LOCUS       NM_024066               1733 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens ERI1 exoribonuclease family member 3 (ERI3),
            transcript variant 1, mRNA.
ACCESSION   NM_024066 XM_290941
VERSION     NM_024066.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1733)
  AUTHORS   Doyle,G.A. and Berrettini,W.H.
  TITLE     Failure to Replicate an Association of a LINE-1 Element in ERI1
            Exoribonuclease Family Member 3 (ERI3) with Schizophrenia
  JOURNAL   Neuropsychopharmacology 42 (13), 2471 (2017)
   PUBMED   29123232
  REMARK    GeneRIF: The conclude of this study that the particular LINE-1
            element within the ERI3 gene does not associate with the
            schizophrenia phenotype in European Americans.
REFERENCE   2  (bases 1 to 1733)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   3  (bases 1 to 1733)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   4  (bases 1 to 1733)
  AUTHORS   Bailey,S.D., Xie,C., Do,R., Montpetit,A., Diaz,R., Mohan,V.,
            Keavney,B., Yusuf,S., Gerstein,H.C., Engert,J.C. and Anand,S.
  CONSRTM   DREAM investigators
  TITLE     Variation at the NFATC2 locus increases the risk of
            thiazolidinedione-induced edema in the Diabetes REduction
            Assessment with ramipril and rosiglitazone Medication (DREAM) study
  JOURNAL   Diabetes Care 33 (10), 2250-2253 (2010)
   PUBMED   20628086
  REMARK    GeneRIF: Observational study of gene-disease association,
            gene-environment interaction, and pharmacogenomic / toxicogenomic.
            (HuGE Navigator)
REFERENCE   5  (bases 1 to 1733)
  AUTHORS   Talmud,P.J., Drenos,F., Shah,S., Shah,T., Palmen,J., Verzilli,C.,
            Gaunt,T.R., Pallas,J., Lovering,R., Li,K., Casas,J.P., Sofat,R.,
            Kumari,M., Rodriguez,S., Johnson,T., Newhouse,S.J., Dominiczak,A.,
            Samani,N.J., Caulfield,M., Sever,P., Stanton,A., Shields,D.C.,
            Padmanabhan,S., Melander,O., Hastie,C., Delles,C., Ebrahim,S.,
            Marmot,M.G., Smith,G.D., Lawlor,D.A., Munroe,P.B., Day,I.N.,
            Kivimaki,M., Whittaker,J., Humphries,S.E. and Hingorani,A.D.
  CONSRTM   ASCOT investigators; NORDIL investigators; BRIGHT Consortium
  TITLE     Gene-centric association signals for lipids and apolipoproteins
            identified via the HumanCVD BeadChip
  JOURNAL   Am J Hum Genet 85 (5), 628-642 (2009)
   PUBMED   19913121
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   6  (bases 1 to 1733)
  AUTHORS   Spielhaupter,C. and Schatzl,H.M.
  TITLE     PrPC directly interacts with proteins involved in signaling
            pathways
  JOURNAL   J Biol Chem 276 (48), 44604-44612 (2001)
   PUBMED   11571277
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK290567.1, AF007157.1 and AK293833.1.
            
            On May 17, 2019 this sequence version replaced NM_024066.2.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF007157.1, SRR14038194.465258.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000372257.7/ ENSP00000361331.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-479               AK290567.1         11-489
            480-480             AF007157.1         431-431
            481-1268            AK290567.1         491-1278
            1269-1709           AK293833.1         635-1075
            1710-1733           AF007157.1         1661-1684
FEATURES             Location/Qualifiers
     source          1..1733
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p34.1"
     gene            1..1733
                     /gene="ERI3"
                     /gene_synonym="PINT1; PRNPIP"
                     /note="ERI1 exoribonuclease family member 3"
                     /db_xref="GeneID:79033"
                     /db_xref="HGNC:HGNC:17276"
                     /db_xref="MIM:609917"
     exon            1..366
                     /gene="ERI3"
                     /gene_synonym="PINT1; PRNPIP"
                     /inference="alignment:Splign:2.1.0"
     CDS             232..1245
                     /gene="ERI3"
                     /gene_synonym="PINT1; PRNPIP"
                     /note="isoform 1 is encoded by transcript variant 1;
                     enhanced RNAi three prime mRNA exonuclease homolog 3; ERI1
                     exoribonuclease 3; prion interactor 1; prion
                     protein-interacting protein"
                     /codon_start=1
                     /product="ERI1 exoribonuclease 3 isoform 1"
                     /protein_id="NP_076971.1"
                     /db_xref="CCDS:CCDS30696.1"
                     /db_xref="GeneID:79033"
                     /db_xref="HGNC:HGNC:17276"
                     /db_xref="MIM:609917"
                     /translation="MATASPAADGGRGRPWEGGLVSWPPAPPLTLPWTWMGPSWGQHP
                     GHWGFPALTEPSASPAAGLGIFEVRRVLDASGCSMLAPLQTGAARFSSYLLSRARKVL
                     GSHLFSPCGVPEFCSISTRKLAAHGFGASMAAMVSFPPQRYHYFLVLDFEATCDKPQI
                     HPQEIIEFPILKLNGRTMEIESTFHMYVQPVVHPQLTPFCTELTGIIQAMVDGQPSLQ
                     QVLERVDEWMAKEGLLDPNVKSIFVTCGDWDLKVMLPGQCQYLGLPVADYFKQWINLK
                     KAYSFAMGCWPKNGLLDMNKGLSLQHIGRPHSGIDDCKNIANIMKTLAYRGFIFKQTS
                     KPF"
     exon            367..442
                     /gene="ERI3"
                     /gene_synonym="PINT1; PRNPIP"
                     /inference="alignment:Splign:2.1.0"
     exon            443..720
                     /gene="ERI3"
                     /gene_synonym="PINT1; PRNPIP"
                     /inference="alignment:Splign:2.1.0"
     exon            721..837
                     /gene="ERI3"
                     /gene_synonym="PINT1; PRNPIP"
                     /inference="alignment:Splign:2.1.0"
     exon            838..897
                     /gene="ERI3"
                     /gene_synonym="PINT1; PRNPIP"
                     /inference="alignment:Splign:2.1.0"
     exon            898..989
                     /gene="ERI3"
                     /gene_synonym="PINT1; PRNPIP"
                     /inference="alignment:Splign:2.1.0"
     exon            990..1062
                     /gene="ERI3"
                     /gene_synonym="PINT1; PRNPIP"
                     /inference="alignment:Splign:2.1.0"
     exon            1063..1162
                     /gene="ERI3"
                     /gene_synonym="PINT1; PRNPIP"
                     /inference="alignment:Splign:2.1.0"
     exon            1163..1733
                     /gene="ERI3"
                     /gene_synonym="PINT1; PRNPIP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1690..1695
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ERI3"
                     /gene_synonym="PINT1; PRNPIP"
                     /note="hexamer: AATAAA"
     polyA_site      1709
                     /gene="ERI3"
                     /gene_synonym="PINT1; PRNPIP"
                     /note="major polyA site"
ORIGIN      
        1 gagtcggtgt gttgtggact cgtggtgctg gctgccgctg ttcaggcggc cgggaacggg
       61 cggtggggag cgggcggagc tggccctgcc tctgcctggc cggcgccgca gtcggcgcgg
      121 gccgcgcccg ccgccgccaa ctgccctgag cgcttgctga ggccgaggga gacgtcgggg
      181 cctgcacctg gagggagcct gccgcgctgg ccccgaggag ggggcgttgc catggcgaca
      241 gcctctcccg ctgctgacgg ggggcggggg cggccctggg aaggagggct ggtctcctgg
      301 ccccccgccc ctccccttac tctcccctgg acttggatgg gcccgagttg ggggcaacac
      361 cccgggcatt ggggctttcc agctctcaca gaaccttcag catccccagc tgccggtctt
      421 ggcatcttcg aagtaaggag agttttagat gcttctggat gttcaatgct agcaccttta
      481 cagactggag cagctcgatt ttcttcgtat ttactttcaa gagcaagaaa agtgctgggc
      541 tcccacttat tttctccctg tggtgttccg gagttctgct ccatatccac cagaaagctg
      601 gcggcccacg gctttggcgc atccatggcg gcaatggtgt ccttccctcc ccagaggtat
      661 cactactttt tagtgctgga ctttgaggcc acgtgcgaca agccacagat tcatcctcag
      721 gaaatcatcg agttccccat cctaaagcta aatggccgga ccatggagat tgagtctacc
      781 tttcacatgt atgtccagcc tgtagtccat ccacagctta ccccattctg tacagagctc
      841 accgggatta ttcaagccat ggtggatggt cagccaagcc tgcagcaagt gctggagagg
      901 gtcgatgaat ggatggcgaa ggaaggcctc ttagatccaa acgtcaagtc aatttttgtc
      961 acctgtggag actgggactt aaaagtcatg ctcccaggcc agtgccagta cttgggcttg
     1021 ccagtggcgg attacttcaa gcagtggatt aatctgaaaa aggcttacag cttcgccatg
     1081 ggctgctggc ccaagaatgg acttctagac atgaacaagg gcctcagcct gcaacacata
     1141 ggccggcccc acagcggcat tgacgactgc aagaacattg ccaacatcat gaagacactc
     1201 gcctatcgag gcttcatctt caagcagaca tcgaagccgt tctgattggc cgaggacagg
     1261 atggggcagg acagggtagc tgtttggccc agcccagaat cctcctctcc ctcaccagag
     1321 gggaagaggg agagtggcat agctctgtgt ccagagtgtc cccagctgcc ctgtgggctc
     1381 atgcccttgg cgtgggcttg tgcccttgca agggcttggc cacttggccc ttctggagca
     1441 gacactttgt gccccccatc cccacccctc aatctcagcc cagtatcagc ccctcccatt
     1501 gcgggcctgg gctaggggga cccaggcact caccgcctcc tccctggtac acaggcttct
     1561 gtggggccac caagcccctc ctgtgccccc tcccatccat agtgcatggt gtgtggtgcc
     1621 cccagggctc caggacagat caggccccac cttgtgtcta cccccatccc cgctgtgaac
     1681 gtgccactga ataaagtcgg ggaaacgagg cactgggtgt gtgtgcaaag cca
//
