LOCUS       XM_017010377            6448 bp    mRNA    linear   PRI 25-AUG-2024
DEFINITION  PREDICTED: Homo sapiens estrogen receptor 1 (ESR1), transcript
            variant X2, mRNA.
ACCESSION   XM_017010377
VERSION     XM_017010377.2
DBLINK      BioProject: PRJNA168
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000006.12) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Apr 5, 2022 this sequence version replaced XM_017010377.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2024_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/23/2024
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..6448
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
     gene            1..6448
                     /gene="ESR1"
                     /gene_synonym="ER; Era; ESR; ESRA; ESTRR; NR3A1"
                     /note="estrogen receptor 1; Derived by automated
                     computational analysis using gene prediction method:
                     Gnomon. Supporting evidence includes similarity to: 6
                     mRNAs, 5 ESTs, 299 long SRA reads, 88 Proteins, and 100%
                     coverage of the annotated genomic feature by RNAseq
                     alignments, including 2 samples with support for all
                     annotated introns"
                     /db_xref="GeneID:2099"
                     /db_xref="HGNC:HGNC:3467"
                     /db_xref="MIM:133430"
     CDS             353..2140
                     /gene="ESR1"
                     /gene_synonym="ER; Era; ESR; ESRA; ESTRR; NR3A1"
                     /codon_start=1
                     /product="estrogen receptor isoform X1"
                     /protein_id="XP_016865866.1"
                     /db_xref="GeneID:2099"
                     /db_xref="HGNC:HGNC:3467"
                     /db_xref="MIM:133430"
                     /translation="MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYL
                     DSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNS
                     VSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQG
                     GRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHND
                     YMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEG
                     RGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPT
                     RPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLV
                     WRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKS
                     IILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLL
                     LILSHIRHMSNKGMEHLYSMKCKNVVPLYDLLLEMLDAHRLHAPTSRGGASVEETDQS
                     HLATAGSTSSHSLQKYYITGEAEGFPATV"
ORIGIN      
        1 agtcagagaa ataatcgcag agcctcaaat atctccaaaa tctgatacca atccttttga
       61 ttgtgaatta tattctgtag ctaccaaaga agggaaaagt gcatgttcct gttctctggt
      121 agaagggcca cccaaggaat tcaggttcct ggaagaagaa aactaggaag gagtaagcac
      181 aaagatctct tcacattctc cgggactgcg gtaccaaata tcagcacagc acttcttgaa
      241 aaaggatgta gattttaatc tgaactttga accatcactg aggtggcccg ccggtttctg
      301 agccttctgc cctgcgggga cacggtctgc accctgcccg cggccacgga ccatgaccat
      361 gaccctccac accaaagcat ctgggatggc cctactgcat cagatccaag ggaacgagct
      421 ggagcccctg aaccgtccgc agctcaagat ccccctggag cggcccctgg gcgaggtgta
      481 cctggacagc agcaagcccg ccgtgtacaa ctaccccgag ggcgccgcct acgagttcaa
      541 cgccgcggcc gccgccaacg cgcaggtcta cggtcagacc ggcctcccct acggccccgg
      601 gtctgaggct gcggcgttcg gctccaacgg cctggggggt ttccccccac tcaacagcgt
      661 gtctccgagc ccgctgatgc tactgcaccc gccgccgcag ctgtcgcctt tcctgcagcc
      721 ccacggccag caggtgccct actacctgga gaacgagccc agcggctaca cggtgcgcga
      781 ggccggcccg ccggcattct acaggccaaa ttcagataat cgacgccagg gtggcagaga
      841 aagattggcc agtaccaatg acaagggaag tatggctatg gaatctgcca aggagactcg
      901 ctactgtgca gtgtgcaatg actatgcttc aggctaccat tatggagtct ggtcctgtga
      961 gggctgcaag gccttcttca agagaagtat tcaaggacat aacgactata tgtgtccagc
     1021 caccaaccag tgcaccattg ataaaaacag gaggaagagc tgccaggcct gccggctccg
     1081 taaatgctac gaagtgggaa tgatgaaagg tgggatacga aaagaccgaa gaggagggag
     1141 aatgttgaaa cacaagcgcc agagagatga tggggagggc aggggtgaag tggggtctgc
     1201 tggagacatg agagctgcca acctttggcc aagcccgctc atgatcaaac gctctaagaa
     1261 gaacagcctg gccttgtccc tgacggccga ccagatggtc agtgccttgt tggatgctga
     1321 gcccccgata ctctattccg agtatgatcc taccagaccc ttcagtgaag cttcgatgat
     1381 gggcttactg accaacctgg cagacaggga gctggttcac atgatcaact gggcgaagag
     1441 ggtgccaggc tttgtggatt tgaccctcca tgatcaggtc caccttctag aatgtgcctg
     1501 gctagagatc ctgatgattg gtctcgtctg gcgctccatg gagcacccag ggaagctact
     1561 gtttgctcct aacttgctct tggacaggaa ccagggaaaa tgtgtagagg gcatggtgga
     1621 gatcttcgac atgctgctgg ctacatcatc tcggttccgc atgatgaatc tgcagggaga
     1681 ggagtttgtg tgcctcaaat ctattatttt gcttaattct ggagtgtaca catttctgtc
     1741 cagcaccctg aagtctctgg aagagaagga ccatatccac cgagtcctgg acaagatcac
     1801 agacactttg atccacctga tggccaaggc aggcctgacc ctgcagcagc agcaccagcg
     1861 gctggcccag ctcctcctca tcctctccca catcaggcac atgagtaaca aaggcatgga
     1921 gcatctgtac agcatgaagt gcaagaacgt ggtgcccctc tatgacctgc tgctggagat
     1981 gctggacgcc caccgcctac atgcgcccac tagccgtgga ggggcatccg tggaggagac
     2041 ggaccaaagc cacttggcca ctgcgggctc tacttcatcg cattccttgc aaaagtatta
     2101 catcacgggg gaggcagagg gtttccctgc cacggtctga gagctccctg gctcccacac
     2161 ggttcagata atccctgctg cattttaccc tcatcatgca ccactttagc caaattctgt
     2221 ctcctgcata cactccggca tgcatccaac accaatggct ttctagatga gtggccattc
     2281 atttgcttgc tcagttctta gtggcacatc ttctgtcttc tgttgggaac agccaaaggg
     2341 attccaaggc taaatctttg taacagctct ctttccccct tgctatgtta ctaagcgtga
     2401 ggattcccgt agctcttcac agctgaactc agtctatggg ttggggctca gataactctg
     2461 tgcatttaag ctacttgtag agacccaggc ctggagagta gacattttgc ctctgataag
     2521 cactttttaa atggctctaa gaataagcca cagcaaagaa tttaaagtgg ctcctttaat
     2581 tggtgacttg gagaaagcta ggtcaagggt ttattatagc accctcttgt attcctatgg
     2641 caatgcatcc ttttatgaaa gtggtacacc ttaaagcttt tatatgactg tagcagagta
     2701 tctggtgatt gtcaattcat tccccctata ggaatacaag gggcacacag ggaaggcaga
     2761 tcccctagtt ggcaagacta ttttaacttg atacactgca gattcagatg tgctgaaagc
     2821 tctgcctctg gctttccggt catgggttcc agttaattca tgcctcccat ggacctatgg
     2881 agagcagcaa gttgatctta gttaagtctc cctatatgag ggataagttc ctgatttttg
     2941 tttttatttt tgtgttacaa aagaaagccc tccctccctg aacttgcagt aaggtcagct
     3001 tcaggacctg ttccagtggg cactgtactt ggatcttccc ggcgtgtgtg tgccttacac
     3061 aggggtgaac tgttcactgt ggtgatgcat gatgagggta aatggtagtt gaaaggagca
     3121 ggggccctgg tgttgcattt agccctgggg catggagctg aacagtactt gtgcaggatt
     3181 gttgtggcta ctagagaaca agagggaaag tagggcagaa actggataca gttctgaggc
     3241 acagccagac ttgctcaggg tggccctgcc acaggctgca gctacctagg aacattcctt
     3301 gcagaccccg cattgccctt tgggggtgcc ctgggatccc tggggtagtc cagctcttct
     3361 tcatttccca gcgtggccct ggttggaaga agcagctgtc acagctgctg tagacagctg
     3421 tgttcctaca attggcccag caccctgggg cacgggagaa gggtggggac cgttgctgtc
     3481 actactcagg ctgactgggg cctggtcaga ttacgtatgc ccttggtggt ttagagataa
     3541 tccaaaatca gggtttggtt tggggaagaa aatcctcccc cttcctcccc cgccccgttc
     3601 cctaccgcct ccactcctgc cagctcattt ccttcaattt cctttgacct ataggctaaa
     3661 aaagaaaggc tcattccagc cacagggcag ccttccctgg gcctttgctt ctctagcaca
     3721 attatgggtt acttcctttt tcttaacaaa aaagaatgtt tgatttcctc tgggtgacct
     3781 tattgtctgt aattgaaacc ctattgagag gtgatgtctg tgttagccaa tgacccaggt
     3841 gagctgctcg ggcttctctt ggtatgtctt gtttggaaaa gtggatttca ttcatttctg
     3901 attgtccagt taagtgatca ccaaaggact gagaatctgg gagggcaaaa aaaaaaaaaa
     3961 agtttttatg tgcacttaaa tttggggaca attttatgta tctgtgttaa ggatatgttt
     4021 aagaacataa ttcttttgtt gctgtttgtt taagaagcac cttagtttgt ttaagaagca
     4081 ccttatatag tataatatat atttttttga aattacattg cttgtttatc agacaattga
     4141 atgtagtaat tctgttctgg atttaatttg actgggttaa catgcaaaaa ccaaggaaaa
     4201 atatttagtt tttttttttt tttttgtata cttttcaagc taccttgtca tgtatacagt
     4261 catttatgcc taaagcctgg tgattattca tttaaatgaa gatcacattt catatcaact
     4321 tttgtatcca cagtagacaa aatagcacta atccagatgc ctattgttgg atactgaatg
     4381 acagacaatc ttatgtagca aagattatgc ctgaaaagga aaattattca gggcagctaa
     4441 ttttgctttt accaaaatat cagtagtaat atttttggac agtagctaat gggtcagtgg
     4501 gttcttttta atgtttatac ttagattttc ttttaaaaaa attaaaataa aacaaaaaaa
     4561 aatttctagg actagacgat gtaataccag ctaaagccaa acaattatac agtggaaggt
     4621 tttacattat tcatccaatg tgtttctatt catgttaaga tactactaca tttgaagtgg
     4681 gcagagaaca tcagatgatt gaaatgttcg cccaggggtc tccagcaact ttggaaatct
     4741 ctttgtattt ttacttgaag tgccactaat ggacagcaga tattttctgg ctgatgttgg
     4801 tattgggtgt aggaacatga tttaaaaaaa aactcttgcc tctgctttcc cccactctga
     4861 ggcaagttaa aatgtaaaag atgtgattta tctggggggc tcaggtatgg tggggaagtg
     4921 gattcaggaa tctggggaat ggcaaatata ttaagaagag tattgaaagt atttggagga
     4981 aaatggttaa ttctgggtgt gcaccagggt tcagtagagt ccacttctgc cctggagacc
     5041 acaaatcaac tagctccatt tacagccatt tctaaaatgg cagcttcagt tctagagaag
     5101 aaagaacaac atcagcagta aagtccatgg aatagctagt ggtctgtgtt tcttttcgcc
     5161 attgcctagc ttgccgtaat gattctataa tgccatcatg cagcaattat gagaggctag
     5221 gtcatccaaa gagaagaccc tatcaatgta ggttgcaaaa tctaacccct aaggaagtgc
     5281 agtctttgat ttgatttccc tagtaacctt gcagatatgt ttaaccaagc catagcccat
     5341 gccttttgag ggctgaacaa ataagggact tactgataat ttacttttga tcacattaag
     5401 gtgttctcac cttgaaatct tatacactga aatggccatt gatttaggcc actggcttag
     5461 agtactcctt cccctgcatg acactgatta caaatacttt cctattcata ctttccaatt
     5521 atgagatgga ctgtgggtac tgggagtgat cactaacacc atagtaatgt ctaatattca
     5581 caggcagatc tgcttgggga agctagttat gtgaaaggca aatagagtca tacagtagct
     5641 caaaaggcaa ccataattct ctttggtgca ggtcttggga gcgtgatcta gattacactg
     5701 caccattccc aagttaatcc cctgaaaact tactctcaac tggagcaaat gaactttggt
     5761 cccaaatatc catcttttca gtagcgttaa ttatgctctg tttccaactg catttccttt
     5821 ccaattgaat taaagtgtgg cctcgttttt agtcatttaa aattgttttc taagtaattg
     5881 ctgcctctat tatggcactt caattttgca ctgtcttttg agattcaaga aaaatttcta
     5941 ttcttttttt tgcatccaat tgtgcctgaa cttttaaaat atgtaaatgc tgccatgttc
     6001 caaacccatc gtcagtgtgt gtgtttagag ctgtgcaccc tagaaacaac atattgtccc
     6061 atgagcaggt gcctgagaca cagacccctt tgcattcaca gagaggtcat tggttataga
     6121 gacttgaatt aataagtgac attatgccag tttctgttct ctcacaggtg ataaacaatg
     6181 ctttttgtgc actacatact cttcagtgta gagctcttgt tttatgggaa aaggctcaaa
     6241 tgccaaattg tgtttgatgg attaatatgc ccttttgccg atgcatacta ttactgatgt
     6301 gactcggttt tgtcgcagct ttgctttgtt taatgaaaca cacttgtaaa cctcttttgc
     6361 actttgaaaa agaatccagc gggatgctcg agcacctgta aacaattttc tcaacctatt
     6421 tgatgttcaa ataaagaatt aaactaaa
//
