LOCUS       XM_011535543            6549 bp    mRNA    linear   PRI 25-AUG-2024
DEFINITION  PREDICTED: Homo sapiens estrogen receptor 1 (ESR1), transcript
            variant X4, mRNA.
ACCESSION   XM_011535543
VERSION     XM_011535543.3
DBLINK      BioProject: PRJNA168
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000006.12) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Apr 5, 2022 this sequence version replaced XM_011535543.2.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2024_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/23/2024
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..6549
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
     gene            1..6549
                     /gene="ESR1"
                     /gene_synonym="ER; Era; ESR; ESRA; ESTRR; NR3A1"
                     /note="estrogen receptor 1; Derived by automated
                     computational analysis using gene prediction method:
                     Gnomon. Supporting evidence includes similarity to: 6
                     mRNAs, 5 ESTs, 344 long SRA reads, 88 Proteins, and 100%
                     coverage of the annotated genomic feature by RNAseq
                     alignments, including 3 samples with support for all
                     annotated introns"
                     /db_xref="GeneID:2099"
                     /db_xref="HGNC:HGNC:3467"
                     /db_xref="MIM:133430"
     CDS             454..2241
                     /gene="ESR1"
                     /gene_synonym="ER; Era; ESR; ESRA; ESTRR; NR3A1"
                     /codon_start=1
                     /product="estrogen receptor isoform X1"
                     /protein_id="XP_011533845.1"
                     /db_xref="GeneID:2099"
                     /db_xref="HGNC:HGNC:3467"
                     /db_xref="MIM:133430"
                     /translation="MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYL
                     DSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNS
                     VSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQG
                     GRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHND
                     YMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEG
                     RGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPT
                     RPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLV
                     WRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKS
                     IILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLL
                     LILSHIRHMSNKGMEHLYSMKCKNVVPLYDLLLEMLDAHRLHAPTSRGGASVEETDQS
                     HLATAGSTSSHSLQKYYITGEAEGFPATV"
ORIGIN      
        1 agaacggatt ttaccaaaac tgaaaatgca ggctccatgc tcagaagctc tttaacaggc
       61 tcgaaaggtc catgctcctt tctcctgccc attctatagc ataagaagac agtctctgag
      121 tgataatctt ctcttcaaga agaagaaaac taggaaggag taagcacaaa gatctcttca
      181 cattctccgg gactgcggta ccaaatatca gcacagcact tcttgaaaaa ggatgtagat
      241 tttaatctga actttgaacc atcactgaga ccctgagagt ctggaagaaa tatattctgg
      301 tcagagcaga ctgagctgga gctggcctag aaccttggat cctgacctca gaattgctgc
      361 tcaaattact gctctctgaa agagtggccc gccggtttct gagccttctg ccctgcgggg
      421 acacggtctg caccctgccc gcggccacgg accatgacca tgaccctcca caccaaagca
      481 tctgggatgg ccctactgca tcagatccaa gggaacgagc tggagcccct gaaccgtccg
      541 cagctcaaga tccccctgga gcggcccctg ggcgaggtgt acctggacag cagcaagccc
      601 gccgtgtaca actaccccga gggcgccgcc tacgagttca acgccgcggc cgccgccaac
      661 gcgcaggtct acggtcagac cggcctcccc tacggccccg ggtctgaggc tgcggcgttc
      721 ggctccaacg gcctgggggg tttcccccca ctcaacagcg tgtctccgag cccgctgatg
      781 ctactgcacc cgccgccgca gctgtcgcct ttcctgcagc cccacggcca gcaggtgccc
      841 tactacctgg agaacgagcc cagcggctac acggtgcgcg aggccggccc gccggcattc
      901 tacaggccaa attcagataa tcgacgccag ggtggcagag aaagattggc cagtaccaat
      961 gacaagggaa gtatggctat ggaatctgcc aaggagactc gctactgtgc agtgtgcaat
     1021 gactatgctt caggctacca ttatggagtc tggtcctgtg agggctgcaa ggccttcttc
     1081 aagagaagta ttcaaggaca taacgactat atgtgtccag ccaccaacca gtgcaccatt
     1141 gataaaaaca ggaggaagag ctgccaggcc tgccggctcc gtaaatgcta cgaagtggga
     1201 atgatgaaag gtgggatacg aaaagaccga agaggaggga gaatgttgaa acacaagcgc
     1261 cagagagatg atggggaggg caggggtgaa gtggggtctg ctggagacat gagagctgcc
     1321 aacctttggc caagcccgct catgatcaaa cgctctaaga agaacagcct ggccttgtcc
     1381 ctgacggccg accagatggt cagtgccttg ttggatgctg agcccccgat actctattcc
     1441 gagtatgatc ctaccagacc cttcagtgaa gcttcgatga tgggcttact gaccaacctg
     1501 gcagacaggg agctggttca catgatcaac tgggcgaaga gggtgccagg ctttgtggat
     1561 ttgaccctcc atgatcaggt ccaccttcta gaatgtgcct ggctagagat cctgatgatt
     1621 ggtctcgtct ggcgctccat ggagcaccca gggaagctac tgtttgctcc taacttgctc
     1681 ttggacagga accagggaaa atgtgtagag ggcatggtgg agatcttcga catgctgctg
     1741 gctacatcat ctcggttccg catgatgaat ctgcagggag aggagtttgt gtgcctcaaa
     1801 tctattattt tgcttaattc tggagtgtac acatttctgt ccagcaccct gaagtctctg
     1861 gaagagaagg accatatcca ccgagtcctg gacaagatca cagacacttt gatccacctg
     1921 atggccaagg caggcctgac cctgcagcag cagcaccagc ggctggccca gctcctcctc
     1981 atcctctccc acatcaggca catgagtaac aaaggcatgg agcatctgta cagcatgaag
     2041 tgcaagaacg tggtgcccct ctatgacctg ctgctggaga tgctggacgc ccaccgccta
     2101 catgcgccca ctagccgtgg aggggcatcc gtggaggaga cggaccaaag ccacttggcc
     2161 actgcgggct ctacttcatc gcattccttg caaaagtatt acatcacggg ggaggcagag
     2221 ggtttccctg ccacggtctg agagctccct ggctcccaca cggttcagat aatccctgct
     2281 gcattttacc ctcatcatgc accactttag ccaaattctg tctcctgcat acactccggc
     2341 atgcatccaa caccaatggc tttctagatg agtggccatt catttgcttg ctcagttctt
     2401 agtggcacat cttctgtctt ctgttgggaa cagccaaagg gattccaagg ctaaatcttt
     2461 gtaacagctc tctttccccc ttgctatgtt actaagcgtg aggattcccg tagctcttca
     2521 cagctgaact cagtctatgg gttggggctc agataactct gtgcatttaa gctacttgta
     2581 gagacccagg cctggagagt agacattttg cctctgataa gcacttttta aatggctcta
     2641 agaataagcc acagcaaaga atttaaagtg gctcctttaa ttggtgactt ggagaaagct
     2701 aggtcaaggg tttattatag caccctcttg tattcctatg gcaatgcatc cttttatgaa
     2761 agtggtacac cttaaagctt ttatatgact gtagcagagt atctggtgat tgtcaattca
     2821 ttccccctat aggaatacaa ggggcacaca gggaaggcag atcccctagt tggcaagact
     2881 attttaactt gatacactgc agattcagat gtgctgaaag ctctgcctct ggctttccgg
     2941 tcatgggttc cagttaattc atgcctccca tggacctatg gagagcagca agttgatctt
     3001 agttaagtct ccctatatga gggataagtt cctgattttt gtttttattt ttgtgttaca
     3061 aaagaaagcc ctccctccct gaacttgcag taaggtcagc ttcaggacct gttccagtgg
     3121 gcactgtact tggatcttcc cggcgtgtgt gtgccttaca caggggtgaa ctgttcactg
     3181 tggtgatgca tgatgagggt aaatggtagt tgaaaggagc aggggccctg gtgttgcatt
     3241 tagccctggg gcatggagct gaacagtact tgtgcaggat tgttgtggct actagagaac
     3301 aagagggaaa gtagggcaga aactggatac agttctgagg cacagccaga cttgctcagg
     3361 gtggccctgc cacaggctgc agctacctag gaacattcct tgcagacccc gcattgccct
     3421 ttgggggtgc cctgggatcc ctggggtagt ccagctcttc ttcatttccc agcgtggccc
     3481 tggttggaag aagcagctgt cacagctgct gtagacagct gtgttcctac aattggccca
     3541 gcaccctggg gcacgggaga agggtgggga ccgttgctgt cactactcag gctgactggg
     3601 gcctggtcag attacgtatg cccttggtgg tttagagata atccaaaatc agggtttggt
     3661 ttggggaaga aaatcctccc ccttcctccc ccgccccgtt ccctaccgcc tccactcctg
     3721 ccagctcatt tccttcaatt tcctttgacc tataggctaa aaaagaaagg ctcattccag
     3781 ccacagggca gccttccctg ggcctttgct tctctagcac aattatgggt tacttccttt
     3841 ttcttaacaa aaaagaatgt ttgatttcct ctgggtgacc ttattgtctg taattgaaac
     3901 cctattgaga ggtgatgtct gtgttagcca atgacccagg tgagctgctc gggcttctct
     3961 tggtatgtct tgtttggaaa agtggatttc attcatttct gattgtccag ttaagtgatc
     4021 accaaaggac tgagaatctg ggagggcaaa aaaaaaaaaa aagtttttat gtgcacttaa
     4081 atttggggac aattttatgt atctgtgtta aggatatgtt taagaacata attcttttgt
     4141 tgctgtttgt ttaagaagca ccttagtttg tttaagaagc accttatata gtataatata
     4201 tatttttttg aaattacatt gcttgtttat cagacaattg aatgtagtaa ttctgttctg
     4261 gatttaattt gactgggtta acatgcaaaa accaaggaaa aatatttagt tttttttttt
     4321 ttttttgtat acttttcaag ctaccttgtc atgtatacag tcatttatgc ctaaagcctg
     4381 gtgattattc atttaaatga agatcacatt tcatatcaac ttttgtatcc acagtagaca
     4441 aaatagcact aatccagatg cctattgttg gatactgaat gacagacaat cttatgtagc
     4501 aaagattatg cctgaaaagg aaaattattc agggcagcta attttgcttt taccaaaata
     4561 tcagtagtaa tatttttgga cagtagctaa tgggtcagtg ggttcttttt aatgtttata
     4621 cttagatttt cttttaaaaa aattaaaata aaacaaaaaa aaatttctag gactagacga
     4681 tgtaatacca gctaaagcca aacaattata cagtggaagg ttttacatta ttcatccaat
     4741 gtgtttctat tcatgttaag atactactac atttgaagtg ggcagagaac atcagatgat
     4801 tgaaatgttc gcccaggggt ctccagcaac tttggaaatc tctttgtatt tttacttgaa
     4861 gtgccactaa tggacagcag atattttctg gctgatgttg gtattgggtg taggaacatg
     4921 atttaaaaaa aaactcttgc ctctgctttc ccccactctg aggcaagtta aaatgtaaaa
     4981 gatgtgattt atctgggggg ctcaggtatg gtggggaagt ggattcagga atctggggaa
     5041 tggcaaatat attaagaaga gtattgaaag tatttggagg aaaatggtta attctgggtg
     5101 tgcaccaggg ttcagtagag tccacttctg ccctggagac cacaaatcaa ctagctccat
     5161 ttacagccat ttctaaaatg gcagcttcag ttctagagaa gaaagaacaa catcagcagt
     5221 aaagtccatg gaatagctag tggtctgtgt ttcttttcgc cattgcctag cttgccgtaa
     5281 tgattctata atgccatcat gcagcaatta tgagaggcta ggtcatccaa agagaagacc
     5341 ctatcaatgt aggttgcaaa atctaacccc taaggaagtg cagtctttga tttgatttcc
     5401 ctagtaacct tgcagatatg tttaaccaag ccatagccca tgccttttga gggctgaaca
     5461 aataagggac ttactgataa tttacttttg atcacattaa ggtgttctca ccttgaaatc
     5521 ttatacactg aaatggccat tgatttaggc cactggctta gagtactcct tcccctgcat
     5581 gacactgatt acaaatactt tcctattcat actttccaat tatgagatgg actgtgggta
     5641 ctgggagtga tcactaacac catagtaatg tctaatattc acaggcagat ctgcttgggg
     5701 aagctagtta tgtgaaaggc aaatagagtc atacagtagc tcaaaaggca accataattc
     5761 tctttggtgc aggtcttggg agcgtgatct agattacact gcaccattcc caagttaatc
     5821 ccctgaaaac ttactctcaa ctggagcaaa tgaactttgg tcccaaatat ccatcttttc
     5881 agtagcgtta attatgctct gtttccaact gcatttcctt tccaattgaa ttaaagtgtg
     5941 gcctcgtttt tagtcattta aaattgtttt ctaagtaatt gctgcctcta ttatggcact
     6001 tcaattttgc actgtctttt gagattcaag aaaaatttct attctttttt ttgcatccaa
     6061 ttgtgcctga acttttaaaa tatgtaaatg ctgccatgtt ccaaacccat cgtcagtgtg
     6121 tgtgtttaga gctgtgcacc ctagaaacaa catattgtcc catgagcagg tgcctgagac
     6181 acagacccct ttgcattcac agagaggtca ttggttatag agacttgaat taataagtga
     6241 cattatgcca gtttctgttc tctcacaggt gataaacaat gctttttgtg cactacatac
     6301 tcttcagtgt agagctcttg ttttatggga aaaggctcaa atgccaaatt gtgtttgatg
     6361 gattaatatg cccttttgcc gatgcatact attactgatg tgactcggtt ttgtcgcagc
     6421 tttgctttgt ttaatgaaac acacttgtaa acctcttttg cactttgaaa aagaatccag
     6481 cgggatgctc gagcacctgt aaacaatttt ctcaacctat ttgatgttca aataaagaat
     6541 taaactaaa
//
