LOCUS       NM_001437               6842 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens estrogen receptor 2 (ESR2), transcript variant a,
            mRNA.
ACCESSION   NM_001437 XM_495993
VERSION     NM_001437.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6842)
  AUTHORS   Tatenuma,T., Matsukawa,T., Goto,T., Jiang,G., Sharma,A.,
            Najafi,M.A.E., Teramoto,Y. and Miyamoto,H.
  TITLE     GULP1 as a Downstream Effector of the Estrogen Receptor-beta
            Modulates Cisplatin Sensitivity in Bladder Cancer
  JOURNAL   Cancer Genomics Proteomics 21 (6), 557-565 (2024)
   PUBMED   39467629
  REMARK    GeneRIF: GULP1 as a Downstream Effector of the Estrogen
            Receptor-beta Modulates Cisplatin Sensitivity in Bladder Cancer.
REFERENCE   2  (bases 1 to 6842)
  AUTHORS   Guo,B., Zhu,H., Xiao,C., Zhang,J., Liu,X., Fang,Y., Wei,B.,
            Zhang,J., Cao,Y. and Zhan,L.
  TITLE     NLRC5 exerts anti-endometriosis effects through inhibiting
            ERbeta-mediated inflammatory response
  JOURNAL   BMC Med 22 (1), 351 (2024)
   PUBMED   39218863
  REMARK    GeneRIF: NLRC5 exerts anti-endometriosis effects through inhibiting
            ERbeta-mediated inflammatory response.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6842)
  AUTHORS   He,M., Jiang,W., Li,X., Liu,H., Ren,H. and Lin,Y.
  TITLE     25-hydroxycholesterol promotes proliferation and metastasis of lung
            adenocarcinoma cells by regulating ERbeta/TNFRSF17 axis
  JOURNAL   BMC Cancer 24 (1), 505 (2024)
   PUBMED   38649856
  REMARK    GeneRIF: 25-hydroxycholesterol promotes proliferation and
            metastasis of lung adenocarcinoma cells by regulating
            ERbeta/TNFRSF17 axis.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6842)
  AUTHORS   Sun,Y., Zhang,S., Zhang,X., Li,G., Sun,F., Wang,M., Ren,C.,
            Jiang,A. and Yang,T.
  TITLE     AURKA Enhances the Glycolysis and Development of Ovarian
            Endometriosis Through ERbeta
  JOURNAL   Endocrinology 165 (4) (2024)
   PUBMED   38340326
  REMARK    GeneRIF: AURKA Enhances the Glycolysis and Development of Ovarian
            Endometriosis Through ERbeta.
REFERENCE   5  (bases 1 to 6842)
  AUTHORS   Lee,M.T., Ouyang,B., Ho,S.M. and Leung,Y.K.
  TITLE     Differential expression of estrogen receptor beta isoforms in
            prostate cancer through interplay between transcriptional and
            translational regulation
  JOURNAL   Mol Cell Endocrinol 376 (1-2), 125-135 (2013)
   PUBMED   23806560
  REMARK    GeneRIF: Whereas the expression of ERbeta1 is controlled
            predominantly by transcriptional regulation in prostate cancer,
            expression of ERbeta2 and 5 is tightly regulated at both
            transcriptional and post-transcriptional levels.
REFERENCE   6  (bases 1 to 6842)
  AUTHORS   Smith,L., Brannan,R.A., Hanby,A.M., Shaaban,A.M., Verghese,E.T.,
            Peter,M.B., Pollock,S., Satheesha,S., Szynkiewicz,M., Speirs,V. and
            Hughes,T.A.
  TITLE     Differential regulation of oestrogen receptor beta isoforms by 5'
            untranslated regions in cancer
  JOURNAL   J Cell Mol Med 14 (8), 2172-2184 (2010)
   PUBMED   20920096
  REMARK    GeneRIF: Data demonstrate that two alternative ERbeta 5'UTRs have
            potent and differential influences on expression acting at the
            level of translation.
REFERENCE   7  (bases 1 to 6842)
  AUTHORS   Chen,H., Lin,R.J., Schiltz,R.L., Chakravarti,D., Nash,A., Nagy,L.,
            Privalsky,M.L., Nakatani,Y. and Evans,R.M.
  TITLE     Nuclear receptor coactivator ACTR is a novel histone
            acetyltransferase and forms a multimeric activation complex with
            P/CAF and CBP/p300
  JOURNAL   Cell 90 (3), 569-580 (1997)
   PUBMED   9267036
REFERENCE   8  (bases 1 to 6842)
  AUTHORS   Mosselman,S., Polman,J. and Dijkema,R.
  TITLE     ER beta: identification and characterization of a novel human
            estrogen receptor
  JOURNAL   FEBS Lett 392 (1), 49-53 (1996)
   PUBMED   8769313
REFERENCE   9  (bases 1 to 6842)
  AUTHORS   Halachmi,S., Marden,E., Martin,G., MacKay,H., Abbondanza,C. and
            Brown,M.
  TITLE     Estrogen receptor-associated proteins: possible mediators of
            hormone-induced transcription
  JOURNAL   Science 264 (5164), 1455-1458 (1994)
   PUBMED   8197458
REFERENCE   10 (bases 1 to 6842)
  AUTHORS   Schwabe,J.W., Chapman,L., Finch,J.T. and Rhodes,D.
  TITLE     The crystal structure of the estrogen receptor DNA-binding domain
            bound to DNA: how receptors discriminate between their response
            elements
  JOURNAL   Cell 75 (3), 567-578 (1993)
   PUBMED   8221895
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AF060555.1, AF051427.1,
            AL161756.6 and AL355094.3.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Aug 10, 2020 this sequence version replaced NM_001437.2.
            
            Summary: This gene encodes a member of the family of estrogen
            receptors and superfamily of nuclear receptor transcription
            factors. The gene product contains an N-terminal DNA binding domain
            and C-terminal ligand binding domain and is localized to the
            nucleus, cytoplasm, and mitochondria. Upon binding to
            17beta-estradiol or related ligands, the encoded protein forms
            homo- or hetero-dimers that interact with specific DNA sequences to
            activate transcription. Some isoforms dominantly inhibit the
            activity of other estrogen receptor family members. Several
            alternatively spliced transcript variants of this gene have been
            described, but the full-length nature of some of these variants has
            not been fully characterized. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (a) encodes the longest isoform
            (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR18074968.716099.1, AF051427.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000341099.6/ ENSP00000343925.4
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      longest protein
            regulatory uORF        :: PMID: 20920096
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 5' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-11                AF060555.1         40-50
            12-2022             AF051427.1         1-2011
            2023-3153           AL161756.6         143227-144357
            3154-6842           AL355094.3         1-3689
FEATURES             Location/Qualifiers
     source          1..6842
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q23.2-q23.3"
     gene            1..6842
                     /gene="ESR2"
                     /gene_synonym="ER-BETA; Erb; ESR-BETA; ESRB; ESTRB; NR3A2;
                     ODG8"
                     /note="estrogen receptor 2"
                     /db_xref="GeneID:2100"
                     /db_xref="HGNC:HGNC:3468"
                     /db_xref="MIM:601663"
     exon            1..339
                     /gene="ESR2"
                     /gene_synonym="ER-BETA; Erb; ESR-BETA; ESRB; ESTRB; NR3A2;
                     ODG8"
                     /inference="alignment:Splign:2.1.0"
     regulatory      279..308
                     /regulatory_class="uORF"
                     /gene="ESR2"
                     /gene_synonym="ER-BETA; Erb; ESR-BETA; ESRB; ESTRB; NR3A2;
                     ODG8"
                     /experiment="DESCRIPTION:regulatory uORF[PMID:20920096]"
                     /note="this uORF is predicted to encode a 9 aa peptide
                     (PMID:20920096)"
     exon            340..791
                     /gene="ESR2"
                     /gene_synonym="ER-BETA; Erb; ESR-BETA; ESRB; ESTRB; NR3A2;
                     ODG8"
                     /inference="alignment:Splign:2.1.0"
     regulatory      377..439
                     /regulatory_class="uORF"
                     /gene="ESR2"
                     /gene_synonym="ER-BETA; Erb; ESR-BETA; ESRB; ESTRB; NR3A2;
                     ODG8"
                     /experiment="DESCRIPTION:regulatory uORF[PMID:20920096]"
                     /note="this uORF is predicted to encode a 20 aa peptide
                     (PMID:20920096)"
     CDS             430..2022
                     /gene="ESR2"
                     /gene_synonym="ER-BETA; Erb; ESR-BETA; ESRB; ESTRB; NR3A2;
                     ODG8"
                     /note="isoform 1 is encoded by transcript variant a;
                     estrogen receptor beta 4; nuclear receptor subfamily 3
                     group A member 2; oestrogen receptor beta; estrogen
                     receptor beta 2"
                     /codon_start=1
                     /product="estrogen receptor beta isoform 1"
                     /protein_id="NP_001428.1"
                     /db_xref="CCDS:CCDS9762.1"
                     /db_xref="GeneID:2100"
                     /db_xref="HGNC:HGNC:3468"
                     /db_xref="MIM:601663"
                     /translation="MDIKNSPSSLNSPSSYNCSQSILPLEHGSIYIPSSYVDSHHEYP
                     AMTFYSPAVMNYSIPSNVTNLEGGPGRQTTSPNVLWPTPGHLSPLVVHRQLSHLYAEP
                     QKSPWCEARSLEHTLPVNRETLKRKVSGNRCASPVTGPGSKRDAHFCAVCSDYASGYH
                     YGVWSCEGCKAFFKRSIQGHNDYICPATNQCTIDKNRRKSCQACRLRKCYEVGMVKCG
                     SRRERCGYRLVRRQRSADEQLHCAGKAKRSGGHAPRVRELLLDALSPEQLVLTLLEAE
                     PPHVLISRPSAPFTEASMMMSLTKLADKELVHMISWAKKIPGFVELSLFDQVRLLESC
                     WMEVLMMGLMWRSIDHPGKLIFAPDLVLDRDEGKCVEGILEIFDMLLATTSRFRELKL
                     QHKEYLCVKAMILLNSSMYPLVTATQDADSSRKLAHLLNAVTDALVWVIAKSGISSQQ
                     QSMRLANLLMLLSHVRHASNKGMEHLLNMKCKNVVPVYDLLLEMLNAHVLRGCKSSIT
                     GSECSPAEDSKSKEGSQNPQSQ"
     exon            792..964
                     /gene="ESR2"
                     /gene_synonym="ER-BETA; Erb; ESR-BETA; ESRB; ESTRB; NR3A2;
                     ODG8"
                     /inference="alignment:Splign:2.1.0"
     exon            965..1081
                     /gene="ESR2"
                     /gene_synonym="ER-BETA; Erb; ESR-BETA; ESRB; ESTRB; NR3A2;
                     ODG8"
                     /inference="alignment:Splign:2.1.0"
     exon            1082..1381
                     /gene="ESR2"
                     /gene_synonym="ER-BETA; Erb; ESR-BETA; ESRB; ESTRB; NR3A2;
                     ODG8"
                     /inference="alignment:Splign:2.1.0"
     exon            1382..1520
                     /gene="ESR2"
                     /gene_synonym="ER-BETA; Erb; ESR-BETA; ESRB; ESTRB; NR3A2;
                     ODG8"
                     /inference="alignment:Splign:2.1.0"
     exon            1521..1654
                     /gene="ESR2"
                     /gene_synonym="ER-BETA; Erb; ESR-BETA; ESRB; ESTRB; NR3A2;
                     ODG8"
                     /inference="alignment:Splign:2.1.0"
     exon            1655..1835
                     /gene="ESR2"
                     /gene_synonym="ER-BETA; Erb; ESR-BETA; ESRB; ESTRB; NR3A2;
                     ODG8"
                     /inference="alignment:Splign:2.1.0"
     exon            1836..6842
                     /gene="ESR2"
                     /gene_synonym="ER-BETA; Erb; ESR-BETA; ESRB; ESTRB; NR3A2;
                     ODG8"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6811..6816
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ESR2"
                     /gene_synonym="ER-BETA; Erb; ESR-BETA; ESRB; ESTRB; NR3A2;
                     ODG8"
                     /note="hexamer: AATAAA"
     polyA_site      6842
                     /gene="ESR2"
                     /gene_synonym="ER-BETA; Erb; ESR-BETA; ESRB; ESTRB; NR3A2;
                     ODG8"
                     /note="major polyA site"
ORIGIN      
        1 gcttgtgatc ttttcagttt ctccagctgc tggctttttg gacacccact cccccgccag
       61 gaggcagttg caagcgcgga ggctgcgaga aataactgcc tcttgaaact tgcagggcga
      121 agagcaggcg gcgagcgctg ggccggggag ggaccacccg agctgcgacg ggctctgggg
      181 ctgcggggca gggctggcgc ccggagcctg agctgcagga ggtgcgctcg ctttcctcaa
      241 caggtggcgg cggggcgcgc gccgggagac cccccctaat gcgggaaaag cacgtgtccg
      301 cattttagag aaggcaaggc cggtgtgttt atctgcaagc cattatactt gcccacgaat
      361 ctttgagaac attataatga cctttgtgcc tcttcttgca aggtgttttc tcagctgtta
      421 tctcaagaca tggatataaa aaactcacca tctagcctta attctccttc ctcctacaac
      481 tgcagtcaat ccatcttacc cctggagcac ggctccatat acataccttc ctcctatgta
      541 gacagccacc atgaatatcc agccatgaca ttctatagcc ctgctgtgat gaattacagc
      601 attcccagca atgtcactaa cttggaaggt gggcctggtc ggcagaccac aagcccaaat
      661 gtgttgtggc caacacctgg gcacctttct cctttagtgg tccatcgcca gttatcacat
      721 ctgtatgcgg aacctcaaaa gagtccctgg tgtgaagcaa gatcgctaga acacacctta
      781 cctgtaaaca gagagacact gaaaaggaag gttagtggga accgttgcgc cagccctgtt
      841 actggtccag gttcaaagag ggatgctcac ttctgcgctg tctgcagcga ttacgcatcg
      901 ggatatcact atggagtctg gtcgtgtgaa ggatgtaagg ccttttttaa aagaagcatt
      961 caaggacata atgattatat ttgtccagct acaaatcagt gtacaatcga taaaaaccgg
     1021 cgcaagagct gccaggcctg ccgacttcgg aagtgttacg aagtgggaat ggtgaagtgt
     1081 ggctcccgga gagagagatg tgggtaccgc cttgtgcgga gacagagaag tgccgacgag
     1141 cagctgcact gtgccggcaa ggccaagaga agtggcggcc acgcgccccg agtgcgggag
     1201 ctgctgctgg acgccctgag ccccgagcag ctagtgctca ccctcctgga ggctgagccg
     1261 ccccatgtgc tgatcagccg ccccagtgcg cccttcaccg aggcctccat gatgatgtcc
     1321 ctgaccaagt tggccgacaa ggagttggta cacatgatca gctgggccaa gaagattccc
     1381 ggctttgtgg agctcagcct gttcgaccaa gtgcggctct tggagagctg ttggatggag
     1441 gtgttaatga tggggctgat gtggcgctca attgaccacc ccggcaagct catctttgct
     1501 ccagatcttg ttctggacag ggatgagggg aaatgcgtag aaggaattct ggaaatcttt
     1561 gacatgctcc tggcaactac ttcaaggttt cgagagttaa aactccaaca caaagaatat
     1621 ctctgtgtca aggccatgat cctgctcaat tccagtatgt accctctggt cacagcgacc
     1681 caggatgctg acagcagccg gaagctggct cacttgctga acgccgtgac cgatgctttg
     1741 gtttgggtga ttgccaagag cggcatctcc tcccagcagc aatccatgcg cctggctaac
     1801 ctcctgatgc tcctgtccca cgtcaggcat gcgagtaaca agggcatgga acatctgctc
     1861 aacatgaagt gcaaaaatgt ggtcccagtg tatgacctgc tgctggagat gctgaatgcc
     1921 cacgtgcttc gcgggtgcaa gtcctccatc acggggtccg agtgcagccc ggcagaggac
     1981 agtaaaagca aagagggctc ccagaaccca cagtctcagt gacgcctggc cctgaggtga
     2041 actggcccac agaggtcaca ggctgaagcg tgaactccag tgtgtcagga gcctgggctt
     2101 catctttctg ctgtgtggtc cctcatttgg tgatggcagg cttggtcatg taccatcctt
     2161 ccctccacct tcccaactct caggagtcgg tgtgaggaag ccatagtttc ccttgttagc
     2221 agagggcaca tttgaatgca gcgtttccac actcaatggc ctcataggat ctcagtgtgg
     2281 tctttcttac tttccttctt ccttcctccc ctttgtgaaa catcttaaag gttttggaat
     2341 gaatggtgga aatctgactt ggaagggctg cgaatcagaa aggggagagg aagtgacacg
     2401 cttacagaag tgggctaacc cttcttgtgt ggcacacact acccttccct ctgagagttg
     2461 acctttgctg ttttccggac cactccattg taagattgaa aacccctgtg gcaattgcgt
     2521 acttacctcc caggcctgtg gggactgatc atatcatatg atgcttattc tgtcaaaggc
     2581 cagagggact gtggttaagc tgggatgtga gtcatgttct ctccctgacc ttgctgccag
     2641 ctgcacacag atttgtccct ctcgatttgt attcacagag cctgccaata atttggggta
     2701 tgtgtgtatg agcgtgtgat cattttcatg caggactgtg ggagatacaa atctcgctgc
     2761 ttctggagct gctcttcctt aaacctgttg tcccatgggg ccagcgtggg tgctggagaa
     2821 aggccgtgtt tgcaggaatg gggttctctc ctgtgggtgt gggtgacagc cacagtgttt
     2881 ccctggggca atgtggatgc agtttccatc ttgtacaacc tcataagtag cagccacaat
     2941 tgccccatca gtcaccacaa gtagtcaggg atactttggg ctgtggatgt gtgcagtgtg
     3001 ctgttttatg gatggatgag tagctatgca ccccagtgtg tcagctctgg ggccacactg
     3061 tatagccttg atgagtacgc cccttgaaca agacccagtt tgtgaactct ccttaaagag
     3121 aaatatttag ggataattat ttatagcaag aaagaattct tttacacttg agagctcttt
     3181 taaaaatatt ttcttattgg aaaatttata tggtgggcag ggtgaaaaag aaacagtaaa
     3241 aatattagtt cttattccaa gtggaacata aataggacat gaagaagggc acctctgaaa
     3301 tgacaacttt aactcacctt ttaaaagatg tgaaatttcc agttttggat acacggtgaa
     3361 tatgtaaaat gagtaacagc atactatgga agccagcaat taaataatca tgtttcatta
     3421 ttgcagtaac gttttaaaca attaccttgt gatatgatat taaatatatt ttctttttga
     3481 aaatatgttc actttgggta gcacatcctg tatttactaa gtcattagga agactgcatt
     3541 cagtgttacc aagactggtt tttgctagta agacctcgaa taatccataa ttttgatatt
     3601 ggtgcaattt tactataagt tgagcttagc tgtttcagaa atgcttggac aagtacctag
     3661 agaacacact gatgtctgtg ttctgaggca gtctgaagtt attcttagag actcagttac
     3721 agctttagta agatttagta caggcaggat aagcttggtt tcataggaac cagggaacca
     3781 gtgttagtgt cagcttcttt cctcctggtc agcctagaat cccccactcc caatagaggg
     3841 gtttggaagc tggagagtag gaagtaagag gcaaagaagg cagccttcag caactcatta
     3901 tctgccagtg aaattctatt aaatgtattt ttaaaagaga ttaccaggta acaaaaacat
     3961 aaaaaaccaa aacaaggcca gatgtggtgg ctcacgcctg taatcccagc actttgggag
     4021 gccgaggtgg gcgaaccact tgagcccatg agtttgactc caggctgggc aacatggaaa
     4081 ccctgtccta caaaagatac aaaaattagc caggcgtggt ggtgcaggcc tgtagttcca
     4141 gctacctggg aggctgaggt gggaggatca cctgagcctg gggagatcaa ggctgcagtc
     4201 cattgcactc cagcctgggt gacagaggga gaccctgtct caaaaaaaaa aaaaaaaaaa
     4261 ttgccacgaa atatatatat atatatatat ataatttttt ttttttgaga gtagatctta
     4321 agacagagat cacttctact cctgggagtg aactggcaat ggcaatccct ttagagcctc
     4381 gagtgggcag tatcaggagc gccgcacagt gagtttccag ctgagctatt ctcaccgaat
     4441 ctcgctctgt tctcacagca cccctctgtc aggcctgtct catagtgact gcccaccagg
     4501 actgactaca aaagacttga ccctaaaata gtcttgaagg gatttttctc aaaaaattaa
     4561 ggcgggaaca caagacaaag ctgtcagcct agtcacaaat ctgaagactc aactgcatta
     4621 aaaatagtgc aaaatcggca ggagctgtac agtgcgagtc ttggtctgga atactccccc
     4681 tgctaactca gctggaaggg caactatctt agatttcagt aaggaagaaa aatcagttac
     4741 caatacttgg cagagccata ttatatatcc atatatattt atgtatataa gtggaattga
     4801 agcaattcta gaattttcta gcatgtgaaa gcagggttta gttcttattt acgtctgcta
     4861 agggactttt caaattcaaa gtgaaccttc tgtttatagg cctattttga aacaaagtat
     4921 cctcacttaa taagatttga cacctttttt tttttttttt tgagacaggg tctgactcct
     4981 gttgctcagg ctagagtgca gtggcgccat catggctcac tgcagcctcg acctcctggg
     5041 ctcaagcgat cctcccacca cagtgcccca tcccacccca ttcccgccct cgccgagtag
     5101 ctggggtgca caccaccact cctggctaat tcttttaata tttgtagaga tggggtttta
     5161 ctatgctccc caggctggtc ctgaactcct gggctccagc gatctgcctg ccaaggcctc
     5221 ccaaagtgct gagattacag gcatgagcca ctgtgcccag ccccgccaca ttttttttta
     5281 agttgctgaa aatcttttaa aaagataaaa acacattatt tagtatctaa agataatatc
     5341 tgtgccagac acagttctca gtgcctcaga cattcacatt taatccttat tataataact
     5401 gctatttcct tattttctgg ttgtggaact agacacggtc taagcaaact tgctgaaggt
     5461 cacgtgggga gtaggtgatt gagctgaaca caggcagtcc aagtccagtg ctgacagtga
     5521 ccatgcactt caaacagttt aaaaatttaa agaaaaatat tttaaaactg cagaatctat
     5581 caggtgcaac ctgacatgca cggctgctgt gatttaaatg gggccccctt gtgatacccc
     5641 cttacctccc accacaatgt ccagaacacc cctacagaca cagtaagttt gtaaacctct
     5701 cacatcaaag ttcaactcca cctttcatat ctgtgtaaat taaagcccac gggggcaaat
     5761 tcacctattc aaggtcataa aactactcat ggcaaagctt ggactggcac gcaagtcttc
     5821 tgcttgccta gcgggccagt attgctcctg ccccaggact tgcttctgtg agaatctgct
     5881 ttgtgagctg agtcgcagca gaatggaggg gcggtgaagt tagggttgtc ttctgctgta
     5941 cctttagatc ccatctcctc agcttagatg ggtctgcatg agcctttaca caacagcagc
     6001 aatgacagat ggaaaaataa gatgcataat ctgttattcc cattgtccca tctcaggttc
     6061 atgagctcta gtgggtactg tgatcacctc ctgtctgtga ctgctttccc caaacacgtg
     6121 gaatatgttc cttggaagtg tactcatgta aaattcacat cttttaggca ctgctgcttc
     6181 cctgtggagt gtgatatact acagtgtgaa aacacgtgcc acttattctt tatagctctc
     6241 aaacttgctg gaattttggc tccagtggca gctcttaaga tgtgcattgt ctgtgatgta
     6301 tgatcgtagt gccatttttg ttgctttgga gtcagggagg ttttttgttt gtttgtttgt
     6361 ttgtttttta attccgagga tcctattcac ttgtagggcc agccactggt aaactggtgg
     6421 tgggtttcct ctatgggaag cacataagga gtggtgatac cagccgcgaa cagttcctgt
     6481 taactgtaca atggatgttt ttgcatttgt ttcctctgtt gggtgtctaa atgccttaac
     6541 tgttggtcct ataccttttg tcattcaatg tgtacttcag agcctgttgg ttggctataa
     6601 tttgccattt tctcagacga atgctttgta tcattacact aatttgttga cttcatttgc
     6661 aggctttaca tttgggcctt gtagaaatga atgtttgctg ctctgtgaaa gcagattttg
     6721 agacctgctt tcccttcctc cagggagtgt tttccttact gtgtcccttt aatgtctatg
     6781 gcactgtcgt agagagttta acatgatata aataaagtgt ttcattattt tggctttaaa
     6841 aa
//
