LOCUS       NM_001007253            3206 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens endogenous retrovirus group 3 member 1, envelope
            (ERV3-1), transcript variant 1, mRNA.
ACCESSION   NM_001007253
VERSION     NM_001007253.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3206)
  AUTHORS   Alldredge,J., Kumar,V., Nguyen,J., Sanders,B.E., Gomez,K.,
            Jayachandran,K., Zhang,J., Schwarz,J. and Rahmatpanah,F.
  TITLE     Endogenous Retrovirus RNA Expression Differences between Race,
            Stage and HPV Status Offer Improved Prognostication among Women
            with Cervical Cancer
  JOURNAL   Int J Mol Sci 24 (2), 1492 (2023)
   PUBMED   36675007
  REMARK    GeneRIF: Endogenous Retrovirus RNA Expression Differences between
            Race, Stage and HPV Status Offer Improved Prognostication among
            Women with Cervical Cancer.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3206)
  AUTHORS   Roberts,R.M., Ezashi,T., Schulz,L.C., Sugimoto,J., Schust,D.J.,
            Khan,T. and Zhou,J.
  TITLE     Syncytins expressed in human placental trophoblast
  JOURNAL   Placenta 113, 8-14 (2021)
   PUBMED   33504453
  REMARK    Review article
REFERENCE   3  (bases 1 to 3206)
  AUTHORS   Nakagawa,S., Kawashima,M., Miyatake,Y., Kudo,K., Kotaki,R., Ando,K.
            and Kotani,A.
  TITLE     Expression of ERV3-1 in leukocytes of acute myelogenous leukemia
            patients
  JOURNAL   Gene 773, 145363 (2021)
   PUBMED   33338509
  REMARK    GeneRIF: Expression of ERV3-1 in leukocytes of acute myelogenous
            leukemia patients.
REFERENCE   4  (bases 1 to 3206)
  AUTHORS   Bustamante Rivera,Y.Y., Brutting,C., Schmidt,C., Volkmer,I. and
            Staege,M.S.
  TITLE     Endogenous Retrovirus 3 - History, Physiology, and Pathology
  JOURNAL   Front Microbiol 8, 2691 (2018)
   PUBMED   29379485
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3206)
  AUTHORS   Herve,C.A., Forrest,G., Lower,R., Griffiths,D.J. and Venables,P.J.
  TITLE     Conservation and loss of the ERV3 open reading frame in primates
  JOURNAL   Genomics 83 (5), 940-943 (2004)
   PUBMED   15081124
  REMARK    GeneRIF: molecular evolution and comparison with other primates
REFERENCE   6  (bases 1 to 3206)
  AUTHORS   Venables,P.J., Brookes,S.M., Griffiths,D., Weiss,R.A. and Boyd,M.T.
  TITLE     Abundance of an endogenous retroviral envelope protein in placental
            trophoblasts suggests a biological function
  JOURNAL   Virology 211 (2), 589-592 (1995)
   PUBMED   7645262
REFERENCE   7  (bases 1 to 3206)
  AUTHORS   Kato,N., Shimotohno,K., VanLeeuwen,D. and Cohen,M.
  TITLE     Human proviral mRNAs down regulated in choriocarcinoma encode a
            zinc finger protein related to Kruppel
  JOURNAL   Mol Cell Biol 10 (8), 4401-4405 (1990)
   PUBMED   2115127
REFERENCE   8  (bases 1 to 3206)
  AUTHORS   Kato,N., Larsson,E. and Cohen,M.
  TITLE     Absence of expression of a human endogenous retrovirus is
            correlated with choriocarcinoma
  JOURNAL   Int J Cancer 41 (3), 380-385 (1988)
   PUBMED   3346101
REFERENCE   9  (bases 1 to 3206)
  AUTHORS   Cohen,M., Kato,N. and Larsson,E.
  TITLE     ERV3 human endogenous provirus mRNAs are expressed in normal and
            malignant tissues and cells, but not in choriocarcinoma tumor cells
  JOURNAL   J Cell Biochem 36 (2), 121-128 (1988)
   PUBMED   3356751
REFERENCE   10 (bases 1 to 3206)
  AUTHORS   Kato,N., Pfeifer-Ohlsson,S., Kato,M., Larsson,E., Rydnert,J.,
            Ohlsson,R. and Cohen,M.
  TITLE     Tissue-specific expression of human provirus ERV3 mRNA in human
            placenta: two of the three ERV3 mRNAs contain human cellular
            sequences
  JOURNAL   J Virol 61 (7), 2182-2191 (1987)
   PUBMED   2884330
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA198800.1, AC073210.8 and
            AK074464.1.
            
            On Nov 23, 2018 this sequence version replaced NM_001007253.3.
            
            Summary: This gene contains sequence derived from endogenous
            retrovirus, and is therefore similar to multiple other loci in the
            genome. Transcripts at this locus encode a conserved protein with a
            predicted signal peptide and similarity to the Env polyprotein.
            This protein is overexpressed in colorectal and other cancers.
            [provided by RefSeq, Jan 2017].
            
            Transcript Variant: This variant (1) encodes the protein related to
            endogenous retrovirus.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN03568911
                              [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            endogenous retrovirus  :: PMID: 15081124
            MANE Ensembl match     :: ENST00000394323.3/ ENSP00000391594.1
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-324               DA198800.1         60-383
            325-3137            AC073210.8         54377-57189         c
            3138-3206           AK074464.1         2339-2407
FEATURES             Location/Qualifiers
     source          1..3206
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q11.21"
     gene            1..3206
                     /gene="ERV3-1"
                     /gene_synonym="envR; ERV-R; ERV3; ERVR; HERV-R; HERVR"
                     /note="endogenous retrovirus group 3 member 1, envelope"
                     /db_xref="GeneID:2086"
                     /db_xref="HGNC:HGNC:3454"
                     /db_xref="MIM:131170"
     exon            1..147
                     /gene="ERV3-1"
                     /gene_synonym="envR; ERV-R; ERV3; ERVR; HERV-R; HERVR"
                     /inference="alignment:Splign:2.1.0"
     exon            148..3206
                     /gene="ERV3-1"
                     /gene_synonym="envR; ERV-R; ERV3; ERVR; HERV-R; HERVR"
                     /inference="alignment:Splign:2.1.0"
     CDS             536..2350
                     /gene="ERV3-1"
                     /gene_synonym="envR; ERV-R; ERV3; ERVR; HERV-R; HERVR"
                     /note="HERV-R_7q21.2 provirus ancestral Env polyprotein;
                     ERV-R envelope protein; HERV-R envelope protein; ERV3-1
                     envelope protein; endogenous retrovirus group 3 member 1
                     Env polyprotein; endogenous retroviral sequence 3;
                     endogenous retrovirus group 3, member 1"
                     /codon_start=1
                     /product="endogenous retrovirus group 3 member 1 Env
                     polyprotein precursor"
                     /protein_id="NP_001007254.2"
                     /db_xref="CCDS:CCDS47595.1"
                     /db_xref="GeneID:2086"
                     /db_xref="HGNC:HGNC:3454"
                     /db_xref="MIM:131170"
                     /translation="MLGMNMLLITLFLLLPLSMLKGEPWEGCLHCTHTTWSGNIMTKT
                     LLYHTYYECAGTCLGTCTHNQTTYSVCDPGRGQPYVCYDPKSSPGTWFEIHVGSKEGD
                     LLNQTKVFPSGKDVVSLYFDVCQIVSMGSLFPVIFSSMEYYSSCHKNRYAHPACSTDS
                     PVTTCWDCTTWSTNQQSLGPIMLTKIPLEPDCKTSTCNSVNLTILEPDQPIWTTGLKA
                     PLGARVSGEEIGPGAYVYLYIIKKTRTRSTQQFRVFESFYEHVNQKLPEPPPLASNLF
                     AQLAENIASSLHVASCYVCGGMNMGDQWPWEARELMPQDNFTLTASSLEPAPSSQSIW
                     FLKTSIIGKFCIARWGKAFTDPVGELTCLGQQYYNETLGKTLWRGKSNNSESPHPSPF
                     SRFPSLNHSWYQLEAPNTWQAPSGLYWICGPQAYRQLPAKWSGACVLGTIRPSFFLMP
                     LKQGEALGYPIYDETKRKSKRGITIGDWKDNEWPPERIIQYYGPATWAEDGMWGYRTP
                     VYMLNRIIRLQAVLEIITNETAGALNLLAQQATKMRNVIYQNRLALDYLLAQEEGVCG
                     KFNLTNCCLELDDEGKVIKEITAKIQKLAHIPVQTWKG"
     regulatory      3183..3188
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ERV3-1"
                     /gene_synonym="envR; ERV-R; ERV3; ERVR; HERV-R; HERVR"
                     /note="hexamer: AATAAA"
     polyA_site      3206
                     /gene="ERV3-1"
                     /gene_synonym="envR; ERV-R; ERV3; ERVR; HERV-R; HERVR"
                     /note="major polyA site"
ORIGIN      
        1 gtctctggcg gcagccggag cttctggtgt agtcttcact gctctgtgtc ttctgctcct
       61 agaggcccag cttctgtggc ctcgttacct gcaggtattg ggagatccac agctaagacg
      121 ccaggaccca ctggaagcct agaaatgttg caggaattgt gccttggatc catccatcca
      181 gtcagctgaa accagcagcc caggacaagt ggaccagcca acaggaccta gaccatgcaa
      241 cccagctgat cctacgatgg aaccaaggtg ccagtgagat gacaacagcc ctgctctggt
      301 cactccggaa gctgaccagt ccacacacgg ctgaagcttg aggagacaac agccctgctc
      361 tagtcacccc agaagctgac tagtctatgc acggccgaag cttgagtcat catcagggaa
      421 gtaaatgtgg ttagaaatct gaagtccagt aattttcctt gtcatattaa ttactttgct
      481 attaagctgt cactttgctt agccttctcc ccccaggaaa aagccttttc tgtccatgct
      541 gggtatgaac atgctactca tcactttgtt cttgctactc cccttatcca tgttaaaagg
      601 agaaccctgg gagggatgcc tccactgcac ccacactacg tggtcgggga acatcatgac
      661 taaaaccctg ttgtatcaca cttattatga gtgtgctggg acctgcctag gaacttgtac
      721 tcacaaccag acaacctact cagtctgtga cccaggaagg ggccagcctt atgtgtgtta
      781 tgaccctaag tcttcacctg ggacctggtt tgaaattcat gtcgggtcaa aggaagggga
      841 tcttctaaac caaaccaagg tatttccctc tggcaaggat gtcgtatcct tatactttga
      901 tgtttgccag atagtatcca tgggctcact ctttcccgta atcttcagtt ccatggagta
      961 ctatagtagc tgccataaaa ataggtatgc acaccctgct tgttccaccg attccccagt
     1021 aacaacttgc tgggactgca caacgtggtc cactaaccaa caatcactag ggccaattat
     1081 gcttaccaaa ataccattag aaccagattg taaaacaagc acttgcaatt ctgtaaatct
     1141 taccatctta gagccagatc agcccatatg gacaacaggt ttaaaagcac cgctaggggc
     1201 acgagtcagc ggtgaagaaa ttggcccagg agcctatgtc tatctatata tcataaagaa
     1261 aactcggacc cgctcaaccc aacagttccg agtttttgag tcattctatg agcatgttaa
     1321 ccagaaattg cctgagcccc ctcccttggc cagtaattta ttcgcccaac tggctgaaaa
     1381 catagccagc agcctgcacg ttgcttcatg ttatgtctgt gggggaatga acatgggaga
     1441 ccaatggcca tgggaagcaa gggaactaat gccccaagat aatttcacac taaccgcctc
     1501 ttccctcgaa cctgcaccat caagtcagag catctggttc ttaaaaacct ccattattgg
     1561 aaaattctgt attgctcgct ggggaaaggc ctttacagac ccagtaggag agttaacttg
     1621 cctaggacaa caatattaca acgagacact aggaaagact ttatggaggg gcaaaagcaa
     1681 taattctgaa tcaccacacc caagcccatt ctctcgtttc ccatctttaa accattcttg
     1741 gtaccaactt gaagctccaa atacctggca ggcaccctct ggcctctact ggatctgtgg
     1801 gccacaagca tatcgacaac tgccagctaa atggtcaggg gcctgtgtac tggggacaat
     1861 taggccgtcc ttcttcctaa tgcccctaaa acagggagaa gccttaggat accccatcta
     1921 tgatgaaact aaaaggaaaa gcaaaagagg cataactata ggagattgga aggacaatga
     1981 atggcctcct gaaagaataa ttcaatatta tggcccagcc acctgggcag aagatggaat
     2041 gtggggatac cgcaccccag tttacatgct taaccgcatt ataagattgc aggcagtact
     2101 agaaatcatt accaatgaaa ctgcaggggc cttgaatctg cttgcccagc aagccacaaa
     2161 aatgagaaat gtcatttatc aaaatagact ggccttagac tacctcctag cccaggaaga
     2221 gggagtatgc ggaaagttca accttactaa ctgctgcctg gaacttgatg acgaaggaaa
     2281 ggtcatcaaa gaaataactg ctaaaatcca aaagttagct cacatcccag ttcagacttg
     2341 gaaaggatag tctccagatt cccttttcag aggttggttc tcatcccttg gaggatttaa
     2401 aaccttagta caaatagtcc tagccatatt gggagtttgc cttatactcc cttgtctctt
     2461 acccctcatt gtcaaaaata tccaaacagc catagaggct cttgtggaca gacggactac
     2521 cacacgacta atggccctaa ctaagtatta acccctgcca agaaaagagc tacttcctct
     2581 tgaagtaaat gaagatagtg atgctttctc ttaaacttta cttataaaaa gcatcaaagg
     2641 ggggaatgaa gcaggaaata taaaaggaaa aacaagtaaa gggaaaacaa gtcctttcct
     2701 gaccagtctg actcactcca aagtcctgct ggagctatga taattatctg caaggccagg
     2761 caggggctcc gaaggagtgg gctccaggag cagggatgag aaaaacaagt tctccttatc
     2821 agtttccctg tttgaaattc tctccccata acattattct ttgttctgct ctcacaacta
     2881 tttttgtaac tatttctgca agtctgtaaa gattttgtaa gttcttgttt ttctttctgt
     2941 agcatggcaa ggtcacaaga catgtttaag taaggtaggc tcatgttgca aatcctgttg
     3001 taaaacctgt cacggtatga ttaactgcct ttgttctgct tctgtaagac tgctttctca
     3061 cctcgcaggt tttgcgccaa aaacccgact tgcccctgcc tgatgcatgt ataaaagtca
     3121 agccctgtct ttgttcaggg ctcagccttt ggatgttaat ccgctgggcc agtggccacc
     3181 taaataaaac cttcctgttg caccca
//
