LOCUS       NM_001276380            3188 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens ESF1 nucleolar pre-rRNA processing protein homolog
            (ESF1), transcript variant 2, mRNA.
ACCESSION   NM_001276380
VERSION     NM_001276380.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3188)
  AUTHORS   Deryabin,A., Moraleva,A., Dobrochaeva,K., Kovaleva,D., Rubtsova,M.,
            Dontsova,O. and Rubtsov,Y.
  TITLE     Human RPF1 and ESF1 in Pre-rRNA Processing and the Assembly of
            Pre-Ribosomal Particles: A Functional Study
  JOURNAL   Cells 13 (4), 326 (2024)
   PUBMED   38391939
  REMARK    GeneRIF: Human RPF1 and ESF1 in Pre-rRNA Processing and the
            Assembly of Pre-Ribosomal Particles: A Functional Study.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3188)
  AUTHORS   Benyamin,B., Pourcain,B., Davis,O.S., Davies,G., Hansell,N.K.,
            Brion,M.J., Kirkpatrick,R.M., Cents,R.A., Franic,S., Miller,M.B.,
            Haworth,C.M., Meaburn,E., Price,T.S., Evans,D.M., Timpson,N.,
            Kemp,J., Ring,S., McArdle,W., Medland,S.E., Yang,J., Harris,S.E.,
            Liewald,D.C., Scheet,P., Xiao,X., Hudziak,J.J., de Geus,E.J.,
            Jaddoe,V.W., Starr,J.M., Verhulst,F.C., Pennell,C., Tiemeier,H.,
            Iacono,W.G., Palmer,L.J., Montgomery,G.W., Martin,N.G.,
            Boomsma,D.I., Posthuma,D., McGue,M., Wright,M.J., Davey Smith,G.,
            Deary,I.J., Plomin,R. and Visscher,P.M.
  CONSRTM   Wellcome Trust Case Control Consortium 2 (WTCCC2)
  TITLE     Childhood intelligence is heritable, highly polygenic and
            associated with FNBP1L
  JOURNAL   Mol Psychiatry 19 (2), 253-258 (2014)
   PUBMED   23358156
REFERENCE   3  (bases 1 to 3188)
  AUTHORS   Pieragostino,D., Agnifili,L., Fasanella,V., D'Aguanno,S.,
            Mastropasqua,R., Di Ilio,C., Sacchetta,P., Urbani,A. and Del
            Boccio,P.
  TITLE     Shotgun proteomics reveals specific modulated protein patterns in
            tears of patients with primary open angle glaucoma naive to therapy
  JOURNAL   Mol Biosyst 9 (6), 1108-1116 (2013)
   PUBMED   23580065
REFERENCE   4  (bases 1 to 3188)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   5  (bases 1 to 3188)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   6  (bases 1 to 3188)
  AUTHORS   Nousiainen,M., Sillje,H.H., Sauer,G., Nigg,E.A. and Korner,R.
  TITLE     Phosphoproteome analysis of the human mitotic spindle
  JOURNAL   Proc Natl Acad Sci U S A 103 (14), 5391-5396 (2006)
   PUBMED   16565220
REFERENCE   7  (bases 1 to 3188)
  AUTHORS   Andersen,J.S., Lam,Y.W., Leung,A.K., Ong,S.E., Lyon,C.E.,
            Lamond,A.I. and Mann,M.
  TITLE     Nucleolar proteome dynamics
  JOURNAL   Nature 433 (7021), 77-83 (2005)
   PUBMED   15635413
REFERENCE   8  (bases 1 to 3188)
  AUTHORS   Oda,T., Fukuda,A., Hagiwara,H., Masuho,Y., Muramatsu,M.A.,
            Hisatake,K. and Yamashita,T.
  TITLE     ABT1-associated protein (ABTAP), a novel nuclear protein conserved
            from yeast to mammals, represses transcriptional activation by ABT1
  JOURNAL   J Cell Biochem 93 (4), 788-806 (2004)
   PUBMED   15660422
  REMARK    GeneRIF: The Rattus rattus ABT1-associated protein formed a complex
            with ABT1 and suppressed activation of Pol II-directed
            transcription in mammalian cells. It binds and negatively regulates
            ABT1.
REFERENCE   9  (bases 1 to 3188)
  AUTHORS   Beausoleil,S.A., Jedrychowski,M., Schwartz,D., Elias,J.E.,
            Villen,J., Li,J., Cohn,M.A., Cantley,L.C. and Gygi,S.P.
  TITLE     Large-scale characterization of HeLa cell nuclear phosphoproteins
  JOURNAL   Proc Natl Acad Sci U S A 101 (33), 12130-12135 (2004)
   PUBMED   15302935
REFERENCE   10 (bases 1 to 3188)
  AUTHORS   Deloukas,P., Matthews,L.H., Ashurst,J., Burton,J., Gilbert,J.G.,
            Jones,M., Stavrides,G., Almeida,J.P., Babbage,A.K., Bagguley,C.L.,
            Bailey,J., Barlow,K.F., Bates,K.N., Beard,L.M., Beare,D.M.,
            Beasley,O.P., Bird,C.P., Blakey,S.E., Bridgeman,A.M., Brown,A.J.,
            Buck,D., Burrill,W., Butler,A.P., Carder,C., Carter,N.P.,
            Chapman,J.C., Clamp,M., Clark,G., Clark,L.N., Clark,S.Y.,
            Clee,C.M., Clegg,S., Cobley,V.E., Collier,R.E., Connor,R.,
            Corby,N.R., Coulson,A., Coville,G.J., Deadman,R., Dhami,P.,
            Dunn,M., Ellington,A.G., Frankland,J.A., Fraser,A., French,L.,
            Garner,P., Grafham,D.V., Griffiths,C., Griffiths,M.N., Gwilliam,R.,
            Hall,R.E., Hammond,S., Harley,J.L., Heath,P.D., Ho,S., Holden,J.L.,
            Howden,P.J., Huckle,E., Hunt,A.R., Hunt,S.E., Jekosch,K.,
            Johnson,C.M., Johnson,D., Kay,M.P., Kimberley,A.M., King,A.,
            Knights,A., Laird,G.K., Lawlor,S., Lehvaslaiho,M.H., Leversha,M.,
            Lloyd,C., Lloyd,D.M., Lovell,J.D., Marsh,V.L., Martin,S.L.,
            McConnachie,L.J., McLay,K., McMurray,A.A., Milne,S., Mistry,D.,
            Moore,M.J., Mullikin,J.C., Nickerson,T., Oliver,K., Parker,A.,
            Patel,R., Pearce,T.A., Peck,A.I., Phillimore,B.J.,
            Prathalingam,S.R., Plumb,R.W., Ramsay,H., Rice,C.M., Ross,M.T.,
            Scott,C.E., Sehra,H.K., Shownkeen,R., Sims,S., Skuce,C.D.,
            Smith,M.L., Soderlund,C., Steward,C.A., Sulston,J.E., Swann,M.,
            Sycamore,N., Taylor,R., Tee,L., Thomas,D.W., Thorpe,A., Tracey,A.,
            Tromans,A.C., Vaudin,M., Wall,M., Wallis,J.M., Whitehead,S.L.,
            Whittaker,P., Willey,D.L., Williams,L., Williams,S.A., Wilming,L.,
            Wray,P.W., Hubbard,T., Durbin,R.M., Bentley,D.R., Beck,S. and
            Rogers,J.
  TITLE     The DNA sequence and comparative analysis of human chromosome 20
  JOURNAL   Nature 414 (6866), 865-871 (2001)
   PUBMED   11780052
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA472223.1, AK000375.1, AK074299.1 and AL161659.17.
            
            On Aug 13, 2020 this sequence version replaced NM_001276380.1.
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Variants 1 and 2 both encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR18074969.1425318.1,
                                           SRR1660805.65018.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000617257.2/ ENSP00000480783.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-308               DA472223.1         15-322
            309-499             AK000375.1         334-524
            500-764             AK000375.1         526-790
            765-1183            AK074299.1         276-694
            1184-1502           AK000375.1         1210-1528
            1503-1731           AK074299.1         1014-1242
            1732-2121           AK000375.1         1758-2147
            2122-2552           AK074299.1         1633-2063
            2553-3188           AL161659.17        24666-25301         c
FEATURES             Location/Qualifiers
     source          1..3188
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20p12.1"
     gene            1..3188
                     /gene="ESF1"
                     /gene_synonym="ABTAP; bA526K24.1; C20orf6; HDCMC28P"
                     /note="ESF1 nucleolar pre-rRNA processing protein homolog"
                     /db_xref="GeneID:51575"
                     /db_xref="HGNC:HGNC:15898"
                     /db_xref="MIM:618765"
     exon            1..40
                     /gene="ESF1"
                     /gene_synonym="ABTAP; bA526K24.1; C20orf6; HDCMC28P"
                     /inference="alignment:Splign:2.1.0"
     exon            41..720
                     /gene="ESF1"
                     /gene_synonym="ABTAP; bA526K24.1; C20orf6; HDCMC28P"
                     /inference="alignment:Splign:2.1.0"
     CDS             84..2639
                     /gene="ESF1"
                     /gene_synonym="ABTAP; bA526K24.1; C20orf6; HDCMC28P"
                     /note="ABT1-associated protein"
                     /codon_start=1
                     /product="ESF1 homolog"
                     /protein_id="NP_001263309.1"
                     /db_xref="CCDS:CCDS13117.1"
                     /db_xref="GeneID:51575"
                     /db_xref="HGNC:HGNC:15898"
                     /db_xref="MIM:618765"
                     /translation="MSSKQEIMSDQRFRRVAKDPRFWEMPEKDRKVKIDKRFRAMFHD
                     KKFKLNYAVDKRGRPISHSTTEDLKRFYDLSDSDSNLSGEDSKALSQKKIKKKKTQTK
                     KEIDSKNLVEKKKETKKANHKGSENKTDLDNSIGIKKMKTSCKFKIDSNISPKKDSKE
                     FTQKNKKEKKNIVQHTTDSSLEEKQRTLDSGTSEIVKSPRIECSKTRREMQSVVQLIM
                     TRDSDGYENSTDGEMCDKDALEEDSESVSEIGSDEESENEITSVGRASGDDDGSEDDE
                     EEDEDEEEDEDEDSEDDDKSDSGPDLARGKGNIETSSEDEDDTADLFPEESGFEHAWR
                     ELDKDAPRADEITRRLAVCNMDWDRLKAKDLLALFNSFKPKGGVIFSVKIYPSEFGKE
                     RMKEEQVQGPVELLSIPEDAPEKDWTSREKLRDYQFKRLKYYYAVVDCDSPETASKIY
                     EDCDGLEFESSCSFIDLRFIPDDITFDDEPKDVASEVNLTAYKPKYFTSAAMGTSTVE
                     ITWDETDHERITMLNRKFKKEELLDMDFQAYLASSSEDEEEIEEELQGDDGVNVEEDG
                     KTKKSQKDDEEQIAKYRQLLQVIQEKEKKGKENDMEMEIKWVPGLKESAEEMVKNKLE
                     GKDKLTPWEQFLEKKKEKKRLKRKQKALAEEASEEELPSDVDLNDPYFAEEVKQIGIN
                     KKSVKSAKDGTSPEEEIEIERQKAEMALLMMDEDEDSKKHFNYNKIVEHQNLSKKKKK
                     QLMKKKELIEDDFEVNVNDARFQAMYTSHLFNLDPSDPNFKKTKAMEKILEEKARQRE
                     RKEQELTQAIKKKESEIEKESQRKSIDPALSMLIKSIKTKTEQFQARKKQKVK"
     exon            721..1118
                     /gene="ESF1"
                     /gene_synonym="ABTAP; bA526K24.1; C20orf6; HDCMC28P"
                     /inference="alignment:Splign:2.1.0"
     exon            1119..1232
                     /gene="ESF1"
                     /gene_synonym="ABTAP; bA526K24.1; C20orf6; HDCMC28P"
                     /inference="alignment:Splign:2.1.0"
     exon            1233..1333
                     /gene="ESF1"
                     /gene_synonym="ABTAP; bA526K24.1; C20orf6; HDCMC28P"
                     /inference="alignment:Splign:2.1.0"
     exon            1334..1486
                     /gene="ESF1"
                     /gene_synonym="ABTAP; bA526K24.1; C20orf6; HDCMC28P"
                     /inference="alignment:Splign:2.1.0"
     exon            1487..1601
                     /gene="ESF1"
                     /gene_synonym="ABTAP; bA526K24.1; C20orf6; HDCMC28P"
                     /inference="alignment:Splign:2.1.0"
     exon            1602..1749
                     /gene="ESF1"
                     /gene_synonym="ABTAP; bA526K24.1; C20orf6; HDCMC28P"
                     /inference="alignment:Splign:2.1.0"
     exon            1750..1911
                     /gene="ESF1"
                     /gene_synonym="ABTAP; bA526K24.1; C20orf6; HDCMC28P"
                     /inference="alignment:Splign:2.1.0"
     exon            1912..2033
                     /gene="ESF1"
                     /gene_synonym="ABTAP; bA526K24.1; C20orf6; HDCMC28P"
                     /inference="alignment:Splign:2.1.0"
     exon            2034..2121
                     /gene="ESF1"
                     /gene_synonym="ABTAP; bA526K24.1; C20orf6; HDCMC28P"
                     /inference="alignment:Splign:2.1.0"
     exon            2122..2198
                     /gene="ESF1"
                     /gene_synonym="ABTAP; bA526K24.1; C20orf6; HDCMC28P"
                     /inference="alignment:Splign:2.1.0"
     exon            2199..2345
                     /gene="ESF1"
                     /gene_synonym="ABTAP; bA526K24.1; C20orf6; HDCMC28P"
                     /inference="alignment:Splign:2.1.0"
     exon            2346..3188
                     /gene="ESF1"
                     /gene_synonym="ABTAP; bA526K24.1; C20orf6; HDCMC28P"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3166..3171
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ESF1"
                     /gene_synonym="ABTAP; bA526K24.1; C20orf6; HDCMC28P"
                     /note="hexamer: AATAAA"
     polyA_site      3188
                     /gene="ESF1"
                     /gene_synonym="ABTAP; bA526K24.1; C20orf6; HDCMC28P"
                     /note="major polyA site"
ORIGIN      
        1 gggtgtgagc cccacgtgag gcttggtagg actgcggacg tatttgtttt cttcaagcat
       61 ttggtcgaga ttaagaatta aaaatgtcat ccaaacaaga aataatgagt gaccagcggt
      121 ttagacgggt tgcaaaggac ccgagatttt gggaaatgcc agaaaaggat cgaaaagtca
      181 aaattgacaa gagatttcga gccatgtttc atgacaagaa gttcaagttg aactatgccg
      241 tggataaaag agggcgcccc attagccata gcactacaga ggatttgaag cgtttttacg
      301 acctttcaga ttctgattcc aatctctctg gtgaagatag caaagcattg agtcaaaaga
      361 aaataaagaa gaaaaaaacc cagactaaaa aagaaatcga ttcaaaaaat ctagttgaga
      421 aaaagaaaga aaccaagaag gctaatcaca agggttctga aaataaaact gatttagata
      481 attctatagg aattaaaaaa atgaaaacct catgtaaatt taagatagat tcaaacataa
      541 gtccgaagaa ggatagcaaa gaatttacac aaaaaaataa gaaagagaaa aaaaacattg
      601 ttcaacatac tacagactct tctctcgaag aaaaacaaag gacattagac tcaggcacct
      661 ctgaaattgt gaaatctccc agaatcgagt gttctaagac aagaagagaa atgcaatcag
      721 tggttcaact cataatgaca agagacagtg atggttatga aaactcaaca gatggtgaaa
      781 tgtgtgacaa agatgctctg gaggaagatt cagaaagcgt tagtgaaata ggaagtgatg
      841 aggaatctga aaatgaaatt acaagtgttg gtagagcttc aggtgatgac gatggaagtg
      901 aagatgatga agaggaggat gaagatgaag aggaggatga agatgaggat agtgaggatg
      961 atgataaaag tgacagtggc cctgatcttg caaggggtaa aggaaatata gaaactagtt
     1021 ctgaagatga agatgatacg gcagatttgt ttccagaaga atctggtttt gagcatgctt
     1081 ggagagaatt agataaagat gctcctcgtg ctgatgagat tacacgtcga ttagcagttt
     1141 gtaacatgga ctgggataga ttaaaggcaa aagatttgct ggctctgttc aattcattta
     1201 aacccaaagg aggtgtaata ttttccgtca agatatatcc ttcagaattt ggaaaggaga
     1261 ggatgaagga agagcaagtt caaggaccag tagagctatt aagtattcct gaagatgccc
     1321 cagaaaaaga ctggacgtct agagaaaaat tgagagatta tcaattcaaa cgactgaagt
     1381 actattatgc agtagtagac tgtgattctc cggaaacagc tagtaaaatt tatgaggatt
     1441 gtgatggcct ggaatttgaa agtagttgtt ctttcataga tctaaggttt ataccagatg
     1501 atattacttt tgatgatgag cctaaggatg tagcctcaga agtgaattta acagcatata
     1561 aaccaaaata tttcacttct gctgcaatgg gaacatcaac ggtggaaatc acttgggatg
     1621 agactgatca tgaaagaatt acaatgctca acaggaagtt taaaaaggaa gagcttttgg
     1681 acatggattt tcaagcctac ttagcttcct ctagtgaaga tgaagaggag atagaagagg
     1741 agctacaagg tgatgatgga gtcaatgtag aagaagatgg gaaaacaaag aaaagtcaga
     1801 aggatgatga agaacaaatt gctaaataca ggcagctctt gcaggttatt caagaaaaag
     1861 aaaagaaagg caaagaaaat gatatggaaa tggaaattaa atgggttcca ggtcttaaag
     1921 aaagtgcaga agagatggtc aaaaacaaat tggaaggaaa ggataaactg accccttggg
     1981 aacaattttt agagaagaag aaagagaaaa aaagactgaa aaggaaacag aaggctcttg
     2041 ctgaagaggc cagtgaagag gaacttccct ctgatgttga tttgaatgac ccatactttg
     2101 ctgaagaagt taaacaaata ggtataaata aaaaatcggt aaaatctgca aaagatggca
     2161 catctccaga agaagaaatt gaaatagaaa gacaaaaggc tgaaatggct ttgcttatga
     2221 tggatgagga cgaggacagt aagaaacact tcaattacaa caagattgtg gagcaccaga
     2281 atctgagcaa aaagaagaaa aagcagctca tgaaaaagaa ggaattaata gaggatgact
     2341 ttgaggtaaa tgttaacgat gcacggtttc aggcaatgta cacttcccac ttgttcaatt
     2401 tggacccctc agatcccaat ttcaagaaaa caaaagctat ggaaaaaatc cttgaggaga
     2461 aggcccggca aagagaacgg aaagaacaag aacttactca ggcaataaag aaaaaagaga
     2521 gtgagattga aaaggaatca caaaggaagt ccattgatcc tgctttgtca atgttgatta
     2581 aatctataaa aaccaaaaca gagcagtttc aagcaagaaa aaagcaaaaa gtcaaataac
     2641 tggatgttac ttatttttga actgaataca tcttttccta aaatgtacaa aaataatagg
     2701 agggaatatt tattgggaac aaagctatct ttcaagaaca tgaataaaat ctttttctgg
     2761 acatagtaaa atttttctcc ataaataatt gtacttaatt gtggatgact gacaaatttt
     2821 tattgtatat tcctacagat cagtcataat taaattacct gcattatagg gtttataaaa
     2881 tttttatatt ttacaatgtt cagttctaac tagtggaaag ttactctagc tttttaaaag
     2941 gctgtttaca attctgtgta aaaatagagc agtatctact caagtttgtg taaatgttag
     3001 ggataatttg aaaaatatat atatttaata cattaatttc tctggaagca ggaggcatgt
     3061 ttaaataact attaaaataa tttatttttc tagccataaa ggatggaagt caagaacttt
     3121 ttgttgttta gtcatgttaa gtatagttta tgaaattaac ttgtaaataa aagtgtaaaa
     3181 tattttca
//
