LOCUS       NM_001242690            3614 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens endogenous retrovirus group MER34 member 1, envelope
            (ERVMER34-1), transcript variant 2, mRNA.
ACCESSION   NM_001242690 XM_002342451 XM_003119926 XM_003120436
VERSION     NM_001242690.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3614)
  AUTHORS   Kasperek,A., Beguin,A., Bawa,O., De Azevedo,K., Job,B., Massard,C.,
            Scoazec,J.Y., Heidmann,T. and Heidmann,O.
  TITLE     Therapeutic potential of the human endogenous retroviral envelope
            protein HEMO: a pan-cancer analysis
  JOURNAL   Mol Oncol 16 (7), 1451-1473 (2022)
   PUBMED   34318590
REFERENCE   2  (bases 1 to 3614)
  AUTHORS   Roberts,R.M., Ezashi,T., Schulz,L.C., Sugimoto,J., Schust,D.J.,
            Khan,T. and Zhou,J.
  TITLE     Syncytins expressed in human placental trophoblast
  JOURNAL   Placenta 113, 8-14 (2021)
   PUBMED   33504453
  REMARK    Review article
REFERENCE   3  (bases 1 to 3614)
  AUTHORS   Heidmann,O., Beguin,A., Paternina,J., Berthier,R., Deloger,M.,
            Bawa,O. and Heidmann,T.
  TITLE     HEMO, an ancestral endogenous retroviral envelope protein shed in
            the blood of pregnant women and expressed in pluripotent stem cells
            and tumors
  JOURNAL   Proc Natl Acad Sci U S A 114 (32), E6642-E6651 (2017)
   PUBMED   28739914
REFERENCE   4  (bases 1 to 3614)
  AUTHORS   Tsuritani,K., Irie,T., Yamashita,R., Sakakibara,Y., Wakaguri,H.,
            Kanai,A., Mizushima-Sugano,J., Sugano,S., Nakai,K. and Suzuki,Y.
  TITLE     Distinct class of putative 'non-conserved' promoters in humans:
            comparative studies of alternative promoters of human and mouse
            genes
  JOURNAL   Genome Res 17 (7), 1005-1014 (2007)
   PUBMED   17567985
REFERENCE   5  (bases 1 to 3614)
  AUTHORS   Wan,D., Gong,Y., Qin,W., Zhang,P., Li,J., Wei,L., Zhou,X., Li,H.,
            Qiu,X., Zhong,F., He,L., Yu,J., Yao,G., Jiang,H., Qian,L., Yu,Y.,
            Shu,H., Chen,X., Xu,H., Guo,M., Pan,Z., Chen,Y., Ge,C., Yang,S. and
            Gu,J.
  TITLE     Large-scale cDNA transfection screening for genes related to cancer
            development and progression
  JOURNAL   Proc Natl Acad Sci U S A 101 (44), 15724-15729 (2004)
   PUBMED   15498874
  REMARK    Erratum:[Proc Natl Acad Sci U S A. 2004 Dec 14:101(50):17565]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA633167.1, AC104066.3 and AY189288.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001242690.1.
            
            Transcript Variant: This variant (2) lacks an alternate exon in the
            5' UTR, compared to variant 1. Both variants 1 and 2 encode the
            same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DA442578.1, DA633167.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000443173.6/ ENSP00000460602.1
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-308               DA633167.1         216-523
            309-2345            AC104066.3         81628-83664         c
            2346-2650           AY189288.1         2441-2745
            2651-3614           AC104066.3         80359-81322         c
FEATURES             Location/Qualifiers
     source          1..3614
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q12"
     gene            1..3614
                     /gene="ERVMER34-1"
                     /gene_synonym="envMER34; HEMO"
                     /note="endogenous retrovirus group MER34 member 1,
                     envelope"
                     /db_xref="GeneID:100288413"
                     /db_xref="HGNC:HGNC:42970"
     exon            1..83
                     /gene="ERVMER34-1"
                     /gene_synonym="envMER34; HEMO"
                     /inference="alignment:Splign:2.1.0"
     exon            84..223
                     /gene="ERVMER34-1"
                     /gene_synonym="envMER34; HEMO"
                     /inference="alignment:Splign:2.1.0"
     exon            224..3614
                     /gene="ERVMER34-1"
                     /gene_synonym="envMER34; HEMO"
                     /inference="alignment:Splign:2.1.0"
     CDS             647..2338
                     /gene="ERVMER34-1"
                     /gene_synonym="envMER34; HEMO"
                     /note="LP9056 protein; HERV-MER_4q12 provirus ancestral
                     Env polyprotein; endogenous retrovirus group MER34 member
                     1 Env polyprotein; endogenous retrovirus group MER34,
                     member 1; endogenous MER34
                     (medium-reiteration-frequency-family-34) ORF; human
                     endogenous MER34 ORF; endogenous retroviral envelope
                     protein HEMO; Human Endogenous
                     MEdium-Reiteration-frequency-family-34 ORF"
                     /codon_start=1
                     /product="endogenous retroviral envelope protein HEMO
                     precursor"
                     /protein_id="NP_001229619.1"
                     /db_xref="GeneID:100288413"
                     /db_xref="HGNC:HGNC:42970"
                     /translation="MGSLSNYALLQLTLTAFLTILVQPQHLLAPVFRTLSILTNQSNC
                     WLCEHLDNAEQPELVFVPASASTWWTYSGQWMYERVWYPQAEVQNHSTSSYRKVTWHW
                     EASMEAQGLSFAQVRLLEGNFSLCVENKNGSGPFLGNIPKQYCNQILWFDSTDGTFMP
                     SIDVTNESRNDDDDTSVCLGTRQCSWFAGCTNRTWNSSAVPLIGLPNTQDYKWVDRNS
                     GLTWSGNDTCLYSCQNQTKGLLYQLFRNLFCSYGLTEAHGKWRCADASITNDKGHDGH
                     RTPTWWLTGSNLTLSVNNSGLFFLCGNGVYKGFPPKWSGRCGLGYLVPSLTRYLTLNA
                     SQITNLRSFIHKVTPHRCTQGDTDNPPLYCNPKDNSTIRALFPSLGTYDLEKAILNIS
                     KAMEQEFSATKQTLEAHQSKVSSLASASRKDHVLDIPTTQRQTACGTVGKQCCLYINY
                     SEEIKSNIQRLHEASENLKNVPLLDWQGIFAKVGDWFRSWGYVLLIVLFCLFIFVLIY
                     VRVFRKSRRSLNSQPLNLALSPQQSAQLLVSETSCQVSNRAMKGLTTHQYDTSLL"
     regulatory      2622..2627
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ERVMER34-1"
                     /gene_synonym="envMER34; HEMO"
                     /note="hexamer: AATAAA"
     polyA_site      2650
                     /gene="ERVMER34-1"
                     /gene_synonym="envMER34; HEMO"
                     /note="major polyA site"
     regulatory      2843..2848
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ERVMER34-1"
                     /gene_synonym="envMER34; HEMO"
                     /note="hexamer: AATAAA"
     polyA_site      2864
                     /gene="ERVMER34-1"
                     /gene_synonym="envMER34; HEMO"
     regulatory      3592..3597
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ERVMER34-1"
                     /gene_synonym="envMER34; HEMO"
                     /note="hexamer: AATAAA"
     polyA_site      3614
                     /gene="ERVMER34-1"
                     /gene_synonym="envMER34; HEMO"
ORIGIN      
        1 acttcagttc ccgccgcgag ccttcttctt ggtcttctgg cctggcggcg atcgtcggcc
       61 agtttatccc tcggagttgc actggcagac acgccgctac tttgtagcgg gtttcgggcg
      121 ggccacgcgt gcggcgacag gaacccaacc ccggccgacc ttgggctcca ggaattcgtt
      181 gtctacgtct gcggaggtgc ggcagcctca gttttaagcg caggtgatca agtatatctg
      241 aaagttttta gaagaaaaga tgtgttgtaa cctccctgga aaaagaagag accttatgaa
      301 gtactgctaa ccacctacat agtcatcaaa ataaaattcc tgaatttgta caagccacag
      361 gaagctagat tgagatcatt atatgacaac tggaaggcca aggctatggg ttacctcaaa
      421 ttgaggaatt ttggcaccta ctcacaggct ccatgagcag atgaagtaga cagctttact
      481 cagtatctca gaccaagaac ttcatctcca tctccaacta gctgaaacat cttccctcct
      541 caacctggaa aattctctga cttagaaatt taaacaaaac cctccccttt cattgaatct
      601 ccattgtctg gagtttgctt gttttaatct agcctgttcc tccactatgg gctccctttc
      661 aaactatgcc ctgcttcaac taacccttac tgcttttttg acaattctag tacaacctca
      721 gcacctgctt gctccagttt tccggacact atctatcttg actaatcagt ctaattgctg
      781 gttatgtgaa catctagata atgcagaaca acccgaacta gtttttgttc ctgccagtgc
      841 aagcacctgg tggacctatt ctggacaatg gatgtatgaa agggtgtggt atccacaagc
      901 agaagtacag aatcactcta cttcctccta tcgtaaagtg acttggcact gggaagcctc
      961 catggaagct caaggtctat cctttgctca agtaaggtta ttggagggaa atttttctct
     1021 ttgcgtagaa aataaaaatg gcagtggacc cttcctaggt aatataccta aacaatactg
     1081 taatcaaata ctatggtttg attctacaga tggcaccttc atgccctcta tagatgttac
     1141 aaatgaatcc aggaacgatg atgatgatac aagtgtttgc ctaggcacta gacaatgttc
     1201 ctggtttgca ggttgcacaa accggacctg gaacagctca gctgttccct tgattggtct
     1261 gcccaatacc caagactaca aatgggtaga tcgaaattct ggattgacct ggtcaggtaa
     1321 tgacacctgt ctctatagct gccaaaacca aaccaaaggc cttctgtacc agctatttcg
     1381 caacctattt tgctcttatg gcctgacaga ggcacatggg aaatggagat gtgcagatgc
     1441 cagcataact aatgacaaag gtcatgatgg acaccggacc cccacctggt ggctcacagg
     1501 ttccaatctg accttgtctg tgaacaactc tggcctcttt tttttgtgcg gcaatggggt
     1561 gtacaaaggg tttccaccta aatggtctgg gcgatgtgga cttgggtatc ttgtaccttc
     1621 cctcaccaga tacctcacct taaatgctag ccaaattaca aacctgagat ccttcattca
     1681 taaagtaaca ccgcatagat gcacccaagg agacacagac aatccacctc tgtattgcaa
     1741 ccccaaggac aattcaacaa taagggccct ttttccaagt ttgggaactt atgatttaga
     1801 aaaggcaatt ctaaacattt ccaaagcaat ggaacaggaa ttcagtgcca ctaagcagac
     1861 cttggaagca caccaatcaa aagttagcag tttagcctct gcatcccgaa aggatcatgt
     1921 cttggatata ccgaccaccc aacgacaaac ggcttgtgga actgttggca aacagtgttg
     1981 cctctatata aattattcgg aagaaataaa gtctaatata cagcgtctcc acgaagcatc
     2041 cgagaacctg aagaatgtac cgttacttga ttggcaaggc atatttgcaa aagtgggaga
     2101 ctggttcaga tcatggggct atgtgctttt aattgttctt ttctgcttat tcatctttgt
     2161 tttaatctat gttcgtgtct ttcgcaaatc tcgcagatcc cttaactccc aacctctgaa
     2221 cctagcctta tctccacagc aatcagcaca gctccttgtc agtgaaactt catgtcaagt
     2281 ttcaaatagg gcaatgaagg gactaacaac ccatcaatat gacacaagtc tactttgaga
     2341 atatctgaac aaacagcagc tgcagacaaa aagccttagc taaactttga tgagtaaagc
     2401 aggtcttacc gagaattcag ctgccaaaac cctcctctga gtgttcctct tataagggca
     2461 cttagcacta ggacctccca aggtattgta aataagcctt atcagaactt tttgtagttt
     2521 cattctgaag ccttaagaca cacaccataa agctgatctg taaaccctta ccccttgctg
     2581 ttcagagagc tactctttgt agtgttcttg catgcatata taataaatgt tttttctatt
     2641 gatctgttaa tttgcaagcc cccaaacact ggaactaagt tgggggcagg atagtttctc
     2701 ccaacagcac tttgtaggct tctggataga ccaaagagtg tgtttgaata gataagggaa
     2761 ttttgttccc ttgattttgg ttgaaggtag aagaatccaa tgtacacata cacaaaacta
     2821 tgtccttaaa tttgtctcaa agaataaata ttgggtagtc atcagaattg actgaaaact
     2881 tactttaggg agaaagccac aaataattta ggctggtatg atctgagctt tcctgatttc
     2941 ccatgggcat tttagtggtc taatggaata ttagtctgat atgcatttta gccatcttat
     3001 gaaatgggcc gcaggtggaa gtaggatgca gggagtgttg aggtggcatc tattatatca
     3061 aatgcttcac tctgcccagt cctctggtga gttccttaca tgcatctttc tagttaatcc
     3121 tctcggtgtt catattttac agattaatca actcaaaggg tagatagctt gctaaagatt
     3181 atactattac tgaaaaatag caagatgcag aacagcatac ctagtatgtt actctttttt
     3241 tttttttttt gaggcagagt ctggcccttt cacccaggct ggagtgcagt ggctcaatct
     3301 cggctcactg caacctctgc ccccttgggt tcatgccatt ctcctgcctc cctcctgagt
     3361 agctgggact acaggcgcct gccaccacgc ctgactaatt ttttgtgttt ttagtagaga
     3421 cggggtttca ccgtgttagc caggatggtc tcagtctcct gacctcatga cccgcccacc
     3481 tcaacctccc aaagtcctag gattataggt gtgagccact gcacccagcc tcgtatgtta
     3541 ctttttattt taaaaaaggg gaaatgatat gtatatgtgt atgtatttgc aaataaaaca
     3601 ggaaaagcca ttca
//
