LOCUS       NM_006817               1623 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens endoplasmic reticulum protein 29 (ERP29), transcript
            variant 1, mRNA.
ACCESSION   NM_006817
VERSION     NM_006817.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1623)
  AUTHORS   Lu,T., Xie,F., Huang,C., Zhou,L., Lai,K., Gong,Y., Li,Z., Li,L.,
            Liang,J., Cong,Q., Li,W., Ju,R., Zhang,S.X. and Jin,C.
  TITLE     ERp29 Attenuates Nicotine-Induced Endoplasmic Reticulum Stress and
            Inhibits Choroidal Neovascularization
  JOURNAL   Int J Mol Sci 24 (21), 15523 (2023)
   PUBMED   37958506
  REMARK    GeneRIF: ERp29 Attenuates Nicotine-Induced Endoplasmic Reticulum
            Stress and Inhibits Choroidal Neovascularization.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1623)
  AUTHORS   Huang,Z.C., Huang,J., Huang,C.K., Hou,Y. and Zhu,B.
  TITLE     Euchromatic histone lysine methyltransferase 2 facilitates
            radioresistance in prostate cancer by repressing endoplasmic
            reticulum protein 29 transcription
  JOURNAL   Kaohsiung J Med Sci 39 (6), 576-586 (2023)
   PUBMED   36825520
  REMARK    GeneRIF: Euchromatic histone lysine methyltransferase 2 facilitates
            radioresistance in prostate cancer by repressing endoplasmic
            reticulum protein 29 transcription.
REFERENCE   3  (bases 1 to 1623)
  AUTHORS   Huang,J., Jing,M., Chen,X., Gao,Y., Hua,H., Pan,C., Wu,J., Wang,X.,
            Chen,X., Gao,Y., Xu,C. and Li,P.
  TITLE     ERp29 forms a feedback regulation loop with microRNA-135a-5p and
            promotes progression of colorectal cancer
  JOURNAL   Cell Death Dis 12 (11), 965 (2021)
   PUBMED   34667160
  REMARK    GeneRIF: ERp29 forms a feedback regulation loop with
            microRNA-135a-5p and promotes progression of colorectal cancer.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1623)
  AUTHORS   Nakao,H., Seko,A., Ito,Y. and Sakono,M.
  TITLE     Dimerization of ER-resident molecular chaperones mediated by ERp29
  JOURNAL   Biochem Biophys Res Commun 536, 52-58 (2021)
   PUBMED   33360823
  REMARK    GeneRIF: Dimerization of ER-resident molecular chaperones mediated
            by ERp29.
REFERENCE   5  (bases 1 to 1623)
  AUTHORS   Zhu,B., Huang,Z.C., Deng,H.H., Dong,Z.T., Zhao,X.K., Yang,L.Y. and
            Jiang,H.Y.
  TITLE     [Silencing ERp29 promotes the invasiveness of human PCa cells in
            vitro: Molecular mechanisms]
  JOURNAL   Zhonghua Nan Ke Xue 26 (7), 579-587 (2020)
   PUBMED   33377711
  REMARK    GeneRIF: [Silencing ERp29 promotes the invasiveness of human PCa
            cells in vitro: Molecular mechanisms].
REFERENCE   6  (bases 1 to 1623)
  AUTHORS   Hubbard,M.J. and McHugh,N.J.
  TITLE     Human ERp29: isolation, primary structural characterisation and
            two-dimensional gel mapping
  JOURNAL   Electrophoresis 21 (17), 3785-3796 (2000)
   PUBMED   11271497
REFERENCE   7  (bases 1 to 1623)
  AUTHORS   Ferrari,D.M., Nguyen Van,P., Kratzin,H.D. and Soling,H.D.
  TITLE     ERp28, a human endoplasmic-reticulum-lumenal protein, is a member
            of the protein disulfide isomerase family but lacks a CXXC
            thioredoxin-box motif
  JOURNAL   Eur J Biochem 255 (3), 570-579 (1998)
   PUBMED   9738895
REFERENCE   8  (bases 1 to 1623)
  AUTHORS   Mkrtchian,S., Fang,C., Hellman,U. and Ingelman-Sundberg,M.
  TITLE     A stress-inducible rat liver endoplasmic reticulum protein, ERp29
  JOURNAL   Eur J Biochem 251 (1-2), 304-313 (1998)
   PUBMED   9492298
REFERENCE   9  (bases 1 to 1623)
  AUTHORS   Hughes,G.J., Frutiger,S., Paquet,N., Pasquali,C., Sanchez,J.C.,
            Tissot,J.D., Bairoch,A., Appel,R.D. and Hochstrasser,D.F.
  TITLE     Human liver protein map: update 1993
  JOURNAL   Electrophoresis 14 (11), 1216-1222 (1993)
   PUBMED   8313870
REFERENCE   10 (bases 1 to 1623)
  AUTHORS   Hochstrasser,D.F., Frutiger,S., Paquet,N., Bairoch,A., Ravier,F.,
            Pasquali,C., Sanchez,J.C., Tissot,J.D., Bjellqvist,B., Vargas,R. et
            al.
  TITLE     Human liver protein map: a reference database established by
            microsequencing and gel comparison
  JOURNAL   Electrophoresis 13 (12), 992-1001 (1992)
   PUBMED   1286669
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC101493.1 and AC073575.30.
            
            On Nov 23, 2018 this sequence version replaced NM_006817.3.
            
            Summary: This gene encodes a protein which localizes to the lumen
            of the endoplasmic reticulum (ER). It is a member of the protein
            disulfide isomerase (PDI) protein family but lacks an active
            thioredoxin motif, suggesting that this protein does not function
            as a disulfide isomerase. The canonical protein dimerizes and is
            thought to play a role in the processing of secretory proteins
            within the ER. Alternative splicing results in multiple transcript
            variants encoding different isoforms. [provided by RefSeq, Dec
            2016].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BM749474.1, SRR1660803.95519.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000261735.4/ ENSP00000261735.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-863               BC101493.1         19-881
            864-1623            AC073575.30        157634-158393       c
FEATURES             Location/Qualifiers
     source          1..1623
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q24.13"
     gene            1..1623
                     /gene="ERP29"
                     /gene_synonym="C12orf8; ERp28; ERp31; HEL-S-107; PDI-DB;
                     PDIA9"
                     /note="endoplasmic reticulum protein 29"
                     /db_xref="GeneID:10961"
                     /db_xref="HGNC:HGNC:13799"
                     /db_xref="MIM:602287"
     exon            1..184
                     /gene="ERP29"
                     /gene_synonym="C12orf8; ERp28; ERp31; HEL-S-107; PDI-DB;
                     PDIA9"
                     /inference="alignment:Splign:2.1.0"
     CDS             41..826
                     /gene="ERP29"
                     /gene_synonym="C12orf8; ERp28; ERp31; HEL-S-107; PDI-DB;
                     PDIA9"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; protein disulfide isomerase family A, member 9;
                     endoplasmic reticulum lumenal protein ERp28; epididymis
                     secretory protein Li 107; endoplasmic reticulum resident
                     protein 29; endoplasmic reticulum resident protein 28;
                     endoplasmic reticulum resident protein 31"
                     /codon_start=1
                     /product="endoplasmic reticulum resident protein 29
                     isoform 1 precursor"
                     /protein_id="NP_006808.1"
                     /db_xref="CCDS:CCDS9158.1"
                     /db_xref="GeneID:10961"
                     /db_xref="HGNC:HGNC:13799"
                     /db_xref="MIM:602287"
                     /translation="MAAAVPRAAFLSPLLPLLLGFLLLSAPHGGSGLHTKGALPLDTV
                     TFYKVIPKSKFVLVKFDTQYPYGEKQDEFKRLAENSASSDDLLVAEVGISDYGDKLNM
                     ELSEKYKLDKESYPVFYLFRDGDFENPVPYTGAVKVGAIQRWLKGQGVYLGMPGCLPV
                     YDALAGEFIRASGVEARQALLKQGQDNLSSVKETQKKWAEQYLKIMGKILDQGEDFPA
                     SEMTRIARLIEKNKMSDGKKEELQKSLNILTAFQKKGAEKEEL"
     exon            185..323
                     /gene="ERP29"
                     /gene_synonym="C12orf8; ERp28; ERp31; HEL-S-107; PDI-DB;
                     PDIA9"
                     /inference="alignment:Splign:2.1.0"
     exon            324..1623
                     /gene="ERP29"
                     /gene_synonym="C12orf8; ERp28; ERp31; HEL-S-107; PDI-DB;
                     PDIA9"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1135..1140
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ERP29"
                     /gene_synonym="C12orf8; ERp28; ERp31; HEL-S-107; PDI-DB;
                     PDIA9"
                     /note="hexamer: ATTAAA"
     polyA_site      1159
                     /gene="ERP29"
                     /gene_synonym="C12orf8; ERp28; ERp31; HEL-S-107; PDI-DB;
                     PDIA9"
                     /note="major polyA site"
     regulatory      1400..1405
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ERP29"
                     /gene_synonym="C12orf8; ERp28; ERp31; HEL-S-107; PDI-DB;
                     PDIA9"
                     /note="hexamer: AATATA"
     polyA_site      1424
                     /gene="ERP29"
                     /gene_synonym="C12orf8; ERp28; ERp31; HEL-S-107; PDI-DB;
                     PDIA9"
     regulatory      1539..1544
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ERP29"
                     /gene_synonym="C12orf8; ERp28; ERp31; HEL-S-107; PDI-DB;
                     PDIA9"
                     /note="hexamer: ATTAAA"
     polyA_site      1562
                     /gene="ERP29"
                     /gene_synonym="C12orf8; ERp28; ERp31; HEL-S-107; PDI-DB;
                     PDIA9"
     regulatory      1575..1580
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ERP29"
                     /gene_synonym="C12orf8; ERp28; ERp31; HEL-S-107; PDI-DB;
                     PDIA9"
                     /note="hexamer: AATAAA"
     regulatory      1601..1606
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ERP29"
                     /gene_synonym="C12orf8; ERp28; ERp31; HEL-S-107; PDI-DB;
                     PDIA9"
                     /note="hexamer: AATAAA"
     polyA_site      1606
                     /gene="ERP29"
                     /gene_synonym="C12orf8; ERp28; ERp31; HEL-S-107; PDI-DB;
                     PDIA9"
     polyA_site      1623
                     /gene="ERP29"
                     /gene_synonym="C12orf8; ERp28; ERp31; HEL-S-107; PDI-DB;
                     PDIA9"
ORIGIN      
        1 actatcgctt acctacctcc ctctgcagga acccggcgat atggctgccg ctgtgccccg
       61 cgccgcattt ctctccccgc tgcttcccct tctcctgggc ttcctgctcc tctccgctcc
      121 gcatggcggc agcggcctgc acaccaaggg cgcccttccc ctggatacgg tcactttcta
      181 caaggtcatt cccaaaagca agttcgtctt ggtgaagttc gacacccagt acccctacgg
      241 tgagaagcag gatgagttca agcgtcttgc tgaaaactcg gcttccagcg atgatctctt
      301 ggtggcagag gtggggatct cagattatgg tgacaagctg aacatggagc tgagtgagaa
      361 atacaagctg gacaaagaga gctacccagt cttctacctc ttccgggatg gggactttga
      421 gaacccagtc ccatacactg gggcagttaa ggttggagcc atccagcgct ggctgaaggg
      481 gcaaggggtc tacctaggta tgcctggttg cctgcctgta tacgacgccc tggccgggga
      541 gttcatcagg gcctctggtg tggaggcccg ccaggccctc ttgaagcagg ggcaagataa
      601 cctctcaagt gtgaaggaga ctcagaagaa gtgggccgag caatacctga agatcatggg
      661 gaagatctta gaccaagggg aggacttccc agcatcagag atgacacgga tcgccaggct
      721 gattgagaag aacaagatga gtgacgggaa gaaggaggag ctccagaaga gcttaaacat
      781 cctgactgcc ttccagaaga agggggccga gaaagaggag ctgtaaaaag gctgtctgtg
      841 attttccagg gtttggtggg ggtagggagg ggagagttaa cctgctggct gtgagtccct
      901 tgtggaatat aagggggtag tgggaaaagt ggtactaacc cacgattctg agccctgagt
      961 atgcctggac attgatgcta acatgaccat gcttgggatg tctctagctg gtctggggat
     1021 agctggagca cttactcagg tggctggtga aatgacacct cagaaggaat gagtgctata
     1081 gagaggagag aggagtgtac tgcccaggtc tttgacagat gtaattctca ttcaattaaa
     1141 gtttcagtgt tttggttaag tggacctgaa gccattcttt tttcttttca aattatactt
     1201 tcgtctatga cctgctttcc tctttgaatc taagctggta tagactccac tttcccaggg
     1261 taacaaacta tcctcataac actgtggaaa ctggcatacc tttgttattt tccagtgata
     1321 ttcagactga catggattga ctgtcaatgg taaagtttgt ctattttcca gtccttaaaa
     1381 ctcaatagca gtattgatga atatattgaa ccaacattga tggaccatgg tgtaattatt
     1441 ttccatgctt tgtgaggtac acatagcaaa ttcttagttt tactgatata ttctgtgact
     1501 tggatttaca cagctaaatg atatagtccg atttcaaaat taaaaaatat tttccatcta
     1561 aatcactatc actaaataaa tactaacttc tagaaagcag aataaagagc acttgtgcca
     1621 aca
//
