LOCUS       NM_152473               2203 bp    mRNA    linear   PRI 12-JUN-2024
DEFINITION  Homo sapiens endogenous retrovirus group V member 1, envelope
            (ERVV-1), mRNA.
ACCESSION   NM_152473
VERSION     NM_152473.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2203)
  AUTHORS   Roberts,R.M., Ezashi,T., Schulz,L.C., Sugimoto,J., Schust,D.J.,
            Khan,T. and Zhou,J.
  TITLE     Syncytins expressed in human placental trophoblast
  JOURNAL   Placenta 113, 8-14 (2021)
   PUBMED   33504453
  REMARK    Review article
REFERENCE   2  (bases 1 to 2203)
  AUTHORS   Esnault,C., Cornelis,G., Heidmann,O. and Heidmann,T.
  TITLE     Differential evolutionary fate of an ancestral primate endogenous
            retrovirus envelope gene, the EnvV syncytin, captured for a
            function in placentation
  JOURNAL   PLoS Genet 9 (3), e1003400 (2013)
   PUBMED   23555306
  REMARK    GeneRIF: In the Old World monkeys, we show that envV is both
            specifically expressed at the level of the placental
            syncytiotrophoblast and fusogenic.
REFERENCE   3  (bases 1 to 2203)
  AUTHORS   Strissel,P.L., Ruebner,M., Thiel,F., Wachter,D., Ekici,A.B.,
            Wolf,F., Thieme,F., Ruprecht,K., Beckmann,M.W. and Strick,R.
  TITLE     Reactivation of codogenic endogenous retroviral (ERV) envelope
            genes in human endometrial carcinoma and prestages: Emergence of
            new molecular targets
  JOURNAL   Oncotarget 3 (10), 1204-1219 (2012)
   PUBMED   23085571
REFERENCE   4  (bases 1 to 2203)
  AUTHORS   Mayer,J., Blomberg,J. and Seal,R.L.
  TITLE     A revised nomenclature for transcribed human endogenous retroviral
            loci
  JOURNAL   Mob DNA 2 (1), 7 (2011)
   PUBMED   21542922
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2203)
  AUTHORS   Kjeldbjerg,A.L., Villesen,P., Aagaard,L. and Pedersen,F.S.
  TITLE     Gene conversion and purifying selection of a placenta-specific
            ERV-V envelope gene during simian evolution
  JOURNAL   BMC Evol Biol 8, 266 (2008)
   PUBMED   18826608
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2203)
  AUTHORS   Colland,F., Jacq,X., Trouplin,V., Mougin,C., Groizeleau,C.,
            Hamburger,A., Meil,A., Wojcik,J., Legrain,P. and Gauthier,J.M.
  TITLE     Functional proteomics mapping of a human signaling pathway
  JOURNAL   Genome Res 14 (7), 1324-1332 (2004)
   PUBMED   15231748
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC010328.4.
            
            On Jan 8, 2021 this sequence version replaced NM_152473.2.
            
            Summary: Many different human endogenous retrovirus (HERV) families
            are expressed in normal placental tissue at high levels, suggesting
            that HERVs are functionally important in reproduction. This gene is
            part of an HERV provirus on human chromosome 19 that has
            inactivating mutations in the gag and pol genes. The gene's
            envelope protein is expressed in the human placenta but is
            truncated at its C-terminus. [provided by RefSeq, Oct 2015].
            
            Sequence Note: The RefSeq transcript was derived from the reference
            genome assembly. The genomic coordinates were determined from
            transcript alignments.
            
            ##RefSeq-Attributes-START##
            endogenous retrovirus  :: PMID: 23555306
            MANE Ensembl match     :: ENST00000602168.2/ ENSP00000473153.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2203              AC010328.4         130078-132280       c
FEATURES             Location/Qualifiers
     source          1..2203
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.41"
     gene            1..2203
                     /gene="ERVV-1"
                     /gene_synonym="ENVV1; HERV-V1"
                     /note="endogenous retrovirus group V member 1, envelope"
                     /db_xref="GeneID:147664"
                     /db_xref="HGNC:HGNC:26501"
     exon            1..2203
                     /gene="ERVV-1"
                     /gene_synonym="ENVV1; HERV-V1"
                     /inference="alignment:Splign:2.1.0"
     CDS             171..1604
                     /gene="ERVV-1"
                     /gene_synonym="ENVV1; HERV-V1"
                     /note="envelope glycoprotein ENVV1; envelope protein
                     ENVV1; endogenous retrovirus group V member 1 Env
                     polyprotein; endogenous retrovirus group V, member 2;
                     HERV-V_19q13.41 provirus ancestral Env polyprotein 1;
                     endogenous retrovirus group V, member 1"
                     /codon_start=1
                     /product="endogenous retrovirus group V member 1 Env
                     polyprotein precursor"
                     /protein_id="NP_689686.2"
                     /db_xref="CCDS:CCDS59419.1"
                     /db_xref="GeneID:147664"
                     /db_xref="HGNC:HGNC:26501"
                     /translation="MTEKFLFLYLSLLPMPLLSQAQWNENSLVSFSKIIASGNHLSNC
                     WICHNFITRSSSYQYILVRNFSLNLTFGSGIPEGQHKSVPLQVSLANSAHQVPCLDLT
                     PPFNQSSKTSFYFYNCSSLNQTCCPCPEGHCDRKNTSEEGFPSPTIHPMSFSPAGCHP
                     NLTHWCPAKQMNDYRDKSPQNRCAAWEGKELITWRVLYLLPKAHTVPTWPKSTVPLGG
                     PLSPACNQTIPAGWKSQLHKWFDSHIPRWACTPPGYVFLCGPQKNKLPFDGSPKITYS
                     TPPVANLYTCINNIQHTGECAVGLLGPRGIGVTIYNTTQPRQKRALGLILAGMGAAIG
                     MIAPWGGFTYHDVTLRNLSRQIDNIAKSTRDSISKLKASIDSLANVVMNNRLALDYLL
                     AEQGGVCAVISKSCCIYVNNSGAIEEDIKKIYDEVTWLHNFGKGDSAGSIWEAVKSAL
                     PSLTWFVPLLGPAALNSLLSPLWPLSL"
     regulatory      2154..2159
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ERVV-1"
                     /gene_synonym="ENVV1; HERV-V1"
                     /note="hexamer: AATAAT"
     polyA_site      2175
                     /gene="ERVV-1"
                     /gene_synonym="ENVV1; HERV-V1"
                     /note="major polyA site"
ORIGIN      
        1 tgcggtggca tcggttcttc tccttatttt gacccacact ggcatgccac ctgaagtccc
       61 gataacagcc tgatttctca ctaaacactc catcgaacca tttcattatt tgtctctcct
      121 attttcagca ctttcctttt gctttcacaa agcttaaggg agaatcagct atgacagaga
      181 aattcctttt cctttatctt tccctccttc ccatgcccct actctcacag gcacagtgga
      241 atgaaaattc ccttgtcagt ttttccaaaa taattgcttc gggaaaccat ctaagcaact
      301 gttggatctg ccacaacttc atcaccaggt cctcatctta ccaatatatt ttggtaagaa
      361 atttttcttt aaacctaaca tttggttcag gaatccctga aggccaacat aaatctgttc
      421 cgctccaggt ttcgcttgct aactcagcgc accaagtccc ctgcctggat ctcactccac
      481 ctttcaatca aagctctaaa acttctttct atttctacaa ctgctcttct ctaaaccaaa
      541 cctgttgtcc atgccctgaa ggacactgtg acaggaagaa cacctctgag gagggattcc
      601 ccagtcccac catccatccc atgagcttct ccccagcagg ctgccaccct aacttgactc
      661 actggtgtcc agctaaacaa atgaacgatt atcgagacaa gtcaccccaa aaccgctgtg
      721 cagcttggga aggaaaagag ctaatcacat ggagggttct atatttgctt cccaaggcac
      781 acactgtccc cacatggcca aaatctactg ttcccctggg agggcctcta tcccctgcat
      841 gcaatcaaac tattccagca gggtggaaat cgcagttaca caagtggttc gacagccaca
      901 tcccccggtg ggcctgtacc cctcctggct atgtattttt atgtgggcca caaaaaaata
      961 aactgccctt tgatggaagt cctaagataa cttattcaac cccccctgtg gcaaacctct
     1021 acacttgcat taataacatc caacatacgg gagaatgtgc tgtgggactt ttgggaccac
     1081 gggggatagg tgtgaccatt tataacacca cccaacccag acagaaaaga gctctgggtc
     1141 taatactggc agggatgggt gcggccatag gaatgatcgc cccatgggga gggttcactt
     1201 atcatgatgt caccctcaga aatctctcca gacaaataga caacatagct aagagtacca
     1261 gagatagcat ctctaaactc aaggcctcca tagattctct agcaaatgta gtcatgaaca
     1321 acagattggc cttagattac ctcttagcag agcagggtgg agtctgtgca gtgatcagta
     1381 aatcctgttg catttatgtc aataacagtg gggcgataga ggaggatata aaaaagatct
     1441 atgatgaggt tacgtggctc cataactttg gaaaaggtga ttcagcaggg tccatttggg
     1501 aggctgtgaa gtctgccctc ccctccctca catggtttgt ccctttactg ggaccagctg
     1561 cacttaatag cctgctttct cctctttggc ccttgtctct ataattcact aattaaatat
     1621 gtctcttcca ggatatggca atttcacaca gagcccctaa aaatggaaag agatcatcca
     1681 atcttccttg gaggtcccag cacctacaag tacatatctc ccttggatgc cagtgggcaa
     1741 agattctgca actacggagg ggctccttcc ctgacagaga gcaagagagg gagaccctga
     1801 tgacttcttc gtcccacgtc agcaggaagt agttacagaa gacccacgac gtccttatgc
     1861 ccaaagcttt tcagggtctc caactcttga gggggaatac tgttagggta ggcaggtagc
     1921 cagacaagag caggcaagga agcccctggg aaaggaatct ttagaaatgc agcccgctga
     1981 tggcctcctt ggaaacgctg cacgctgagt cagcaaaagg aggagcgtgg ctacactggc
     2041 tacacctggc cttgtggctg cattcctctg ttccagaagg gaacttatca aggcccagcc
     2101 agaggttacc aaggtaggag ctattcccca ctaagaagca tgtatacttc tctaataatt
     2161 caccctaata taccattttg ttcattaaaa taataaaaaa aac
//
