LOCUS       XM_011535545            6364 bp    mRNA    linear   PRI 25-AUG-2024
DEFINITION  PREDICTED: Homo sapiens estrogen receptor 1 (ESR1), transcript
            variant X9, mRNA.
ACCESSION   XM_011535545
VERSION     XM_011535545.3
DBLINK      BioProject: PRJNA168
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000006.12) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Apr 5, 2022 this sequence version replaced XM_011535545.2.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2024_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/23/2024
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..6364
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
     gene            1..6364
                     /gene="ESR1"
                     /gene_synonym="ER; Era; ESR; ESRA; ESTRR; NR3A1"
                     /note="estrogen receptor 1; Derived by automated
                     computational analysis using gene prediction method:
                     Gnomon. Supporting evidence includes similarity to: 5
                     mRNAs, 6 ESTs, 340 long SRA reads, 88 Proteins, and 100%
                     coverage of the annotated genomic feature by RNAseq
                     alignments, including 2 samples with support for all
                     annotated introns"
                     /db_xref="GeneID:2099"
                     /db_xref="HGNC:HGNC:3467"
                     /db_xref="MIM:133430"
     CDS             269..2056
                     /gene="ESR1"
                     /gene_synonym="ER; Era; ESR; ESRA; ESTRR; NR3A1"
                     /codon_start=1
                     /product="estrogen receptor isoform X1"
                     /protein_id="XP_011533847.1"
                     /db_xref="GeneID:2099"
                     /db_xref="HGNC:HGNC:3467"
                     /db_xref="MIM:133430"
                     /translation="MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYL
                     DSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNS
                     VSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQG
                     GRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHND
                     YMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEG
                     RGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPT
                     RPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLV
                     WRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKS
                     IILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLL
                     LILSHIRHMSNKGMEHLYSMKCKNVVPLYDLLLEMLDAHRLHAPTSRGGASVEETDQS
                     HLATAGSTSSHSLQKYYITGEAEGFPATV"
ORIGIN      
        1 attagcagtg tgaaaatgga ctaatacatg agccacattg ttacagagtt tctgaaggtc
       61 attaagagaa gtccatgctg tgggctgagc tgggactcaa gaatctcaaa ggagagccag
      121 tgcaatcaac acgaagggcc catcttgaac tcctaaggca gggcagagct gggtcttatg
      181 gagacatgtg gctttcaggt ggcccgccgg tttctgagcc ttctgccctg cggggacacg
      241 gtctgcaccc tgcccgcggc cacggaccat gaccatgacc ctccacacca aagcatctgg
      301 gatggcccta ctgcatcaga tccaagggaa cgagctggag cccctgaacc gtccgcagct
      361 caagatcccc ctggagcggc ccctgggcga ggtgtacctg gacagcagca agcccgccgt
      421 gtacaactac cccgagggcg ccgcctacga gttcaacgcc gcggccgccg ccaacgcgca
      481 ggtctacggt cagaccggcc tcccctacgg ccccgggtct gaggctgcgg cgttcggctc
      541 caacggcctg gggggtttcc ccccactcaa cagcgtgtct ccgagcccgc tgatgctact
      601 gcacccgccg ccgcagctgt cgcctttcct gcagccccac ggccagcagg tgccctacta
      661 cctggagaac gagcccagcg gctacacggt gcgcgaggcc ggcccgccgg cattctacag
      721 gccaaattca gataatcgac gccagggtgg cagagaaaga ttggccagta ccaatgacaa
      781 gggaagtatg gctatggaat ctgccaagga gactcgctac tgtgcagtgt gcaatgacta
      841 tgcttcaggc taccattatg gagtctggtc ctgtgagggc tgcaaggcct tcttcaagag
      901 aagtattcaa ggacataacg actatatgtg tccagccacc aaccagtgca ccattgataa
      961 aaacaggagg aagagctgcc aggcctgccg gctccgtaaa tgctacgaag tgggaatgat
     1021 gaaaggtggg atacgaaaag accgaagagg agggagaatg ttgaaacaca agcgccagag
     1081 agatgatggg gagggcaggg gtgaagtggg gtctgctgga gacatgagag ctgccaacct
     1141 ttggccaagc ccgctcatga tcaaacgctc taagaagaac agcctggcct tgtccctgac
     1201 ggccgaccag atggtcagtg ccttgttgga tgctgagccc ccgatactct attccgagta
     1261 tgatcctacc agacccttca gtgaagcttc gatgatgggc ttactgacca acctggcaga
     1321 cagggagctg gttcacatga tcaactgggc gaagagggtg ccaggctttg tggatttgac
     1381 cctccatgat caggtccacc ttctagaatg tgcctggcta gagatcctga tgattggtct
     1441 cgtctggcgc tccatggagc acccagggaa gctactgttt gctcctaact tgctcttgga
     1501 caggaaccag ggaaaatgtg tagagggcat ggtggagatc ttcgacatgc tgctggctac
     1561 atcatctcgg ttccgcatga tgaatctgca gggagaggag tttgtgtgcc tcaaatctat
     1621 tattttgctt aattctggag tgtacacatt tctgtccagc accctgaagt ctctggaaga
     1681 gaaggaccat atccaccgag tcctggacaa gatcacagac actttgatcc acctgatggc
     1741 caaggcaggc ctgaccctgc agcagcagca ccagcggctg gcccagctcc tcctcatcct
     1801 ctcccacatc aggcacatga gtaacaaagg catggagcat ctgtacagca tgaagtgcaa
     1861 gaacgtggtg cccctctatg acctgctgct ggagatgctg gacgcccacc gcctacatgc
     1921 gcccactagc cgtggagggg catccgtgga ggagacggac caaagccact tggccactgc
     1981 gggctctact tcatcgcatt ccttgcaaaa gtattacatc acgggggagg cagagggttt
     2041 ccctgccacg gtctgagagc tccctggctc ccacacggtt cagataatcc ctgctgcatt
     2101 ttaccctcat catgcaccac tttagccaaa ttctgtctcc tgcatacact ccggcatgca
     2161 tccaacacca atggctttct agatgagtgg ccattcattt gcttgctcag ttcttagtgg
     2221 cacatcttct gtcttctgtt gggaacagcc aaagggattc caaggctaaa tctttgtaac
     2281 agctctcttt cccccttgct atgttactaa gcgtgaggat tcccgtagct cttcacagct
     2341 gaactcagtc tatgggttgg ggctcagata actctgtgca tttaagctac ttgtagagac
     2401 ccaggcctgg agagtagaca ttttgcctct gataagcact ttttaaatgg ctctaagaat
     2461 aagccacagc aaagaattta aagtggctcc tttaattggt gacttggaga aagctaggtc
     2521 aagggtttat tatagcaccc tcttgtattc ctatggcaat gcatcctttt atgaaagtgg
     2581 tacaccttaa agcttttata tgactgtagc agagtatctg gtgattgtca attcattccc
     2641 cctataggaa tacaaggggc acacagggaa ggcagatccc ctagttggca agactatttt
     2701 aacttgatac actgcagatt cagatgtgct gaaagctctg cctctggctt tccggtcatg
     2761 ggttccagtt aattcatgcc tcccatggac ctatggagag cagcaagttg atcttagtta
     2821 agtctcccta tatgagggat aagttcctga tttttgtttt tatttttgtg ttacaaaaga
     2881 aagccctccc tccctgaact tgcagtaagg tcagcttcag gacctgttcc agtgggcact
     2941 gtacttggat cttcccggcg tgtgtgtgcc ttacacaggg gtgaactgtt cactgtggtg
     3001 atgcatgatg agggtaaatg gtagttgaaa ggagcagggg ccctggtgtt gcatttagcc
     3061 ctggggcatg gagctgaaca gtacttgtgc aggattgttg tggctactag agaacaagag
     3121 ggaaagtagg gcagaaactg gatacagttc tgaggcacag ccagacttgc tcagggtggc
     3181 cctgccacag gctgcagcta cctaggaaca ttccttgcag accccgcatt gccctttggg
     3241 ggtgccctgg gatccctggg gtagtccagc tcttcttcat ttcccagcgt ggccctggtt
     3301 ggaagaagca gctgtcacag ctgctgtaga cagctgtgtt cctacaattg gcccagcacc
     3361 ctggggcacg ggagaagggt ggggaccgtt gctgtcacta ctcaggctga ctggggcctg
     3421 gtcagattac gtatgccctt ggtggtttag agataatcca aaatcagggt ttggtttggg
     3481 gaagaaaatc ctcccccttc ctcccccgcc ccgttcccta ccgcctccac tcctgccagc
     3541 tcatttcctt caatttcctt tgacctatag gctaaaaaag aaaggctcat tccagccaca
     3601 gggcagcctt ccctgggcct ttgcttctct agcacaatta tgggttactt cctttttctt
     3661 aacaaaaaag aatgtttgat ttcctctggg tgaccttatt gtctgtaatt gaaaccctat
     3721 tgagaggtga tgtctgtgtt agccaatgac ccaggtgagc tgctcgggct tctcttggta
     3781 tgtcttgttt ggaaaagtgg atttcattca tttctgattg tccagttaag tgatcaccaa
     3841 aggactgaga atctgggagg gcaaaaaaaa aaaaaaagtt tttatgtgca cttaaatttg
     3901 gggacaattt tatgtatctg tgttaaggat atgtttaaga acataattct tttgttgctg
     3961 tttgtttaag aagcacctta gtttgtttaa gaagcacctt atatagtata atatatattt
     4021 ttttgaaatt acattgcttg tttatcagac aattgaatgt agtaattctg ttctggattt
     4081 aatttgactg ggttaacatg caaaaaccaa ggaaaaatat ttagtttttt tttttttttt
     4141 tgtatacttt tcaagctacc ttgtcatgta tacagtcatt tatgcctaaa gcctggtgat
     4201 tattcattta aatgaagatc acatttcata tcaacttttg tatccacagt agacaaaata
     4261 gcactaatcc agatgcctat tgttggatac tgaatgacag acaatcttat gtagcaaaga
     4321 ttatgcctga aaaggaaaat tattcagggc agctaatttt gcttttacca aaatatcagt
     4381 agtaatattt ttggacagta gctaatgggt cagtgggttc tttttaatgt ttatacttag
     4441 attttctttt aaaaaaatta aaataaaaca aaaaaaaatt tctaggacta gacgatgtaa
     4501 taccagctaa agccaaacaa ttatacagtg gaaggtttta cattattcat ccaatgtgtt
     4561 tctattcatg ttaagatact actacatttg aagtgggcag agaacatcag atgattgaaa
     4621 tgttcgccca ggggtctcca gcaactttgg aaatctcttt gtatttttac ttgaagtgcc
     4681 actaatggac agcagatatt ttctggctga tgttggtatt gggtgtagga acatgattta
     4741 aaaaaaaact cttgcctctg ctttccccca ctctgaggca agttaaaatg taaaagatgt
     4801 gatttatctg gggggctcag gtatggtggg gaagtggatt caggaatctg gggaatggca
     4861 aatatattaa gaagagtatt gaaagtattt ggaggaaaat ggttaattct gggtgtgcac
     4921 cagggttcag tagagtccac ttctgccctg gagaccacaa atcaactagc tccatttaca
     4981 gccatttcta aaatggcagc ttcagttcta gagaagaaag aacaacatca gcagtaaagt
     5041 ccatggaata gctagtggtc tgtgtttctt ttcgccattg cctagcttgc cgtaatgatt
     5101 ctataatgcc atcatgcagc aattatgaga ggctaggtca tccaaagaga agaccctatc
     5161 aatgtaggtt gcaaaatcta acccctaagg aagtgcagtc tttgatttga tttccctagt
     5221 aaccttgcag atatgtttaa ccaagccata gcccatgcct tttgagggct gaacaaataa
     5281 gggacttact gataatttac ttttgatcac attaaggtgt tctcaccttg aaatcttata
     5341 cactgaaatg gccattgatt taggccactg gcttagagta ctccttcccc tgcatgacac
     5401 tgattacaaa tactttccta ttcatacttt ccaattatga gatggactgt gggtactggg
     5461 agtgatcact aacaccatag taatgtctaa tattcacagg cagatctgct tggggaagct
     5521 agttatgtga aaggcaaata gagtcataca gtagctcaaa aggcaaccat aattctcttt
     5581 ggtgcaggtc ttgggagcgt gatctagatt acactgcacc attcccaagt taatcccctg
     5641 aaaacttact ctcaactgga gcaaatgaac tttggtccca aatatccatc ttttcagtag
     5701 cgttaattat gctctgtttc caactgcatt tcctttccaa ttgaattaaa gtgtggcctc
     5761 gtttttagtc atttaaaatt gttttctaag taattgctgc ctctattatg gcacttcaat
     5821 tttgcactgt cttttgagat tcaagaaaaa tttctattct tttttttgca tccaattgtg
     5881 cctgaacttt taaaatatgt aaatgctgcc atgttccaaa cccatcgtca gtgtgtgtgt
     5941 ttagagctgt gcaccctaga aacaacatat tgtcccatga gcaggtgcct gagacacaga
     6001 cccctttgca ttcacagaga ggtcattggt tatagagact tgaattaata agtgacatta
     6061 tgccagtttc tgttctctca caggtgataa acaatgcttt ttgtgcacta catactcttc
     6121 agtgtagagc tcttgtttta tgggaaaagg ctcaaatgcc aaattgtgtt tgatggatta
     6181 atatgccctt ttgccgatgc atactattac tgatgtgact cggttttgtc gcagctttgc
     6241 tttgtttaat gaaacacact tgtaaacctc ttttgcactt tgaaaaagaa tccagcggga
     6301 tgctcgagca cctgtaaaca attttctcaa cctatttgat gttcaaataa agaattaaac
     6361 taaa
//
