg aagtctgcgg acagagcatt tatggctgca cagaagtgtc ataaaaaaaa
     1681 catgaaggac agatatgttg aagtctttca gtgttcagct gaggagatga actttgtgtt
     1741 aatggggggc actttaaatc gaaatggctt atccccaccg ccatgtaagt taccatgcct
     1801 gtctcctccc tcctacacat ttccagctcc tgctgcagtt attcctacag aagctgccat
     1861 ttaccagccc tctgtgattt tgaatccacg agcactgcag ccctccacag cgtactaccc
     1921 agcaggcact cagctcttca tgaattacac agcgtactat cccagccccc caggttcgcc
     1981 taatagtctt ggctacttcc ctacagctgc taatcttagc ggtgtccctc cacagcctgg
     2041 cacggtggtc agaatgcagg gcctggccta caatactgga gttaaggaaa ttcttaactt
     2101 cttccaaggt taccagtatg caaccgagga tggacttata cacacaaatg accaggccag
     2161 gactctaccc aaagaatggg tttgtattta agggccccag cagttagaac atcctcagaa
     2221 aagaagtgtt tgaaagatgt atggtgatct tgaaacctcc agacacaaga aaacttctag
     2281 caaattcagg ggaagtttgt ctacactcag gctgcagtat tttcagcaaa cttgattgga
     2341 caaacgggcc tgtgccttat cttttggtgg agtgaaaaaa tttgagctag tgaagccaaa
     2401 tcgtaactta cagcaagcag catgcagcat acctggctct ttgctgattg caaataggca
     2461 tttaaaatgt gaatttggaa tcagatgtct ccattacttc cagttaaagt ggcatcatag
     2521 gtgtttccta agttttaagt cttggataaa aactccacca gtgtctacca tctccaccat
     2581 gaactctgtt aaggaagctt catttttgta tattcccgct cttttctctt catttccctg
     2641 tcttctgcat aatcatgcct tcttgctaag taattcaagc ataagatctt ggaataataa
     2701 aatcacaatc ttaggagaaa gaataaaatt gttattttcc cagtctcttg gccatgatga
     2761 tatcttatga ttaaaaacaa attaaatttt aaaacacctg aagataaatt agaagaaatt
     2821 gtgcaccctc cacaaaacat acaaagttta aaagtttgga tctttttctc agcaggtatc
     2881 agttgtaaat aatgaattag gggccaaaat gcaaaacgaa aaatgaagca gctacatgta
     2941 gttagtaatt tctagtttga actgtaattg aatattgtgg cttcatatgt attattttat
     3001 attgtacttt tttcattatt gatggtttgg actttaataa gagaaattcc atagttttta
     3061 atatcccaga agtgagacaa tttgaacagt gtattctaga aaacaataca ctaactgaac
     3121 agaagtgaat gcttatatat attatgatag ccttaaacct ttttcctcta atgccttaac
     3181 tgtcaaataa ttataacctt ttaaagcata ggactatagt cagcatgcta gactgagagg
     3241 taaacactga tgcaattaga acaggtactg atgctgtcag tgtttaacac tatgtttagc
     3301 tgtgtttatg ctataaaagt gcaatattag acactagcta gtactgctgc ctcatgtaac
     3361 tccaaagaaa acaggatttc attaagtgca ttgaatgtgg atatttctct aagttactca
     3421 tattgtcctt tgcttgaatg caatgccgtg cagatttatg aggctgctat ttttattttc
     3481 tgtgcattac tttaacacct taaagggaga agcaaacatt tccttcttca gctgactggc
     3541 aatggccctt taactgcaat aggaagaaaa aaaaaaaggt ttgtgtgaaa attggtgata
     3601 actggcactt aagatcgaaa agaaatttct gtatacttga tgccttaaga tgcccaaagc
     3661 tgcccaaagc tctgaaagac tttaagatag gcagtaatgc ttactacaat actactgagt
     3721 ttttgtagag ttaacatttg ataataaaac ttgcctgttt aatctcaa
//
