LOCUS       NM_024896               5377 bp    mRNA    linear   PRI 04-AUG-2024
DEFINITION  Homo sapiens endoplasmic reticulum metallopeptidase 1 (ERMP1),
            transcript variant 1, mRNA.
ACCESSION   NM_024896 XM_291315
VERSION     NM_024896.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5377)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 5377)
  AUTHORS   Grandi,A., Santi,A., Campagnoli,S., Parri,M., De Camilli,E.,
            Song,C., Jin,B., Lacombe,A., Castori-Eppenberger,S., Sarmientos,P.,
            Grandi,G., Viale,G., Terracciano,L., Chiarugi,P., Pileri,P. and
            Grifantini,R.
  TITLE     ERMP1, a novel potential oncogene involved in UPR and oxidative
            stress defense, is highly expressed in human cancer
  JOURNAL   Oncotarget 7 (39), 63596-63610 (2016)
   PUBMED   27566589
  REMARK    GeneRIF: High expression of ERMP1 is correlated with cancer.
REFERENCE   3  (bases 1 to 5377)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   4  (bases 1 to 5377)
  AUTHORS   Garcia-Rudaz,C., Luna,F., Tapia,V., Kerr,B., Colgin,L., Galimi,F.,
            Dissen,G.A., Rawlings,N.D. and Ojeda,S.R.
  TITLE     Fxna, a novel gene differentially expressed in the rat ovary at the
            time of folliculogenesis, is required for normal ovarian
            histogenesis
  JOURNAL   Development 134 (5), 945-957 (2007)
   PUBMED   17267443
  REMARK    GeneRIF: Functional analysis of the rat Fxna ortholog.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL365360.9, CN390893.1, AK127218.1, AL834191.1, AK093217.1,
            BC031630.1, AK172831.1, AK026962.1, AB058718.2 and AW295384.1.
            
            On Nov 22, 2018 this sequence version replaced NM_024896.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660807.45710.1,
                                           SRR1660809.223774.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000339450.10/ ENSP00000340427.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-36                AL365360.9         14122-14157         c
            37-47               CN390893.1         15-25
            48-389              AK127218.1         1-342
            390-730             AL834191.1         114-454
            731-1682            AK093217.1         62-1013
            1683-2914           BC031630.1         11-1242
            2915-2920           AK172831.1         1632-1637
            2921-3664           AK026962.1         1191-1934
            3665-4164           AB058718.2         3506-4005
            4165-4455           AK026962.1         2435-2725
            4456-5362           AB058718.2         4294-5200
            5363-5377           AW295384.1         15-29               c
FEATURES             Location/Qualifiers
     source          1..5377
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9p24.1"
     gene            1..5377
                     /gene="ERMP1"
                     /gene_synonym="bA207C16.3; FXNA; KIAA1815"
                     /note="endoplasmic reticulum metallopeptidase 1"
                     /db_xref="GeneID:79956"
                     /db_xref="HGNC:HGNC:23703"
                     /db_xref="MIM:611156"
     exon            1..428
                     /gene="ERMP1"
                     /gene_synonym="bA207C16.3; FXNA; KIAA1815"
                     /inference="alignment:Splign:2.1.0"
     CDS             91..2805
                     /gene="ERMP1"
                     /gene_synonym="bA207C16.3; FXNA; KIAA1815"
                     /note="isoform 1 is encoded by transcript variant 1;
                     Felix-ina; aminopeptidase Fxna"
                     /codon_start=1
                     /product="endoplasmic reticulum metallopeptidase 1 isoform
                     1"
                     /protein_id="NP_079172.2"
                     /db_xref="CCDS:CCDS34983.1"
                     /db_xref="GeneID:79956"
                     /db_xref="HGNC:HGNC:23703"
                     /db_xref="MIM:611156"
                     /translation="MEWGSESAAVRRHRVGVERREGAAAAPPPEREARAQEPLVDGCS
                     GGGRTRKRSPGGSGGASRGAGTGLSEVRAALGLALYLIALRTLVQLSLQQLVLRGAAG
                     HRGEFDALQARDYLEHITSIGPRTTGSPENEILTVHYLLEQIKLIEVQSNSLHKISVD
                     VQRPTGSFSIDFLGGFTSYYDNITNVVVKLEPRDGAQHAVLANCHFDSVANSPGASDD
                     AVSCSVMLEVLRVLSTSSEALHHAVIFLFNGAEENVLQASHGFITQHPWASLIRAFIN
                     LEAAGVGGKELVFQTGPENPWLVQAYVSAAKHPFASVVAQEVFQSGIIPSDTDFRIYR
                     DFGNIPGIDLAFIENGYIYHTKYDTADRILTDSIQRAGDNILAVLKHLATSDMLAAAS
                     KYRHGNMVFFDVLGLFVIAYPSRIGSIINYMVVMGVVLYLGKKFLQPKHKTGNYKKDF
                     LCGLGITLISWFTSLVTVLIIAVFISLIGQSLSWYNHFYVSVCLYGTATVAKIILIHT
                     LAKRFYYMNASAQYLGEVFFDISLFVHCCFLVTLTYQGLCSAFISAVWVAFPLLTKLC
                     VHKDFKQHGAQGKFIAFYLLGMFIPYLYALYLIWAVFEMFTPILGRSGSEIPPDVVLA
                     SILAGCTMILSSYFINFIYLAKSTKKTMLTLTLVCAITFLLVCSGTFFPYSSNPANPK
                     PKRVFLQHMTRTFHDLEGNAVKRDSGIWINGFDYTGISHITPHIPEINDSIRAHCEEN
                     APLCGFPWYLPVHFLIRKNWYLPAPEVSPRNPPHFRLISKEQTPWDSIKLTFEATGPS
                     HMSFYVRAHKGSTLSQWSLGNGTPVTSKGGDYFVFYSHGLQASAWQFWIEVQVSEEHP
                     EGMVTVAIAAHYLSGEDKRSPQLDALKEKFPDWTFPSAWVCTYDLFVF"
     exon            429..730
                     /gene="ERMP1"
                     /gene_synonym="bA207C16.3; FXNA; KIAA1815"
                     /inference="alignment:Splign:2.1.0"
     exon            731..858
                     /gene="ERMP1"
                     /gene_synonym="bA207C16.3; FXNA; KIAA1815"
                     /inference="alignment:Splign:2.1.0"
     exon            859..964
                     /gene="ERMP1"
                     /gene_synonym="bA207C16.3; FXNA; KIAA1815"
                     /inference="alignment:Splign:2.1.0"
     exon            965..1111
                     /gene="ERMP1"
                     /gene_synonym="bA207C16.3; FXNA; KIAA1815"
                     /inference="alignment:Splign:2.1.0"
     exon            1112..1204
                     /gene="ERMP1"
                     /gene_synonym="bA207C16.3; FXNA; KIAA1815"
                     /inference="alignment:Splign:2.1.0"
     exon            1205..1417
                     /gene="ERMP1"
                     /gene_synonym="bA207C16.3; FXNA; KIAA1815"
                     /inference="alignment:Splign:2.1.0"
     exon            1418..1638
                     /gene="ERMP1"
                     /gene_synonym="bA207C16.3; FXNA; KIAA1815"
                     /inference="alignment:Splign:2.1.0"
     exon            1639..1813
                     /gene="ERMP1"
                     /gene_synonym="bA207C16.3; FXNA; KIAA1815"
                     /inference="alignment:Splign:2.1.0"
     exon            1814..2004
                     /gene="ERMP1"
                     /gene_synonym="bA207C16.3; FXNA; KIAA1815"
                     /inference="alignment:Splign:2.1.0"
     exon            2005..2157
                     /gene="ERMP1"
                     /gene_synonym="bA207C16.3; FXNA; KIAA1815"
                     /inference="alignment:Splign:2.1.0"
     exon            2158..2360
                     /gene="ERMP1"
                     /gene_synonym="bA207C16.3; FXNA; KIAA1815"
                     /inference="alignment:Splign:2.1.0"
     exon            2361..2476
                     /gene="ERMP1"
                     /gene_synonym="bA207C16.3; FXNA; KIAA1815"
                     /inference="alignment:Splign:2.1.0"
     exon            2477..2640
                     /gene="ERMP1"
                     /gene_synonym="bA207C16.3; FXNA; KIAA1815"
                     /inference="alignment:Splign:2.1.0"
     exon            2641..5377
                     /gene="ERMP1"
                     /gene_synonym="bA207C16.3; FXNA; KIAA1815"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5360..5365
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ERMP1"
                     /gene_synonym="bA207C16.3; FXNA; KIAA1815"
                     /note="hexamer: AATAAA"
     polyA_site      5377
                     /gene="ERMP1"
                     /gene_synonym="bA207C16.3; FXNA; KIAA1815"
                     /note="major polyA site"
ORIGIN      
        1 aggaggcgct gcggcagcga cggcggcgtc ggcggcggcc ggggctgtcg cgggttgggg
       61 cggttgggct ggcagctgag gctcgtggcc atggagtggg gttctgagtc ggctgctgtg
      121 aggcggcacc gcgtcggagt agagcgtcga gagggagcgg cggccgcgcc accgccggag
      181 agggaggccc gagcgcagga gcctctggtg gatgggtgca gcggcggcgg gaggacgcgg
      241 aagaggagcc ccgggggtag cggcggcgcg agcaggggcg cggggaccgg gctgtctgag
      301 gtgcgcgccg cgctggggct cgcgctctac ctgatcgcgc tgcggacgct ggtgcagctc
      361 tcgctgcagc agctcgtgct acgcggggcc gctggacacc gcggggagtt cgacgcgctc
      421 caagccaggg attatcttga acacataacc tccattggcc ccaggactac aggaagtcca
      481 gaaaatgaaa ttctgaccgt gcactacctt ttggaacaga ttaaactgat tgaagtgcaa
      541 agcaacagcc ttcataagat ttcagtagat gtacaacggc ccacaggctc ttttagcatt
      601 gatttcttgg gaggttttac aagctattat gacaacatca ccaatgttgt ggtaaagctg
      661 gaacccagag atggagccca gcatgctgtc ttggctaatt gtcattttga ctcagtagca
      721 aactcaccag gtgccagtga tgatgcagtt agctgctcag tgatgctgga agtccttcgc
      781 gtcttgtcaa catcttcaga agccttgcat catgctgtca tatttctctt taatggtgct
      841 gaggaaaatg tcttgcaagc cagtcatggt ttcattactc agcacccctg ggctagcttg
      901 attcgtgcat tcattaacct agaggcagca ggtgtaggag ggaaagaact tgtattccaa
      961 acaggtcctg aaaatccttg gttggttcaa gcttatgttt cagcagctaa acaccctttt
     1021 gcttctgtgg tggctcagga ggtttttcag agtggaatca ttccttcaga tactgacttt
     1081 cgtatctaca gggattttgg gaacattcca ggaatagact tagcttttat tgagaatgga
     1141 tacatttatc acaccaagta tgacacagcg gacagaattc taacagattc cattcagaga
     1201 gcaggtgaca acattttagc agttcttaag catctagcta catctgatat gctggctgct
     1261 gcttctaagt atcgacatgg aaacatggtc ttctttgatg tgctgggcct gtttgtcatt
     1321 gcctacccct ctcgtattgg ctcaatcata aactacatgg tggtaatggg tgttgttttg
     1381 tacctgggca aaaaattttt gcagcccaaa cataagactg gtaactacaa gaaggacttc
     1441 ttgtgtggac ttggcatcac tttgatcagc tggttcacta gccttgttac cgttctcatt
     1501 atagcagtgt tcatctctct tattggacag tctctctcat ggtataacca cttctatgtc
     1561 tccgtttgtc tgtatggaac tgcaactgta gccaaaataa tacttataca tactcttgcg
     1621 aaaagatttt attacatgaa tgccagtgcc cagtatctgg gagaagtatt ttttgacatt
     1681 tcgctgtttg tccattgctg ttttcttgtt accctcactt accaaggact ttgctcggcg
     1741 tttattagtg ctgtctgggt agcattccca ttgctcacaa agctctgtgt gcataaggac
     1801 ttcaagcagc atggtgccca aggaaaattt attgcttttt accttttggg gatgtttatt
     1861 ccttatcttt atgcattgta cctcatctgg gcagtatttg agatgtttac ccctatcctc
     1921 gggagaagtg gttctgaaat cccacctgat gttgtgctgg catccatttt ggctggctgt
     1981 acaatgattc tctcgtccta ttttattaac ttcatctacc ttgccaagag cacaaaaaaa
     2041 accatgctaa ctttaacttt ggtatgtgca attacattcc tccttgtttg cagtggaaca
     2101 ttttttccat atagctccaa tcctgctaat ccgaagccaa agagagtgtt tcttcagcat
     2161 atgactagaa cattccatga cttggaagga aatgcagtta aacgggactc tggaatatgg
     2221 atcaatgggt ttgattatac tggaatttct cacataaccc ctcacattcc tgagatcaat
     2281 gatagtatcc gagctcactg tgaggagaat gcacctcttt gtggttttcc ttggtatctt
     2341 ccagtgcact ttctgatcag gaaaaactgg tatcttcctg ccccagaagt ttctccaaga
     2401 aatcctcctc atttccgact catatccaaa gaacagacac cttgggattc tataaaattg
     2461 acttttgaag caacaggacc aagccatatg tccttctatg ttcgagccca caaagggtca
     2521 acactttctc agtggtctct tggcaatggc accccagtca caagtaaagg aggagactac
     2581 tttgtctttt actcccatgg actccaggcc tctgcatggc agttctggat agaagtgcag
     2641 gtttcagaag aacatcctga aggaatggtc accgtggcca ttgctgccca ctatctgtct
     2701 ggggaagaca agagatcccc tcaactggat gctctgaagg aaaagttccc agattggaca
     2761 tttccctctg cctgggtgtg cacctacgat ctctttgtat tttaatcttg tggatgagct
     2821 ctaagtacat gcccagtgga tactccatgt gacatggttt ctccctatgt tacgtggatg
     2881 tttgtaacgt aagtcaatga attttaatga tcatatgttc aaagagcttt ctgggttaac
     2941 gcttttcagg gccaagcact ataagggttt agctgtggcg cagtgatgca tggcctgttg
     3001 acacttgaaa atgccagtct tttggcactt cagcacatgt gggtactgcc actacacaca
     3061 cgtcatttta tatgacctta aggacaaagc caacaatcca cttcaatagc tgccccttta
     3121 ggatcaagaa agatgtacac tgtcagagca ttgttaatga gacaaaagtt gtttccaatt
     3181 taagccccaa aaccatttgt tgtattagtg gatggtgggt aaaatatcat tcactgaggt
     3241 aatgattccc cttgagaata taactctgtg taggtcactg gaaagtgatt gccatagggc
     3301 tgggagagaa gcattgcact cttgaggctg tagcctgtgt caagctgttt cttcaggcag
     3361 cctctcaaat gtgctttgtc tctctgtgct gaggcctgga ccctgtgctg agctggtgac
     3421 tcactgtcct gacaagtgga cacacagatg cactgctgtg ctgctttcct gaggtggttt
     3481 tctatgcctg ttttcctctg aaacatgtct gttacccctc tccatcttac caagttgaaa
     3541 aggggaatat ttggccacat acccctctgg ttttcgtagg ttcttttggt tcagaatatt
     3601 gtttgtgcca gtacatgacc ttaacttcct tcctcagagc actgagctgc catctgggct
     3661 attctggggt agaaggaagg ctgggagtgg tgggaatttt ataaatattt attctctttt
     3721 ctttgtttca taggagtctt gtgttataca aggttagtcc ttcatggtat aatcttactg
     3781 atgcactggg cctatctttt tgttttccag ccagttgaat agattagttt ttctcagtaa
     3841 cttactatcc agcagactgg ctttcctgag acttgaggtt gtggcttata ctggaatgag
     3901 accactgtac gtgtaggtgg ttcagatcct gcgtaatggc agcatgagga cttaaaaggt
     3961 ggttttcatt ttgaagatgg ctatgtagct tgtaaggtgt atcacagcag tacctctcat
     4021 ggctttttgg ttccagcagt gagggcattg gtgagatcaa tggtaaactg tgcaagcttt
     4081 ctttttatca ttaggaaatg tgaaacgttg gacaaatttt gagttttaac aaggacaaaa
     4141 agttgaaaga aaaggcacag ttaacaaaaa agggtggcta gatttatctt gggtgatgga
     4201 ggaaatgaga gaggaatgct cttgaaaggt ggtctgtgga tctgtctgaa tagaaagagc
     4261 acagtaagta tgcattgccg gagaaaacgt ccttgaagct gcttgtctca tgtgtatgat
     4321 gtgcttttta aatcatgccc ctcgttgcct gcctaatctg tgactcccta aaaactaact
     4381 gggcccatgt agatggggct gcaaccagag ctgaataaca tgttaggctc acacatgcat
     4441 cagcactgca cactggaatc attgctcttc ctggactttg tagaaatcag tctcaagtgc
     4501 ttcaagagtc tggctcctgc tacttttatc tgtcaggtag cacataaggt ttgcagggtt
     4561 tatattttgt atagaatcac agttgtggag aaaaagtaat aatttctcaa tgaattttaa
     4621 aaatgggcct attttctatc cccgtggttc atctgatata attagtgttc cctgtgaatt
     4681 ccccccctct atgggaagga tgcctttact ctttatcagt aataaattat gactgttttc
     4741 atattgcctt agggttattt ccctgtgtaa accattgtct tttgttttgg ttttctttag
     4801 cattatgaag ctttggtatt gtacaaggtc agtagtaaga tgctcactag tctcagggct
     4861 tgtgtaatat tctgggaggt catttaaatg ccagaaatgg tcaagcaatt atacacagta
     4921 tttatgactc tgttaagcat accgtttgtc tgtcacatta gtagattctg agattaaaaa
     4981 aaatttttaa agagtgatca tttaaataat ttctaaaagg gtcttttcaa gctctaacaa
     5041 agtcactaac aaatgcatta ttttctacag aattagatgt tagtagtaca gtactgcata
     5101 ttcagggaaa aagtgtgagg aattgatttc aaaatagttc gttcttgtgt ttgacctaag
     5161 aatgattgtc gcatgaagtg tttgttttta cagtttagca tatataaaca aacatgatag
     5221 gattccttaa gatgttacca cccagggggc cacaagccag cctgctgtct caggaagctg
     5281 tagaaggagt gtttgtcaat ttcttgtcac tggtttgctg acttactgag gattaattgt
     5341 tgccttacaa tgttactgaa ataaactgtt taatata
//
