LOCUS       NM_001348050            8196 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens ERV3-1-ZNF117 readthrough (ERV3-1-ZNF117), mRNA.
ACCESSION   NM_001348050
VERSION     NM_001348050.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8196)
  AUTHORS   Bellefroid,E.J., Poncelet,D.A., Lecocq,P.J., Revelant,O. and
            Martial,J.A.
  TITLE     The evolutionarily conserved Kruppel-associated box domain defines
            a subfamily of eukaryotic multifingered proteins
  JOURNAL   Proc Natl Acad Sci U S A 88 (9), 3608-3612 (1991)
   PUBMED   2023909
REFERENCE   2  (bases 1 to 8196)
  AUTHORS   Kato,N., Shimotohno,K., VanLeeuwen,D. and Cohen,M.
  TITLE     Human proviral mRNAs down regulated in choriocarcinoma encode a
            zinc finger protein related to Kruppel
  JOURNAL   Mol Cell Biol 10 (8), 4401-4405 (1990)
   PUBMED   2115127
REFERENCE   3  (bases 1 to 8196)
  AUTHORS   Bellefroid,E.J., Lecocq,P.J., Benhida,A., Poncelet,D.A., Belayew,A.
            and Martial,J.A.
  TITLE     The human genome contains hundreds of genes coding for finger
            proteins of the Kruppel type
  JOURNAL   DNA 8 (6), 377-387 (1989)
   PUBMED   2505992
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC073210.8.
            
            On May 20, 2019 this sequence version replaced NM_001348050.1.
            
            Summary: This locus represents naturally occurring readthrough
            transcription between the endogenous retrovirus group 3 member 1
            (ERV3-1) and the zinc finger protein 117 (ZNF117) genes on
            chromosome 7. Readthrough transcripts may encode the same protein
            as the ZNF117 gene. [provided by RefSeq, Jan 2017].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660807.108813.1,
                                           SRR1660803.251645.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2151119, SAMN03267754
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            readthrough transcript :: includes exons from GeneID 2086, 51351
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-206               AC073210.8         70493-70698         c
            207-339             AC073210.8         45936-46068         c
            340-435             AC073210.8         45339-45434         c
            436-8196            AC073210.8         35728-43488         c
FEATURES             Location/Qualifiers
     source          1..8196
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q11.21"
     gene            1..8196
                     /gene="ERV3-1-ZNF117"
                     /gene_synonym="h-PLK"
                     /note="ERV3-1-ZNF117 readthrough"
                     /db_xref="GeneID:109504726"
     exon            1..206
                     /gene="ERV3-1-ZNF117"
                     /gene_synonym="h-PLK"
                     /inference="alignment:Splign:2.1.0"
     exon            207..339
                     /gene="ERV3-1-ZNF117"
                     /gene_synonym="h-PLK"
                     /inference="alignment:Splign:2.1.0"
     exon            340..435
                     /gene="ERV3-1-ZNF117"
                     /gene_synonym="h-PLK"
                     /inference="alignment:Splign:2.1.0"
     CDS             402..1853
                     /gene="ERV3-1-ZNF117"
                     /gene_synonym="h-PLK"
                     /note="provirus-linked krueppel; zinc finger protein HPF9"
                     /codon_start=1
                     /product="zinc finger protein 117"
                     /protein_id="NP_001334979.1"
                     /db_xref="GeneID:109504726"
                     /translation="MKRHEMVAKHLVMFYYFAQHLWPEQNIRDSFQKVTLRRYRKCGY
                     ENLQLRKGCKSVVECKQHKGDYSGLNQCLKTTLSKIFQCNKYVEVFHKISNSNRHKMR
                     HTENKHFKCKECRKTFCMLSHLTQHKRIQTRVNFYKCEAYGRAFNWSSTLNKHKRIHT
                     GEKPYKCKECGKAFNQTSHLIRHKRIHTEEKPYKCEECGKAFNQSSTLTTHNIIHTGE
                     IPYKCEKCVRAFNQASKLTEHKLIHTGEKRYECEECGKAFNRSSKLTEHKYIHTGEKL
                     YKCEECGKAFNQSSTLTTHKRIHSGEKPYKCEECGKAFKQFSNLTDHKKIHTGEKPYK
                     CEECGKAFNQLSNLTRHKVIHTGEKPYKCGECGKAFNQSSALNTHKIIHTGENPHKCR
                     ESGKVFHLSSKLSTCKKIHTGEKLYKCEECGKAFNRSSTLIGHKRIHTGEKPYKCEEC
                     GKAFNQSSTLTTHKIIHTEEKQYKCDECGKAST"
     exon            436..8196
                     /gene="ERV3-1-ZNF117"
                     /gene_synonym="h-PLK"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5384..5389
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ERV3-1-ZNF117"
                     /gene_synonym="h-PLK"
                     /note="hexamer: AATAAA"
     polyA_site      5405
                     /gene="ERV3-1-ZNF117"
                     /gene_synonym="h-PLK"
                     /note="major polyA site"
     regulatory      6742..6747
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ERV3-1-ZNF117"
                     /gene_synonym="h-PLK"
                     /note="hexamer: AATAAA"
     polyA_site      6766
                     /gene="ERV3-1-ZNF117"
                     /gene_synonym="h-PLK"
     regulatory      7063..7068
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ERV3-1-ZNF117"
                     /gene_synonym="h-PLK"
                     /note="hexamer: AATAAA"
     polyA_site      7089
                     /gene="ERV3-1-ZNF117"
                     /gene_synonym="h-PLK"
ORIGIN      
        1 gtccaatcag gcactcagct ggagcagaca ggacggcttc cgggtttggt ggggcctttg
       61 tctctggcgg cagccggagc ttctggtgta gtcttcactg ctctgtgtct tctgctccta
      121 gaggcccagc ttctgtggcc tcgttacctg caggtattgg gagatccaca gctaagacgc
      181 caggacccac tggaagccta gaaatgggac cattgacatt tatggatgtg gccatagaat
      241 tctctttgga ggagtggcaa tgcctggaca ctgcacagca gaatttatat aggcatgtga
      301 tgtgagagaa ctacagaaac ctggttttct tgggtgaagg tattgctgtc tctaagccag
      361 acctgattac ctgtctggag caaggaaaag agccctggaa tatgaagaga catgagatgg
      421 tagctaaaca tttagttatg ttttattatt ttgcccaaca cctttggcca gagcagaaca
      481 taagagattc tttccagaaa gtgaccctaa gaagatatag aaaatgtgga tatgagaatt
      541 tacagttaag aaaaggctgt aaaagtgtgg ttgagtgtaa acagcacaaa ggagattata
      601 gtggacttaa ccaatgtttg aaaactacct tgagcaaaat atttcaatgt aataaatatg
      661 tagaagtttt ccataaaatt tcaaattcaa atagacacaa gatgagacat actgaaaata
      721 aacattttaa atgtaaagaa tgtcgcaaaa cattttgcat gctttcacac ctaactcaac
      781 ataaaagaat ccaaactaga gtgaatttct acaaatgtga agcatatgga agagccttta
      841 actggtcctc aacccttaat aaacataaga gaattcatac tggagaaaaa ccttacaaat
      901 gtaaagaatg tggcaaagcc tttaaccaga cctcacacct tattagacat aagagaattc
      961 atactgaaga gaaaccctac aaatgtgaag aatgtggcaa agcctttaac cagtcatcga
     1021 cccttactac acataatata attcatactg gggaaattcc ctacaaatgt gagaaatgtg
     1081 ttagagcttt taaccaagcc tcaaagctta ctgaacataa gttaattcat accggagaga
     1141 aacgttatga atgtgaagaa tgcggcaaag cttttaaccg atcctcaaaa cttactgaac
     1201 ataagtacat tcatactgga gagaagctgt acaaatgtga agaatgtggt aaagccttta
     1261 accagtcctc aacccttact acacataaga gaattcatag tggagagaag ccctacaaat
     1321 gtgaagaatg tggcaaagct tttaaacaat tttcaaatct tactgaccat aaaaaaattc
     1381 atactggaga gaaaccctac aaatgtgagg aatgtggcaa agcttttaac caactctcaa
     1441 accttactag acataaggta attcatactg gagagaaacc ctacaaatgt ggagaatgtg
     1501 gcaaagcctt taaccagtcc tcagccctta atacacataa gataatccat actggagaga
     1561 atccccacaa atgtagagaa tctggcaaag ttttccacct atcctcaaaa cttagtacat
     1621 gtaagaaaat tcatactgga gagaaactct acaaatgtga agaatgtggc aaagccttta
     1681 accgatcttc aacccttatt ggacataaga gaattcatac tggagagaaa ccctacaaat
     1741 gtgaagaatg tggcaaagct tttaaccaat cttcaacact tactacacat aagataattc
     1801 atactgaaga gaaacagtac aaatgtgatg aatgtggcaa agcttctacc tgatcctcaa
     1861 aactcattga acacaagaaa attcatactg gagagaaacc ttacaagtgt gaagaatgtg
     1921 gcaaaacttc taaccatttc tcaaccctta ctaaacataa gatgattcat actggagaga
     1981 agttacacaa atgtgatgaa tgtgacaaag cttttaacca atcttcaacc ctttctacac
     2041 ataaaagaat tcatactgga gagaaaccct acaaatgtga agaatgtggc agagctttta
     2101 attgatcatc aaaccttatt aaacataaga aaattcatat tggagagaaa ccctacaaat
     2161 gtgaagaatg tggaaaagct tttaaccagt tctcaactct tactacacat aaaataattc
     2221 atactggaga gaaaccatat aaatgtgaag aatgtggcaa agctttcaac ctatacgtaa
     2281 accttactac acataagaaa attcatactg gagagaaacc ctacaagtgt gaagaatgtg
     2341 gcaaagcttt tagccaagtg tcaactctta ctatacataa aagaattcat actggagaga
     2401 aaccctacaa gtgtgaagaa tgtggcaaag cttttaacca agtgtcaact cttactatac
     2461 ataaaagaat tcatactgga gagaaacctt acaaatgtga ggaatgtggc aaaactttca
     2521 gtcgatgctc aaaacttact acacataaga aaattcatac aggagagaaa ccttacaaat
     2581 gtgaaaaatg tgctaaagct tttagccagt cttcaaccct ttctacatat aagataattc
     2641 acactggaga gaaatgctac aaatgtgaag aatgtggcaa agtttttaac cgatcttcaa
     2701 accttacaga ccataaaaaa attcatacag gagagaaatc ctacaaatgt gaagaatgtg
     2761 acaaggcctt taacctgtcc tcaacgctta ctaaacataa ggtaattcat actggagaga
     2821 aactgtacaa atgtaaagaa tgtggtaaag cttttaaaca gttctcacac cttgctatac
     2881 ataatataat tcatactgga gagaaactct acaaatgtga agaatgtggc aaagctttta
     2941 acttatcctc aaaccttact gcacataaga aaaatcgtac tggagagaaa ccctacaaat
     3001 gtgaagaatg tggcaaagct aacctatcat caacccttac tccacataag acaattcata
     3061 tttgagagaa accctgcaaa tgtgaagaat gtggcaatgc ttgtaactaa atctcaaact
     3121 ttactaaaca taagaaaatt aatactggaa actttacaaa cctgaaagat gtgacaatga
     3181 ttttgacaac accttcaaac ttttctaaac ataaaataaa tcatactggt gagaaatctt
     3241 aaaaatatga agaatggtac aaagccttta aatggttgtc acacttgatt gtaggtaaga
     3301 taatttatac tggaggaaac tcccagaagt gtgaagaatg tggcaaaact tttaattttt
     3361 cacaccttat agcacaggaa agcacttcag aaaaattgta caaatataaa tgtggaaaag
     3421 ccattaatat ctgcttacat cttactcaac attagagagt tagtgcttaa taaaagcatt
     3481 ataaaagcaa ttagtgtaaa atcagaaaat gaaagttttt tttttttttt tagatggagt
     3541 cttgctctgt cacccaggct ggagtgcagt ggtgtgatct tggctcactg caacctctgc
     3601 ctcccaggtt caagcaattc tcctgcctta gcctccagag tagctgagac tacaggcaca
     3661 caccaccaca tttggctaat ttttttattt ttagtagaga ctggctatca ccatgttggc
     3721 caggctgatc ttgaactcct gacctcaagt gatccacatg cctctgcctc ccaaagtgct
     3781 gggattatag gtgtgagtca ctgtgcctga caaatataag cctttaaaga gaagaaggtt
     3841 ttcattttga agacaaacat taggtacata aagagggttg tagtgtcttt atttgtatca
     3901 cagattttat tgtacacatt atgtactaaa ggaaaatcct gaagcagtgc tcaaactttg
     3961 atcaacatca gggagtttat attggagaaa aactgcaaat gtaatatatt tggaaaaaca
     4021 tttttcaaaa actactgctt agaaaacacc aggggattta tactaaaata tatttttgca
     4081 gatgcagtaa gtataaaaga aatttaatcc aaaattaagt gtgtgtaaat atcagagaat
     4141 tcacagtaga aatatctaag gcactgacat tttagacatt gaactaatca gtgtgctgag
     4201 tacagaaaat aatccaaaat taaagttggt agataaatta tttatatata actttaaaag
     4261 aggtagaaat atttttagtt ataattacat ttaaagtata cttttttctt tgaaaaaatt
     4321 acaaaatttt taaaaagtga atgatgtaat tcaactcaaa ttacttcatg cttttcattc
     4381 tattgtattc acatgtgaaa gcatgtgatc aattgctgct tcatcaaaga tatgagacat
     4441 tcttttttgt taggtgggca atatttttta ccttttctat ggaagagtaa agacattaca
     4501 atgtaggatg catgataaaa atctaagtgg agaggctctt tgtgtttaat ttataatatt
     4561 gaatgatgta tgagggaagt gttcagagga atattctgca ttctagtgaa aatatctttt
     4621 attttagtta aaattaaatt aaaattagta gtatatcatt ttactaactg tacttttatg
     4681 taataaaatg cagcacattt aaaaaatttt agattattgt gaacttaatt ttttaattaa
     4741 actttttttt taacatgtta agaccaattg tgcattcagt gaagtattat catgccacta
     4801 acttcaacct atcccacctt actcaagggt gttggtaaaa gatagtaaca atgtactatt
     4861 taataacaga gtggactaac atctctaata atttctcttg ccagtgactt taaactaaag
     4921 aacttaatta aagaacattg ttcccatagg ttaaattttt attctttttc ttatttaaac
     4981 atatttttct taacttttgt gggtacatag tgtgtgtata tatttatgcc atatatggca
     5041 tattttgata caggcatatg aataggtatt aatcacatca gggcaaatga aatatccatc
     5101 aactccagca tttatcattt gtattacaaa ccgattctac acttttagtt actttaaaat
     5161 gtacaagtaa attgctattg actatagggt cattttcatg ggtataataa aaattatata
     5221 caagtataaa taaaatcctg agtcttaaaa ttctgagtcc tgcttaaaca ttttaaaaat
     5281 tttgttatgt atttttcttt gaacatgtct ctctgcctgc aaacataaca gaattttagt
     5341 attggtttac atagagttaa ctatacccat atattactct aaaaataaat gttaagtgca
     5401 agaaagttat ggactgtttt tgtgtgagtg tgagtttgta cctattttca aaagaaaaga
     5461 gcaatattgg agcaaaacaa atattttaat aaagtaatgt actagacaac tgaaaacttc
     5521 aaaaatgctg aaagtaaatg tatactctgc tttgtattga attcattact gccaaatctt
     5581 ctgacttatg attcagaatc tctccatgca aattatgttt ttacttgcct gttagtcatg
     5641 ctagacctat aattttcttg tttcttacca tttttttctt ttatacttta tgaggtatta
     5701 tgtgagctgt tcatggatta taagaatgat ttttataaaa ttcagtactg cacacaagat
     5761 aagttttaga tgtatttcca aaattgtgta ttaattatat ttagttagaa cattccattt
     5821 gttcttttaa ttggagaatc ctatataagc ctatatttct tattcttttc tcttgttata
     5881 attgacataa gtaaatttat ttatttattg agccaatttg ttcaggtaag aactaggaat
     5941 gcttcataag tcatgaggat gtttttatat atatatgtgg caaacaaata tgacagtgct
     6001 tgctgtgtaa cagatgttcc ataataacct gtaaacattc ctgctggagt tagtttgtaa
     6061 cttcaagtca gagatggaaa ataccaatag tgaagaaata acattgattc ttcatgtgca
     6121 gataacattt tttttccatg ctgcaaagct aaattttgct gaatttaaaa agaaattttg
     6181 gttcttttat ttcctaatta cctttagttt tgtttgtctt attatgtgac ttctgtgtat
     6241 tcatcacagc ccttctcctt ctttttctat gtgatggcta cactttgctc actgttgtct
     6301 tcatgccatg tcattttata cagtactttg taggttttga tgagaaagtt ggtattttta
     6361 atgcactcaa aaattgcttt ttattggaga gtacttatca atataacttt ctgatcagtt
     6421 aattaagata aaaggcatac attgtccaca ggtgagagga ttaaatcagt tagcattatt
     6481 tttttctgtt tgtaaaagga aaaacttatt aaatttttaa acggagttat taaacagagt
     6541 ttcactctta ttgcccaggc tggagtgcaa atatattgtg gcaaatataa aatttgctag
     6601 aaaatacatc ttagaaatta agttataaga gagcaaatgg taagtgaaga attttaaatt
     6661 taattttcta tgatatagca taacatacat ttccatgcag aatcttttat ttttaaatgt
     6721 gaaatttaaa ggttgcaaaa taataaaatg acttctgtgg atttgatatt tggaatgata
     6781 tttctttttt atattgatat tacaattccg aggaattttt cactcattat ttttttagtg
     6841 ggtgaaggtg agtgtacagt tattgctttt tgtcacctaa ctatagtcag cttcttggtc
     6901 attttctcta gaaaactttt gaagattatg gcagcttttt gattaaacat tttctgttat
     6961 ttttatgcaa attcatttat tgtgttcaca gggtggccag tcatgagacc ataagcaaca
     7021 gctgcccttt tagtgtcttt catgccatta ccatctgtaa taaataaatg tgtactttat
     7081 tctgcaaaac atgatgtttg gaagtatatg ttgtcaaatg cttaattcta ggtaattaag
     7141 gctttacctc acatcgttaa catttttgtg gtcagagtat gtgacattgt caatgttttt
     7201 caaaaacaca actacattat tatgatctgt agtcactatg ctgtacaaaa agatctctta
     7261 aacttattcc tcctattaaa ctataattat gtattctttg accaacatct tccaaaaccc
     7321 cccttttttc taaatacctt ggtgtctggt ggtcaccact ttactctcta ctttaatggg
     7381 attaagtttc ttagaatccc tgtgtaagta aaatcatgaa aaataatctt tgtgtctggc
     7441 tcatgtagac aaatatgatg tcctccaggt taattcatgt gattgaaaat aatagaaatt
     7501 tcttttttaa agacgaagag tattccattg tgtatatgta ccacattgtc tttatttact
     7561 cataaatgtt gaactgttga ttgtgtattt tggtaattgt gaagagtgtt gcaaacaaca
     7621 tagaagcata aatgtttctt cattctgatt tcacttgttt tggatatata cagtaaaatt
     7681 gctgtattgt ggtttaattt taaatttttt gacaaatttt tgtttttcat agtgactctc
     7741 ctcattcaca ttcaaaccaa cagtgtgcaa gcattccttt tcttcatact ttgactaaca
     7801 ctttcttttc tttttagtaa gagtaattct aacaggagtg agttgataat ctcctggttt
     7861 ttctttttgc tttcctgatt atagttgata ttgagcattt tttatatatc ttgaccattt
     7921 gtcttttctt gaaaaatatt taagcctttt gctcattttt aatagttatt tgtcttctgt
     7981 tgtatagtca tttaagttgt ttatatgttt ctgttattaa ccctttgtcc cacgtatgat
     8041 ttgcaaatat tttctcccat ttttttcagt tgtctcattt tgttgattgt atcagattcc
     8101 atgaagcagc tttttaattt caagtaatct aacgtatcta tttttctttt gatttccttg
     8161 gattttgagg ttaaataata aaagtcacag cctaga
//
