LOCUS       NM_194312               4653 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens espin like (ESPNL), transcript variant 1, mRNA.
ACCESSION   NM_194312 XM_291006
VERSION     NM_194312.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4653)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 4653)
  AUTHORS   Ebrahim,S., Avenarius,M.R., Grati,M., Krey,J.F., Windsor,A.M.,
            Sousa,A.D., Ballesteros,A., Cui,R., Millis,B.A., Salles,F.T.,
            Baird,M.A., Davidson,M.W., Jones,S.M., Choi,D., Dong,L.,
            Raval,M.H., Yengo,C.M., Barr-Gillespie,P.G. and Kachar,B.
  TITLE     Stereocilia-staircase spacing is influenced by myosin III motors
            and their cargos espin-1 and espin-like
  JOURNAL   Nat Commun 7, 10833 (2016)
   PUBMED   26926603
  REMARK    Erratum:[Nat Commun. 2017 Aug 14;8:16133. doi:
            10.1038/ncomms16133.. PMID: 28805204]
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4653)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC016757.10, AK124559.1, AK128187.1 and BC080639.1.
            
            On Nov 22, 2018 this sequence version replaced NM_194312.3.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK124559.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000343063.8/ ENSP00000339115.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-69                AC016757.10        14559-14627
            70-838              AK124559.1         25-793
            839-860             AC016757.10        22096-22117
            861-1907            AK124559.1         816-1862
            1908-3922           AK128187.1         709-2723
            3923-3923           AC016757.10        46776-46776
            3924-4653           BC080639.1         2881-3610
FEATURES             Location/Qualifiers
     source          1..4653
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q37.3"
     gene            1..4653
                     /gene="ESPNL"
                     /note="espin like"
                     /db_xref="GeneID:339768"
                     /db_xref="HGNC:HGNC:27937"
                     /db_xref="MIM:619974"
     exon            1..374
                     /gene="ESPNL"
                     /inference="alignment:Splign:2.1.0"
     CDS             81..3098
                     /gene="ESPNL"
                     /note="isoform 1 is encoded by transcript variant 1;
                     espin-like protein"
                     /codon_start=1
                     /product="espin-like protein isoform 1"
                     /protein_id="NP_919288.2"
                     /db_xref="CCDS:CCDS2525.1"
                     /db_xref="GeneID:339768"
                     /db_xref="HGNC:HGNC:27937"
                     /db_xref="MIM:619974"
                     /translation="MEKQRALVAAKDGDVATLERLLEAGALGPGITDALGAGLVHHAT
                     RAGHLDCVKFLVQRAQLPGNQRAHNGATPAHDAAATGSLAELCWLVREGGCGLQDQDA
                     SGVSPLHLAARFGHPVLVEWLLHEGHSATLETREGARPLHHAAVSGDLTCLKLLTAAH
                     GSSVNRRTRSGASPLYLACQEGHLHLAQFLVKDCGADVHLRALDGMSALHAAAARGHY
                     SLVVWLVTFTDIGLTARDNEGATALHFAARGGHTPILDRLLLMGTPILRDSWGGTPLH
                     DAAENGQMECCQTLVSHHVDPSLRDEDGYTAADLAEYHGHRDCAQYLREVAQPVPLLM
                     TPPPPPFPPPPLLATRRSLEDGRRGGPGPGNPSPMSLSPAWPGHPDQPLPREQMTSPA
                     PPRIITSATADPEGTETALAGDTSDGLAALQLDGLPSGDIDGLVPTRDERGQPIPEWK
                     RQVMVRKLQARLGAESSAEAQDNGGSSGPTEQAAWRYSQTHQAILGPFGELLTEDDLV
                     YLEKQIADLQLRRRCQEYESELGRLAAELQALLPEPLVSITVNSHFLPRAPGLEVEEA
                     SIPAAEPAGSAEASEVAPGVQPLPFWCSHISRLVRSLSLLLKGVHGLVQGDEKPSTRP
                     LQDTCREASASPPRSEAQRQIQEWGVSVRTLRGNFESASGPLCGFNPGPCEPGAQHRQ
                     CLSGCWPALPKPRSGLASGEPRPGDTEEASDSGISCEEVPSEAGAAAGPDLASLRKER
                     IIMLFLSHWRRSAYTPALKTVACRTLGARHAGLRGQEAARSPGPPSPPSEGPRLGHLW
                     QQRSTITHLLGNWKAIMAHVPARQLRRLSRQPRGALSPEQFLPHVDGAPVPYSSLSLD
                     LFMLGYFQLLECDLPAEERKLRHLLCFEVFEHLGTHGWEAVRAFHKAVTDEVAAGRRA
                     WTDGFEDIKARFFGSSQRPAWDTEPGRKSGLTLLGPLPHAAVPCSGPEPTAQRLGSRS
                     QQGSFNGEDICGYINRSFAFWKEKEAEMFNFGE"
     exon            375..565
                     /gene="ESPNL"
                     /inference="alignment:Splign:2.1.0"
     exon            566..752
                     /gene="ESPNL"
                     /inference="alignment:Splign:2.1.0"
     exon            753..935
                     /gene="ESPNL"
                     /inference="alignment:Splign:2.1.0"
     exon            936..1067
                     /gene="ESPNL"
                     /inference="alignment:Splign:2.1.0"
     exon            1068..1182
                     /gene="ESPNL"
                     /inference="alignment:Splign:2.1.0"
     exon            1183..1295
                     /gene="ESPNL"
                     /inference="alignment:Splign:2.1.0"
     exon            1296..1493
                     /gene="ESPNL"
                     /inference="alignment:Splign:2.1.0"
     exon            1494..4653
                     /gene="ESPNL"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4629..4634
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ESPNL"
                     /note="hexamer: AATAAA"
     polyA_site      4653
                     /gene="ESPNL"
                     /note="major polyA site"
ORIGIN      
        1 agagccggca gcttcatcca cgtctgaaac aggaagcccc agcctgtgca tgagtcgcca
       61 ctgagagccc gggccagagg atggagaagc agcgggcact cgtggccgcc aaggatgggg
      121 atgtggcgac gttggagcgg ctgctggagg ctggcgccct gggcccgggc atcaccgatg
      181 ctctgggggc cggcctggtt caccacgcca cccgggctgg ccacctggac tgcgtcaagt
      241 tcttggtgca gcgggcccag ctgcccggca accagcgggc ccacaacggg gccaccccag
      301 cgcatgacgc cgctgccacg ggcagcctgg ccgagctgtg ctggctggtc cgcgaggggg
      361 gctgcggtct gcaggaccaa gatgcctcgg gcgtctcccc gctgcacctg gccgcccgtt
      421 ttggacaccc agtgctggtg gagtggctgc tccacgaggg ccactcggcc acgctagaga
      481 cccgggaggg agcccggccg ctgcaccacg ctgccgtcag tggggacctg acctgcctca
      541 agctcctgac agccgcgcat ggcagcagcg tgaaccggcg gacacgcagt ggcgcctccc
      601 cactctacct ggcctgccag gagggccacc tgcacctggc ccagttcctg gtgaaggact
      661 gtggcgctga cgtgcacctt cgtgctctcg atggcatgag cgccctgcac gctgccgccg
      721 cccgtggcca ctactccctc gtcgtctggc tggtcacatt caccgacatc ggactcacgg
      781 cacgggacaa tgagggggcc acggccctgc actttgcagc ccgaggcggc cacacgccca
      841 ttctagaccg actcctgctc atgggtaccc ccatcctgag agactcctgg ggtgggaccc
      901 ccctccacga cgcagcagag aacgggcaga tggagtgctg ccagacccta gtctcccacc
      961 acgtggaccc ctccctgcgg gatgaagatg gttacacggc ggcagacctg gcggagtacc
     1021 atggacaccg ggactgcgcc cagtacctgc gggaggtggc ccagccggtg cccctgctga
     1081 tgacgccccc accaccaccg ttccccccac ctccactgtt ggccacgagg cgctccctgg
     1141 aggatggaag aagaggaggc ccagggccag ggaaccccag ccccatgtcc ctcagcccgg
     1201 cctggcctgg ccatcctgac cagcctcttc ccagggagca gatgaccagc ccggcccctc
     1261 cgaggatcat caccagtgcc acggctgacc ccgaggggac agagacggcg ctggcggggg
     1321 acacctcaga tggcctggcc gcactacagc tggatgggct gccctcaggc gacatcgacg
     1381 ggctggtgcc cacgcgggat gagcgcggcc agcccatccc agagtggaag cggcaggtga
     1441 tggtgcggaa gctgcaggcg cgcctgggcg cagagagctc cgcagaggcc caggacaatg
     1501 gtgggagctc aggccccacg gagcaggcgg cctggaggta ctcacagact catcaggcca
     1561 tcctggggcc ctttggggag ctgctgacag aggatgacct ggtctacctg gagaagcaga
     1621 ttgcagacct gcagcttcgg cgccgctgtc aggagtatga gagtgagctg ggccggttgg
     1681 cggctgagct gcaggccctg ctgcccgagc ccctggtcag catcacggtc aacagccact
     1741 tcctgccccg ggcgcccgga ctggaggttg aggaggcctc aatcccagcg gctgagcccg
     1801 cagggtctgc ggaggcctca gaggtggccc ccggggtgca gcccctgccc ttctggtgca
     1861 gccacatctc ccgcctggta cgcagcctgt ccctgctgct gaagggcgtg catgggctag
     1921 tacaggggga tgagaagcca tccacccggc ccctgcagga cacctgcagg gaggcctcgg
     1981 ccagcccccc tcggagcgag gcccagcgcc agatccagga gtggggggtg tctgtgcgga
     2041 cgctgcgggg caacttcgag tcggcctctg gcccactctg tggcttcaac cctggcccct
     2101 gcgagccggg ggcccagcac aggcagtgcc tgagtggctg ctggccagcc ctgcctaagc
     2161 cccgcagtgg cctggcttca ggggagccca ggcctggcga cacagaggag gccagcgact
     2221 ctggcatcag ctgcgaggag gtgccatcag aggcgggtgc cgcagccggc ccagacctgg
     2281 ccagcctgcg caaggagcgc atcatcatgc tcttcctcag ccactggagg agatcggcct
     2341 acacgccggc cctcaagaca gtggcctgca ggaccctagg agcccgccac gcggggttgc
     2401 ggggccagga ggccgccagg agccctgggc caccctcccc gcccagcgag ggcccccggc
     2461 tgggccacct gtggcagcag cgcagcacca tcacccacct gctgggcaac tggaaggcca
     2521 tcatggctca cgtgcccgcc cggcagctgc ggcggctgag ccggcagccc cgcggggctt
     2581 tgtcccccga gcagttcctg ccccacgtgg acggggctcc ggtgccctac agcagcctct
     2641 cactggatct cttcatgctg ggttacttcc agctgctgga gtgcgacctg ccggcggagg
     2701 agcggaagct gcgccacctg ctgtgcttcg aggtcttcga gcacctgggc acccacggct
     2761 gggaggctgt gcgcgccttc cacaaggccg tgaccgacga ggtggccgcc ggccgccggg
     2821 cctggaccga cggcttcgag gacatcaaag cccgcttctt tggctccagc cagcgtcccg
     2881 cctgggatac ggagcctggc cgcaagtcag gtctgaccct gctcgggccc ctgcctcacg
     2941 ccgccgtccc ctgcagcggc cctgagccca cagcacagcg gctggggtcc cgctcccagc
     3001 agggcagctt caacggtgag gacatctgcg gctacatcaa ccgcagcttt gccttctgga
     3061 aggagaagga agctgagatg ttcaactttg gagaatgacc ctactggcag cctgctttcc
     3121 agaatgtggt ttgggggtga cttggagttt ctcttttctt ttccttgctc acacccttgg
     3181 tgttcaggtg agccgggcaa ggctgcctcc agtcctacca gttatcggag gctgcgggac
     3241 tgttctgttg tggcatggtt ctcctccgag ctgggactca gactccttct caccactgca
     3301 cccaggaagc cccttggcag gtcctgaagt gaggcaatgg gccaccccag tccagggcac
     3361 ctctgcccag ccggcccccg agacctggga tgctgcctgt ttctcacttg tccttcccca
     3421 gtgtcaccag ttcccttggc gtcctgtccc tcagtttctg tggtgctggt ggcctcggcc
     3481 acatccatct ttcatgtgag tctgaggtgg ccccaggccc tggtcctgcc cctgtttctc
     3541 ctgctgacct tgggtcacac cccttcacct cccatctgtg aatttggggg agctggagtg
     3601 attccgagga cagattccat gggcaggagg ccttcctgcc aggccatccc tgctggtcac
     3661 acaccgatgc ccgccaggcc agtgccccag cccagggtgc tccggaggcc ctgcttcctc
     3721 aaaggaggct ccccatgggg cccctgtcct ccagcctgac cagccctggc ctagtcgtgg
     3781 gccccagcaa ggctggagag cagggacgtg ggagtagcag tggctgagag agtcctccag
     3841 gcagggtggc tggtgcccac tctcaaaggc tgctgcacac agaggagaat gccggcaggg
     3901 gtgggcagca gccagacctc aggggggcgt ggatactccg tgagggcacc tgggtgtcac
     3961 ccacagtgca cctcttcaca ggggcctggg tactggaggg agggatacag gaagggagat
     4021 ggattccgtc ctcgggggct ctgggtgctg cggagtattc ctgggcatgg tgctgggcat
     4081 ggctggcata gggtgtggct tgtccccagc ttctgatggc agccaggaga atgggtcatc
     4141 acccaggctc tggggctgag gagggctggg cccaagccca cagggacttt ggaggtgggg
     4201 ctctgcagct gtgagatggc ccagcaggga gtggcaggga cgggaggctt caggaatatt
     4261 cctcctggca tccaggcccc ctgggacaga ggagggtgca gtcaggcgac aggcttatca
     4321 ggactccctg cctcaatccc tggggattgt ccaggcaaaa cctggagggc agcgggcaag
     4381 ctgttggatg gaacagagag accctcgcag ctgactaggg cccaagggga cggacactca
     4441 agaagatgta aaattgggag gggtggtatt ggccattggg gcaggcaggg ccgggaaggg
     4501 aagtagcacc ggccgcagcc ccaagccagt ggcttttcca caagggccta tcctgcagcc
     4561 ggcccgctcc ggcttcctcc actgctgaag accctgctgt agagctgaag ctgaacatgt
     4621 gtttgctaaa taaagattcc cattcctagc gca
//
