LOCUS       NM_001290030            1698 bp    mRNA    linear   PRI 21-JUN-2024
DEFINITION  Homo sapiens glutamate rich 2 (ERICH2), transcript variant 1, mRNA.
ACCESSION   NM_001290030 XM_001714892 XM_003960300 XM_209489
VERSION     NM_001290030.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1698)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   2  (bases 1 to 1698)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 1698)
  AUTHORS   Harrington,J.J., Sherf,B., Rundlett,S., Jackson,P.D., Perry,R.,
            Cain,S., Leventhal,C., Thornton,M., Ramachandran,R.,
            Whittington,J., Lerner,L., Costanzo,D., McElligott,K., Boozer,S.,
            Mays,R., Smith,E., Veloso,N., Klika,A., Hess,J., Cothren,K., Lo,K.,
            Offenbacher,J., Danzig,J. and Ducar,M.
  TITLE     Creation of genome-wide protein expression libraries using random
            activation of gene expression
  JOURNAL   Nat Biotechnol 19 (5), 440-445 (2001)
   PUBMED   11329013
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC007405.6.
            
            On Nov 5, 2020 this sequence version replaced NM_001290030.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes isoform 1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038194.2755746.1,
                                           SRR5189655.42927.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2144333
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000697325.1/ ENSP00000513252.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-810               AC007405.6         118215-119024       c
            811-841             AC007405.6         112225-112255       c
            842-890             AC007405.6         111977-112025       c
            891-927             AC007405.6         111722-111758       c
            928-1023            AC007405.6         109514-109609       c
            1024-1172           AC007405.6         107013-107161       c
            1173-1360           AC007405.6         104569-104756       c
            1361-1418           AC007405.6         96482-96539         c
            1419-1490           AC007405.6         91290-91361         c
            1491-1698           AC007405.6         90425-90632         c
FEATURES             Location/Qualifiers
     source          1..1698
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q31.1"
     gene            1..1698
                     /gene="ERICH2"
                     /note="glutamate rich 2"
                     /db_xref="GeneID:285141"
                     /db_xref="HGNC:HGNC:44395"
                     /db_xref="MIM:620858"
     exon            1..810
                     /gene="ERICH2"
                     /inference="alignment:Splign:2.1.0"
     CDS             305..1615
                     /gene="ERICH2"
                     /note="isoform 1 is encoded by transcript variant 1;
                     glutamate-rich protein 2"
                     /codon_start=1
                     /product="glutamate-rich protein 2 isoform 1"
                     /protein_id="NP_001276959.1"
                     /db_xref="CCDS:CCDS92894.1"
                     /db_xref="GeneID:285141"
                     /db_xref="HGNC:HGNC:44395"
                     /db_xref="MIM:620858"
                     /translation="MDTDIPTFFPSSALLKVTGARAHVNPRVCAPSFRRRGTPTTAGL
                     SLSSAARPAPPPRTRLPAPPRALLAAPAPSRALHRPTAWARLHPASPWFPGLPLPPPP
                     PPPPPPPSPNSPSPHPRLLPELPPRAVQSPRRRCVPDSEPPAPREQLAGLALGVCPSD
                     GLLKRAASWTSVDKTDTVKTAKNKQNGRLLMFDPNEKVMIESNEAMSDKCLFGRRPRL
                     TSKLNTSPTQVSVNVAKTFSEKKEVPSKNIANKVSLQTTENRVSSRSIESKDILTNLQ
                     SDLLSSSCLKESTGEVSKDAVIVKQEKNNEYCLQDIDDKLSESAEDDGEDDTNDEDDD
                     EDSNPKKNTQAPLELMAEFLRAEMAREYQLAKKLCQMILIYEPENPEAKEFFTLIEEM
                     LLMEKTQNHEQDGENSDEDSSGESKGESDEELSDESSDEGEDGS"
     exon            811..841
                     /gene="ERICH2"
                     /inference="alignment:Splign:2.1.0"
     exon            842..890
                     /gene="ERICH2"
                     /inference="alignment:Splign:2.1.0"
     exon            891..927
                     /gene="ERICH2"
                     /inference="alignment:Splign:2.1.0"
     exon            928..1023
                     /gene="ERICH2"
                     /inference="alignment:Splign:2.1.0"
     exon            1024..1172
                     /gene="ERICH2"
                     /inference="alignment:Splign:2.1.0"
     exon            1173..1360
                     /gene="ERICH2"
                     /inference="alignment:Splign:2.1.0"
     exon            1361..1418
                     /gene="ERICH2"
                     /inference="alignment:Splign:2.1.0"
     exon            1419..1490
                     /gene="ERICH2"
                     /inference="alignment:Splign:2.1.0"
     exon            1491..1698
                     /gene="ERICH2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1671..1676
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ERICH2"
                     /note="hexamer: TATAAA"
     polyA_site      1698
                     /gene="ERICH2"
                     /note="major polyA site"
ORIGIN      
        1 gtggcagagc agcagctctg gcgctagagg gaacctgggc tgctctagct gggggagagc
       61 cgggtctctg gttctaatca cttgaatctg acttctggga aaactggcgt ccagggactc
      121 cccccggaga cccataatct tcttggggcg acctcaggtt gggggactaa gtcctgcagg
      181 ggacacttgt tcatccacta ccagggacac ccatctctcc caactcaaga cttcttttta
      241 ctccccaagt ttaaaactct gaggccaccc cgcccccttc cctctccctc gcttagaatc
      301 aggtatggac accgacattc caaccttctt tccttcttcg gcgctcctga aggtaaccgg
      361 tgcgcgtgcg cacgtcaatc cgagggtgtg tgcgcccagt ttccggcgcc gcgggacacc
      421 cacaaccgcg gggctgtccc tcagctcggc cgcccgcccc gccccgcccc cccggacccg
      481 cctcccagcc ccgccccggg ccctcctcgc cgcgcccgct ccgtcccgcg ccctccaccg
      541 ccctacggcc tgggcccgcc tccaccctgc ctctccgtgg ttccccgggc tgcccctgcc
      601 cccgcccccg cccccgccac ctcccccgcc gtcgcccaat tcccccagcc cccaccctcg
      661 gctgctgccc gagcttcctc cacgcgccgt gcagtctcca cggcgacgct gcgttcccga
      721 ctcggagccc ccagctccgc gcgagcagct agccgggctg gctctcggtg tgtgcccttc
      781 ggatggtctg ctgaagaggg ccgccagctg gacttctgta gacaagacag atactgtaaa
      841 gacagcaaag aacaaacaga atggcagatt gctaatgttt gatccaaacg aaaaagtgat
      901 gattgaatca aacgaagcaa tgtcagataa atgcctcttt ggacgcagac caagattgac
      961 aagcaaactt aatacctcac caacacaggt ctctgtaaat gtagctaaaa cattctcaga
     1021 aaagaaggaa gtcccttcta agaatattgc aaataaagtc tctttacaga ctactgaaaa
     1081 tagagtatct tcaaggagta tcgaaagtaa agatatctta acaaatctac agtctgacct
     1141 attgtcatct tcctgcttaa aagaaagcac aggtgaagtg agcaaagatg cagtcattgt
     1201 aaagcaggag aaaaataatg aatattgcct tcaggatatt gatgataaat tgtcagaatc
     1261 agcagaggat gatggtgaag atgataccaa tgatgaagat gatgatgaag atagtaaccc
     1321 taaaaagaat actcaggccc cactagagtt aatggcagaa tttctgagag cagaaatggc
     1381 ccgagagtac cagctggcaa aaaaattatg tcagatgatc ctaatctatg aaccagaaaa
     1441 tcctgaggcc aaggagtttt tcacacttat tgaagaaatg ttgctgatgg agaaaactca
     1501 gaatcatgag caagacggtg aaaacagtga tgaagacagc agtggtgaga gtaaaggaga
     1561 aagcgatgag gagctgagtg acgagagctc tgacgaaggt gaagatggat catgagtgtt
     1621 gctgcaatac ttgaagcttc atgtattttc attaatgtat accatgcaaa tataaagaca
     1681 agtgacattt tagtctaa
//
