LOCUS       NM_173549               1503 bp    mRNA    linear   PRI 16-JUL-2024
DEFINITION  Homo sapiens glutamate rich 5 (ERICH5), transcript variant 1, mRNA.
ACCESSION   NM_173549
VERSION     NM_173549.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1503)
  AUTHORS   Lim,S.H., Snider,J., Birimberg-Schwartz,L., Ip,W., Serralha,J.C.,
            Botelho,H.M., Lopes-Pacheco,M., Pinto,M.C., Moutaoufik,M.T.,
            Zilocchi,M., Laselva,O., Esmaeili,M., Kotlyar,M., Lyakisheva,A.,
            Tang,P., Lopez Vazquez,L., Akula,I., Aboualizadeh,F., Wong,V.,
            Grozavu,I., Opacak-Bernardi,T., Yao,Z., Mendoza,M., Babu,M.,
            Jurisica,I., Gonska,T., Bear,C.E., Amaral,M.D. and Stagljar,I.
  TITLE     CFTR interactome mapping using the mammalian membrane two-hybrid
            high-throughput screening system
  JOURNAL   Mol Syst Biol 18 (2), e10629 (2022)
   PUBMED   35156780
REFERENCE   2  (bases 1 to 1503)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 1503)
  AUTHORS   Rothenberg,M.E., Spergel,J.M., Sherrill,J.D., Annaiah,K.,
            Martin,L.J., Cianferoni,A., Gober,L., Kim,C., Glessner,J.,
            Frackelton,E., Thomas,K., Blanchard,C., Liacouras,C., Verma,R.,
            Aceves,S., Collins,M.H., Brown-Whitehorn,T., Putnam,P.E.,
            Franciosi,J.P., Chiavacci,R.M., Grant,S.F., Abonia,J.P.,
            Sleiman,P.M. and Hakonarson,H.
  TITLE     Common variants at 5q22 associate with pediatric eosinophilic
            esophagitis
  JOURNAL   Nat Genet 42 (4), 289-291 (2010)
   PUBMED   20208534
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK096872.1 and BC062359.1.
            
            On Nov 22, 2018 this sequence version replaced NM_173549.2.
            
            Transcript Variant: This variant represents the longer transcript
            and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK096872.1, SRR3476690.14670.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000318528.8/ ENSP00000315614.3
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1078              AK096872.1         47-1124
            1079-1391           BC062359.1         1069-1381
            1392-1503           AK096872.1         1438-1549
FEATURES             Location/Qualifiers
     source          1..1503
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q22.2"
     gene            1..1503
                     /gene="ERICH5"
                     /gene_synonym="C8orf47"
                     /note="glutamate rich 5"
                     /db_xref="GeneID:203111"
                     /db_xref="HGNC:HGNC:26823"
                     /db_xref="MIM:620895"
     exon            1..160
                     /gene="ERICH5"
                     /gene_synonym="C8orf47"
                     /inference="alignment:Splign:2.1.0"
     CDS             103..1227
                     /gene="ERICH5"
                     /gene_synonym="C8orf47"
                     /note="isoform 1 is encoded by transcript variant 1;
                     glutamate-rich protein 5"
                     /codon_start=1
                     /product="glutamate-rich protein 5 isoform 1"
                     /protein_id="NP_775820.2"
                     /db_xref="CCDS:CCDS34929.1"
                     /db_xref="GeneID:203111"
                     /db_xref="HGNC:HGNC:26823"
                     /db_xref="MIM:620895"
                     /translation="MGCSSSALNKAGDSSRFPSVTSNEHFSTAEESESCFAQPKPHAL
                     GRESTVDGNVQRESRPPLQKLKVSAEPTANGVKPLQEQPLAKDVAPGRDATDQSGSTE
                     KTQPGEGLEESGPPQPGGKEDAPAAEGKKKDAGAGTEAESLKGNAEAQPLGPEAKGQP
                     LQAAVEKDSLRAVEVTENPQTAAEMKPLGTTENVLTLQIAGELQPQGTVGKDEQAPLL
                     ETISKENESPEILEGSQFVETAEEQQLQATLGKEEQPQLLERIPKENVTPEVLDRSQL
                     VEKPVMNDPFHKTPEGPGNMEQIQPEGIVGSMEHPARNVEAGAYVEMIRNIHTNEEDQ
                     RIEGETGEKVETDMENEKVSEGAETKEEETGEVVDLSAAT"
     exon            161..1114
                     /gene="ERICH5"
                     /gene_synonym="C8orf47"
                     /inference="alignment:Splign:2.1.0"
     exon            1115..1503
                     /gene="ERICH5"
                     /gene_synonym="C8orf47"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1480..1485
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ERICH5"
                     /gene_synonym="C8orf47"
                     /note="hexamer: AATAAA"
     polyA_site      1503
                     /gene="ERICH5"
                     /gene_synonym="C8orf47"
                     /note="major polyA site"
ORIGIN      
        1 agagctggag aaacttccgc ggctacgggt gcagttgcct tcggttcccg gttccgggcc
       61 gacacccgcg cagggctgag acaggtgtct gcgctccccg caatgggctg ctccagcagc
      121 gccctcaaca aggccggcga cagcagcagg ttccccagcg taacttcaaa tgagcatttt
      181 tcaactgcag aagaaagtga gtcctgcttt gcccaaccaa agccacatgc actgggaaga
      241 gaatctactg ttgatggcaa tgtacaaagg gaaagccgtc ctcccttaca aaagctcaag
      301 gtttcagcag agcctacagc taatggtgtt aaacccctcc aagaacagcc cctggccaag
      361 gacgtagccc ctggaaggga tgccacagac caatcagggt ccacagaaaa gactcagcct
      421 ggagagggac tggaggaatc tgggccgcct caaccaggtg gcaaagagga tgccccagca
      481 gcagaaggaa agaagaaaga tgcaggagca gggacagagg ccgagtctct aaaaggaaat
      541 gctgaagctc agcctttagg accagaagcc aagggtcagc ctttgcaggc agcagtagag
      601 aaggactctc tcagagcagt ggaggtcact gagaatccac aaactgctgc agagatgaag
      661 cctctaggaa caactgagaa cgttctgact ctgcaaatag ctggagagct acaacctcag
      721 ggcacagtgg gaaaggatga gcaggccccg cttctagaaa caatttccaa agagaatgaa
      781 tctccagaaa tattggaagg aagtcagttt gtggaaacag ctgaagagca gcaacttcag
      841 gcaacattgg gaaaagagga gcagccccag cttctagaaa gaattcccaa agagaatgta
      901 acaccagaag tattggacag aagtcagctt gtggaaaagc ctgttatgaa tgatccattc
      961 cataaaactc ctgaaggtcc aggaaacatg gagcagattc aacctgaagg aatagttgga
     1021 agcatggagc atccagcacg aaatgtagag gcaggagcat atgtggaaat gatcaggaac
     1081 atccatacta atgaagagga ccaacgcatt gaaggtgaga caggggaaaa ggtggaaaca
     1141 gacatggaga atgagaaagt gagtgaaggg gctgaaacca aagaagaaga aacaggagaa
     1201 gtggtggacc tttcagcagc cacatagata gaagagtgaa ccgacacagt gtgttatcat
     1261 agaggagaca aaaatggtag tgaagcttgt ggttatgtat cttatctttc tacatttaca
     1321 tgttttctgt aaggagtgtg gttatagaga gactgttgga accatgagaa ggatgtttct
     1381 gtgttcttga ttatattgtt ctgcaaaact gctaagccat gaacagtttt cttagctact
     1441 tagaatggtt atacatttaa aagtataaaa accaaagcca ataaaaatga tgtgattatt
     1501 taa
//
