LOCUS       NM_052911               4488 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens establishment of sister chromatid cohesion
            N-acetyltransferase 1 (ESCO1), mRNA.
ACCESSION   NM_052911 XM_056302
VERSION     NM_052911.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4488)
  AUTHORS   Ajam,T., De,I., Petkau,N., Whelan,G., Pena,V. and Eichele,G.
  TITLE     Alternative catalytic residues in the active site of Esco
            acetyltransferases
  JOURNAL   Sci Rep 10 (1), 9828 (2020)
   PUBMED   32555289
  REMARK    GeneRIF: Alternative catalytic residues in the active site of Esco
            acetyltransferases.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4488)
  AUTHORS   Wutz,G., Ladurner,R., St Hilaire,B.G., Stocsits,R.R., Nagasaka,K.,
            Pignard,B., Sanborn,A., Tang,W., Varnai,C., Ivanov,M.P.,
            Schoenfelder,S., van der Lelij,P., Huang,X., Durnberger,G.,
            Roitinger,E., Mechtler,K., Davidson,I.F., Fraser,P.,
            Lieberman-Aiden,E. and Peters,J.M.
  TITLE     ESCO1 and CTCF enable formation of long chromatin loops by
            protecting cohesinSTAG1 from WAPL
  JOURNAL   Elife 9, e52091 (2020)
   PUBMED   32065581
  REMARK    GeneRIF: ESCO1 and CTCF enable formation of long chromatin loops by
            protecting cohesin(STAG1) from WAPL.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4488)
  AUTHORS   Faramarz,A., Balk,J.A., van Schie,J.J.M., Oostra,A.B.,
            Ghandour,C.A., Rooimans,M.A., Wolthuis,R.M.F. and de Lange,J.
  TITLE     Non-redundant roles in sister chromatid cohesion of the DNA
            helicase DDX11 and the SMC3 acetyl transferases ESCO1 and ESCO2
  JOURNAL   PLoS One 15 (1), e0220348 (2020)
   PUBMED   31935221
  REMARK    GeneRIF: DDX11, ESCO1 and ESCO2 control different fractions of
            cohesin that are spatially and mechanistically separated.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4488)
  AUTHORS   Alomer,R.M., da Silva,E.M.L., Chen,J., Piekarz,K.M., McDonald,K.,
            Sansam,C.G., Sansam,C.L. and Rankin,S.
  TITLE     Esco1 and Esco2 regulate distinct cohesin functions during cell
            cycle progression
  JOURNAL   Proc Natl Acad Sci U S A 114 (37), 9906-9911 (2017)
   PUBMED   28847955
  REMARK    GeneRIF: Data indicate that Esco1 and Esco2 contribute to distinct
            and separable activities of cohesin in vertebrate cells.
REFERENCE   5  (bases 1 to 4488)
  AUTHORS   Rivera-Colon,Y., Maguire,A., Liszczak,G.P., Olia,A.S. and
            Marmorstein,R.
  TITLE     Molecular Basis for Cohesin Acetylation by Establishment of Sister
            Chromatid Cohesion N-Acetyltransferase ESCO1
  JOURNAL   J Biol Chem 291 (51), 26468-26477 (2016)
   PUBMED   27803161
  REMARK    GeneRIF: these studies reveal the molecular basis for SMC3
            acetylation by ESCO1 and have broader implications for
            understanding the structure/function of non-histone
            acetyltransferases.
REFERENCE   6  (bases 1 to 4488)
  AUTHORS   Enjuanes,A., Benavente,Y., Bosch,F., Martin-Guerrero,I.,
            Colomer,D., Perez-Alvarez,S., Reina,O., Ardanaz,M.T., Jares,P.,
            Garcia-Orad,A., Pujana,M.A., Montserrat,E., de Sanjose,S. and
            Campo,E.
  TITLE     Genetic variants in apoptosis and immunoregulation-related genes
            are associated with risk of chronic lymphocytic leukemia
  JOURNAL   Cancer Res 68 (24), 10178-10186 (2008)
   PUBMED   19074885
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 4488)
  AUTHORS   Zhang,J., Shi,X., Li,Y., Kim,B.J., Jia,J., Huang,Z., Yang,T.,
            Fu,X., Jung,S.Y., Wang,Y., Zhang,P., Kim,S.T., Pan,X. and Qin,J.
  TITLE     Acetylation of Smc3 by Eco1 is required for S phase sister
            chromatid cohesion in both human and yeast
  JOURNAL   Mol Cell 31 (1), 143-151 (2008)
   PUBMED   18614053
  REMARK    GeneRIF: This study identified a molecular target for the
            acetyltransferase Eco1 and revealed that Smc3 acetylation is a
            conserved mechanism in regulating sister chromatid cohesion.
REFERENCE   8  (bases 1 to 4488)
  AUTHORS   Hou,F. and Zou,H.
  TITLE     Two human orthologues of Eco1/Ctf7 acetyltransferases are both
            required for proper sister-chromatid cohesion
  JOURNAL   Mol Biol Cell 16 (8), 3908-3918 (2005)
   PUBMED   15958495
  REMARK    GeneRIF: EFO1 and EFO2 are targeted to different chromosome
            structures to help establish or maintain sister-chromatid cohesion
REFERENCE   9  (bases 1 to 4488)
  AUTHORS   Bellows,A.M., Kenna,M.A., Cassimeris,L. and Skibbens,R.V.
  TITLE     Human EFO1p exhibits acetyltransferase activity and is a unique
            combination of linker histone and Ctf7p/Eco1p chromatid cohesion
            establishment domains
  JOURNAL   Nucleic Acids Res 31 (21), 6334-6343 (2003)
   PUBMED   14576321
  REMARK    GeneRIF: identification of the first full-length human ortholog of
            yeast Ctf7p and characterization of its enzymatic activity,
            localization and novel genetic composition
REFERENCE   10 (bases 1 to 4488)
  AUTHORS   Fallone,C.A.
  TITLE     Epidemiology of the antibiotic resistance of Helicobacter pylori in
            Canada
  JOURNAL   Can J Gastroenterol 14 (10), 879-882 (2000)
   PUBMED   11111111
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BG492713.1, AB067498.1, BC089426.1, AK096746.1 and AC011774.9.
            
            On Nov 22, 2018 this sequence version replaced NM_052911.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803615.252007.1,
                                           SRR1660803.110398.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000269214.10/ ENSP00000269214.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-36                BG492713.1         52-87
            37-2056             AB067498.1         1-2020
            2057-2216           BC089426.1         1505-1664
            2217-2263           AK096746.1         2247-2293
            2264-4471           AB067498.1         2228-4435
            4472-4488           AC011774.9         72725-72741
FEATURES             Location/Qualifiers
     source          1..4488
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="18"
                     /map="18q11.2"
     gene            1..4488
                     /gene="ESCO1"
                     /gene_synonym="A930014I12Rik; CTF; ECO1; EFO1; ESO1"
                     /note="establishment of sister chromatid cohesion
                     N-acetyltransferase 1"
                     /db_xref="GeneID:114799"
                     /db_xref="HGNC:HGNC:24645"
                     /db_xref="MIM:609674"
     exon            1..82
                     /gene="ESCO1"
                     /gene_synonym="A930014I12Rik; CTF; ECO1; EFO1; ESO1"
                     /inference="alignment:Splign:2.1.0"
     exon            83..213
                     /gene="ESCO1"
                     /gene_synonym="A930014I12Rik; CTF; ECO1; EFO1; ESO1"
                     /inference="alignment:Splign:2.1.0"
     exon            214..319
                     /gene="ESCO1"
                     /gene_synonym="A930014I12Rik; CTF; ECO1; EFO1; ESO1"
                     /inference="alignment:Splign:2.1.0"
     exon            320..2436
                     /gene="ESCO1"
                     /gene_synonym="A930014I12Rik; CTF; ECO1; EFO1; ESO1"
                     /inference="alignment:Splign:2.1.0"
     CDS             907..3429
                     /gene="ESCO1"
                     /gene_synonym="A930014I12Rik; CTF; ECO1; EFO1; ESO1"
                     /note="establishment of cohesion 1 homolog 1; EFO1p;
                     hEFO1; CTF7 homolog 1; ECO1 homolog 1; ESO1 homolog 1;
                     establishment factor-like protein 1"
                     /codon_start=1
                     /product="N-acetyltransferase ESCO1"
                     /protein_id="NP_443143.2"
                     /db_xref="CCDS:CCDS32800.1"
                     /db_xref="GeneID:114799"
                     /db_xref="HGNC:HGNC:24645"
                     /db_xref="MIM:609674"
                     /translation="MMSIQEKSKENSSKVTKKSDDKNSETEIQDSQKNLAKKSGPKET
                     IKSQAKSSSESKINQPELETRMSTRSSKAASNDKATKSINKNTVTVRGYSQESTKKKL
                     SQKKLVHENPKANEQLNRRSQRLQQLTEVSRRSLRSREIQGQVQAVKQSLPPTKKEQC
                     SSTQSKSNKTSQKHVKRKVLEVKSDSKEDENLVINEVINSPKGKKRKVEHQTACACSS
                     QCTQGSEKCPQKTTRRDETKPVPVTSEVKRSKMATSVVPKKNEMKKSVHTQVNTNTTL
                     PKSPQPSVPEQSDNELEQAGKSKRGSILQLCEEIAGEIESDNVEVKKESSQMESVKEE
                     KPTEIKLEETSVERQILHQKETNQDVQCNRFFPSRKTKPVKCILNGINSSAKKNSNWT
                     KIKLSKFNSVQHNKLDSQVSPKLGLLRTSFSPPALEMHHPVTQSTFLGTKLHDRNITC
                     QQEKMKEINSEEVKINDITVEINKTTERAPENCHLANEIKPSDPPLDNQMKHSFDSAS
                     NKNFSQCLESKLENSPVENVTAASTLLSQAKIDTGENKFPGSAPQQHSILSNQTSKSS
                     DNRETPRNHSLPKCNSHLEITIPKDLKLKEAEKTDEKQLIIDAGQKRFGAVSCNVCGM
                     LYTASNPEDETQHLLFHNQFISAVKYVGWKKERILAEYPDGRIIMVLPEDPKYALKKV
                     DEIREMVDNDLGFQQAPLMCYSRTKTLLFISNDKKVVGCLIAEHIQWGYRVIEEKLPV
                     IRSEEEKVRFERQKAWCCSTLPEPAICGISRIWVFSMMRRKKIASRMIECLRSNFIYG
                     SYLSKEEIAFSDPTPDGKLFATQYCGTGQFLVYNFINGQNST"
     exon            2437..2551
                     /gene="ESCO1"
                     /gene_synonym="A930014I12Rik; CTF; ECO1; EFO1; ESO1"
                     /inference="alignment:Splign:2.1.0"
     exon            2552..2612
                     /gene="ESCO1"
                     /gene_synonym="A930014I12Rik; CTF; ECO1; EFO1; ESO1"
                     /inference="alignment:Splign:2.1.0"
     exon            2613..2727
                     /gene="ESCO1"
                     /gene_synonym="A930014I12Rik; CTF; ECO1; EFO1; ESO1"
                     /inference="alignment:Splign:2.1.0"
     exon            2728..2859
                     /gene="ESCO1"
                     /gene_synonym="A930014I12Rik; CTF; ECO1; EFO1; ESO1"
                     /inference="alignment:Splign:2.1.0"
     exon            2860..2949
                     /gene="ESCO1"
                     /gene_synonym="A930014I12Rik; CTF; ECO1; EFO1; ESO1"
                     /inference="alignment:Splign:2.1.0"
     exon            2950..3093
                     /gene="ESCO1"
                     /gene_synonym="A930014I12Rik; CTF; ECO1; EFO1; ESO1"
                     /inference="alignment:Splign:2.1.0"
     exon            3094..3281
                     /gene="ESCO1"
                     /gene_synonym="A930014I12Rik; CTF; ECO1; EFO1; ESO1"
                     /inference="alignment:Splign:2.1.0"
     exon            3282..4488
                     /gene="ESCO1"
                     /gene_synonym="A930014I12Rik; CTF; ECO1; EFO1; ESO1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4442..4447
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ESCO1"
                     /gene_synonym="A930014I12Rik; CTF; ECO1; EFO1; ESO1"
                     /note="hexamer: AATAAA"
     polyA_site      4488
                     /gene="ESCO1"
                     /gene_synonym="A930014I12Rik; CTF; ECO1; EFO1; ESO1"
ORIGIN      
        1 agaagcagct gagtgtctcc tgatacccgg atgtgaggcg atccgctggc gctagtctga
       61 ccctccgcca ggcaaaagga agattgtctt tggctataga gttttttttt ttaaagatta
      121 ctaaacatac aggaagtgat aagaagtatc attcatcaga agcatcattc atcaatcaac
      181 ttgaagaaaa aggtgatata ttatttcttt aaggtgctgt gtgatgtgtt aagagcatat
      241 tagaaggaat ggttttgtct aattttcttc atgagttatg gtggctgaga catcgagtct
      301 atattttggg gcaaaaacta aacggcagca caaaaggaaa tctatattaa tagaatattt
      361 tgttgaacaa aggaggttag ataagaactg caaaccaaca gactcagcaa acaaggaaag
      421 aaacgtgtta gccataagac atgtttcaag tgaatcgaag tccaataact gtagacttca
      481 gaagaaaaaa gttttcaaaa attttatcaa aacaggtcac tgataaataa ctcctccagt
      541 aatagagcta ggcctgaaac caaaattaat taaaaaatta acaaaacaga ttgaacctga
      601 attaaatttc ttttgataaa aaaacttatt aaaaataatc aaaattttcc tcaaattttt
      661 attaccttgt ccaaagtaaa gcaagtgtct tttagcattc atgccagctt ttctcatgtt
      721 ctaggaatga cagaaacctt acttgaagca aactagtatt tttgttgaaa atgtatatca
      781 gcatcagtta aagttgattt ttcagacctg ctcctcagta ataatactag ctagtcagca
      841 ttcacgccta ccaggacaca aaaatcctct tcaaaactac tcagaaaaga aagtcattac
      901 tcaggaatga tgtccattca ggagaaatca aaagagaatt cctccaaagt tactaaaaaa
      961 agtgacgata agaattcaga aacagaaatt caggattctc aaaagaatct agcaaaaaaa
     1021 tcaggtccaa aggagactat aaaatcacag gctaaatctt ccagtgaaag taaaataaat
     1081 cagccagaat tggaaacacg catgagtaca aggtcatcaa aggcagcatc taatgataaa
     1141 gctactaaat ccattaataa aaatacggtg actgtgaggg gatattcaca agaatctaca
     1201 aaaaagaaat tatctcagaa aaaattagta catgaaaacc ctaaagcaaa tgaacagctt
     1261 aaccggagat cacaaaggct acaacaatta acagaggttt caagaaggtc gttacgcagt
     1321 agagaaattc agggtcaagt tcaagcagtt aaacagagtt tgccaccaac taaaaaagag
     1381 cagtgtagca gtactcagag taaatctaat aaaacaagtc aaaaacatgt gaagagaaaa
     1441 gtactggaag taaagtctga ctctaaagaa gatgaaaatc tagtaattaa tgaagtaata
     1501 aattctccca aagggaaaaa acgcaaggta gaacatcaga cagcttgtgc ttgtagttct
     1561 caatgcacgc aaggatctga aaagtgtcct cagaagacta ctagaagaga cgaaacgaaa
     1621 cctgtgcctg taacttctga ggtgaaaaga tcaaaaatgg ctacttcagt ggtcccgaaa
     1681 aagaatgaga tgaagaagtc ggttcataca caagtgaata ctaacacaac actcccaaaa
     1741 agtccacagc catcagtgcc tgaacaaagt gataatgagc tggagcaagc aggaaagagc
     1801 aaacgaggta gtattctcca gctctgtgaa gaaattgctg gtgaaattga gtcagataat
     1861 gtagaggtaa aaaaggaatc ttcacaaatg gaaagtgtaa aggaagaaaa gcccacagaa
     1921 ataaaattgg aagagaccag tgttgaaaga caaatacttc atcagaagga aacaaatcag
     1981 gatgtgcaat gtaatcgttt tttcccaagt agaaaaacaa agcctgtgaa atgtatacta
     2041 aatggaataa acagctcagc caagaagaac tccaactgga ctaaaattaa actctcaaaa
     2101 tttaactctg tgcagcacaa taagttggac tctcaagttt cccctaaatt aggcttatta
     2161 cgaaccagtt tttcaccacc agctttagaa atgcatcatc cagtgactca aagtacgttt
     2221 ttagggacaa agctacatga tagaaatata acttgccagc aggaaaaaat gaaagaaatt
     2281 aattctgaag aagtgaaaat taatgatatt acagtagaaa ttaataaaac cacagaaagg
     2341 gctcctgaaa attgtcattt ggccaatgag ataaaacctt ctgacccacc attggataat
     2401 cagatgaaac attcttttga ttcagcatca aataagaatt tcagccaatg tttggaatcc
     2461 aagctagaaa acagtccagt ggaaaatgtt actgctgctt cgactctgct cagtcaagca
     2521 aaaattgata caggagagaa taaatttcca ggttcagctc cccaacagca tagtattctc
     2581 agtaaccaga catctaaaag cagtgataac agggagacac cacgaaatca ttctttgcct
     2641 aagtgtaatt cccatttgga gataacaatt ccaaaggact tgaaactaaa agaagcagag
     2701 aaaactgatg aaaaacagtt gattatagat gcaggacaaa aaagatttgg agcagtttct
     2761 tgtaatgttt gtggaatgct gtatacagct tcaaatccag aagatgaaac acagcatctg
     2821 cttttccaca accagtttat aagtgctgtt aaatatgtgg gctggaagaa agaaagaatt
     2881 ctggctgaat accctgatgg caggataata atggttcttc ctgaagaccc aaagtatgcc
     2941 ctgaaaaagg ttgacgagat tagagagatg gttgacaatg atttaggttt tcaacaggct
     3001 ccactaatgt gctattccag aactaaaaca cttctcttca tttccaatga caaaaaagta
     3061 gttggctgcc taattgcgga acatatccaa tggggctaca gagttataga agagaaactt
     3121 ccagttatca ggtcagaaga agaaaaagtc agatttgaaa ggcaaaaagc ctggtgctgc
     3181 tcaacattac cagagcctgc aatctgcggg atcagtcgaa tatgggtatt cagcatgatg
     3241 cgtcggaaga aaattgcttc tcgcatgatt gaatgcctaa ggagtaactt tatatatggc
     3301 tcatatttga gcaaagaaga aattgctttc tcagatccca ctcctgatgg aaagctgttt
     3361 gcaacacagt actgtggcac tggtcaattt ctggtatata attttattaa tggacagaat
     3421 agcacgtaaa acaaattctt gcctacacca ctagaagaca tctattgaag agaatggatt
     3481 ggttgctgac tttaaccagg aactagggcc atttttatta caatgaactc aggactggca
     3541 acaaccatat ggttgttcca ttttcataaa attggaaaca atgcagtaat agcttattgt
     3601 tttgtttttt aaagaagata ttttattatc ttttacagaa atttatgatt gatgtatttt
     3661 atctatagtt atttagacat gtttacatgc agcagataat tgttcatagt ggactgaaaa
     3721 ctaatgcaag gactatggtc tcagtgataa gtatattttg aagttcttaa tatggaaata
     3781 taccagtgta gcttggtact gtattttttt atattgatct gctgatacca gtgataggct
     3841 taaagattgt attttcacag agtggaaacc aattttttta gttattgttc aaggagggtg
     3901 caatattaag tgttttggaa tttgaagcta atttttaaaa ggcctgaact atactttgaa
     3961 gaaaccccta tagaaaagga aagctccagc taaataggaa gaattagaat attgagcttt
     4021 tttttcctga tttttctctt tcctatcttt gatggaagga ggaagtagaa agtggtaaag
     4081 aattgaggct ttccttcttg gagagctgta aatgacaagc attaggaaag gtaccctcct
     4141 agattcatta ttctttcatt ctggtttcac ttttaaaata aatggcaact tggcacacct
     4201 aggctgttaa caaatctcaa agaggtttat aaaaacgtat agaatacttg gaagcaaagt
     4261 atggatgact cggtatctgc tttgttattc ctcagaaata ctgcactgag tatatgccct
     4321 cattactgga cttcattttg atacttgtct atccttcata gtgccctcta cttttaaagg
     4381 gtttatatgt tgaaaaactg ctgtggcctt ttatgacctg tatataatgt agaataaaaa
     4441 taataaaata cttgatagct ttttctaagt gaccaatgta ctaactga
//
