LOCUS       NM_001191055            3033 bp    mRNA    linear   PRI 03-AUG-2024
DEFINITION  Homo sapiens endogenous retrovirus group V member 2, envelope
            (ERVV-2), mRNA.
ACCESSION   NM_001191055
VERSION     NM_001191055.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3033)
  AUTHORS   Pramono,D., Sugimoto,K., Kimura,T., Miyake,A. and Nishigaki,K.
  TITLE     Characterization of the endogenous retrovirus-derived
            placenta-specific soluble protein EnvV-Fca from domestic cats
  JOURNAL   FEBS Lett 598 (14), 1792-1806 (2024)
   PUBMED   38604984
REFERENCE   2  (bases 1 to 3033)
  AUTHORS   Roberts,R.M., Ezashi,T., Schulz,L.C., Sugimoto,J., Schust,D.J.,
            Khan,T. and Zhou,J.
  TITLE     Syncytins expressed in human placental trophoblast
  JOURNAL   Placenta 113, 8-14 (2021)
   PUBMED   33504453
  REMARK    Review article
REFERENCE   3  (bases 1 to 3033)
  AUTHORS   Esnault,C., Cornelis,G., Heidmann,O. and Heidmann,T.
  TITLE     Differential evolutionary fate of an ancestral primate endogenous
            retrovirus envelope gene, the EnvV syncytin, captured for a
            function in placentation
  JOURNAL   PLoS Genet 9 (3), e1003400 (2013)
   PUBMED   23555306
REFERENCE   4  (bases 1 to 3033)
  AUTHORS   Strissel,P.L., Ruebner,M., Thiel,F., Wachter,D., Ekici,A.B.,
            Wolf,F., Thieme,F., Ruprecht,K., Beckmann,M.W. and Strick,R.
  TITLE     Reactivation of codogenic endogenous retroviral (ERV) envelope
            genes in human endometrial carcinoma and prestages: Emergence of
            new molecular targets
  JOURNAL   Oncotarget 3 (10), 1204-1219 (2012)
   PUBMED   23085571
REFERENCE   5  (bases 1 to 3033)
  AUTHORS   Vargas,A., Thiery,M., Lafond,J. and Barbeau,B.
  TITLE     Transcriptional and functional studies of Human Endogenous
            Retrovirus envelope EnvP(b) and EnvV genes in human trophoblasts
  JOURNAL   Virology 425 (1), 1-10 (2012)
   PUBMED   22277806
REFERENCE   6  (bases 1 to 3033)
  AUTHORS   Mayer,J., Blomberg,J. and Seal,R.L.
  TITLE     A revised nomenclature for transcribed human endogenous retroviral
            loci
  JOURNAL   Mob DNA 2 (1), 7 (2011)
   PUBMED   21542922
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 3033)
  AUTHORS   Kjeldbjerg,A.L., Villesen,P., Aagaard,L. and Pedersen,F.S.
  TITLE     Gene conversion and purifying selection of a placenta-specific
            ERV-V envelope gene during simian evolution
  JOURNAL   BMC Evol Biol 8, 266 (2008)
   PUBMED   18826608
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 3033)
  AUTHORS   Blaise,S., de Parseval,N. and Heidmann,T.
  TITLE     Functional characterization of two newly identified Human
            Endogenous Retrovirus coding envelope genes
  JOURNAL   Retrovirology 2, 19 (2005)
   PUBMED   15766379
  REMARK    Publication Status: Online-Only
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA863698.1 and AC010328.4.
            
            On May 17, 2019 this sequence version replaced NM_001191055.1.
            
            Summary: Many different human endogenous retrovirus (HERV) families
            are expressed in normal placental tissue at high levels, suggesting
            that HERVs are functionally important in reproduction. This gene is
            part of an HERV provirus on human chromosome 19 that has
            inactivating mutations in the gag and pol genes. This envelope
            glycoprotein gene appears to have been selectively preserved. The
            gene's protein product is expressed in the placenta and acts as a
            syncytin in Old World monkeys, but has lost the fusogenic activity
            in humans and other primate lineages. [provided by RefSeq, Jun
            2015].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA2142853,
                              SAMEA2144120 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            endogenous retrovirus  :: PMID: 23555306
            MANE Ensembl match     :: ENST00000601417.3/ ENSP00000472919.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-571               DA863698.1         3-573
            572-3033            AC010328.4         94521-96982         c
FEATURES             Location/Qualifiers
     source          1..3033
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.41"
     gene            1..3033
                     /gene="ERVV-2"
                     /gene_synonym="ENVV2; HERV-V2"
                     /note="endogenous retrovirus group V member 2, envelope"
                     /db_xref="GeneID:100271846"
                     /db_xref="HGNC:HGNC:39051"
     exon            1..219
                     /gene="ERVV-2"
                     /gene_synonym="ENVV2; HERV-V2"
                     /inference="alignment:Splign:2.1.0"
     exon            220..3033
                     /gene="ERVV-2"
                     /gene_synonym="ENVV2; HERV-V2"
                     /inference="alignment:Splign:2.1.0"
     CDS             605..2212
                     /gene="ERVV-2"
                     /gene_synonym="ENVV2; HERV-V2"
                     /note="envelope glycoprotein ENVV2; endogenous retrovirus
                     group V, member 2; endogenous retrovirus HSV2;
                     HERV-V_19q13.41 provirus ancestral Env polyprotein 2;
                     envelope protein ENVV2; endogenous retrovirus group V
                     member 2 Env polyprotein; mac-syncytin-3"
                     /codon_start=1
                     /product="endogenous retrovirus group V member 2 Env
                     polyprotein precursor"
                     /protein_id="NP_001177984.1"
                     /db_xref="CCDS:CCDS59420.1"
                     /db_xref="GeneID:100271846"
                     /db_xref="HGNC:HGNC:39051"
                     /translation="MTEKFLFLYLSLLPMPLLSQAQWNENSLVSFSKIIASGNHLSNC
                     WICHNFITRSSSYQYILVRNFSLNLTFGSGIPEGQHKSVPLQVSLANSAHQVPCLDLT
                     PPFNQSSKTSFYFYNCSSLNQTCCPCPEGHCDRKNTSEEGFPSPTIHPMSFSPAGCHP
                     NLTHWCPAKQMNDYRDKSPQNRCAAWEGKELITWRVLYSLPKAHTVPTWPKSTVPLGG
                     PLSPACNQTIPAGWKSQLHKWFDSHIPRWACTPPGYVFLCGPQKNKLPFDGSPKITYS
                     TPPVANLYTCINNIQHTGECAVGLLGPRGIGVTIYNTTQPRQKRALGLILAGMGAAIG
                     MIAPWGGFTYHDVTLRNLSRQIDNIAKSTRDSISKLKASIDSLANVVMDNRLALDYLL
                     AEQGGVCAVINKSCCVYVNNSGAIEEDIKKIYDEATWLHDFGKGGASARAIWEAVKSA
                     LPSLNWFVPLLGPATVILLLFLFGPCFFNLLIKCVSSRIKQFHMKSPQMERYQLSVIG
                     GPSTYKHISPLDASGQRFRETMEEFSL"
     regulatory      3010..3015
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ERVV-2"
                     /gene_synonym="ENVV2; HERV-V2"
                     /note="hexamer: AATAAA"
     polyA_site      3033
                     /gene="ERVV-2"
                     /gene_synonym="ENVV2; HERV-V2"
                     /note="major polyA site"
ORIGIN      
        1 agactccttc ttttcaggag cccactcggt tctgtcgttc agggtgtcgc ttctttctga
       61 gctcctgtct ctttaaatga agggcattta ccctttaact ctttctgcgc atctcttgac
      121 tgaatccaag aagaccaaga accagaggac ttccacaccc ctctgggtaa catctggtgt
      181 tttcacctgg ttacctggtt acctcgcctg gttatccagc tatcaacatt tctggcatct
      241 ccagttggat acatcagtct caagtgaaac tgtgggaagg tcccgaagaa ccacagaaga
      301 acaacagaat tcagcacctg agcattcttg tgagccactg gagaacttaa aattccactt
      361 caagtgaaaa gataagtaaa gccttctctc tgttcaccca aaactaaagt caatctcagt
      421 acggggaatc ttggttgcgg tggcattggt tcttctcctt attttgaccc aactggcatg
      481 ccacctgaag tcccgataac agcctgattt ctcactaaac actccatcga accacttcat
      541 tatttgtctc tcctattttc agcactttcc ttttgctttc acaaagctta agggagaatc
      601 agctatgaca gagaaattcc ttttccttta tctttccctc cttcccatgc ccctactctc
      661 acaggcacag tggaatgaaa attcccttgt cagtttttcc aaaataattg cttcgggaaa
      721 ccatctaagc aactgttgga tctgccacaa cttcatcacc aggtcctcat cttaccaata
      781 tattttggta agaaattttt ctttaaacct aacatttggt tcaggaatcc ctgaaggcca
      841 acataaatct gttccgctcc aggtttcgct tgctaactca gcgcaccaag tcccctgcct
      901 ggatctcact ccacctttca atcaaagctc taaaacttct ttctatttct acaactgctc
      961 ttctctaaac caaacctgtt gtccatgccc tgaaggacac tgtgacagga agaacacctc
     1021 tgaggaggga ttccccagtc ccaccatcca tcccatgagc ttctccccag caggctgcca
     1081 ccctaacttg actcactggt gtccagctaa acaaatgaac gattatcgag acaagtcacc
     1141 ccaaaaccgc tgtgcagctt gggaaggaaa agagctaatc acatggaggg ttctatattc
     1201 gcttcccaag gcacacactg tccccacatg gccaaaatct actgttcccc tgggagggcc
     1261 tctatcccct gcatgcaatc aaactattcc agcagggtgg aaatcgcagt tacacaagtg
     1321 gttcgacagc cacatccccc ggtgggcctg tacccctcct ggctatgtat ttttatgtgg
     1381 gccacaaaaa aataaactgc cctttgatgg aagtcctaag ataacctatt caaccccccc
     1441 tgtggcaaac ctctacactt gcattaataa catccaacat acgggagaat gtgctgtggg
     1501 acttttggga ccacggggga taggtgtgac catttataac accacccaac ccagacagaa
     1561 aagagctctg ggtctaatac tggcagggat gggtgcggcc ataggaatga tcgccccatg
     1621 gggagggttc acttatcatg atgtcaccct cagaaatctc tccagacaaa tagacaacat
     1681 agctaagagt accagagata gcatctctaa actcaaggcc tccatagatt ctctagcaaa
     1741 tgtagtcatg gacaacagat tggccttaga ttacctctta gcagagcagg gtggagtctg
     1801 tgcagtgatc aataaatcct gttgcgttta tgtcaataac agtggggcga tagaggagga
     1861 tataaaaaag atctatgatg aggctacgtg gctccatgac tttggaaaag gaggtgcttc
     1921 agcaagggcc atctgggagg ctgtgaagtc tgccctcccc tccctcaact ggtttgtccc
     1981 tttactggga ccagcaacag ttatactctt acttttcctc tttggccctt gtttctttaa
     2041 tttactgatt aagtgtgtct cttctaggat aaagcaattt cacatgaagt ccccccaaat
     2101 ggaaagatat cagctatctg tcattggagg ccccagcacc tataagcaca tctccccctt
     2161 ggatgccagt gggcaaagat tccgggaaac tatggaggaa ttttctctct gagacagagc
     2221 aagagaggga gaccctgatg acttcttcgc cccatgtcag caggaagtag ttacagaaga
     2281 cccacgacgt ccttacaacc agagcttttc agggtctcca tctcttgagg agggaaatat
     2341 tagggtaggc aggtaggcag gcatgagcag gcaagagagc ccttgggaaa ggaatcttta
     2401 gaaacgcagc ccactgatag cttccttggt gatgctgccc acagacagtc agcacttctc
     2461 taataaccca tcctagaaca gccttttgct tttttttttt tttttttttt tttttttgag
     2521 acaagttctt gctctgtctc ccaggctgga gtacaatggt gcgatctcgg ctcactgcac
     2581 cctccacctc ccaggttcaa ttgattctcc tgtttcagcc tcctcagtag ctgggactac
     2641 aggcatgtgc cgccatgccc ggctaatttt gtatttttag tagagatggg gtttcaccat
     2701 gttggtcagg ctagtctcaa actcctgact tcaggtgatt cgctcgcctc ggcctcctaa
     2761 agtgctggga ttatagacgt gagccactgc gcctggctac tcagaacgct tctgaatggc
     2821 acattcatga aaaatcatgt aaggttctca taaaaacatc tgcccagcca ttagtaggag
     2881 tagacacgtc cttttgatca gcccgccctg ttctgtcttt ctgggtgtac tgttttgatg
     2941 actttaaaag ctcccataaa aactaaggca ctagcagctg gctcattctt ctgatgtcct
     3001 ctctttttaa ataaagctta cttaaccctt taa
//
