LOCUS       NM_019891               4994 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens endoplasmic reticulum oxidoreductase 1 beta (ERO1B),
            mRNA.
ACCESSION   NM_019891
VERSION     NM_019891.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4994)
  AUTHORS   Yarapureddy,S., Abril,J., Foote,J., Kumar,S., Asad,O., Sharath,V.,
            Faraj,J., Daniel,D., Dickman,P., White-Collins,A., Hingorani,P. and
            Sertil,A.R.
  TITLE     ATF6alpha Activation Enhances Survival against Chemotherapy and
            Serves as a Prognostic Indicator in Osteosarcoma
  JOURNAL   Neoplasia 21 (6), 516-532 (2019)
   PUBMED   31029032
  REMARK    GeneRIF: Pharmacologic inhibition or knock-down of downstream
            targets of ATF6a, protein disulfide isomerases (PDI) and ERO1b, a
            thiol oxidase that is involved in the re-oxidation of PDIs also
            independently induced pronounced killing of osteosarcoma (OS) cells
            following chemotherapy.
REFERENCE   2  (bases 1 to 4994)
  AUTHORS   Zhu,T., Gao,Y.F., Chen,Y.X., Wang,Z.B., Yin,J.Y., Mao,X.Y., Li,X.,
            Zhang,W., Zhou,H.H. and Liu,Z.Q.
  TITLE     Genome-scale analysis identifies GJB2 and ERO1LB as prognosis
            markers in patients with pancreatic cancer
  JOURNAL   Oncotarget 8 (13), 21281-21289 (2017)
   PUBMED   28177904
  REMARK    GeneRIF: GJB2 and ERO1LB are implicated in pancreatic cancer
            progression and can be used to predict patient survival
REFERENCE   3  (bases 1 to 4994)
  AUTHORS   Xie,J., Zhu,Y., Chen,H., Shi,M., Gu,J., Zhang,J., Shen,B., Deng,X.,
            Zhan,X. and Peng,C.
  TITLE     The Immunohistochemical Evaluation of Solid Pseudopapillary Tumors
            of the Pancreas and Pancreatic Neuroendocrine Tumors Reveals
            ERO1Lbeta as a New Biomarker
  JOURNAL   Medicine (Baltimore) 95 (2), e2509 (2016)
   PUBMED   26765469
  REMARK    GeneRIF: upregulated in pancreatic neuroendocrine tumors
REFERENCE   4  (bases 1 to 4994)
  AUTHORS   Hansen,H.G., Soltoft,C.L., Schmidt,J.D., Birk,J.,
            Appenzeller-Herzog,C. and Ellgaard,L.
  TITLE     Biochemical evidence that regulation of Ero1beta activity in human
            cells does not involve the isoform-specific cysteine 262
  JOURNAL   Biosci Rep 34 (2), e00103 (2014)
   PUBMED   27919037
  REMARK    GeneRIF: This peptide, Ac-VDTTD-AFC, was efficiently cleaved by
            purified caspase-2 and auto-activating caspase-2 in mammalian
            cells, and exhibited better selectivity for caspase-2 relative to
            caspase-3 than reagents that are currently available.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4994)
  AUTHORS   Wang,L., Zhu,L. and Wang,C.C.
  TITLE     The endoplasmic reticulum sulfhydryl oxidase Ero1beta drives
            efficient oxidative protein folding with loose regulation
  JOURNAL   Biochem J 434 (1), 113-121 (2011)
   PUBMED   21091435
  REMARK    GeneRIF: In the present work, it was shown that recombinant human
            Ero1beta is twice as active as Ero1alpha in enzymatic assays.
REFERENCE   6  (bases 1 to 4994)
  AUTHORS   Molteni,S.N., Fassio,A., Ciriolo,M.R., Filomeni,G., Pasqualetto,E.,
            Fagioli,C. and Sitia,R.
  TITLE     Glutathione limits Ero1-dependent oxidation in the endoplasmic
            reticulum
  JOURNAL   J Biol Chem 279 (31), 32667-32673 (2004)
   PUBMED   15161913
  REMARK    GeneRIF: glutathione limits Ero1-dependent oxidation in the
            endoplasmic reticulum
REFERENCE   7  (bases 1 to 4994)
  AUTHORS   Gess,B., Hofbauer,K.H., Wenger,R.H., Lohaus,C., Meyer,H.E. and
            Kurtz,A.
  TITLE     The cellular oxygen tension regulates expression of the endoplasmic
            oxidoreductase ERO1-Lalpha
  JOURNAL   Eur J Biochem 270 (10), 2228-2235 (2003)
   PUBMED   12752442
REFERENCE   8  (bases 1 to 4994)
  AUTHORS   Anelli,T., Alessio,M., Mezghrani,A., Simmen,T., Talamo,F., Bachi,A.
            and Sitia,R.
  TITLE     ERp44, a novel endoplasmic reticulum folding assistant of the
            thioredoxin family
  JOURNAL   EMBO J 21 (4), 835-844 (2002)
   PUBMED   11847130
REFERENCE   9  (bases 1 to 4994)
  AUTHORS   Mezghrani,A., Fassio,A., Benham,A., Simmen,T., Braakman,I. and
            Sitia,R.
  TITLE     Manipulation of oxidative protein folding and PDI redox state in
            mammalian cells
  JOURNAL   EMBO J 20 (22), 6288-6296 (2001)
   PUBMED   11707400
REFERENCE   10 (bases 1 to 4994)
  AUTHORS   Pagani,M., Fabbri,M., Benedetti,C., Fassio,A., Pilati,S.,
            Bulleid,N.J., Cabibbo,A. and Sitia,R.
  TITLE     Endoplasmic reticulum oxidoreductin 1-lbeta (ERO1-Lbeta), a human
            gene induced in the course of the unfolded protein response
  JOURNAL   J Biol Chem 275 (31), 23685-23692 (2000)
   PUBMED   10818100
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BG723126.1, AL450309.14, BC044573.1, AL139162.20 and CR749523.1.
            
            On May 17, 2019 this sequence version replaced NM_019891.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC044573.1, AK315351.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000354619.10/ ENSP00000346635.5
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-46                BG723126.1         85-130
            47-47               AL450309.14        55441-55441         c
            48-560              BC044573.1         75-587
            561-561             AL450309.14        23459-23459         c
            562-2935            BC044573.1         589-2962
            2936-3887           AL139162.20        62056-63007         c
            3888-4973           CR749523.1         2156-3241
            4974-4994           AL139162.20        60949-60969         c
FEATURES             Location/Qualifiers
     source          1..4994
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q42.3"
     gene            1..4994
                     /gene="ERO1B"
                     /gene_synonym="Ero1beta; ERO1LB"
                     /note="endoplasmic reticulum oxidoreductase 1 beta"
                     /db_xref="GeneID:56605"
                     /db_xref="HGNC:HGNC:14355"
                     /db_xref="MIM:615437"
     exon            1..277
                     /gene="ERO1B"
                     /gene_synonym="Ero1beta; ERO1LB"
                     /inference="alignment:Splign:2.1.0"
     CDS             176..1579
                     /gene="ERO1B"
                     /gene_synonym="Ero1beta; ERO1LB"
                     /note="endoplasmic reticulum oxidoreductase beta;
                     ERO1-like protein beta; ERO1-L-beta;
                     oxidoreductin-1-L-beta; endoplasmic oxidoreductin-1-like
                     protein B; endoplasmic reticulum oxidoreductin-1-like
                     protein B; ERO1-like beta"
                     /codon_start=1
                     /product="ERO1-like protein beta precursor"
                     /protein_id="NP_063944.3"
                     /db_xref="CCDS:CCDS31064.1"
                     /db_xref="GeneID:56605"
                     /db_xref="HGNC:HGNC:14355"
                     /db_xref="MIM:615437"
                     /translation="MSQGVRRAGAGQGVAAAVQLLVTLSFLRSVVEAQVTGVLDDCLC
                     DIDSIDNFNTYKIFPKIKKLQERDYFRYYKVNLKRPCPFWAEDGHCSIKDCHVEPCPE
                     SKIPVGIKAGHSNKYLKMANNTKELEDCEQANKLGAINSTLSNQSKEAFIDWARYDDS
                     RDHFCELDDERSPAAQYVDLLLNPERYTGYKGTSAWRVWNSIYEENCFKPRSVYRPLN
                     PLAPSRGEDDGESFYTWLEGLCLEKRVFYKLISGLHASINLHLCANYLLEETWGKPSW
                     GPNIKEFKHRFDPVETKGEGPRRLKNLYFLYLIELRALSKVAPYFERSIVDLYTGNAE
                     EDADTKTLLLNIFQDTKSFPMHFDEKSMFAGDKKGAKSLKEEFRLHFKNISRIMDCVG
                     CDKCRLWGKLQTQGLGTALKILFSEKEIQKLPENSPSKGFQLTRQEIVALLNAFGRLS
                     TSIRDLQNFKVLLQHSR"
     exon            278..397
                     /gene="ERO1B"
                     /gene_synonym="Ero1beta; ERO1LB"
                     /inference="alignment:Splign:2.1.0"
     exon            398..481
                     /gene="ERO1B"
                     /gene_synonym="Ero1beta; ERO1LB"
                     /inference="alignment:Splign:2.1.0"
     exon            482..523
                     /gene="ERO1B"
                     /gene_synonym="Ero1beta; ERO1LB"
                     /inference="alignment:Splign:2.1.0"
     exon            524..606
                     /gene="ERO1B"
                     /gene_synonym="Ero1beta; ERO1LB"
                     /inference="alignment:Splign:2.1.0"
     exon            607..680
                     /gene="ERO1B"
                     /gene_synonym="Ero1beta; ERO1LB"
                     /inference="alignment:Splign:2.1.0"
     exon            681..801
                     /gene="ERO1B"
                     /gene_synonym="Ero1beta; ERO1LB"
                     /inference="alignment:Splign:2.1.0"
     exon            802..848
                     /gene="ERO1B"
                     /gene_synonym="Ero1beta; ERO1LB"
                     /inference="alignment:Splign:2.1.0"
     exon            849..860
                     /gene="ERO1B"
                     /gene_synonym="Ero1beta; ERO1LB"
                     /inference="alignment:Splign:2.1.0"
     exon            861..887
                     /gene="ERO1B"
                     /gene_synonym="Ero1beta; ERO1LB"
                     /inference="alignment:Splign:2.1.0"
     exon            888..980
                     /gene="ERO1B"
                     /gene_synonym="Ero1beta; ERO1LB"
                     /inference="alignment:Splign:2.1.0"
     exon            981..1227
                     /gene="ERO1B"
                     /gene_synonym="Ero1beta; ERO1LB"
                     /inference="alignment:Splign:2.1.0"
     exon            1228..1297
                     /gene="ERO1B"
                     /gene_synonym="Ero1beta; ERO1LB"
                     /inference="alignment:Splign:2.1.0"
     exon            1298..1384
                     /gene="ERO1B"
                     /gene_synonym="Ero1beta; ERO1LB"
                     /inference="alignment:Splign:2.1.0"
     exon            1385..1518
                     /gene="ERO1B"
                     /gene_synonym="Ero1beta; ERO1LB"
                     /inference="alignment:Splign:2.1.0"
     exon            1519..4994
                     /gene="ERO1B"
                     /gene_synonym="Ero1beta; ERO1LB"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4014..4019
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ERO1B"
                     /gene_synonym="Ero1beta; ERO1LB"
                     /note="hexamer: ATTAAA"
     polyA_site      4035
                     /gene="ERO1B"
                     /gene_synonym="Ero1beta; ERO1LB"
     regulatory      4519..4524
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ERO1B"
                     /gene_synonym="Ero1beta; ERO1LB"
                     /note="hexamer: ATTAAA"
     polyA_site      4540
                     /gene="ERO1B"
                     /gene_synonym="Ero1beta; ERO1LB"
                     /note="major polyA site"
     regulatory      4945..4950
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ERO1B"
                     /gene_synonym="Ero1beta; ERO1LB"
                     /note="hexamer: ATTAAA"
     polyA_site      4994
                     /gene="ERO1B"
                     /gene_synonym="Ero1beta; ERO1LB"
ORIGIN      
        1 actcgcagct gccgggtgtt ggggaaagag tcgcctgcct ccggactgga gtgcagacct
       61 ctgaccctgg agtcgctcgg ccgctgggaa ccgtcccctt gggtcgtcgc ctgggccgcc
      121 cgtcgttccc cggccccgag gggtccggct ggccgcggtg tgggtagagg tcagcatgag
      181 ccaaggggtc cgccgggcag gcgctgggca gggggtagcg gccgcggtgc agctgctggt
      241 caccctgagc ttcctgcgga gcgtcgtcga ggcgcaggtc actggagttc tggatgattg
      301 cttgtgtgat attgacagca tcgataactt caatacctac aaaatcttcc ccaaaataaa
      361 aaaattgcaa gagagagact attttcgtta ttacaaggtt aatctgaagc gaccttgtcc
      421 tttctgggca gaagatggcc actgttcaat aaaagactgt catgtggagc cctgtccaga
      481 gagtaaaatt ccggttggaa taaaagctgg gcattctaat aagtacttga aaatggcaaa
      541 caataccaaa gaattagaag attgtgagca agctaataaa ctgggagcaa ttaacagcac
      601 attaagtaat caaagcaaag aagctttcat tgactgggca agatatgatg attcacggga
      661 tcacttttgt gaacttgatg atgagagatc tccagctgct cagtatgtag acctattgct
      721 gaacccagag cgttacactg gctataaagg gacctctgca tggagagtgt ggaacagcat
      781 ctatgaagag aactgtttca agcctcgatc tgtttatcgt cctttaaatc ctctggcgcc
      841 tagccgaggc gaagatgatg gagaatcatt ctacacatgg ctagaaggtt tgtgtctgga
      901 gaaaagagtc ttctataagc ttatatcggg acttcatgct agcatcaatt tacatctatg
      961 cgcaaattat cttttggaag aaacctgggg taagcccagt tggggaccta atattaaaga
     1021 attcaaacac cgctttgacc ctgtggaaac caagggagaa ggtccaagaa ggctcaagaa
     1081 tctttacttt ttatacttga ttgagcttcg agctttgtca aaggtggctc catattttga
     1141 gcgctcaatt gtcgatcttt acactggaaa tgcagaagaa gatgctgaca caaaaactct
     1201 tctactgaat atctttcaag atacaaagtc ctttcccatg cactttgatg agaaatccat
     1261 gtttgcaggt gacaaaaaag gggccaagtc actaaaggag gaattccgat tacatttcaa
     1321 gaatatctcc cgtataatgg actgtgttgg atgtgacaaa tgcagattat ggggaaaatt
     1381 acagactcag ggtttaggaa ctgccctgaa gatattattc tctgaaaaag aaatccaaaa
     1441 gcttccagag aatagtccat ctaaaggctt ccaactcacc cgacaggaaa tagttgctct
     1501 tttaaatgct tttggaaggc tttctacaag tataagagac ttacagaatt ttaaagtctt
     1561 attacaacac agtaggtaat aaaggctttt atgtgtctaa ctagagacat aaagtgactg
     1621 tggaaagcct tttaattatg gacattcatc agaaagacac taatctgact tcaagaattc
     1681 tgaactatta aatagaaaat ttaaatgctc acttgaatat ttatgattct taatagatta
     1741 ttatcaacta gagatattta taaatgaagt atatactttt aaaacatgta agttatacta
     1801 attttgtgtt taatttcata tgttttcatg taatgaaaat tctatttttt ttagaattgg
     1861 ttttgttttt attctattat cctttatttc cagttgtcaa actttaaatg gctatgtctg
     1921 cattctaata acactgttca gtctgttatg gaaaaggaga actagggaac aaatgttgct
     1981 cagggctggt gtcagtgaga aaaatttatc aatgcttttt aatgtgtttt tacccttgcc
     2041 tcactgtgtg tgtgtcactt tctataatat aaagaaatac tataatattt ctagaatctg
     2101 gaactgtcac catgatgaat ggccctttca atgcatagtt acagaaattc ctgaagattc
     2161 cccaggactt caatttcatt ggtttttatt tgcagttttt agttgctgta attgttgctg
     2221 tttccagtct aaaggacctc ctttggtaaa ggtgaacaag acctctcccc tatgctaccc
     2281 agccagattt tgtgtgtgta atgggctggc ccaagagtgt tcttttactt agaactcctt
     2341 ttgattttgc ttttctctgc ccctagaaat tttagggaca aagacatttt ggaaattgtc
     2401 agttactttt agaaagaaaa cactgcagaa atatttaaca gattacttct tgataaaatt
     2461 taaatgggat tatatgaatt tataatgcca attgaaaata ttatatacac aaaatttgct
     2521 attttcactt aaagtaagca tttttaaagg atttatttta gaatacaatc tatgcaatcc
     2581 tcgaactcag tgtgcttttc cctgacagga tatataaaaa ggtagattag gtcaaccctc
     2641 ctttaagctt actctcccct caccttttct tttcactgta tataaacggt actttctgtg
     2701 attcatacca acagaggact ttctgtgatt cataccaaca gtcctaaact gtcattttct
     2761 aaatctggga tttaaaatct ttagacaata tttaaaatct tgattttttt taaatgtcag
     2821 cagatacaat ttggaagatt gcatctgtgt agaagtaatg caggtacaag atctagagtt
     2881 tttccttaga ctctttagtc ttttctgaat taaagaataa gtgctcttaa atccatattt
     2941 tatcctgtca aagtctgaaa tgtgttcatt gatgatttgg tgacatctaa aaaattgtat
     3001 ttagttggct tggctcaccc ctcttaaaaa tacttagcca tctcttggtg ggatgtggtg
     3061 ggggtattaa ggtctcagag ttatttattt tctcacctaa tttcaaacct ttataaactt
     3121 ggggttttgt tgttgatggt ggtagtattt tttgttaagt tgtttaaaag gctgacttga
     3181 ttggagcctc ctctactttt tcttgagggt tgcaagtatt gtatggtggg ggaggggggc
     3241 cttaaggcaa actgtctaaa aagtgactat ccaattaatt taactagtaa attagtaaga
     3301 attattctta gtattcactc agagtttaag atgtgaaaaa tctgcacttt gtttatcact
     3361 ctaaatgtaa agaacttttt gatagtgtta tttcaccact ccctcagtta aaggctatta
     3421 tttaaactgt ttactggaga aaatcctcgc tcatgtccat ttattgtttt tttctgtact
     3481 gtgatttgtt tcaagcttag gaaaactagt atattagagt atgttctagg aaattaaaag
     3541 atctggttag agtaaaaagt tctttttaag gttcttaact aattttttca caactaagaa
     3601 aataaatgaa gtattcttag gctgaaattc atcttatttt atcataaatt agattgtagg
     3661 ggcagcctac atttttgtgt atgtgttttt atttcttaaa tgattgtgtg agcctggtga
     3721 cattttatgg ttcttgtgat ctaaactgtt tttccaattc acatcttttg tcgtgaagtg
     3781 atattatact agagtactgt ttgcattgta aaaatgcttt gctggtgctc tggcattttg
     3841 tctttatctc atcacctaat ttaaaaaccc agcacttgat aatataactg acagaaatga
     3901 ttgtacccac tgatgaagta atgaaaatga agaaaaggaa aatattcctt ccttcaatgg
     3961 cgtaagttta ttttttactt aagtggcatc tatgtaagtt agacaaacta tatattaaaa
     4021 ttggtaaact ttgaatgttt ctcctgtttt gattcttaga ttatgaggag gatcagacag
     4081 aataagactc cacacttttg aaatttgata agtcaaaacg ttttattttg acatttttaa
     4141 cattgtgaat tattcgatat ttgtaatctc tgtatgtata tgaaactctg ccatgttttt
     4201 caactttgcc tatgtgccac tgtatataag aaaggacagc tattttgatc ttcatcagca
     4261 ttgccttcag ctgaaaattt gggaacagtt cacagtaaac ctctcagtag tttgcaaact
     4321 gaggtacctg cagaaaccat agctactcac caaaatacac agattaggtg catggtatcg
     4381 tggaaattat ttggtaaaaa aacacacaca caaatctatg tgtactgtat tttaaggaat
     4441 atctacaggt gcagctttga ttttgaacag aattccaaat aatttactgt tgtacccacc
     4501 agaatctaga aaatgtgaat taaagtacat gtttctgcaa tcttttctgt cttgtttttc
     4561 cccgctattt taagtgtttc tttttatggc atgagaattt gattgtaacc tgtggagaag
     4621 ggagaaaatg tatttataag tagtctgagg ttgtttctta tcataatggc aagcattggc
     4681 tggcattgta ttaagggctt ttacatgcat agtttggctt taaaagaata caccgttaat
     4741 cttcacaata gcactagtag gtaggtacaa ttacttctct gttttataag taagaagact
     4801 gaggataaaa aaggctaagt aacctgtcca tagtcacaaa ttctaggttg tggagcaaga
     4861 atttgagacg agaaagactg attctagaac ctttgtgaca ttttgtaagt tggcctattt
     4921 ccattcagct acaaagtggg aacaattaaa agcattgttt gatttgtatt gaatcataaa
     4981 gcttataaaa tatg
//
