LOCUS       NM_001396080            2560 bp    mRNA    linear   PRI 29-OCT-2022
DEFINITION  Homo sapiens endogenous retrovirus group K3 member 1 (ERVK3-1),
            mRNA.
ACCESSION   NM_001396080
VERSION     NM_001396080.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2560)
  AUTHORS   Grandi N, Pisano MP, Scognamiglio S, Pessiu E and Tramontano E.
  TITLE     Comprehensive Analysis of HERV Transcriptome in HIV+ Cells: Absence
            of HML2 Activation and General Downregulation of Individual HERV
            Loci
  JOURNAL   Viruses 12 (4), E481 (2020)
   PUBMED   32340287
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2560)
  AUTHORS   Pisano MP, Grandi N, Cadeddu M, Blomberg J and Tramontano E.
  TITLE     Comprehensive Characterization of the Human Endogenous Retrovirus
            HERV-K(HML-6) Group: Overview of Structure, Phylogeny, and
            Contribution to the Human Genome
  JOURNAL   J Virol 93 (16), e00110-19 (2019)
   PUBMED   31167914
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2560)
  AUTHORS   Mayer J, Blomberg J and Seal RL.
  TITLE     A revised nomenclature for transcribed human endogenous retroviral
            loci
  JOURNAL   Mob DNA 2 (1), 7 (2011)
   PUBMED   21542922
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2560)
  AUTHORS   Seifarth W, Frank O, Zeilfelder U, Spiess B, Greenwood AD, Hehlmann
            R and Leib-Mosch C.
  TITLE     Comprehensive analysis of human endogenous retrovirus
            transcriptional activity in human tissues with a
            retrovirus-specific microarray
  JOURNAL   J Virol 79 (1), 341-352 (2005)
   PUBMED   15596828
REFERENCE   5  (bases 1 to 2560)
  AUTHORS   Okahara G, Matsubara S, Oda T, Sugimoto J, Jinno Y and Kanaya F.
  TITLE     Expression analyses of human endogenous retroviruses (HERVs):
            tissue-specific and developmental stage-dependent expression of
            HERVs
  JOURNAL   Genomics 84 (6), 982-990 (2004)
   PUBMED   15533715
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC020915.6 and AC010642.5.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK054868.1, SRR1660803.229317.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000413518.6/ ENSP00000489018.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-69                AC020915.6         152711-152779
            70-198              AC020915.6         153422-153550
            199-495             AC020915.6         159500-159796
            496-2560            AC010642.5         10688-12752
FEATURES             Location/Qualifiers
     source          1..2560
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.43"
     gene            1..2560
                     /gene="ERVK3-1"
                     /note="endogenous retrovirus group K3 member 1"
                     /db_xref="GeneID:105372481"
                     /db_xref="HGNC:HGNC:30466"
     exon            1..69
                     /gene="ERVK3-1"
                     /inference="alignment:Splign:2.1.0"
     exon            70..198
                     /gene="ERVK3-1"
                     /inference="alignment:Splign:2.1.0"
     exon            199..495
                     /gene="ERVK3-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             202..531
                     /gene="ERVK3-1"
                     /note="HERV-K(HML6-1)"
                     /codon_start=1
                     /product="endogenous retrovirus group K3 member 1"
                     /protein_id="NP_001383009.1"
                     /db_xref="CCDS:CCDS92702.1"
                     /db_xref="GeneID:105372481"
                     /db_xref="HGNC:HGNC:30466"
                     /translation="MDKPCGCPPGVCDHGTGDRRDPWYSTVGLLPPVRAMSQRNLNAK
                     TEQGPTGVTMTSNPITWGQIKKTTQEAEKLLERQGQAKTPDSMFLAMLAVVSCASIGS
                     GEPPTGN"
     exon            496..2560
                     /gene="ERVK3-1"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      952
                     /gene="ERVK3-1"
                     /note="major polyA site"
     regulatory      1375..1380
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ERVK3-1"
                     /note="hexamer: TATAAA"
     polyA_site      1401
                     /gene="ERVK3-1"
     regulatory      2537..2542
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ERVK3-1"
                     /note="hexamer: AATAAA"
     polyA_site      2560
                     /gene="ERVK3-1"
ORIGIN      
        1 agtgtgtaag acgctcacgg gcgcgcggac tatcgggcgg ctaggctctc tgaggaggct
       61 gccacagtga agcaaccgtg acaagtggtg cccgaccagg gacctgaacg aggaaggtct
      121 gccagagcag agaaagtgaa actgatcaga cgaactacga acccctggac gggagagtct
      181 gccggcggag aatataagga gatggacaaa ccgtgtgggt gccctccagg tgtgtgtgac
      241 catggaacgg gagaccggag ggatccatgg tattcaaccg tgggcctgtt acctccagta
      301 cgagccatga gccagcggaa tctgaatgca aagacagaac aagggccgac cggagtcaca
      361 atgacatcca accccataac atggggacag atcaagaaaa cgacacaaga agctgagaaa
      421 ctactggagc gccagggtca ggcaaaaacc cctgactcca tgttcttggc catgctagct
      481 gtagtgtcct gtgcgtctat aggatcgggt gaaccaccaa ccggcaattg aaagctgcac
      541 agcctgaaat tacctttatt caattaatgc aaaaacaaaa ggggagatgt tggaggccga
      601 aggaatgagg gtcgtgacca actcagtata ccactggagg ctctgtgagc aaacagcaaa
      661 ctgttctcat gaaagcagga tgttggcgaa ctgacaaact ctgtctgccg ccagaaggaa
      721 tgctgggggc agtcatgtcc caggtcccgt gctccttgag gttatccaca ggaacatcca
      781 gaacctgttg aacaaagaaa ggaatcatgt gggcctgtgt taaatcaaat agctgaccga
      841 cagttatccc ttcctcccta ttcactctac ctaataaata tgaagggctg taaaagctca
      901 ggtccctgtt ccctaatatc aaggagcccc ctgacccctt ctttcaaaca gatccttttg
      961 tctgtctcat ttctgcattc gtcgtccttc gttcggtcca gaagcaaccg cgacagtcct
     1021 gcatgtgttg atgccacctg tatgtgcagg tgtgacctca ggtgtgtgag tatccctcat
     1081 accccttatc atcactgcct attcgctctt cctccagcct ctggcaacca ctaatccacg
     1141 ttatatgtct agatttgcct cttctggaca cttcatataa atggagtcat acaatatgtg
     1201 gtttcttgtg tctggctttt taccactgaa cgttttcaga gttcatccat gttgtagcat
     1261 gtatcagttt ttcattcctc tttatggctg aataatactg cattgtatgg atataccaca
     1321 gtttgtttac tcattagttc atagacattg gggttgtttc caactctctg atattataaa
     1381 tgctactgct gtgaaaattc atgtacaggt gtttgtgtgg atgtatattt ttaatttggg
     1441 aaggggaggc catgggtggg acctaggctt gtgaagagcc tggcctgggt gtatctgttt
     1501 gtccgaggag tgcctgtatg catggccatg accacaccca ctccttgctg cctgtgctca
     1561 ttagccatac ttcattttcc agaatcccag gcctgggccc ctgaagtcaa agccaggagc
     1621 ctagagccac actgatgtgt aggatcaaag agaaggcggc agtggccctg gaaacaaacc
     1681 tgtctctgca agagtcacta gcaacctggg acctctgccc aggactgaga cctcgggtgc
     1741 cccctaccct gtagctgctg aggccaagca atgtggagac agagagaggg tgaggtgatg
     1801 gagcctgagg tgccgagtga ggtagatggt ggggtggcag tcacagtggc acaggaggca
     1861 ggtacagggc tagatgtttt cagaaaccag atatccctct aaaacacacc ctgcttctgc
     1921 tgccttcatt ccactgccct gccttcctca gcctgctcta caccactacc tcctcatggt
     1981 tctcctgcct cccgttgccc ccttcatcac tctccactca gcattgggta gagagggtct
     2041 tttacccctg actgatgagg ccacccctct ctttaaaccc tccatcactg cccaggccat
     2101 cagagtatgg ttggcaaact cttctgtaaa acacaagcag caggctgggc gcagtggctc
     2161 atgcctgtaa tcccagcatt ttgggaggct gaggcaggcc tgaggttggg cctatgagac
     2221 cagcctggcc aacatggtga aaccctgtct ctactaaaaa tacaaaaaat tagctgggcg
     2281 tggtgatgca tgcctgtaat cccagctact cgggaggctg aggcaggtga atcgcttgtt
     2341 cccaggacat agagattgtg gtgagccaag atcgtgcctt tgcactccag cctgggcaac
     2401 gagcgaaact ctgtctcaaa aaccaaacaa aaaacacaca agcagcaaat gtcagctttg
     2461 taggctcaga gagaaaacca agaatgttac aaaggtacct atctaacaag agaaaaacat
     2521 gtccatacat tttattaata aaatccaaaa ctttgttaaa
//
