LOCUS       NM_007036               2096 bp    mRNA    linear   PRI 08-OCT-2024
DEFINITION  Homo sapiens endothelial cell specific molecule 1 (ESM1),
            transcript variant 1, mRNA.
ACCESSION   NM_007036
VERSION     NM_007036.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2096)
  AUTHORS   Fan,Z., Ye,M., Liu,D., Zhou,W., Zeng,T., He,S. and Li,Y.
  TITLE     Lactate drives the ESM1-SCD1 axis to inhibit the antitumor CD8+
            T-cell response by activating the Wnt/beta-catenin pathway in
            ovarian cancer cells and inducing cisplatin resistance
  JOURNAL   Int Immunopharmacol 137, 112461 (2024)
   PUBMED   38897128
  REMARK    GeneRIF: Lactate drives the ESM1-SCD1 axis to inhibit the antitumor
            CD8[+] T-cell response by activating the Wnt/beta-catenin pathway
            in ovarian cancer cells and inducing cisplatin resistance.
REFERENCE   2  (bases 1 to 2096)
  AUTHORS   Qi,J., Li,J., Zhu,X. and Zhao,S.
  TITLE     Endothelial cell specific molecule 1 promotes
            epithelial-mesenchymal transition of cervical cancer via the E-box
            binding homeobox 1
  JOURNAL   PLoS One 19 (7), e0304597 (2024)
   PUBMED   38954708
  REMARK    GeneRIF: Endothelial cell specific molecule 1 promotes
            epithelial-mesenchymal transition of cervical cancer via the E-box
            binding homeobox 1.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2096)
  AUTHORS   Gaudet,A., Zheng,X., Kambham,N. and Bhalla,V.
  TITLE     Esm-1 mediates transcriptional polarization associated with
            diabetic kidney disease
  JOURNAL   Am J Physiol Renal Physiol 326 (6), F1016-F1031 (2024)
   PUBMED   38601985
  REMARK    GeneRIF: Esm-1 mediates transcriptional polarization associated
            with diabetic kidney disease.
REFERENCE   4  (bases 1 to 2096)
  AUTHORS   Zhang,J., Ouyang,F., Gao,A., Zeng,T., Li,M., Li,H., Zhou,W.,
            Gao,Q., Tang,X., Zhang,Q., Ran,X., Tian,G., Quan,X., Tang,Z.,
            Zou,J., Zeng,Y., Long,Y. and Li,Y.
  TITLE     ESM1 enhances fatty acid synthesis and vascular mimicry in ovarian
            cancer by utilizing the PKM2-dependent warburg effect within the
            hypoxic tumor microenvironment
  JOURNAL   Mol Cancer 23 (1), 94 (2024)
   PUBMED   38720298
  REMARK    GeneRIF: ESM1 enhances fatty acid synthesis and vascular mimicry in
            ovarian cancer by utilizing the PKM2-dependent warburg effect
            within the hypoxic tumor microenvironment.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2096)
  AUTHORS   Xie,L., He,L., Zhang,W. and Wang,H.
  TITLE     Functional analysis of ESM1 by shRNA-mediated knockdown of its
            expression in papillary thyroid cancer cells
  JOURNAL   PLoS One 19 (4), e0298631 (2024)
   PUBMED   38626010
  REMARK    GeneRIF: Functional analysis of ESM1 by shRNA-mediated knockdown of
            its expression in papillary thyroid cancer cells.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2096)
  AUTHORS   Aitkenhead,M., Wang,S.J., Nakatsu,M.N., Mestas,J., Heard,C. and
            Hughes,C.C.
  TITLE     Identification of endothelial cell genes expressed in an in vitro
            model of angiogenesis: induction of ESM-1, (beta)ig-h3, and NrCAM
  JOURNAL   Microvasc Res 63 (2), 159-171 (2002)
   PUBMED   11866539
  REMARK    GeneRIF: Identification of endothelial cell genes expressed in an
            in vitro model of angiogenesis: induction of ESM-1, (beta)ig-h3,
            and NrCAM.
REFERENCE   7  (bases 1 to 2096)
  AUTHORS   Bechard,D., Gentina,T., Delehedde,M., Scherpereel,A., Lyon,M.,
            Aumercier,M., Vazeux,R., Richet,C., Degand,P., Jude,B., Janin,A.,
            Fernig,D.G., Tonnel,A.B. and Lassalle,P.
  TITLE     Endocan is a novel chondroitin sulfate/dermatan sulfate
            proteoglycan that promotes hepatocyte growth factor/scatter factor
            mitogenic activity
  JOURNAL   J Biol Chem 276 (51), 48341-48349 (2001)
   PUBMED   11590178
REFERENCE   8  (bases 1 to 2096)
  AUTHORS   Bechard,D., Scherpereel,A., Hammad,H., Gentina,T., Tsicopoulos,A.,
            Aumercier,M., Pestel,J., Dessaint,J.P., Tonnel,A.B. and Lassalle,P.
  TITLE     Human endothelial-cell specific molecule-1 binds directly to the
            integrin CD11a/CD18 (LFA-1) and blocks binding to intercellular
            adhesion molecule-1
  JOURNAL   J Immunol 167 (6), 3099-3106 (2001)
   PUBMED   11544294
REFERENCE   9  (bases 1 to 2096)
  AUTHORS   Bechard,D., Meignin,V., Scherpereel,A., Oudin,S., Kervoaze,G.,
            Bertheau,P., Janin,A., Tonnel,A. and Lassalle,P.
  TITLE     Characterization of the secreted form of endothelial-cell-specific
            molecule 1 by specific monoclonal antibodies
  JOURNAL   J Vasc Res 37 (5), 417-425 (2000)
   PUBMED   11025405
REFERENCE   10 (bases 1 to 2096)
  AUTHORS   Lassalle,P., Molet,S., Janin,A., Heyden,J.V., Tavernier,J.,
            Fiers,W., Devos,R. and Tonnel,A.B.
  TITLE     ESM-1 is a novel human endothelial cell-specific molecule expressed
            in lung and regulated by cytokines
  JOURNAL   J Biol Chem 271 (34), 20458-20464 (1996)
   PUBMED   8702785
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC034238.4, AK311817.1 and
            AC010436.4.
            
            On Nov 23, 2018 this sequence version replaced NM_007036.4.
            
            Summary: This gene encodes a secreted protein which is mainly
            expressed in the endothelial cells in human lung and kidney
            tissues. The expression of this gene is regulated by cytokines,
            suggesting that it may play a role in endothelium-dependent
            pathological disorders. The transcript contains multiple
            polyadenylation and mRNA instability signals. Two transcript
            variants encoding different isoforms have been found for this gene.
            [provided by RefSeq, Oct 2008].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (a).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DA880688.1, SRR1660805.40125.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000381405.5/ ENSP00000370812.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-7                 AC034238.4         5277-5283           c
            8-631               AK311817.1         8-631
            632-2096            AC010436.4         113396-114860       c
FEATURES             Location/Qualifiers
     source          1..2096
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q11.2"
     gene            1..2096
                     /gene="ESM1"
                     /gene_synonym="endocan"
                     /note="endothelial cell specific molecule 1"
                     /db_xref="GeneID:11082"
                     /db_xref="HGNC:HGNC:3466"
                     /db_xref="MIM:601521"
     exon            1..377
                     /gene="ESM1"
                     /gene_synonym="endocan"
                     /inference="alignment:Splign:2.1.0"
     CDS             77..631
                     /gene="ESM1"
                     /gene_synonym="endocan"
                     /note="isoform a precursor is encoded by transcript
                     variant 1; ESM-1"
                     /codon_start=1
                     /product="endothelial cell-specific molecule 1 isoform a
                     precursor"
                     /protein_id="NP_008967.1"
                     /db_xref="CCDS:CCDS3963.1"
                     /db_xref="GeneID:11082"
                     /db_xref="HGNC:HGNC:3466"
                     /db_xref="MIM:601521"
                     /translation="MKSVLLLTTLLVPAHLVAAWSNNYAVDCPQHCDSSECKSSPRCK
                     RTVLDDCGCCRVCAAGRGETCYRTVSGMDGMKCGPGLRCQPSNGEDPFGEEFGICKDC
                     PYGTFGMDCRETCNCQSGICDRGTGKCLKFPFFQYSVTKSSNRFVSLTEHDMASGDGN
                     IVREEVVKENAAGSPVMRKWLNPR"
     exon            378..527
                     /gene="ESM1"
                     /gene_synonym="endocan"
                     /inference="alignment:Splign:2.1.0"
     exon            528..2096
                     /gene="ESM1"
                     /gene_synonym="endocan"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2076..2081
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ESM1"
                     /gene_synonym="endocan"
                     /note="hexamer: AATAAA"
     polyA_site      2096
                     /gene="ESM1"
                     /gene_synonym="endocan"
                     /note="major polyA site"
ORIGIN      
        1 agctaccagt ttggacggct gcttcccacc agcaaagacc acgactggag agccgagccg
       61 gaggcagctg ggaaacatga agagcgtctt gctgctgacc acgctcctcg tgcctgcaca
      121 cctggtggcc gcctggagca ataattatgc ggtggactgc cctcaacact gtgacagcag
      181 tgagtgcaaa agcagcccgc gctgcaagag gacagtgctc gacgactgtg gctgctgccg
      241 agtgtgcgct gcagggcggg gagaaacttg ctaccgcaca gtctcaggca tggatggcat
      301 gaagtgtggc ccggggctga ggtgtcagcc ttctaatggg gaggatcctt ttggtgaaga
      361 gtttggtatc tgcaaagact gtccctacgg caccttcggg atggattgca gagagacctg
      421 caactgccag tcaggcatct gtgacagggg gacgggaaaa tgcctgaaat tccccttctt
      481 ccaatattca gtaaccaagt cttccaacag atttgtttct ctcacggagc atgacatggc
      541 atctggagat ggcaatattg tgagagaaga agttgtgaaa gagaatgctg ccgggtctcc
      601 cgtaatgagg aaatggttaa atccacgctg atcccggctg tgatttctga gagaaggctc
      661 tattttcgtg attgttcaac acacagccaa cattttagga actttctaga ttatagcata
      721 aggacatgta atttttgaag accaaatgtg atgcatggtg gatccagaaa acaaaaagta
      781 ggatacttac aatccataac atccatatga ctgaacactt gtatgtgttt gttaaatatt
      841 cgaatgcatg tagatttgtt aaatgtgtgt gtatagtaac actgaagaac taaaaatgca
      901 atttaggtaa tcttacgtgg agacaggtca accaaagagg gagctaggca aagctgaaga
      961 ccgcagtgag tcaaattagt tctttgactt tgatgtacat taatgttggg atatggaatg
     1021 aagacttaag agcaggagaa gatggggagg gggtgggagt gggaaataaa atatttagcc
     1081 cttccttggt aggtagcttc tctagaattt aattgtgctt tttttttttt ttttggcttt
     1141 gggaaaagtc aaaataaaac aaccagaaaa cccctgaagg aagtaagatg tttgaagctt
     1201 atggaaattt gagtaacaaa cagctttgaa ctgagagcaa tttcaaaagg ctgctgatgt
     1261 agttcccggg ttacctgtat ctgaaggacg gttctggggc ataggaaaca catacacttc
     1321 cataaatagc tttaacgtat gccacctcag agataaatct aagaagtatt ttacccactg
     1381 gtggtttgtg tgtgtatgaa ggtaaatatt tatatatttt tataaataaa tgtgttagtg
     1441 caagtcatct tccctaccca tatttatcat cctcttgagg aaagaaatct agtattattt
     1501 gttgaaaatg gttagaataa aactatgact ctataaggtt ttcaaacatc tgaggcatga
     1561 taaatttatt atccataatt atagtaataa taaccttaat aagcataaga aaaacagagt
     1621 cactctggat ttcaaaaatg tcaaaaaatg agcaacagag ggtccttatt taaacataag
     1681 tgctgtgact taggtgaatt ttcaatttaa ggtagaaaat aagtttttag gaggtttgta
     1741 aaagaagaat caattttcag cagaaaacat gtcaacttta aaatatagtt tattttcata
     1801 tttttttctt ttaaacttgg ttgataagtg gaattaggag tatatttgaa agaatcttag
     1861 cacaaacagg actgttgtac tagatgttct taggaaatat ctcagaagta ttttatttga
     1921 agtgaagaac ttatttaaga attatttcag tatttacctg tattttattc ttgaagttgg
     1981 ccaacagagt tgtgaatgtg tgtgggaagg cctttgaatg taaagctgca taagctgtta
     2041 ggttttgttt taaaaggaca tgtttattat tgttcaataa aaaagaacaa gataca
//
