LOCUS       NM_001017922            3440 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens erythroblast membrane associated protein (Scianna
            blood group) (ERMAP), transcript variant 1, mRNA.
ACCESSION   NM_001017922
VERSION     NM_001017922.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3440)
  AUTHORS   Li,J., Liu,X.G., Ge,R.L., Yin,Y.P., Liu,Y.D., Lu,W.P., Huang,M.,
            He,X.Y., Wang,J., Cai,G., Sun,S.H. and Yuan,J.H.
  TITLE     The ligation between ERMAP, galectin-9 and dectin-2 promotes
            Kupffer cell phagocytosis and antitumor immunity
  JOURNAL   Nat Immunol 24 (11), 1813-1824 (2023)
   PUBMED   37813965
  REMARK    GeneRIF: The ligation between ERMAP, galectin-9 and dectin-2
            promotes Kupffer cell phagocytosis and antitumor immunity.
REFERENCE   2  (bases 1 to 3440)
  AUTHORS   Su,M., Lin,Y., Cui,C., Tian,X. and Lai,L.
  TITLE     ERMAP is a B7 family-related molecule that negatively regulates T
            cell and macrophage responses
  JOURNAL   Cell Mol Immunol 18 (8), 1920-1933 (2021)
   PUBMED   32620788
  REMARK    GeneRIF: ERMAP is a B7 family-related molecule that negatively
            regulates T cell and macrophage responses.
REFERENCE   3  (bases 1 to 3440)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 3440)
  AUTHORS   Belsito,A., Costa,D., Fiorito,C., De Iorio,G., Casamassimi,A.,
            Perrotta,S. and Napoli,C.
  TITLE     Erythrocyte genotyping for transfusion-dependent patients at the
            Azienda Universitaria Policlinico of Naples
  JOURNAL   Transfus Apher Sci 52 (1), 72-77 (2015)
   PUBMED   25582271
  REMARK    GeneRIF: Through molecular genotyping we also identified
            polymorphisms in RhCE, Kell, Duffy, Colton, Lutheran and Scianna
            loci in donors and patients.
REFERENCE   5  (bases 1 to 3440)
  AUTHORS   Reid,M.E., Hue-Roye,K., Velliquette,R.W., Larimore,K.,
            Moscarelli,S., Ohswaldt,N. and Lomas-Francis,C.
  TITLE     SC*994C>T causes the Sc(null) phenotype in Pacific Islanders and
            successful transfusion of Sc3+ blood to a patient with anti-Sc3
  JOURNAL   Immunohematology 29 (2), 69-72 (2013)
   PUBMED   24094239
  REMARK    GeneRIF: the five known probands with the SC*994C>T silencing
            nucleotide change were from the Pacific Islands.
REFERENCE   6  (bases 1 to 3440)
  AUTHORS   Wagner,F.F., Poole,J. and Flegel,W.A.
  TITLE     Scianna antigens including Rd are expressed by ERMAP
  JOURNAL   Blood 101 (2), 752-757 (2003)
   PUBMED   12393480
  REMARK    GeneRIF: DNA sequencing demonstrates Scianna antigens including Rd
            are expressed by ERMAP.
REFERENCE   7  (bases 1 to 3440)
  AUTHORS   Su,Y.Y., Gordon,C.T., Ye,T.Z., Perkins,A.C. and Chui,D.H.
  TITLE     Human ERMAP: an erythroid adhesion/receptor transmembrane protein
  JOURNAL   Blood Cells Mol Dis 27 (5), 938-949 (2001)
   PUBMED   11783959
  REMARK    GeneRIF: A human cDNA and gene encoding for human ERMAP is cloned
            and characterized. The protein is sequenced and its expression
            analyzed.
REFERENCE   8  (bases 1 to 3440)
  AUTHORS   Xu,H., Foltz,L., Sha,Y., Madlansacay,M.R., Cain,C., Lindemann,G.,
            Vargas,J., Nagy,D., Harriman,B., Mahoney,W. and Schueler,P.A.
  TITLE     Cloning and characterization of human erythroid membrane-associated
            protein, human ERMAP
  JOURNAL   Genomics 76 (1-3), 2-4 (2001)
   PUBMED   11549310
  REMARK    GeneRIF: ERMAP, a unique member of the B30.2 domain protein family,
            is expressed in erythroid cells in fetal liver, adult bone marrow,
            reticulocytes and in circulating erythroblasts in 8-12-week fetal
            cord blood.
REFERENCE   9  (bases 1 to 3440)
  AUTHORS   Lewis,M., Kaita,H., Philipps,S., Giblett,E.R., Anderson,J.E.,
            McAlpine,P.J. and Nickel,B.
  TITLE     The position of the Radin blood group locus in relation to other
            chromosome l loci
  JOURNAL   Ann Hum Genet 44 (2), 179-184 (1980)
   PUBMED   6459052
REFERENCE   10 (bases 1 to 3440)
  AUTHORS   Lewis,M. and Kaita,H.
  TITLE     Genetic linkage between the Radin and Rh blood group loci
  JOURNAL   Vox Sang 37 (5), 286-289 (1979)
   PUBMED   118583
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BX507568.1, AY049028.1,
            AL512353.16 and AF311285.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_001017922.1.
            
            Summary: The protein encoded by this gene is a cell surface
            transmembrane protein that may act as an erythroid cell receptor,
            possibly as a mediator of cell adhesion. Polymorphisms in this gene
            are responsible for the Scianna/Radin blood group system. Two
            transcript variants encoding the same protein have been found for
            this gene. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) is the longer transcript.
            Variants 1 and 2 encode the same protein.
            
            Sequence Note: This RefSeq record represents the ERMAP*001.1.1
            allele.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK314436.1, SRR1803616.246050.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000372517.8/ ENSP00000361595.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-306               BX507568.1         18-323
            307-1700            AY049028.1         238-1631
            1701-3432           AL512353.16        31395-33126
            3433-3438           AF311285.1         3346-3351
            3439-3440           AL512353.16        33133-33134
FEATURES             Location/Qualifiers
     source          1..3440
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p34.2"
     gene            1..3440
                     /gene="ERMAP"
                     /gene_synonym="BTN5; PRO2801; RD; SC"
                     /note="erythroblast membrane associated protein (Scianna
                     blood group)"
                     /db_xref="GeneID:114625"
                     /db_xref="HGNC:HGNC:15743"
                     /db_xref="MIM:609017"
     exon            1..132
                     /gene="ERMAP"
                     /gene_synonym="BTN5; PRO2801; RD; SC"
                     /inference="alignment:Splign:2.1.0"
     exon            133..248
                     /gene="ERMAP"
                     /gene_synonym="BTN5; PRO2801; RD; SC"
                     /inference="alignment:Splign:2.1.0"
     exon            249..338
                     /gene="ERMAP"
                     /gene_synonym="BTN5; PRO2801; RD; SC"
                     /inference="alignment:Splign:2.1.0"
     CDS             254..1681
                     /gene="ERMAP"
                     /gene_synonym="BTN5; PRO2801; RD; SC"
                     /note="erythroid membrane-associated protein; Radin blood
                     group (Rd); Scianna blood group (Sc); radin blood group
                     antigen; scianna blood group antigen"
                     /codon_start=1
                     /product="erythroid membrane-associated protein precursor"
                     /protein_id="NP_001017922.1"
                     /db_xref="CCDS:CCDS475.1"
                     /db_xref="GeneID:114625"
                     /db_xref="HGNC:HGNC:15743"
                     /db_xref="MIM:609017"
                     /translation="MEMASSAGSWLSGCLIPLVFLRLSVHVSGHAGDAGKFHVALLGG
                     TAELLCPLSLWPGTVPKEVRWLRSPFPQRSQAVHIFRDGKDQDEDLMPEYKGRTVLVR
                     DAQEGSVTLQILDVRLEDQGSYRCLIQVGNLSKEDTVILQVAAPSVGSLSPSAVALAV
                     ILPVLVLLIMVCLCLIWKQRRAKEKLLYEHVTEVDNLLSDHAKEKGKLHKAVKKLRSE
                     LKLKRAAANSGWRRARLHFVAVTLDPDTAHPKLILSEDQRCVRLGDRRQPVPDNPQRF
                     DFVVSILGSEYFTTGCHYWEVYVGDKTKWILGVCSESVSRKGKVTASPANGHWLLRQS
                     RGNEYEALTSPQTSFRLKEPPRCVGIFLDYEAGVISFYNVTNKSHIFTFTHNFSGPLR
                     PFFEPCLHDGGKNTAPLVICSELHKSEESIVPRPEGKGHANGDVSLKVNSSLLPPKAP
                     ELKDIILSLPPDLGPALQELKAPSF"
     exon            339..686
                     /gene="ERMAP"
                     /gene_synonym="BTN5; PRO2801; RD; SC"
                     /inference="alignment:Splign:2.1.0"
     exon            687..803
                     /gene="ERMAP"
                     /gene_synonym="BTN5; PRO2801; RD; SC"
                     /inference="alignment:Splign:2.1.0"
     exon            804..836
                     /gene="ERMAP"
                     /gene_synonym="BTN5; PRO2801; RD; SC"
                     /inference="alignment:Splign:2.1.0"
     exon            837..869
                     /gene="ERMAP"
                     /gene_synonym="BTN5; PRO2801; RD; SC"
                     /inference="alignment:Splign:2.1.0"
     exon            870..890
                     /gene="ERMAP"
                     /gene_synonym="BTN5; PRO2801; RD; SC"
                     /inference="alignment:Splign:2.1.0"
     exon            891..911
                     /gene="ERMAP"
                     /gene_synonym="BTN5; PRO2801; RD; SC"
                     /inference="alignment:Splign:2.1.0"
     exon            912..938
                     /gene="ERMAP"
                     /gene_synonym="BTN5; PRO2801; RD; SC"
                     /inference="alignment:Splign:2.1.0"
     exon            939..965
                     /gene="ERMAP"
                     /gene_synonym="BTN5; PRO2801; RD; SC"
                     /inference="alignment:Splign:2.1.0"
     exon            966..3440
                     /gene="ERMAP"
                     /gene_synonym="BTN5; PRO2801; RD; SC"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3414..3419
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ERMAP"
                     /gene_synonym="BTN5; PRO2801; RD; SC"
                     /note="hexamer: AATAAA"
     polyA_site      3440
                     /gene="ERMAP"
                     /gene_synonym="BTN5; PRO2801; RD; SC"
                     /note="major polyA site"
ORIGIN      
        1 ctcttccctc tcctggagga aaatggcggt cgctggagcc gccgaccaag aggcttggga
       61 gtctgtacct ttcccgaccg ggccactgga agttggagcc tccgccgagt cgcagacaac
      121 gcctccggga gggccttcct gatgcgcttg cctgctccct ggtctctctg catggggaag
      181 gagtgttccc agcttgcaaa ctccagcttt gcctgtgaga ggaacaagcg tccctgatcc
      241 agaaggtgtt cggatggaga tggcgagttc tgctggctcc tggctctctg gctgcctcat
      301 ccctctcgtc ttcctccggc tgtctgtgca tgtgtcaggc cacgcagggg atgccggcaa
      361 gttccacgtg gccctactag ggggcacagc cgagctgctc tgccctctct ccctctggcc
      421 cgggacggta cccaaggagg tgaggtggct gcggtcccca ttcccgcagc gctcccaggc
      481 tgttcacata ttccgggatg ggaaggacca ggatgaagat ctgatgccgg aatataaggg
      541 gaggacggtg ctagtgagag atgcccaaga gggaagtgtc actctgcaga tccttgacgt
      601 gcgccttgag gaccaagggt cttaccgatg tctgatccaa gttggaaatc tgagtaaaga
      661 ggacaccgtg atcctgcagg ttgcagcccc atctgtgggg agtctctccc cctcagcagt
      721 ggctctggct gtgatcctgc ctgtcctggt acttctcatc atggtgtgcc tttgccttat
      781 ctggaagcaa agaagagcaa aagaaaagct tctctatgaa catgtgacgg aggtggacaa
      841 tcttctttca gaccatgcta aagaaaaagg aaaactccat aaagctgtca agaaactccg
      901 gagtgaactg aagttgaaaa gagctgcagc aaactcaggc tggagaagag cccggttgca
      961 ttttgtggca gtgaccctgg acccagacac agcacatccc aaactcatcc tttctgagga
     1021 ccaaagatgt gtaaggcttg gagacagacg gcagcctgta cctgacaacc cccagagatt
     1081 tgatttcgtt gtcagcatcc taggctctga gtacttcacg actggctgcc actactggga
     1141 ggtgtatgtg ggagacaaga ccaaatggat tcttggagta tgtagtgagt cagtgagcag
     1201 gaaggggaag gttactgcct cacctgccaa tggacactgg cttctgcgac agagtcgtgg
     1261 gaatgagtat gaagctctca catccccgca gacctccttc cgccttaaag agcctccacg
     1321 gtgtgtgggg attttcctgg actatgaagc aggagtcatc tctttctaca atgtgaccaa
     1381 caagtcccac atctttactt tcacccacaa tttctctggc ccccttcgcc ctttctttga
     1441 accttgcctt catgatggag gaaaaaacac agcacctcta gtcatttgtt cagaactaca
     1501 caaatcagag gaatcaattg tccccaggcc agaagggaaa ggccatgcta atggagatgt
     1561 gtccctcaag gtgaactctt ctttactacc cccgaaggcc ccagagctga aggatataat
     1621 cctgtccttg ccccctgacc ttggcccagc ccttcaggag ctcaaggctc cttcttttta
     1681 gggatatgcc acattacctg ctcccatcac catccagccc agcaccctgg acttcagtcg
     1741 cctggcccaa ccccatgatt atggaacgtc tcttcacctt aacccaaatc cagacccttt
     1801 tgtggtttct atttgtacca cttttctccc aggcctcagt tctgaagctt acctttcttc
     1861 taaggaattg aagctcccag tgacctggag ggaggattcc tggaaaccaa acaatcagtt
     1921 taggtgcagg tggagatgtt gaatatgtgt taccaagata cagcacaggt tcagggaaaa
     1981 gagttcgcta ctccaggggt tatttagaag acactttctc tgcctcatcc tgccctcaag
     2041 ctttagtcaa gaagttatgg cccccagtcc ctgacttctt acttatccca ttgaggactg
     2101 cctttctctc tctcagttct ggcctctgcc ccccaaagtc agctctctaa aagcaagcat
     2161 gttttagacc actcactctt tccctctttc ttcaggaatg aattgggaaa ggctgatgag
     2221 taaaacatac catccttttc tattttcttg atgctgttta caacatagtt tggtgatatc
     2281 cagagctaat gtacatgctt tcaaaagcta atctgcctgt tgatggtaac taggtacagc
     2341 gactttaaat acagttgcta taatcctgaa aagccccagg agcacatcag ggagctggga
     2401 aacacagttg cagagaactc agctgtatgt tgccctctga ccttggccca gaccttcaga
     2461 ggctcagtct gttgagtctg ttgtgactgt cttatgaatc aatctgttgt gccaaccctt
     2521 tctgagattc agagaggtcc agctagaaaa agtggcagtt ttaaccacca acgtagaagc
     2581 ttttttttcc ccacaagacc attgtactgc aatacttgag tatttgtgta gcaaacagcc
     2641 tcttaggttg gagagtattg atttcaaata ggaagttggt agactaggtg tgaggatgaa
     2701 ataatgacct tgatttttgg gtgtgtattg cagaagcctc gtcgctttca agtcacatca
     2761 tatatgcgat ctggcctaac catggagata ttggttatca gtttgcagat gaatacacag
     2821 ttctatccaa cagaaactgt atctttctgt ttgtcagaag ttctccgtta gttcctgtat
     2881 tagtcaaggt tttccagaga aacagaatca atatatattg gggcaggggg gcggtggtta
     2941 ttataaggaa ttggctcacg tgattatgga ggcggttaaa tcccaagatc tgcaggataa
     3001 gtcagcaaga tggagtccca tgagagctga tggtttagtt ccagtctgat ggcagcaggc
     3061 ttgacgccaa ggaagagatg atgtttaatt caagtccgaa ggcaaggaaa aagctgatgg
     3121 tcctgtccaa aggctattag gcaggaagaa ttctcttagg gcagagttag ctcttttgtt
     3181 ctattcaggc cttcaactga ttcagcaagg cccgcccaca tttgggagga cagtctgcat
     3241 tactcagtct actgatttga atgttaatgt cattgagaaa caccctcaca ggaacactca
     3301 gaataatgtt tgaccaaata gctgggcatc ttgtgaccca gttaagtgga tacataagat
     3361 taactatcac agtgactcag tggaattttt tgtttgcttt tgtacagttt taaaataaaa
     3421 gtttggtatt tgtgttttgg
//
