LOCUS       NM_015051               4808 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens endoplasmic reticulum protein 44 (ERP44), mRNA.
ACCESSION   NM_015051 XM_376898
VERSION     NM_015051.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4808)
  AUTHORS   Giannone,C., Chelazzi,M.R., Orsi,A., Anelli,T., Nguyen,T.,
            Buchner,J. and Sitia,R.
  TITLE     Biogenesis of secretory immunoglobulin M requires intermediate
            non-native disulfide bonds and engagement of the protein disulfide
            isomerase ERp44
  JOURNAL   EMBO J 41 (3), e108518 (2022)
   PUBMED   34957576
  REMARK    GeneRIF: Biogenesis of secretory immunoglobulin M requires
            intermediate non-native disulfide bonds and engagement of the
            protein disulfide isomerase ERp44.
REFERENCE   2  (bases 1 to 4808)
  AUTHORS   Yang,Y., Qiu,X. and Wang,F.
  TITLE     Protein tyrosine phosphatase receptor type O (PTPRO) knockdown
            enhances the proliferative, invasive and angiogenic activities of
            trophoblast cells by suppressing ER resident protein 44 (ERp44)
            expression in preeclampsia
  JOURNAL   Bioengineered 12 (2), 9561-9574 (2021)
   PUBMED   34719307
  REMARK    GeneRIF: Protein tyrosine phosphatase receptor type O (PTPRO)
            knockdown enhances the proliferative, invasive and angiogenic
            activities of trophoblast cells by suppressing ER resident protein
            44 (ERp44) expression in preeclampsia.
REFERENCE   3  (bases 1 to 4808)
  AUTHORS   Xia,T., Tian,H., Zhang,K., Zhang,S., Chen,W., Shi,S. and You,Y.
  TITLE     Exosomal ERp44 derived from ER-stressed cells strengthens cisplatin
            resistance of nasopharyngeal carcinoma
  JOURNAL   BMC Cancer 21 (1), 1003 (2021)
   PUBMED   34493236
  REMARK    GeneRIF: Exosomal ERp44 derived from ER-stressed cells strengthens
            cisplatin resistance of nasopharyngeal carcinoma.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4808)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   5  (bases 1 to 4808)
  AUTHORS   Liu,R., Wang,X. and Yan,Q.
  TITLE     The regulatory network of lncRNA DLX6-AS1/miR-149-5p/ERP44 is
            possibly related to the progression of preeclampsia
  JOURNAL   Placenta 93, 34-42 (2020)
   PUBMED   32250737
  REMARK    GeneRIF: The regulatory network of lncRNA DLX6-AS1/miR-149-5p/ERP44
            is possibly related to the progression of preeclampsia.
REFERENCE   6  (bases 1 to 4808)
  AUTHORS   Humphray,S.J., Oliver,K., Hunt,A.R., Plumb,R.W., Loveland,J.E.,
            Howe,K.L., Andrews,T.D., Searle,S., Hunt,S.E., Scott,C.E.,
            Jones,M.C., Ainscough,R., Almeida,J.P., Ambrose,K.D., Ashwell,R.I.,
            Babbage,A.K., Babbage,S., Bagguley,C.L., Bailey,J., Banerjee,R.,
            Barker,D.J., Barlow,K.F., Bates,K., Beasley,H., Beasley,O.,
            Bird,C.P., Bray-Allen,S., Brown,A.J., Brown,J.Y., Burford,D.,
            Burrill,W., Burton,J., Carder,C., Carter,N.P., Chapman,J.C.,
            Chen,Y., Clarke,G., Clark,S.Y., Clee,C.M., Clegg,S., Collier,R.E.,
            Corby,N., Crosier,M., Cummings,A.T., Davies,J., Dhami,P., Dunn,M.,
            Dutta,I., Dyer,L.W., Earthrowl,M.E., Faulkner,L., Fleming,C.J.,
            Frankish,A., Frankland,J.A., French,L., Fricker,D.G., Garner,P.,
            Garnett,J., Ghori,J., Gilbert,J.G., Glison,C., Grafham,D.V.,
            Gribble,S., Griffiths,C., Griffiths-Jones,S., Grocock,R., Guy,J.,
            Hall,R.E., Hammond,S., Harley,J.L., Harrison,E.S., Hart,E.A.,
            Heath,P.D., Henderson,C.D., Hopkins,B.L., Howard,P.J., Howden,P.J.,
            Huckle,E., Johnson,C., Johnson,D., Joy,A.A., Kay,M., Keenan,S.,
            Kershaw,J.K., Kimberley,A.M., King,A., Knights,A., Laird,G.K.,
            Langford,C., Lawlor,S., Leongamornlert,D.A., Leversha,M., Lloyd,C.,
            Lloyd,D.M., Lovell,J., Martin,S., Mashreghi-Mohammadi,M.,
            Matthews,L., McLaren,S., McLay,K.E., McMurray,A., Milne,S.,
            Nickerson,T., Nisbett,J., Nordsiek,G., Pearce,A.V., Peck,A.I.,
            Porter,K.M., Pandian,R., Pelan,S., Phillimore,B., Povey,S.,
            Ramsey,Y., Rand,V., Scharfe,M., Sehra,H.K., Shownkeen,R.,
            Sims,S.K., Skuce,C.D., Smith,M., Steward,C.A., Swarbreck,D.,
            Sycamore,N., Tester,J., Thorpe,A., Tracey,A., Tromans,A.,
            Thomas,D.W., Wall,M., Wallis,J.M., West,A.P., Whitehead,S.L.,
            Willey,D.L., Williams,S.A., Wilming,L., Wray,P.W., Young,L.,
            Ashurst,J.L., Coulson,A., Blocker,H., Durbin,R., Sulston,J.E.,
            Hubbard,T., Jackson,M.J., Bentley,D.R., Beck,S., Rogers,J. and
            Dunham,I.
  TITLE     DNA sequence and analysis of human chromosome 9
  JOURNAL   Nature 429 (6990), 369-374 (2004)
   PUBMED   15164053
REFERENCE   7  (bases 1 to 4808)
  AUTHORS   Anelli,T., Alessio,M., Bachi,A., Bergamelli,L., Bertoli,G.,
            Camerini,S., Mezghrani,A., Ruffato,E., Simmen,T. and Sitia,R.
  TITLE     Thiol-mediated protein retention in the endoplasmic reticulum: the
            role of ERp44
  JOURNAL   EMBO J 22 (19), 5015-5022 (2003)
   PUBMED   14517240
REFERENCE   8  (bases 1 to 4808)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
REFERENCE   9  (bases 1 to 4808)
  AUTHORS   O'Neill,E.E., Brock,C.J., von Kriegsheim,A.F., Pearce,A.C.,
            Dwek,R.A., Watson,S.P. and Hebestreit,H.F.
  TITLE     Towards complete analysis of the platelet proteome
  JOURNAL   Proteomics 2 (3), 288-305 (2002)
   PUBMED   11921445
REFERENCE   10 (bases 1 to 4808)
  AUTHORS   Anelli,T., Alessio,M., Mezghrani,A., Simmen,T., Talamo,F., Bachi,A.
            and Sitia,R.
  TITLE     ERp44, a novel endoplasmic reticulum folding assistant of the
            thioredoxin family
  JOURNAL   EMBO J 21 (4), 835-844 (2002)
   PUBMED   11847130
  REMARK    GeneRIF: contains a thioredoxin domain with a CRFS motif and is
            induced during ER stress
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BQ881761.1, AB011145.1 and AL358937.16.
            
            On Nov 23, 2018 this sequence version replaced NM_015051.2.
            
            Summary: This gene encodes a member of the protein disulfide
            isomerase (PDI) family of endoplasmic reticulum (ER) proteins. It
            has an inferred N-terminal signal peptide, a catalytically active
            thioredoxin (TRX) domain, two TRX-like domains and a C-terminal
            ER-retention sequence. This protein functions as a pH-regulated
            chaperone of the secretory pathway and likely plays a role in
            protein quality control at the endoplasmic reticulum - Golgi
            interface. [provided by RefSeq, Dec 2016].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803613.87410.1,
                                           SRR1803615.261475.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000262455.7/ ENSP00000262455.6
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-24                BQ881761.1         53-76
            25-1576             AB011145.1         1-1552
            1577-4808           AL358937.16        141063-144294       c
FEATURES             Location/Qualifiers
     source          1..4808
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q31.1"
     gene            1..4808
                     /gene="ERP44"
                     /gene_synonym="PDIA10; TXNDC4"
                     /note="endoplasmic reticulum protein 44"
                     /db_xref="GeneID:23071"
                     /db_xref="HGNC:HGNC:18311"
                     /db_xref="MIM:609170"
     exon            1..217
                     /gene="ERP44"
                     /gene_synonym="PDIA10; TXNDC4"
                     /inference="alignment:Splign:2.1.0"
     CDS             161..1381
                     /gene="ERP44"
                     /gene_synonym="PDIA10; TXNDC4"
                     /note="protein disulfide isomerase family A, member 10;
                     endoplasmic reticulum resident protein 44 kDa; thioredoxin
                     domain containing 4 (endoplasmic reticulum); ER protein
                     44; thioredoxin domain-containing protein 4; epididymis
                     secretory sperm binding protein"
                     /codon_start=1
                     /product="endoplasmic reticulum resident protein 44
                     precursor"
                     /protein_id="NP_055866.1"
                     /db_xref="CCDS:CCDS35082.1"
                     /db_xref="GeneID:23071"
                     /db_xref="HGNC:HGNC:18311"
                     /db_xref="MIM:609170"
                     /translation="MHPAVFLSLPDLRCSLLLLVTWVFTPVTTEITSLDTENIDEILN
                     NADVALVNFYADWCRFSQMLHPIFEEASDVIKEEFPNENQVVFARVDCDQHSDIAQRY
                     RISKYPTLKLFRNGMMMKREYRGQRSVKALADYIRQQKSDPIQEIRDLAEITTLDRSK
                     RNIIGYFEQKDSDNYRVFERVANILHDDCAFLSAFGDVSKPERYSGDNIIYKPPGHSA
                     PDMVYLGAMTNFDVTYNWIQDKCVPLVREITFENGEELTEEGLPFLILFHMKEDTESL
                     EIFQNEVARQLISEKGTINFLHADCDKFRHPLLHIQKTPADCPVIAIDSFRHMYVFGD
                     FKDVLIPGKLKQFVFDLHSGKLHREFHHGPDPTDTAPGEQAQDVASSPPESSFQKLAP
                     SEYRYTLLRDRDEL"
     exon            218..290
                     /gene="ERP44"
                     /gene_synonym="PDIA10; TXNDC4"
                     /inference="alignment:Splign:2.1.0"
     exon            291..330
                     /gene="ERP44"
                     /gene_synonym="PDIA10; TXNDC4"
                     /inference="alignment:Splign:2.1.0"
     exon            331..446
                     /gene="ERP44"
                     /gene_synonym="PDIA10; TXNDC4"
                     /inference="alignment:Splign:2.1.0"
     exon            447..631
                     /gene="ERP44"
                     /gene_synonym="PDIA10; TXNDC4"
                     /inference="alignment:Splign:2.1.0"
     exon            632..747
                     /gene="ERP44"
                     /gene_synonym="PDIA10; TXNDC4"
                     /inference="alignment:Splign:2.1.0"
     exon            748..805
                     /gene="ERP44"
                     /gene_synonym="PDIA10; TXNDC4"
                     /inference="alignment:Splign:2.1.0"
     exon            806..922
                     /gene="ERP44"
                     /gene_synonym="PDIA10; TXNDC4"
                     /inference="alignment:Splign:2.1.0"
     exon            923..1034
                     /gene="ERP44"
                     /gene_synonym="PDIA10; TXNDC4"
                     /inference="alignment:Splign:2.1.0"
     exon            1035..1176
                     /gene="ERP44"
                     /gene_synonym="PDIA10; TXNDC4"
                     /inference="alignment:Splign:2.1.0"
     exon            1177..1279
                     /gene="ERP44"
                     /gene_synonym="PDIA10; TXNDC4"
                     /inference="alignment:Splign:2.1.0"
     exon            1280..4808
                     /gene="ERP44"
                     /gene_synonym="PDIA10; TXNDC4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1494..1499
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ERP44"
                     /gene_synonym="PDIA10; TXNDC4"
                     /note="hexamer: AAGAAA"
     polyA_site      1513
                     /gene="ERP44"
                     /gene_synonym="PDIA10; TXNDC4"
                     /note="major polyA site"
     regulatory      1833..1838
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ERP44"
                     /gene_synonym="PDIA10; TXNDC4"
                     /note="hexamer: AATAAA"
     polyA_site      1855
                     /gene="ERP44"
                     /gene_synonym="PDIA10; TXNDC4"
     regulatory      2656..2661
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ERP44"
                     /gene_synonym="PDIA10; TXNDC4"
                     /note="hexamer: AATAAA"
     polyA_site      2679
                     /gene="ERP44"
                     /gene_synonym="PDIA10; TXNDC4"
     regulatory      2767..2772
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ERP44"
                     /gene_synonym="PDIA10; TXNDC4"
                     /note="hexamer: AATAAA"
     polyA_site      2786
                     /gene="ERP44"
                     /gene_synonym="PDIA10; TXNDC4"
     regulatory      4783..4788
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ERP44"
                     /gene_synonym="PDIA10; TXNDC4"
                     /note="hexamer: AATAAA"
     polyA_site      4808
                     /gene="ERP44"
                     /gene_synonym="PDIA10; TXNDC4"
ORIGIN      
        1 gtgttcgccg ctggagcccg ggtcgagagg acgaggtgcc gctgcctgga gaatcctccg
       61 ctgccgtcgg ctcccggagc ccagcccttt cctaacccaa cccaacctag cccagtccca
      121 gccgccagcg cctgtccctg tcacggaccc cagcgttacc atgcatcctg ccgtcttcct
      181 atccttaccc gacctcagat gctcccttct gctcctggta acttgggttt ttactcctgt
      241 aacaactgaa ataacaagtc ttgatacaga gaatatagat gaaattttaa acaatgctga
      301 tgttgcttta gtaaattttt atgctgactg gtgtcgtttc agtcagatgt tgcatccaat
      361 ttttgaggaa gcttccgatg tcattaagga agaatttcca aatgaaaatc aagtagtgtt
      421 tgccagagtt gattgtgatc agcactctga catagcccag agatacagga taagcaaata
      481 cccaaccctc aaattgtttc gtaatgggat gatgatgaag agagaataca ggggtcagcg
      541 atcagtgaaa gcattggcag attacatcag gcaacaaaaa agtgacccca ttcaagaaat
      601 tcgggactta gcagaaatca ccactcttga tcgcagcaaa agaaatatca ttggatattt
      661 tgagcaaaag gactcggaca actatagagt ttttgaacga gtagcgaata ttttgcatga
      721 tgactgtgcc tttctttctg catttgggga tgtttcaaaa ccggaaagat atagtggcga
      781 caacataatc tacaaaccac cagggcattc tgctccggat atggtgtact tgggagctat
      841 gacaaatttt gatgtgactt acaattggat tcaagataaa tgtgttcctc ttgtccgaga
      901 aataacattt gaaaatggag aggaattgac agaagaagga ctgccttttc tcatactctt
      961 tcacatgaaa gaagatacag aaagtttaga aatattccag aatgaagtag ctcggcaatt
     1021 aataagtgaa aaaggtacaa taaacttttt acatgccgat tgtgacaaat ttagacatcc
     1081 tcttctgcac atacagaaaa ctccagcaga ttgtcctgta atcgctattg acagctttag
     1141 gcatatgtat gtgtttggag acttcaaaga tgtattaatt cctggaaaac tcaagcaatt
     1201 cgtatttgac ttacattctg gaaaactgca cagagaattc catcatggac ctgacccaac
     1261 tgatacagcc ccaggagagc aagcccaaga tgtagcaagc agtccacctg agagctcctt
     1321 ccagaaacta gcacccagtg aatataggta tactctattg agggatcgag atgagcttta
     1381 aaaacttgaa aaacagtttg taagcctttc aacagcagca tcaacctacg tggtggaaat
     1441 agtaaaccta tattttcata attctatgtg tatttttatt ttgaataaac agaaagaaat
     1501 tttgggtttt taattttttt ctccccgact caaaatgcat tgtcatttaa tatagtagcc
     1561 tcttaaaaaa aaaaaacctg ctaggattta aaaataaaaa tcagaggcct atctccactt
     1621 taaatctgtc ctgtaaaagt tttataaatc aaatgaaagg tgacattgcc agaaacttac
     1681 cattaacttg cactactagg gtagggagga cttagggatg tttcctgtgt cgtatgtgct
     1741 tttctttctt tcatatgatc aattctgttg gtattttcag tatctcattt ctcaaagcta
     1801 aagagatata cattctggat acttgggagg ggaataaatt aaagttttca cactgtgtac
     1861 tgtgttttac tgattggttg gatattgctt atgaaaattc catagtggta tttttttgga
     1921 ttcttaatgt gtaacttaaa catactttga agtggaggag agtcataaga cagaacattt
     1981 ggcaggaatt gtccttatga aacaagaaaa agaaaatgaa aagtattatt aagcttctgt
     2041 gtttgtctaa aaatgtggca tatggatggc atttaaaact ttgaatgaat tatacctaaa
     2101 tctgggacag ggaggtgaca gtggaacagg ctaccaatca gaactagatg acttttaagg
     2161 ctcctcctat tatgagactt caatttccaa agagaagaac tagcagagaa attgtatttc
     2221 agtaatttta agctccttct gtcttgtaga gtcttgttat agttgtataa atcaaaaaca
     2281 cagaataagg aacatattta actttttttc attataaaat ggttagagga ccctaccccc
     2341 tctagattcc ctgatttccc caggcctgca gcatacagta agatgggtcc ctgtgccagg
     2401 cctcaatact gccagggaat aaaaccagag ggagaggacc ctcagtgtca tatcaggaag
     2461 cccagtgcca gaggacagac aggttcaaaa ctggcttttc ctctgggcct gggttggtgc
     2521 tataggccaa gggtcatttt atacttgggt ataaatcaat cccagtttgg gaaaagatta
     2581 tttttaagct taaaaggctg acatgtgcca ttatatgtag tatgtaatat atgtaacatc
     2641 ttccaattct tttaaaataa aattaatatt tataatggat atttaatgat tgttattttt
     2701 aaaaaccagc ttataattcc tcgttatgca tgatttatcc aaagtttcca tagttttatt
     2761 caaaataata aatgttaata aggtgataag gggtatattt aatgtattgt atcaaattgt
     2821 gaataagaaa gtaggatgga gctttctaga ggttgggcct tagttctgtt atcctcattg
     2881 cttttaacca ataagttaaa tgaagttaga gttatggtct tcaggttaga ttatggacca
     2941 gatctgtgag ggtcagcatg gaaattcaca ttcaacaagg tagcacacag gaccaagagc
     3001 agcacatgca atcaactgga ataatatagt aatcctgtaa ctgggtttga aaaaataatc
     3061 aacaaaagat acaattcaag ggttaggttg cagagagctg gcttgagagt agttattatg
     3121 aaaaaggcct caaggagtac gtgttcagta tgctctaaga tgataaagtg gctgttaaaa
     3181 agggagttga tttgaggaag tattacttag cattcatgca tattgggctt aggctctagc
     3241 cctgccacta tcattgtctt ctctggactg tgaagtcact gaggacaagg aaactaaatt
     3301 taatgtctgt atcactagtg cctagaattt ctggacactt agtagtcacc atcaggcgtt
     3361 tatttaatga atgagaagca aagtgacctt ggttactttt ttaccctgag gggctcagca
     3421 ctcattagga cttggtgcct aattttataa aaagtcacta agctcaagtg cttggatgaa
     3481 aggacagcgt ggataaaaag gtttttaaaa catggatgtt aaggctgttt tgcttggaga
     3541 agacttggga ctgggacagt ctttagatat tatttgaaat gctggcactg tctatctgga
     3601 tcccagggct tgaactagga tttgaggaag tcacagggaa gcagatttca gtctgacatt
     3661 tattcagtgc aagttttttg gtgctgtagt atatgatgaa agatgtaaag ctgaataaag
     3721 cattatttct gccctagagt tgttcacagc ctagtcaggc atatggatat gtaaacaatg
     3781 actgtaacgt gttatagatg taaagacaaa ataaaggtta aagagggcat aaaggagcac
     3841 tcaattgcag agatttgagg acattatttt tattttgagc tttaaaaaga tgaataggtg
     3901 ttctcaggag gtagggatct ggctgagagg gaataatctg agcaaaggta tgaaacagcc
     3961 taatgcatta gagaaaaaag ttcttttagt aaggcatttg gggttgggga agctagaaaa
     4021 agaaatggga gctggtcaca cagggccttg tgtgccagac taaggggttt gtagtatata
     4081 ttgtaggcag aagagatcca tcaacagatt gcaagcaagg aagtatgttc actttaaagt
     4141 ttgagaaaga atagtgtgga agcacgtctc aaatttagac ttgttccccc tctgaaccgt
     4201 gaatcagacc atttcaggta gaagtcttcc ccggtttatc tgatctactc ggggcctcag
     4261 gcttctcagc tgggaagaga ggatgcaaga ccagactgaa gaacacggtt gagtccccag
     4321 aaccaaaagg gggcctttct gcttcttagc cagctacctc ttcgagtttt tcaaattgtg
     4381 agggggacca taaaaggatg gaaactttta gatgacattc tacaaattat ttttttcttt
     4441 aaattaaaag aacctagcca ataagataga gaatgggcat ctaaggcatc tcagagctct
     4501 ctgatgaagc caggttgtca aagatcattt gcaaaagaag ggaaaactgg catgacaaaa
     4561 gctacagaga ggagagtgaa atatagaagt gtttgaaatg ttcaagctca caataagctt
     4621 aaatttatag aaaatgctaa ggttgtcaag aaggcttttt tttttttctt ttttaaacct
     4681 gagggcaaaa aggaatggat aaagtagtgt aatggattga caatcaggaa gaacagaata
     4741 actcagtttt ttttctccta caaggagata tggctggacc aaaataaaat gacatgaaac
     4801 tgcaaaaa
//
