LOCUS       NM_014584               5139 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens endoplasmic reticulum oxidoreductase 1 alpha (ERO1A),
            transcript variant 2, mRNA.
ACCESSION   NM_014584
VERSION     NM_014584.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5139)
  AUTHORS   Germani,S., Van Ho,A.T., Cherubini,A., Varone,E., Chernorudskiy,A.,
            Renna,G.M., Fumagalli,S., Gobbi,M., Lucchetti,J., Bolis,M.,
            Guarrera,L., Craparotta,I., Rastelli,G., Piccoli,G., de Napoli,C.,
            Nogara,L., Poggio,E., Brini,M., Cattaneo,A., Bachi,A., Simmen,T.,
            Cali,T., Quijano-Roy,S., Boncompagni,S., Blaauw,B., Ferreiro,A. and
            Zito,E.
  TITLE     SEPN1-related myopathy depends on the oxidoreductase ERO1A and is
            druggable with the chemical chaperone TUDCA
  JOURNAL   Cell Rep Med 5 (3), 101439 (2024)
   PUBMED   38402623
  REMARK    GeneRIF: SEPN1-related myopathy depends on the oxidoreductase ERO1A
            and is druggable with the chemical chaperone TUDCA.
REFERENCE   2  (bases 1 to 5139)
  AUTHORS   Chen,P., Sharma,A., Weiher,H. and Schmidt-Wolf,I.G.H.
  TITLE     Biological mechanisms and clinical significance of endoplasmic
            reticulum oxidoreductase 1 alpha (ERO1alpha) in human cancer
  JOURNAL   J Exp Clin Cancer Res 43 (1), 71 (2024)
   PUBMED   38454454
  REMARK    GeneRIF: Biological mechanisms and clinical significance of
            endoplasmic reticulum oxidoreductase 1 alpha (ERO1alpha) in human
            cancer.
            Review article
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5139)
  AUTHORS   Wu,M., Li,R., Qin,J., Wang,Z., Guo,J., Lv,F., Wang,G. and Huang,Y.
  TITLE     ERO1alpha promotes the proliferation and inhibits apoptosis of
            colorectal cancer cells by regulating the PI3K/AKT pathway
  JOURNAL   J Mol Histol 54 (6), 621-631 (2023)
   PUBMED   37776473
  REMARK    GeneRIF: ERO1alpha promotes the proliferation and inhibits
            apoptosis of colorectal cancer cells by regulating the PI3K/AKT
            pathway.
REFERENCE   4  (bases 1 to 5139)
  AUTHORS   Liu,L., Li,S., Qu,Y., Bai,H., Pan,X., Wang,J., Wang,Z., Duan,J.,
            Zhong,J., Wan,R., Fei,K., Xu,J., Yuan,L., Wang,C., Xue,P.,
            Zhang,X., Ma,Z. and Wang,J.
  TITLE     Ablation of ERO1A induces lethal endoplasmic reticulum stress
            responses and immunogenic cell death to activate anti-tumor
            immunity
  JOURNAL   Cell Rep Med 4 (10), 101206 (2023)
   PUBMED   37769655
  REMARK    GeneRIF: Ablation of ERO1A induces lethal endoplasmic reticulum
            stress responses and immunogenic cell death to activate anti-tumor
            immunity.
REFERENCE   5  (bases 1 to 5139)
  AUTHORS   Shergalis,A.G., Hu,S., Bankhead,A. 3rd and Neamati,N.
  TITLE     Role of the ERO1-PDI interaction in oxidative protein folding and
            disease
  JOURNAL   Pharmacol Ther 210, 107525 (2020)
   PUBMED   32201313
  REMARK    Review article
REFERENCE   6  (bases 1 to 5139)
  AUTHORS   Fan,Y. and Simmen,T.
  TITLE     Mechanistic Connections between Endoplasmic Reticulum (ER) Redox
            Control and Mitochondrial Metabolism
  JOURNAL   Cells 8 (9), 1071 (2019)
   PUBMED   31547228
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 5139)
  AUTHORS   Pagani,M., Pilati,S., Bertoli,G., Valsasina,B. and Sitia,R.
  TITLE     The C-terminal domain of yeast Ero1p mediates membrane localization
            and is essential for function
  JOURNAL   FEBS Lett 508 (1), 117-120 (2001)
   PUBMED   11707280
REFERENCE   8  (bases 1 to 5139)
  AUTHORS   Benham,A.M., Cabibbo,A., Fassio,A., Bulleid,N., Sitia,R. and
            Braakman,I.
  TITLE     The CXXCXXC motif determines the folding, structure and stability
            of human Ero1-Lalpha
  JOURNAL   EMBO J 19 (17), 4493-4502 (2000)
   PUBMED   10970843
REFERENCE   9  (bases 1 to 5139)
  AUTHORS   Pagani,M., Fabbri,M., Benedetti,C., Fassio,A., Pilati,S.,
            Bulleid,N.J., Cabibbo,A. and Sitia,R.
  TITLE     Endoplasmic reticulum oxidoreductin 1-lbeta (ERO1-Lbeta), a human
            gene induced in the course of the unfolded protein response
  JOURNAL   J Biol Chem 275 (31), 23685-23692 (2000)
   PUBMED   10818100
REFERENCE   10 (bases 1 to 5139)
  AUTHORS   Cabibbo,A., Pagani,M., Fabbri,M., Rocchi,M., Farmery,M.R.,
            Bulleid,N.J. and Sitia,R.
  TITLE     ERO1-L, a human protein that favors disulfide bond formation in the
            endoplasmic reticulum
  JOURNAL   J Biol Chem 275 (7), 4827-4833 (2000)
   PUBMED   10671517
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC012941.1 and AL133453.3.
            
            On Nov 22, 2018 this sequence version replaced NM_014584.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF081886.1, AK292839.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000395686.8/ ENSP00000379042.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1753              BC012941.1         157-1909
            1754-5139           AL133453.3         103067-106452       c
FEATURES             Location/Qualifiers
     source          1..5139
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q22.1"
     gene            1..5139
                     /gene="ERO1A"
                     /gene_synonym="ERO1-alpha; ERO1-L; ERO1-L-alpha;
                     Ero1alpha; ERO1L; ERO1LA"
                     /note="endoplasmic reticulum oxidoreductase 1 alpha"
                     /db_xref="GeneID:30001"
                     /db_xref="HGNC:HGNC:13280"
                     /db_xref="MIM:615435"
     exon            1..191
                     /gene="ERO1A"
                     /gene_synonym="ERO1-alpha; ERO1-L; ERO1-L-alpha;
                     Ero1alpha; ERO1L; ERO1LA"
                     /inference="alignment:Splign:2.1.0"
     CDS             78..1484
                     /gene="ERO1A"
                     /gene_synonym="ERO1-alpha; ERO1-L; ERO1-L-alpha;
                     Ero1alpha; ERO1L; ERO1LA"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 2; ERO1-like protein alpha;
                     oxidoreductin-1-L-alpha; endoplasmic oxidoreductin-1-like
                     protein; endoplasmic reticulum oxidoreductase alpha"
                     /codon_start=1
                     /product="ERO1-like protein alpha isoform 2 precursor"
                     /protein_id="NP_055399.1"
                     /db_xref="CCDS:CCDS9709.1"
                     /db_xref="GeneID:30001"
                     /db_xref="HGNC:HGNC:13280"
                     /db_xref="MIM:615435"
                     /translation="MGRGWGFLFGLLGAVWLLSSGHGEEQPPETAAQRCFCQVSGYLD
                     DCTCDVETIDRFNNYRLFPRLQKLLESDYFRYYKVNLKRPCPFWNDISQCGRRDCAVK
                     PCQSDEVPDGIKSASYKYSEEANNLIEECEQAERLGAVDESLSEETQKAVLQWTKHDD
                     SSDNFCEADDIQSPEAEYVDLLLNPERYTGYKGPDAWKIWNVIYEENCFKPQTIKRPL
                     NPLASGQGTSEENTFYSWLEGLCVEKRAFYRLISGLHASINVHLSARYLLQETWLEKK
                     WGHNITEFQQRFDGILTEGEGPRRLKNLYFLYLIELRALSKVLPFFERPDFQLFTGNK
                     IQDEENKMLLLEILHEIKSFPLHFDENSFFAGDKKEAHKLKEDFRLHFRNISRIMDCV
                     GCFKCRLWGKLQTQGLGTALKILFSEKLIANMPESGPSYEFHLTRQEIVSLFNAFGRI
                     STSVKELENFRNLLQNIH"
     exon            192..311
                     /gene="ERO1A"
                     /gene_synonym="ERO1-alpha; ERO1-L; ERO1-L-alpha;
                     Ero1alpha; ERO1L; ERO1LA"
                     /inference="alignment:Splign:2.1.0"
     exon            312..395
                     /gene="ERO1A"
                     /gene_synonym="ERO1-alpha; ERO1-L; ERO1-L-alpha;
                     Ero1alpha; ERO1L; ERO1LA"
                     /inference="alignment:Splign:2.1.0"
     exon            396..434
                     /gene="ERO1A"
                     /gene_synonym="ERO1-alpha; ERO1-L; ERO1-L-alpha;
                     Ero1alpha; ERO1L; ERO1LA"
                     /inference="alignment:Splign:2.1.0"
     exon            435..511
                     /gene="ERO1A"
                     /gene_synonym="ERO1-alpha; ERO1-L; ERO1-L-alpha;
                     Ero1alpha; ERO1L; ERO1LA"
                     /inference="alignment:Splign:2.1.0"
     exon            512..585
                     /gene="ERO1A"
                     /gene_synonym="ERO1-alpha; ERO1-L; ERO1-L-alpha;
                     Ero1alpha; ERO1L; ERO1LA"
                     /inference="alignment:Splign:2.1.0"
     exon            586..706
                     /gene="ERO1A"
                     /gene_synonym="ERO1-alpha; ERO1-L; ERO1-L-alpha;
                     Ero1alpha; ERO1L; ERO1LA"
                     /inference="alignment:Splign:2.1.0"
     exon            707..753
                     /gene="ERO1A"
                     /gene_synonym="ERO1-alpha; ERO1-L; ERO1-L-alpha;
                     Ero1alpha; ERO1L; ERO1LA"
                     /inference="alignment:Splign:2.1.0"
     exon            754..765
                     /gene="ERO1A"
                     /gene_synonym="ERO1-alpha; ERO1-L; ERO1-L-alpha;
                     Ero1alpha; ERO1L; ERO1LA"
                     /inference="alignment:Splign:2.1.0"
     exon            766..792
                     /gene="ERO1A"
                     /gene_synonym="ERO1-alpha; ERO1-L; ERO1-L-alpha;
                     Ero1alpha; ERO1L; ERO1LA"
                     /inference="alignment:Splign:2.1.0"
     exon            793..885
                     /gene="ERO1A"
                     /gene_synonym="ERO1-alpha; ERO1-L; ERO1-L-alpha;
                     Ero1alpha; ERO1L; ERO1LA"
                     /inference="alignment:Splign:2.1.0"
     exon            886..1132
                     /gene="ERO1A"
                     /gene_synonym="ERO1-alpha; ERO1-L; ERO1-L-alpha;
                     Ero1alpha; ERO1L; ERO1LA"
                     /inference="alignment:Splign:2.1.0"
     exon            1133..1202
                     /gene="ERO1A"
                     /gene_synonym="ERO1-alpha; ERO1-L; ERO1-L-alpha;
                     Ero1alpha; ERO1L; ERO1LA"
                     /inference="alignment:Splign:2.1.0"
     exon            1203..1289
                     /gene="ERO1A"
                     /gene_synonym="ERO1-alpha; ERO1-L; ERO1-L-alpha;
                     Ero1alpha; ERO1L; ERO1LA"
                     /inference="alignment:Splign:2.1.0"
     exon            1290..1423
                     /gene="ERO1A"
                     /gene_synonym="ERO1-alpha; ERO1-L; ERO1-L-alpha;
                     Ero1alpha; ERO1L; ERO1LA"
                     /inference="alignment:Splign:2.1.0"
     exon            1424..5139
                     /gene="ERO1A"
                     /gene_synonym="ERO1-alpha; ERO1-L; ERO1-L-alpha;
                     Ero1alpha; ERO1L; ERO1LA"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1729..1734
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ERO1A"
                     /gene_synonym="ERO1-alpha; ERO1-L; ERO1-L-alpha;
                     Ero1alpha; ERO1L; ERO1LA"
                     /note="hexamer: AATAAA"
     polyA_site      1753
                     /gene="ERO1A"
                     /gene_synonym="ERO1-alpha; ERO1-L; ERO1-L-alpha;
                     Ero1alpha; ERO1L; ERO1LA"
                     /note="major polyA site"
     regulatory      3147..3152
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ERO1A"
                     /gene_synonym="ERO1-alpha; ERO1-L; ERO1-L-alpha;
                     Ero1alpha; ERO1L; ERO1LA"
                     /note="hexamer: AATAAA"
     polyA_site      3167
                     /gene="ERO1A"
                     /gene_synonym="ERO1-alpha; ERO1-L; ERO1-L-alpha;
                     Ero1alpha; ERO1L; ERO1LA"
                     /note="major polyA site"
     regulatory      4974..4979
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ERO1A"
                     /gene_synonym="ERO1-alpha; ERO1-L; ERO1-L-alpha;
                     Ero1alpha; ERO1L; ERO1LA"
                     /note="hexamer: AATAAA"
     regulatory      4989..4994
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ERO1A"
                     /gene_synonym="ERO1-alpha; ERO1-L; ERO1-L-alpha;
                     Ero1alpha; ERO1L; ERO1LA"
                     /note="hexamer: AATAAA"
     polyA_site      4994
                     /gene="ERO1A"
                     /gene_synonym="ERO1-alpha; ERO1-L; ERO1-L-alpha;
                     Ero1alpha; ERO1L; ERO1LA"
                     /note="major polyA site"
     polyA_site      5009
                     /gene="ERO1A"
                     /gene_synonym="ERO1-alpha; ERO1-L; ERO1-L-alpha;
                     Ero1alpha; ERO1L; ERO1LA"
     regulatory      5117..5122
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ERO1A"
                     /gene_synonym="ERO1-alpha; ERO1-L; ERO1-L-alpha;
                     Ero1alpha; ERO1L; ERO1LA"
                     /note="hexamer: AATAAA"
     polyA_site      5139
                     /gene="ERO1A"
                     /gene_synonym="ERO1-alpha; ERO1-L; ERO1-L-alpha;
                     Ero1alpha; ERO1L; ERO1LA"
ORIGIN      
        1 atctgagggc gcacggcccg cgaccgagcg tgcggactgg cctcccaagc gtggggcgac
       61 aagctgccgg agctgcaatg ggccgcggct ggggattctt gtttggcctc ctgggcgccg
      121 tgtggctgct cagctcgggc cacggagagg agcagccccc ggagacagcg gcacagaggt
      181 gcttctgcca ggttagtggt tacttggatg attgtacctg tgatgttgaa accattgata
      241 gatttaataa ctacaggctt ttcccaagac tacaaaaact tcttgaaagt gactacttta
      301 ggtattacaa ggtaaacctg aagaggccgt gtcctttctg gaatgacatc agccagtgtg
      361 gaagaaggga ctgtgctgtc aaaccatgtc aatctgatga agttcctgat ggaattaaat
      421 ctgcgagcta caagtattct gaagaagcca ataatctcat tgaagaatgt gaacaagctg
      481 aacgacttgg agcagtggat gaatctctga gtgaggaaac acagaaggct gttcttcagt
      541 ggaccaagca tgatgattct tcagataact tctgtgaagc tgatgacatt cagtcccctg
      601 aagctgaata tgtagatttg cttcttaatc ctgagcgcta cactggttac aagggaccag
      661 atgcttggaa aatatggaat gtcatctacg aagaaaactg ttttaagcca cagacaatta
      721 aaagaccttt aaatcctttg gcttctggtc aagggacaag tgaagagaac actttttaca
      781 gttggctaga aggtctctgt gtagaaaaaa gagcattcta cagacttata tctggcctac
      841 atgcaagcat taatgtgcat ttgagtgcaa gatatctttt acaagagacc tggttagaaa
      901 agaaatgggg acacaacatt acagaatttc aacagcgatt tgatggaatt ttgactgaag
      961 gagaaggtcc aagaaggctt aagaacttgt attttctcta cttaatagaa ctaagggctt
     1021 tatccaaagt gttaccattc ttcgagcgcc cagattttca actctttact ggaaataaaa
     1081 ttcaggatga ggaaaacaaa atgttacttc tggaaatact tcatgaaatc aagtcatttc
     1141 ctttgcattt tgatgagaat tcattttttg ctggggataa aaaagaagca cacaaactaa
     1201 aggaggactt tcgactgcat tttagaaata tttcaagaat tatggattgt gttggttgtt
     1261 ttaaatgtcg tctgtgggga aagcttcaga ctcagggttt gggcactgct ctgaagatct
     1321 tattttctga gaaattgata gcaaatatgc cagaaagtgg acctagttat gaattccatc
     1381 taaccagaca agaaatagta tcattattca acgcatttgg aagaatttct acaagtgtga
     1441 aagaattaga aaacttcagg aacttgttac agaatattca ttaaagaaaa caagctgata
     1501 tgtgcctgtt tctggacaat ggaggcgaaa gagtggaatt tcattcaaag gcataatagc
     1561 aatgacagtc ttaagccaaa cattttatat aaagttgctt ttgtaaagga gaattatatt
     1621 gttttaagta aacacatttt taaaaattgt gttaagtcta tgtataatac tactgtgagt
     1681 aaaagtaata ctttaataat gtggtacaaa ttttaaagtt taatattgaa taaaaggagg
     1741 attatcaaat tcatatatga taaaagtgaa tgttctaagt ctctcaaact agcgttttat
     1801 gtaataatat gtaatataaa taaaactatg gtaaatgtga caagcattta ataggaaaat
     1861 gctaaggagg cctcataaat gacccataat taccaacgta gaatttttca gtacatttag
     1921 ggttgctgga tttagcaaat aaaaataaag attgcccagt tagatttgaa tttcagataa
     1981 acaattagtt ttttaatatt ttacatggaa tatttggaaa atacttatac taaaaaatta
     2041 tttgtttgaa attcaaattt aactgggagt cttgtatttt atctggcaat cctaaaatac
     2101 attggtatga aacaaatcac ttttagaagt atattgctat tttgattggg ttgtttttgt
     2161 gtgtagaaac gtacaataac aactcaaagg cacaggagat ttctaaacat tgtgaaaagt
     2221 tgaatagatt atatatttat tctcataata ctttcactaa tactaaataa aatttgggga
     2281 acacttttta tttttatata atttccaatt tacagaaaag tttcaaaaat agtacaaaga
     2341 gctctcttac ccagattcac taattgttca tacgtgcttt atctttcatg ctttctctgt
     2401 acacacacac acacacacaa atttttcctc aatcatttga aagtcagtta taggcatcat
     2461 gccccttaaa ccctaaatac ttcagtgtgt aatactgaat aattactaaa aatgattttc
     2521 tcagaaaaaa aaactcccac aattctggaa ctataatact gtaagcctta gaataaataa
     2581 tactttcaag ttccaatcta aagttctttt tgagttttgt tgcccgtttt atgcttgatg
     2641 tgtatagtaa tagggtaggc tatttatttt attaaaattt tttttagaga caaggttttg
     2701 ctgtgttgcc caagctggaa cttgaacgac tgggctgaag tgatcttccc acctcagcct
     2761 cccaagtagc tgggaataca ggtgtctgcc accataccca gtttcatttt tgttttttat
     2821 acccgaagtt catttccttt gtctccctaa aactgaactg taattttggg aggttttcat
     2881 tagtggaagc tcttcattta taaagctatt tgaaggggtt taggaattta tatcacatgg
     2941 taattgtaga gaaaaagaag ctatatacct caaaatcgtg ccctctttac atatgtctta
     3001 tcaggtataa catgttgaaa tgtcacatta gtagtaaagt ggggtttatt tatatagtgg
     3061 ttaagaaatg tcagtttaca ctgctgtata cttcttcttc tgtgtcccta aggcctggta
     3121 cagtgccaag cacatacttg gtatccaata aatatttgtt ggatgaatgt atgcatatgt
     3181 attcagtata ttttaaatga ataatcacag aagtaagttt aataatttgt cctatttttc
     3241 tctgtcactt cctttttctc taaggcagga aaggaaagac attaaaccat taattaagtc
     3301 aatcctcttg gagactcaaa agactatgaa gtgatcactc tatataaaat ataaatacag
     3361 tgtgggttca aatggccatt ttttgtgtgt ccctctctct catcttatgc ttcccttcct
     3421 ttttttattt ttattttttg gagacggagt cttgctgtgt cgcccaggtt ggagtgcagt
     3481 ggcgtgatct tagctcactg caagctctgc cttccaggtt cacgccattc ttctgcctca
     3541 gccccctgag tagctgggac tacaggcgcc cgccaccacg cccggctaat tttttttttt
     3601 ttttttttgt atttttagta gaggcagtgt ttcaccgtgt tagccaggat ggtcttgatc
     3661 tcctgacctc gtgatccacc cacctcgacc tcccaaagtg ctgggattac aggcgtgagc
     3721 caccacgccc ggcctctttt ttttttagct gccaatcttt ttgaaggaat attcttacct
     3781 ctactttgtc accttctact ggctccttaa ctaaaatctg ccatttggct ctctggttaa
     3841 cagtcccttc ctgtaaagtc taaaatctta attctaaatc cacagtttaa ttcacaagct
     3901 agtacttgac tttttttctg tatttgacat ttttgacaac ccctacttta aagatttatt
     3961 cccttgactt cttacatttt gctcactcct gaaccacccc ccaccttttg gcctcttcat
     4021 ttattcctta aatgttattc ctcagacctc catttttttt ttctctctta atcacaacac
     4081 cacttctcac gcttgggtaa ttttaattca gcagttccta aatccttatc tttagccaga
     4141 ctcctcaatc catctgcctg ttgcactttt cttggttgtc ccagagacac ctgtgtgtgt
     4201 cttaaaacat tcattctctg caaaacctac tctaatgcct gtgtccctta ctttggttaa
     4261 ttttagaacc attatattct aagttttcta ggctcattcc tctcctccac cttcccctat
     4321 catttagtgt ctaagtttta ctgattttat ctccacctct ctgatacatc actctttcat
     4381 cttcattgct attattaata aatacctaca gtactaacct gcctcctata cctagctggt
     4441 ctcctctctg ttgctcaatg ttaccacagc aggctttcta gaagcactct gacagtgtta
     4501 ctccctaata tccttcagtg acttcaggaa ctttcaggag aaagccaaac tcctctgttt
     4561 ggtgtacaag gtcttctgat gtgtttcctc caccgaatgt tctggtgaaa cagacttaca
     4621 cttcttcaga agccacattt ggccaggcct cccgccttgg taaatgctgt actctttgca
     4681 tcaagtatgc tagtcatcct tccccacttg gaaaattcct atgcatcttg caggcctgac
     4741 ataagcattt cctctgtgaa acctcctttg ctccactcaa ggagagtcat ctaacttcca
     4801 ctttcgtgtc accactgtaa ttacaaccta cctctattgt atgtcactta aatcgtactg
     4861 tattgtttta tttttcaaaa gtctttacta gaatgtgagc tccttaaggg caggaaaagg
     4921 aaccttttta ttttttgcat ctccatagca tagtttttgg catatgaatg tttaataaat
     4981 gtttgttgaa taaattgatt ttaaagtgac atctttatta tattagaggt cctacctata
     5041 ttccaaatac tttcactccc ttcactttac agcaagggtc agtagagtcc caaggatttg
     5101 tagactttag ggggtcaata aagctgaaat tgtattcaa
//
