LOCUS       NM_018948               3097 bp    mRNA    linear   PRI 19-AUG-2024
DEFINITION  Homo sapiens ERBB receptor feedback inhibitor 1 (ERRFI1), mRNA.
ACCESSION   NM_018948
VERSION     NM_018948.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3097)
  AUTHORS   Wang,H., Liu,H., Lu,G., Tang,X., Luo,S., Du,M., Christiani,D.C. and
            Wei,Q.
  TITLE     Potentially functional variants of ERRFI1 in hypoxia-related genes
            predict survival of non-small cell lung cancer patients
  JOURNAL   Cancer Med 13 (15), e70073 (2024)
   PUBMED   39096122
  REMARK    GeneRIF: Potentially functional variants of ERRFI1 in
            hypoxia-related genes predict survival of non-small cell lung
            cancer patients.
REFERENCE   2  (bases 1 to 3097)
  AUTHORS   Kondo,N., Utsumi,T., Shimizu,Y., Takemoto,A., Oh-Hara,T.,
            Uchibori,K., Subat-Motoshi,S., Ninomiya,H., Takeuchi,K., Nishio,M.,
            Miyazaki,Y. and Katayama,R.
  TITLE     MIG6 loss confers resistance to ALK/ROS1 inhibitors in NSCLC
            through EGFR activation by low-dose EGF
  JOURNAL   JCI Insight 8 (24), e173688 (2023)
   PUBMED   37917191
  REMARK    GeneRIF: MIG6 loss confers resistance to ALK/ROS1 inhibitors in
            NSCLC through EGFR activation by low-dose EGF.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3097)
  AUTHORS   Jeong,O., Broaddus,R.R., Lessey,B.A., Risinger,J.I., Hunter,M.I.
            and Kim,T.H.
  TITLE     MIG-6 Is Critical for Progesterone Responsiveness in Human Complex
            Atypical Hyperplasia and Early-Stage Endometrial Cancer
  JOURNAL   Int J Mol Sci 23 (23), 14596 (2022)
   PUBMED   36498921
  REMARK    GeneRIF: MIG-6 Is Critical for Progesterone Responsiveness in Human
            Complex Atypical Hyperplasia and Early-Stage Endometrial Cancer.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3097)
  AUTHORS   Kan,Y. and Miller,W.T.
  TITLE     Activity of the nonreceptor tyrosine kinase Ack1 is regulated by
            tyrosine phosphorylation of its Mig6 homology region
  JOURNAL   FEBS Lett 596 (21), 2808-2820 (2022)
   PUBMED   36178070
  REMARK    GeneRIF: Activity of the nonreceptor tyrosine kinase Ack1 is
            regulated by tyrosine phosphorylation of its Mig6 homology region.
REFERENCE   5  (bases 1 to 3097)
  AUTHORS   Li,C., Edeni,D., Platkin,S., Liu,R., Li,J., Hossain,M., Rahman,M.,
            Islam,H., Phillips,J.L. and Xu,D.
  TITLE     Effect of Gene 33/Mig6/ERRFI1 on hexavalent chromium-induced
            transformation of human bronchial epithelial cells depends on the
            length of exposure
  JOURNAL   J Environ Sci Health C Toxicol Carcinog 40 (3-4), 227-247 (2022)
   PUBMED   36715065
  REMARK    GeneRIF: Effect of Gene 33/Mig6/ERRFI1 on hexavalent
            chromium-induced transformation of human bronchial epithelial cells
            depends on the length of exposure.
REFERENCE   6  (bases 1 to 3097)
  AUTHORS   Hackel,P.O., Gishizky,M. and Ullrich,A.
  TITLE     Mig-6 is a negative regulator of the epidermal growth factor
            receptor signal
  JOURNAL   Biol Chem 382 (12), 1649-1662 (2001)
   PUBMED   11843178
REFERENCE   7  (bases 1 to 3097)
  AUTHORS   Fiorentino,L., Pertica,C., Fiorini,M., Talora,C., Crescenzi,M.,
            Castellani,L., Alema,S., Benedetti,P. and Segatto,O.
  TITLE     Inhibition of ErbB-2 mitogenic and transforming activity by RALT, a
            mitogen-induced signal transducer which binds to the ErbB-2 kinase
            domain
  JOURNAL   Mol Cell Biol 20 (20), 7735-7750 (2000)
   PUBMED   11003669
  REMARK    GeneRIF: MIG-6/RALT is a transcriptionally controlled inhibitor of
            mitogenic and transforming signals generated by the ErbB-2
            oncogene. MIG-6/RALT forms a physical complex with activated ErbB-2
            and co-localizes with ErbB-2 in living cells.
REFERENCE   8  (bases 1 to 3097)
  AUTHORS   Makkinje,A., Quinn,D.A., Chen,A., Cadilla,C.L., Force,T.,
            Bonventre,J.V. and Kyriakis,J.M.
  TITLE     Gene 33/Mig-6, a transcriptionally inducible adapter protein that
            binds GTP-Cdc42 and activates SAPK/JNK. A potential marker
            transcript for chronic pathologic conditions, such as diabetic
            nephropathy. Possible role in the response to persistent stress
  JOURNAL   J Biol Chem 275 (23), 17838-17847 (2000)
   PUBMED   10749885
REFERENCE   9  (bases 1 to 3097)
  AUTHORS   Wick,M., Burger,C., Funk,M. and Muller,R.
  TITLE     Identification of a novel mitogen-inducible gene (mig-6):
            regulation during G1 progression and differentiation
  JOURNAL   Exp Cell Res 219 (2), 527-535 (1995)
   PUBMED   7641805
REFERENCE   10 (bases 1 to 3097)
  AUTHORS   Chrapkiewicz,N.B., Davis,C.M., Chu,D.T., Caldwell,C.M. and
            Granner,D.K.
  TITLE     Rat gene 33: analysis of its structure, messenger RNA and basal
            promoter activity
  JOURNAL   Nucleic Acids Res 17 (16), 6651-6667 (1989)
   PUBMED   2780291
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DB033666.1, AK096149.1, BC025337.1 and AL137274.1.
            
            On Nov 23, 2018 this sequence version replaced NM_018948.3.
            
            Summary: ERRFI1 is a cytoplasmic protein whose expression is
            upregulated with cell growth (Wick et al., 1995 [PubMed 7641805]).
            It shares significant homology with the protein product of rat
            gene-33, which is induced during cell stress and mediates cell
            signaling (Makkinje et al., 2000 [PubMed 10749885]; Fiorentino et
            al., 2000 [PubMed 11003669]).[supplied by OMIM, Mar 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803611.181073.1, AK096149.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2151405 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000377482.10/ ENSP00000366702.5
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1                 DB033666.1         51-51
            2-1149              AK096149.1         1-1148
            1150-2417           BC025337.1         1137-2404
            2418-3097           AL137274.1         1291-1970
FEATURES             Location/Qualifiers
     source          1..3097
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p36.23"
     gene            1..3097
                     /gene="ERRFI1"
                     /gene_synonym="GENE-33; MIG-6; MIG6; RALT"
                     /note="ERBB receptor feedback inhibitor 1"
                     /db_xref="GeneID:54206"
                     /db_xref="HGNC:HGNC:18185"
                     /db_xref="MIM:608069"
     exon            1..152
                     /gene="ERRFI1"
                     /gene_synonym="GENE-33; MIG-6; MIG6; RALT"
                     /inference="alignment:Splign:2.1.0"
     exon            153..350
                     /gene="ERRFI1"
                     /gene_synonym="GENE-33; MIG-6; MIG6; RALT"
                     /inference="alignment:Splign:2.1.0"
     CDS             226..1614
                     /gene="ERRFI1"
                     /gene_synonym="GENE-33; MIG-6; MIG6; RALT"
                     /note="receptor-associated late transducer;
                     mitogen-inducible gene 6 protein"
                     /codon_start=1
                     /product="ERBB receptor feedback inhibitor 1"
                     /protein_id="NP_061821.1"
                     /db_xref="CCDS:CCDS94.1"
                     /db_xref="GeneID:54206"
                     /db_xref="HGNC:HGNC:18185"
                     /db_xref="MIM:608069"
                     /translation="MSIAGVAAQEIRVPLKTGFLHNGRAMGNMRKTYWSSRSEFKNNF
                     LNIDPITMAYSLNSSAQERLIPLGHASKSAPMNGHCFAENGPSQKSSLPPLLIPPSEN
                     LGPHEEDQVVCGFKKLTVNGVCASTPPLTPIKNSPSLFPCAPLCERGSRPLPPLPISE
                     ALSLDDTDCEVEFLTSSDTDFLLEDSTLSDFKYDVPGRRSFRGCGQINYAYFDTPAVS
                     AADLSYVSDQNGGVPDPNPPPPQTHRRLRRSHSGPAGSFNKPAIRISNCCIHRASPNS
                     DEDKPEVPPRVPIPPRPVKPDYRRWSAEVTSSTYSDEDRPPKVPPREPLSPSNSRTPS
                     PKSLPSYLNGVMPPTQSFAPDPKYVSSKALQRQNSEGSASKVPCILPIIENGKKVSST
                     HYYLLPERPPYLDKYEKFFREAEETNGGAQIQPLPADCGISSATEKPDSKTKMDLGGH
                     VKRKHLSYVVSP"
     exon            351..427
                     /gene="ERRFI1"
                     /gene_synonym="GENE-33; MIG-6; MIG6; RALT"
                     /inference="alignment:Splign:2.1.0"
     exon            428..3097
                     /gene="ERRFI1"
                     /gene_synonym="GENE-33; MIG-6; MIG6; RALT"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3072..3077
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ERRFI1"
                     /gene_synonym="GENE-33; MIG-6; MIG6; RALT"
                     /note="hexamer: AATAAA"
     polyA_site      3097
                     /gene="ERRFI1"
                     /gene_synonym="GENE-33; MIG-6; MIG6; RALT"
                     /note="major polyA site"
ORIGIN      
        1 gacggcggtc cggtgcgagg cagagtgcta gcgggagcgc gagccagcaa gaggcgcctg
       61 cgcgatgtcc gggcccctga gcccgcggcg ctgagccagc cgggacggac atgcgcggga
      121 gggcgccgcg gggcagccgc cgctcctccg ggggaatgaa agctactggt tgattttaaa
      181 gtgcctgggc ctcacaggtt tggagatgtc ccagaataag gcacaatgtc aatagcagga
      241 gttgctgctc aggagatcag agtcccatta aaaactggat ttctacataa tggccgagcc
      301 atggggaata tgaggaagac ctactggagc agtcgcagtg agtttaaaaa caacttttta
      361 aatattgacc cgataaccat ggcctacagt ctgaactctt ctgctcagga gcgcctaata
      421 ccacttgggc atgcttccaa atctgctccg atgaatggcc actgctttgc agaaaatggt
      481 ccatctcaaa agtccagctt gccccctctt cttattcccc caagtgaaaa cttgggacca
      541 catgaagagg atcaagttgt atgtggtttt aagaaactca cagtgaatgg ggtttgtgct
      601 tccacccctc cactgacacc cataaaaaac tccccttccc ttttcccctg tgcccctctt
      661 tgtgaacggg gttctaggcc tcttccaccg ttgccaatct ctgaagccct ctctctggat
      721 gacacagact gtgaggtgga attcctaact agctcagata cagacttcct tttagaagac
      781 tctacacttt ctgatttcaa atatgatgtt cctggcaggc gaagcttccg tgggtgtgga
      841 caaatcaact atgcatattt tgatacccca gctgtttctg cagcagatct cagctatgtg
      901 tctgaccaaa atggaggtgt cccagatcca aatcctcctc cacctcagac ccaccgaaga
      961 ttaagaaggt ctcattcggg accagctggc tcctttaaca agccagccat aaggatatcc
     1021 aactgttgta tacacagagc ttctcctaac tccgatgaag acaaacctga ggttcccccc
     1081 agagttccca tacctcctag accagtaaag ccagattata gaagatggtc agcagaagtt
     1141 acttcgagca cctatagtga tgaagacagg cctcccaaag taccgccaag agaacctttg
     1201 tcaccgagta actcgcgcac accgagtccc aaaagccttc cgtcttacct caatggggtc
     1261 atgcccccga cacagagctt tgcccctgat cccaagtatg tcagcagcaa agcactgcaa
     1321 agacagaaca gcgaaggatc tgccagtaag gttccttgca ttctgcccat tattgaaaat
     1381 gggaagaagg ttagttcaac acattattac ctactacctg aacgaccacc atacctggac
     1441 aaatatgaaa aattttttag ggaagcagaa gaaacaaatg gaggcgccca aatccagcca
     1501 ttacctgctg actgcggtat atcttcagcc acagaaaagc cagactcaaa aacaaaaatg
     1561 gatctgggtg gccacgtgaa gcgtaaacat ttatcctatg tggtttctcc ttagaccttg
     1621 gggtcatggt tcagcagagg ttacatagga gcaaatggtt ctcaattttc cagtttgatt
     1681 gaagtgcaga gaaaaatccc ttagattgca aaataaaata gttgaactct ctgtcttcat
     1741 gtggaaggtt tagagcagtt gtgagatgct gttatgctga gaaaccctga ctttgttagt
     1801 gttggaaaaa agtcttacaa gtctataatt taaagatgtg atggtgggga ggggaggatg
     1861 gggaagcttt ttatatatgc atacattaca tacctatata taaacttgtg gtataaccat
     1921 agaccatagc tgcaggttaa ccaattagtt actatcgtag agtaatatat attcagaata
     1981 ataaactcaa gctggagaaa tgagtcctga tagactgaaa attgagcaaa tggaagaaga
     2041 tacagtattg tttagatcag aatcattaaa aaatattttt gtttagtaag tttgaagatt
     2101 tctggctttt aggccttttc tattttgttc catttatttt tgcaggcaat cttttccatg
     2161 gagggcaggg tatccattct ttaccatggg tgtacctgct taggttaaaa atcataccaa
     2221 ggcctcatac ttccaggttt catgttgcgt cttgttgagg gagggagagc aggttacttg
     2281 gcaaccatat tgtcacctgt acctgtcaca catcttgaaa aataaaacga taatagaact
     2341 agtgactaat tttcccttac agttcctgct tggtcccacc cactgaagta gctcatcgta
     2401 gtgcgggccg tattagaggc agtggggtac gttagactca gatggaaaag tattctaggt
     2461 gccagtgtta ggatgtcagt tttacaaaat aatgaagcaa ttagctatgt gattgagagt
     2521 tattgtttgg ggatgtgtgt tgtggttttg cttttttttt ttagactgta ttaataaaca
     2581 tacaacacaa gctggccttg tgttgctggt tcctattcag tatttcctgg ggattgtttg
     2641 ctttttaagt aaaacacttc tgacccatag ctcagtatgt ctgaattcca gaggtcacat
     2701 cagcatcttt ctgctttgaa aactctcaca gctgtggctg cttcacttag atgcagtgag
     2761 acacatagtt ggtgttccga ttttcacatc cttccatgta tttatcttga agagataagc
     2821 acagaagaga aggtgctcac taacagaggt acattactgc aatgttctct taacagttaa
     2881 acaagctgtt tacagtttaa actgctgaat attatttgag ctatttaaag cttattatat
     2941 tttagtatga actaaatgaa ggttaaaaca tgcttaagaa aaatgcactg atttctgcat
     3001 tatgtgtaca gtattggaca aaggatttta ttcattttgt tgcattattt tgaatattgt
     3061 cttttcattt taataaagtt ataatactta tttatga
//
