LOCUS       NM_007175               5387 bp    mRNA    linear   PRI 10-OCT-2024
DEFINITION  Homo sapiens ER lipid raft associated 2 (ERLIN2), transcript
            variant 1, mRNA.
ACCESSION   NM_007175
VERSION     NM_007175.8
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5387)
  AUTHORS   Hua,F., Bonzerato,C.G., Keller,K.R., Guo,D., Luo,J. and
            Wojcikiewicz,R.J.H.
  TITLE     The erlin1/erlin2 complex binds to and stabilizes
            phosphatidylinositol 3-phosphate and regulates autophagy
  JOURNAL   Biochem Biophys Res Commun 731, 150397 (2024)
   PUBMED   39018973
  REMARK    GeneRIF: The erlin1/erlin2 complex binds to and stabilizes
            phosphatidylinositol 3-phosphate and regulates autophagy.
REFERENCE   2  (bases 1 to 5387)
  AUTHORS   de Souza,G.C., Malta,M.C., Santos,M.R.S., Fontes,M.I.B., de Sousa
            Anjos,J.L., Ribeiro,D.P., Kok,F. and Figueiredo,T.
  TITLE     Novel ERLIN2 variant expands the phenotype of Spastic Paraplegia 18
  JOURNAL   Neurol Sci 45 (6), 2705-2710 (2024)
   PUBMED   38159148
  REMARK    GeneRIF: Novel ERLIN2 variant expands the phenotype of Spastic
            Paraplegia 18.
REFERENCE   3  (bases 1 to 5387)
  AUTHORS   Xiao,B., Xiang,Q., Deng,Z., Chen,D., Wu,S., Zhang,Y., Liang,Y.,
            Wei,S., Luo,G. and Li,L.
  TITLE     KCNN1 promotes proliferation and metastasis of breast cancer via
            ERLIN2-mediated stabilization and K63-dependent ubiquitination of
            Cyclin B1
  JOURNAL   Carcinogenesis 44 (12), 809-823 (2023)
   PUBMED   37831636
  REMARK    GeneRIF: KCNN1 promotes proliferation and metastasis of breast
            cancer via ERLIN2-mediated stabilization and K63-dependent
            ubiquitination of Cyclin B1.
REFERENCE   4  (bases 1 to 5387)
  AUTHORS   Alazami,A.M., Adly,N., Al Dhalaan,H. and Alkuraya,F.S.
  TITLE     A nullimorphic ERLIN2 mutation defines a complicated hereditary
            spastic paraplegia locus (SPG18)
  JOURNAL   Neurogenetics 12 (4), 333-336 (2011)
   PUBMED   21796390
  REMARK    GeneRIF: study describes an extended consanguineous Saudi family in
            which hereditary spastic paraplegia is linked to SPG18, an
            autosomal recessive locus, and show it is associated with a
            nullimorphic deletion of ERLIN2
REFERENCE   5  (bases 1 to 5387)
  AUTHORS   Lyssand,J.S., DeFino,M.C., Tang,X.B., Hertz,A.L., Feller,D.B.,
            Wacker,J.L., Adams,M.E. and Hague,C.
  TITLE     Blood pressure is regulated by an alpha1D-adrenergic
            receptor/dystrophin signalosome
  JOURNAL   J Biol Chem 283 (27), 18792-18800 (2008)
   PUBMED   18468998
REFERENCE   6  (bases 1 to 5387)
  AUTHORS   Pearce,M.M., Wang,Y., Kelley,G.G. and Wojcikiewicz,R.J.
  TITLE     SPFH2 mediates the endoplasmic reticulum-associated degradation of
            inositol 1,4,5-trisphosphate receptors and other substrates in
            mammalian cells
  JOURNAL   J Biol Chem 282 (28), 20104-20115 (2007)
   PUBMED   17502376
  REMARK    GeneRIF: SPFH2 as a key endoplasmic reticulum associated
            degradation pathway component and suggest that it may act as a
            substrate recognition factor.
REFERENCE   7  (bases 1 to 5387)
  AUTHORS   Browman,D.T., Resek,M.E., Zajchowski,L.D. and Robbins,S.M.
  TITLE     Erlin-1 and erlin-2 are novel members of the prohibitin family of
            proteins that define lipid-raft-like domains of the ER
  JOURNAL   J Cell Sci 119 (Pt 15), 3149-3160 (2006)
   PUBMED   16835267
  REMARK    GeneRIF: Erlin-1 and erlin-2 are novel members of the prohibitin
            family of proteins that define lipid-raft-like domains of the ER.
REFERENCE   8  (bases 1 to 5387)
  AUTHORS   Garcia,M.J., Pole,J.C., Chin,S.F., Teschendorff,A., Naderi,A.,
            Ozdag,H., Vias,M., Kranjac,T., Subkhankulova,T., Paish,C.,
            Ellis,I., Brenton,J.D., Edwards,P.A. and Caldas,C.
  TITLE     A 1 Mb minimal amplicon at 8p11-12 in breast cancer identifies new
            candidate oncogenes
  JOURNAL   Oncogene 24 (33), 5235-5245 (2005)
   PUBMED   15897872
REFERENCE   9  (bases 1 to 5387)
  AUTHORS   Ikegawa,S., Isomura,M., Koshizuka,Y. and Nakamura,Y.
  TITLE     Cloning and characterization of a novel gene (C8orf2), a human
            representative of a novel gene family with homology to C. elegans
            C42.C1.9
  JOURNAL   Cytogenet Cell Genet 85 (3-4), 227-231 (1999)
   PUBMED   10449903
REFERENCE   10 (bases 1 to 5387)
  AUTHORS   Hedera,P.
  TITLE     Hereditary Spastic Paraplegia Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301682
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BP353279.1, BC005950.1,
            AC138356.3, BU608317.1 and BX104878.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_007175.7.
            
            Summary: This gene encodes a member of the SPFH domain-containing
            family of lipid raft-associated proteins. The encoded protein is
            localized to lipid rafts of the endoplasmic reticulum and plays a
            critical role in inositol 1,4,5-trisphosphate (IP3) signaling by
            mediating ER-associated degradation of activated IP3 receptors.
            Mutations in this gene are a cause of spastic paraplegia-18
            (SPG18). Alternatively spliced transcript variants encoding
            multiple isoforms have been observed for this gene. [provided by
            RefSeq, Feb 2012].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803614.263859.1, AY358108.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000519638.3/ ENSP00000428112.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-358               BP353279.1         56-413
            359-1073            BC005950.1         337-1051
            1074-4440           AC138356.3         86603-89969         c
            4441-4766           BU608317.1         16-341              c
            4767-4950           AC138356.3         86093-86276         c
            4951-5387           BX104878.1         21-457              c
FEATURES             Location/Qualifiers
     source          1..5387
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8p11.23"
     gene            1..5387
                     /gene="ERLIN2"
                     /gene_synonym="C8orf2; Erlin-2; NET32; SPFH2; SPG18;
                     SPG18A; SPG18B"
                     /note="ER lipid raft associated 2"
                     /db_xref="GeneID:11160"
                     /db_xref="HGNC:HGNC:1356"
                     /db_xref="MIM:611605"
     exon            1..45
                     /gene="ERLIN2"
                     /gene_synonym="C8orf2; Erlin-2; NET32; SPFH2; SPG18;
                     SPG18A; SPG18B"
                     /inference="alignment:Splign:2.1.0"
     exon            46..167
                     /gene="ERLIN2"
                     /gene_synonym="C8orf2; Erlin-2; NET32; SPFH2; SPG18;
                     SPG18A; SPG18B"
                     /inference="alignment:Splign:2.1.0"
     CDS             61..1080
                     /gene="ERLIN2"
                     /gene_synonym="C8orf2; Erlin-2; NET32; SPFH2; SPG18;
                     SPG18A; SPG18B"
                     /note="isoform 1 is encoded by transcript variant 1; SPFH
                     domain family, member 2; endoplasmic reticulum lipid
                     raft-associated protein 2; epididymis secretory sperm
                     binding protein; stomatin-prohibitin-flotillin-HflC/K
                     domain-containing protein 2; spastic paraplegia 18
                     (autosomal dominant)"
                     /codon_start=1
                     /product="erlin-2 isoform 1"
                     /protein_id="NP_009106.1"
                     /db_xref="CCDS:CCDS6095.1"
                     /db_xref="GeneID:11160"
                     /db_xref="HGNC:HGNC:1356"
                     /db_xref="MIM:611605"
                     /translation="MAQLGAVVAVASSFFCASLFSAVHKIEEGHIGVYYRGGALLTST
                     SGPGFHLMLPFITSYKSVQTTLQTDEVKNVPCGTSGGVMIYFDRIEVVNFLVPNAVYD
                     IVKNYTADYDKALIFNKIHHELNQFCSVHTLQEVYIELFDQIDENLKLALQQDLTSMA
                     PGLVIQAVRVTKPNIPEAIRRNYELMESEKTKLLIAAQKQKVVEKEAETERKKALIEA
                     EKVAQVAEITYGQKVMEKETEKKISEIEDAAFLAREKAKADAECYTAMKIAEANKLKL
                     TPEYLQLMKYKAIASNSKIYFGKDIPNMFMDSAGSVSKQFEGLADKLSFGLEDEPLET
                     ATKEN"
     exon            168..249
                     /gene="ERLIN2"
                     /gene_synonym="C8orf2; Erlin-2; NET32; SPFH2; SPG18;
                     SPG18A; SPG18B"
                     /inference="alignment:Splign:2.1.0"
     exon            250..296
                     /gene="ERLIN2"
                     /gene_synonym="C8orf2; Erlin-2; NET32; SPFH2; SPG18;
                     SPG18A; SPG18B"
                     /inference="alignment:Splign:2.1.0"
     exon            297..358
                     /gene="ERLIN2"
                     /gene_synonym="C8orf2; Erlin-2; NET32; SPFH2; SPG18;
                     SPG18A; SPG18B"
                     /inference="alignment:Splign:2.1.0"
     exon            359..484
                     /gene="ERLIN2"
                     /gene_synonym="C8orf2; Erlin-2; NET32; SPFH2; SPG18;
                     SPG18A; SPG18B"
                     /inference="alignment:Splign:2.1.0"
     exon            485..558
                     /gene="ERLIN2"
                     /gene_synonym="C8orf2; Erlin-2; NET32; SPFH2; SPG18;
                     SPG18A; SPG18B"
                     /inference="alignment:Splign:2.1.0"
     exon            559..617
                     /gene="ERLIN2"
                     /gene_synonym="C8orf2; Erlin-2; NET32; SPFH2; SPG18;
                     SPG18A; SPG18B"
                     /inference="alignment:Splign:2.1.0"
     exon            618..709
                     /gene="ERLIN2"
                     /gene_synonym="C8orf2; Erlin-2; NET32; SPFH2; SPG18;
                     SPG18A; SPG18B"
                     /inference="alignment:Splign:2.1.0"
     exon            710..799
                     /gene="ERLIN2"
                     /gene_synonym="C8orf2; Erlin-2; NET32; SPFH2; SPG18;
                     SPG18A; SPG18B"
                     /inference="alignment:Splign:2.1.0"
     exon            800..879
                     /gene="ERLIN2"
                     /gene_synonym="C8orf2; Erlin-2; NET32; SPFH2; SPG18;
                     SPG18A; SPG18B"
                     /inference="alignment:Splign:2.1.0"
     exon            880..5387
                     /gene="ERLIN2"
                     /gene_synonym="C8orf2; Erlin-2; NET32; SPFH2; SPG18;
                     SPG18A; SPG18B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3867..3872
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ERLIN2"
                     /gene_synonym="C8orf2; Erlin-2; NET32; SPFH2; SPG18;
                     SPG18A; SPG18B"
                     /note="hexamer: ATTAAA"
     polyA_site      3886
                     /gene="ERLIN2"
                     /gene_synonym="C8orf2; Erlin-2; NET32; SPFH2; SPG18;
                     SPG18A; SPG18B"
     regulatory      4335..4340
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ERLIN2"
                     /gene_synonym="C8orf2; Erlin-2; NET32; SPFH2; SPG18;
                     SPG18A; SPG18B"
                     /note="hexamer: TATAAA"
     polyA_site      4355
                     /gene="ERLIN2"
                     /gene_synonym="C8orf2; Erlin-2; NET32; SPFH2; SPG18;
                     SPG18A; SPG18B"
                     /note="major polyA site"
     regulatory      4615..4620
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ERLIN2"
                     /gene_synonym="C8orf2; Erlin-2; NET32; SPFH2; SPG18;
                     SPG18A; SPG18B"
                     /note="hexamer: AGTAAA"
     polyA_site      4637
                     /gene="ERLIN2"
                     /gene_synonym="C8orf2; Erlin-2; NET32; SPFH2; SPG18;
                     SPG18A; SPG18B"
     regulatory      4732..4737
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ERLIN2"
                     /gene_synonym="C8orf2; Erlin-2; NET32; SPFH2; SPG18;
                     SPG18A; SPG18B"
                     /note="hexamer: AATAAA"
     polyA_site      4751
                     /gene="ERLIN2"
                     /gene_synonym="C8orf2; Erlin-2; NET32; SPFH2; SPG18;
                     SPG18A; SPG18B"
     regulatory      5358..5363
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ERLIN2"
                     /gene_synonym="C8orf2; Erlin-2; NET32; SPFH2; SPG18;
                     SPG18A; SPG18B"
                     /note="hexamer: AATAAA"
     polyA_site      5387
                     /gene="ERLIN2"
                     /gene_synonym="C8orf2; Erlin-2; NET32; SPFH2; SPG18;
                     SPG18A; SPG18B"
ORIGIN      
        1 gctcgtgggc tcggacgagt acggagcgcc tgcagggaca gcctggataa aggctcactg
       61 atggctcagt tgggagcagt tgtggctgtg gcttccagtt tcttttgtgc atctctcttc
      121 tcagctgtgc acaagataga agagggacat attggggtat attacagagg cggtgccctg
      181 ctgacttcga ccagcggccc tggtttccat ctcatgctcc ctttcatcac atcatataag
      241 tctgtgcaga ccacactcca gacagatgag gtgaagaatg taccttgtgg gactagtggt
      301 ggtgtgatga tctactttga cagaattgaa gtggtgaact tcctggtccc gaacgcagtg
      361 tatgatatag tgaagaacta tactgctgac tatgacaagg ccctcatctt caacaagatc
      421 caccacgaac tgaaccagtt ctgcagtgtg cacacgcttc aagaggtcta cattgagctg
      481 tttgatcaga ttgatgaaaa tctcaaactg gctttgcaac aggacctgac ctccatggcc
      541 cctgggctgg tcattcaagc tgtgcgggta acaaagccca acataccaga ggcaatccgc
      601 agaaactacg agttgatgga aagtgagaag acaaagcttc tcattgccgc ccagaaacag
      661 aaggtggtgg aaaaggaagc agagacagag cggaagaagg cgctcattga ggcagaaaaa
      721 gtggcccagg tggctgagat cacctacggg cagaaggtga tggagaagga gactgagaag
      781 aagatttcag aaattgaaga tgctgcattt ctggcccggg agaaggcaaa ggcagatgct
      841 gagtgctaca ctgctatgaa aatagccgaa gccaataagc tgaagctaac ccctgaatat
      901 ctgcagctga tgaagtacaa ggccattgct tccaacagca agatttactt tggcaaagac
      961 attcctaaca tgttcatgga ctctgcgggc agtgtgagca agcagtttga ggggctagct
     1021 gacaagctaa gctttggctt agaagatgaa cccttggaga cggccactaa ggagaattga
     1081 aaaaaacttg atatgactgc aaatgatact taagcagatc tttatttttt aagatgaatc
     1141 agaatgttcc tccctccccg actaccttct ctgactgtct tccagttact gtggtgaaaa
     1201 agaagaaatg aacttaaatc cactcccttt ctagggaaag gagggtgggg actgatgatg
     1261 gggggtttta tttcaggtaa gcagtttata tgacttccaa taagatttgt aaatcatggg
     1321 cttgaccttt gacctctaga cactaatttt atcctttgag gctggcttaa ttagggatgc
     1381 tgtcattaag gagagggaga aatgtagagt gttacctcca actcatttga tttcccttac
     1441 ttgggaaaat gcagtccagt gttctcacct ctgcctccaa ggtaggagat gtctgtgggt
     1501 gaggctcagc aactgagcaa atatgtgcct gtgagtttgc cagtagagct gtgaagaaac
     1561 agctgcagag aacatttgac cttcctggca ttcttgtctg catgtgtgtg agttatttta
     1621 gaggtgtgct ttcttgagcc ctcataagga agtactggtg ctaggttttg caagattttg
     1681 tatacacttt gctccttgcc ctagggctca gagtggtggt ttctgactac atttctagag
     1741 tcagagcttg atcaccacaa ctcaattatt tcggcatctt ttcacctatg ctgtgatttg
     1801 tttttttttt ttcttctcaa aaattctgtt cattggttcc actcagcatc aagaagacag
     1861 ggacaaacaa ctcaagtgtc ttaacagctg ctggagtggg atccttgtta tctcttagcc
     1921 actgcaggac ctgcctgaca ggttatgtgt gcacctcgag atgaagtgtc tttctattat
     1981 tgtagagatt ctgtagtgaa gaggtctgac accatgtgtg gaggaggagg aacgatcagt
     2041 caagagatgt cctggtctta atgcctgtgg cttgtgctgg gagtgggtct gacttagtga
     2101 taaaaggact ctattcacta agtagcctgt gtttttaaat ccagggctgc aggcagcaac
     2161 gcaagtcagg ctgaacattc agtctccaga gacagctgtg tggagcaaat cagagttcat
     2221 gcccaagtcc ccaggttgga atggctgtgc caaaatccat tcaaagggtt ttctttttca
     2281 ttactaggtc agaacatttt gagtcacctt gggagattca ggatggggag agcaaatttg
     2341 aacaaaaggt ttttcttata tcctgagatt gaggggtagg gggtgtccaa cctgtatagc
     2401 ccatgggttg tgtctagaat taagtggagg gcagctatct ggagttaact tgcaagcata
     2461 ttggtgccct ccatgaccac ctctggctta ggacttggcc ctgttatgag ctgaccccca
     2521 ccccccaccc cccacccccc ccccccgcca actcctatac ccatcttccc taggtgaatc
     2581 tgtgaatggt cctttctggc agcaatccct gccttctttt tgggcccatg cccagacttc
     2641 tggtttaagg aatggtccca gagcttgggc cagcttgctc agaagttttg ggagcattga
     2701 gcctgcctag aaagatacag tgttagctcc ccttacttca aagttgccct tctctgttct
     2761 gactcctggg acttctggtc ctgggcacac tttttgcagg caacaaaatg tgcctgggag
     2821 tgatggattt taatgtgctc cagagtcctt tcagaaggtg gtcatttccc ttggccgggc
     2881 gcggtggctc acacctgtaa tcccagcact ttgggaggcc aaggcaggcg gatcacctga
     2941 ggttaggagt tcgagaccac cctggccaac atgcgaaacc ccatctctac gaaaaataga
     3001 aatattagcc gggcatggtg tcaggcacct gtaatcccag ctacttggga ggctgaggca
     3061 ggagaattgc ttgaactcgg gaggcagagg ttgcagtgag ccaagatcat gccatcccac
     3121 tctagcttgg gcaatagagc aaggctccgt ctcaagaaaa gaaggtcatt tcccaagact
     3181 agcataggga gtatccattt aaaatacatt catcttcctc ccatttccgt gctattaatc
     3241 acttgttaga gcaacatgac atgcccagca tcccacttcc cgaaaatgtc tactccttct
     3301 actctgagct cttgttgcct agacctcaga aaacaccaat tcaccacagt agaaccggga
     3361 gcagggatag ctcagcttct ctgaatagca cactttgctc aggtcttaac ttgagggcct
     3421 ctccggtact aacatcctgc gatagcttgt cccatgagca cagaagagcc tcagtagagt
     3481 caagtcctgc tgcagctgcc ccaccccaag tttctatcat ttcctcttta aacaaaaaat
     3541 atgttatcct acacattagt gtcaatccaa tggttgtctc ttatctgtct aaatagcaaa
     3601 atcatgaaaa tcagctgttt tatttgcata ggacaactaa cctgtctgtg taactttgtt
     3661 tttattttaa ctcttactag aaaatctaat cttaaaacat ttgaattcta aacatgtaaa
     3721 atgtgacagc ctgcaatttt gtagacagtg aagtaatggc tgctatttat aaatggaaca
     3781 tctatcaaaa taagtaactg tttataaaat tcagtttttg tagggttttc caaggaaaaa
     3841 tcaccttggt tgaatgtttc tcactcatta aactttgcag aagtgattca tattcagtac
     3901 tgtttttaat cactttttaa aatataagga ccgaatgcaa ggaaaccaaa gtttattaat
     3961 aatttttata taactaaaat aaaatagatg tggagggatc tgtgatcata taaaaaggga
     4021 gggttactga aagaatttta gcaatatatt gattcaggaa aaggagctgt tttataaatg
     4081 atcattcact gttcctatgg ttctatgtat ctttcaaacc gataccttta ctatttaaag
     4141 agcgtaaata gtgaaagtaa gatggtcata cttactgact ttatctattt aagtttgatg
     4201 gagataaact atatcttggc tagtggctac tgtgtctgtg aatgtaacca gtacttcttt
     4261 aagctctatt cagtagggtt ccagccactg cttttttgtt gtttctagcc actgtttttt
     4321 ttttcttgtt tccttataaa acaggtaata accaatcatt ttgtgtttgt atttccattc
     4381 ctttttattt ctgcctttgt gtagactgat gattaagtag gcaaactact tctactttca
     4441 aagagcccca agggcttaat gaccccattt gtaactgaga aatgattctt gttttagtaa
     4501 tcattctata aatgatactg ctggattgat tgccgtgggt tgatagctgg aggaattgtt
     4561 ttggacaata ctaacatgtg aatttatgtc ttagttttat ttgcagtctt gctaagtaaa
     4621 atgagtcttt gtatctactt ttttattaaa gtgaaattta gcaatagtta atattaggtg
     4681 acataaataa aacatcccag actagtgagt taagtacaag atctctctaa aaataaacag
     4741 atgaaaatct atccccatta tcgatacaga atttgtgaac gtggcataat tcttggtagg
     4801 tgctatagag atttatcatt ttaaacagtt cacacaccac tgcaattctg ctccaaagga
     4861 caaagatatt ttcaagtgaa ccaaaattca ttttgatatc agttcagtgg acgaactccc
     4921 agtctttact ctggaaagct gcccagctta gggttgccag ataaaacata agatacctag
     4981 ttaaatatga atttcaacaa tgtacaattt ttagtctaag tactatgtgt cctaaacact
     5041 gcatgagaca tactcatacc aaagtatttg ttgcttatgt gtaattcata tttaactggg
     5101 tatcctgtat ttttacttgt taagtccggc aaccctagcc caggctttct caggtttttt
     5161 ttaacaggga tcccaagctt tttctattgg tttgagagcc tgctacacaa ataatatgat
     5221 cttaacaatt gaatagttat gttaagagtg tagttactgc agttagactg ccaaagttca
     5281 aatcactgct ctactacttc ttaggtgtgt ggtcttgaat aagttttttg acctctctaa
     5341 gcctcagttt cttcattaat aaaatgagtt gcatggctta tatgaaa
//
