LOCUS       NM_001142725            3502 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens ERI1 exoribonuclease family member 2 (ERI2),
            transcript variant 1, mRNA.
ACCESSION   NM_001142725
VERSION     NM_001142725.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3502)
  AUTHORS   Bailey,S.D., Xie,C., Do,R., Montpetit,A., Diaz,R., Mohan,V.,
            Keavney,B., Yusuf,S., Gerstein,H.C., Engert,J.C. and Anand,S.
  CONSRTM   DREAM investigators
  TITLE     Variation at the NFATC2 locus increases the risk of
            thiazolidinedione-induced edema in the Diabetes REduction
            Assessment with ramipril and rosiglitazone Medication (DREAM) study
  JOURNAL   Diabetes Care 33 (10), 2250-2253 (2010)
   PUBMED   20628086
  REMARK    GeneRIF: Observational study of gene-disease association,
            gene-environment interaction, and pharmacogenomic / toxicogenomic.
            (HuGE Navigator)
REFERENCE   2  (bases 1 to 3502)
  AUTHORS   Talmud,P.J., Drenos,F., Shah,S., Shah,T., Palmen,J., Verzilli,C.,
            Gaunt,T.R., Pallas,J., Lovering,R., Li,K., Casas,J.P., Sofat,R.,
            Kumari,M., Rodriguez,S., Johnson,T., Newhouse,S.J., Dominiczak,A.,
            Samani,N.J., Caulfield,M., Sever,P., Stanton,A., Shields,D.C.,
            Padmanabhan,S., Melander,O., Hastie,C., Delles,C., Ebrahim,S.,
            Marmot,M.G., Smith,G.D., Lawlor,D.A., Munroe,P.B., Day,I.N.,
            Kivimaki,M., Whittaker,J., Humphries,S.E. and Hingorani,A.D.
  CONSRTM   ASCOT investigators; NORDIL investigators; BRIGHT Consortium
  TITLE     Gene-centric association signals for lipids and apolipoproteins
            identified via the HumanCVD BeadChip
  JOURNAL   Am J Hum Genet 85 (5), 628-642 (2009)
   PUBMED   19913121
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   3  (bases 1 to 3502)
  AUTHORS   Kupsco,J.M., Wu,M.J., Marzluff,W.F., Thapar,R. and Duronio,R.J.
  TITLE     Genetic and biochemical characterization of Drosophila Snipper: A
            promiscuous member of the metazoan 3'hExo/ERI-1 family of 3' to 5'
            exonucleases
  JOURNAL   RNA 12 (12), 2103-2117 (2006)
   PUBMED   17135487
  REMARK    GeneRIF: This paper describes a detailed biochemical and genetic
            characterization of the exonuclease Snipper, the Drosophila
            ortholog of EXOD1. It identifies EXOD1 as a member of a new
            subclass of exonucleases called the 3'hExo/ERI-1 subfamily of DEDDh
            nucleases.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC010503.1, AK292594.1 and BX648185.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001142725.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: DRR138509.7078.1,
                                           SRR7346977.2104182.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000357967.9/ ENSP00000350651.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-545               BC010503.1         2-546
            546-2468            AK292594.1         760-2682
            2469-3502           BX648185.1         2624-3657
FEATURES             Location/Qualifiers
     source          1..3502
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16p12.3"
     gene            1..3502
                     /gene="ERI2"
                     /gene_synonym="EXOD1; ZGRF5"
                     /note="ERI1 exoribonuclease family member 2"
                     /db_xref="GeneID:112479"
                     /db_xref="HGNC:HGNC:30541"
     exon            1..65
                     /gene="ERI2"
                     /gene_synonym="EXOD1; ZGRF5"
                     /inference="alignment:Splign:2.1.0"
     CDS             43..2118
                     /gene="ERI2"
                     /gene_synonym="EXOD1; ZGRF5"
                     /EC_number="3.1.-.-"
                     /note="isoform 1 is encoded by transcript variant 1;
                     exoribonuclease 2; enhanced RNAi three prime mRNA
                     exonuclease homolog 2; exonuclease domain containing 1;
                     ERI1 exoribonuclease 2; exonuclease domain-containing
                     protein 1; zinc finger, GRF-type containing 5"
                     /codon_start=1
                     /product="ERI1 exoribonuclease 2 isoform 1"
                     /protein_id="NP_001136197.1"
                     /db_xref="CCDS:CCDS45436.1"
                     /db_xref="GeneID:112479"
                     /db_xref="HGNC:HGNC:30541"
                     /translation="MATKRLARQLGLIRRKSIAPANGNLGRSKSKQLFDYLIVIDFES
                     TCWNDGKHHHSQEIIEFPAVLLNTSTGQIDSEFQAYVQPQEHPILSEFCMELTGIKQA
                     QVDEGVPLKICLSQFCKWIHKIQQQKNIIFATGISEPSASEVKLCAFVTWSDWDLGVC
                     LEYECKRKQLLKPVFLNSWIDLRATYKLFYRRKPKGLSGALQEVGIEFSGREHSGLDD
                     SRNTALLAWKMIRDGCVMKITRSLNKVPTKKNFSILARNLNTIQVEEMSACNISIQGP
                     SIYNKEPKNIINPHEKVQMKSICANSPIKAQQDQLQVKNNIKASLHNVKSSLPLFNTK
                     SSTSVGQLQSPTLNSPIYMQKQGKNEHLAFNTKSKASTVGSELVLVSTTVPTVHHVSD
                     LEMSSTLDCLPVLADWEDVVLLPASQPEENVDCTVPISDSDLEISFNSGERLMVLKEL
                     EMSSHENFGDIEETPQKSETSKSIVYKSPHTTIYNVKEAKDPGSDISAFKLPEHKSST
                     FNRVNANMSHPLVLGKHPLLSGGTKRNPCSPQAFPPAKKQPFTIHEEKPTSSDCSPVR
                     SSSWRRLPSILTSTVNLQEPWKSGKMTPPLCKCGRRSKRLVVSNNGPNHGKVFYCCPI
                     GKYQENRKCCGYFKWEQTLQKERANSMVPSHSTGGLTFSSPETSHICDRNLSISTKNS
                     LRLRPSMRN"
     exon            66..133
                     /gene="ERI2"
                     /gene_synonym="EXOD1; ZGRF5"
                     /inference="alignment:Splign:2.1.0"
     exon            134..217
                     /gene="ERI2"
                     /gene_synonym="EXOD1; ZGRF5"
                     /inference="alignment:Splign:2.1.0"
     exon            218..345
                     /gene="ERI2"
                     /gene_synonym="EXOD1; ZGRF5"
                     /inference="alignment:Splign:2.1.0"
     exon            346..502
                     /gene="ERI2"
                     /gene_synonym="EXOD1; ZGRF5"
                     /inference="alignment:Splign:2.1.0"
     exon            503..603
                     /gene="ERI2"
                     /gene_synonym="EXOD1; ZGRF5"
                     /inference="alignment:Splign:2.1.0"
     exon            604..685
                     /gene="ERI2"
                     /gene_synonym="EXOD1; ZGRF5"
                     /inference="alignment:Splign:2.1.0"
     exon            686..774
                     /gene="ERI2"
                     /gene_synonym="EXOD1; ZGRF5"
                     /inference="alignment:Splign:2.1.0"
     exon            775..3502
                     /gene="ERI2"
                     /gene_synonym="EXOD1; ZGRF5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3477..3482
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ERI2"
                     /gene_synonym="EXOD1; ZGRF5"
                     /note="hexamer: AATAAA"
     polyA_site      3502
                     /gene="ERI2"
                     /gene_synonym="EXOD1; ZGRF5"
                     /note="major polyA site"
ORIGIN      
        1 gacttccggc agctggactt ggaaaagcaa ggagtgtcgg gaatggcgac caagcggctc
       61 gcgcggcagc ttggattaat taggagaaag tcaattgcgc cagcaaatgg aaatctcgga
      121 agaagcaaat ccaagcagtt gtttgactac ttaattgtca ttgattttga atcgacatgc
      181 tggaatgatg ggaagcacca ccatagccag gaaataattg agtttccagc agtgttgctg
      241 aacacatcaa ctggacagat tgactctgag ttccaggctt atgttcaacc tcaggaacat
      301 ccaattcttt cagaattttg catggaattg acaggcataa agcaggctca agttgatgaa
      361 ggagtccctc tgaagatttg cttatctcag ttctgtaaat ggattcataa gattcagcaa
      421 cagaagaaca ttatttttgc tactgggatt tcagagcctt ctgcttctga agtaaaatta
      481 tgtgcatttg ttacttggtc agactgggac ttgggggttt gcctggagta tgagtgtaaa
      541 agaaagcagc tgttaaaacc tgtgttttta aattcttgga ttgatctcag agcaacttac
      601 aagcttttct ataggagaaa accaaaagga ctaagtggtg ccttgcagga agtaggaata
      661 gaattctcag gacgagaaca ttctgggttg gacgattctc ggaatactgc ccttcttgct
      721 tggaaaatga tcagagatgg ttgtgtaatg aaaattacaa ggtcgttgaa caaggttccc
      781 actaagaaga atttcagcat tctggccaga aatttgaata caattcaagt tgaagaaatg
      841 tctgcctgta acattagcat ccagggtccc agcatatata ataaggagcc taaaaatata
      901 ataaatcctc atgaaaaagt tcaaatgaag tcaatttgtg caaattctcc tataaaggca
      961 caacaggatc aattacaagt aaaaaacaat ataaaagcaa gtcttcacaa tgtcaaaagt
     1021 tccttacctc tttttaatac taagtcctct acttctgtgg ggcagttgca gtctcctacc
     1081 ttgaattcac ctatctatat gcaaaagcaa ggaaaaaatg aacatcttgc atttaatacc
     1141 aaatctaagg cttcaacagt tggttcagaa ttggtacttg tttctaccac cgttccaact
     1201 gttcatcatg tttctgattt ggaaatgagc tctactctgg actgtttacc tgtgttggct
     1261 gattgggagg atgtggtttt actgccagca tctcagcctg aggaaaacgt agactgtaca
     1321 gttcccatta gtgactcaga cttagagatt tcatttaatt ctggagaaag attaatggtt
     1381 ttgaaagaat tggaaatgtc aagtcatgaa aactttggag acatagagga aactcctcaa
     1441 aaatctgaga cttctaagtc tattgtgtac aagagtcctc acactactat ttataatgta
     1501 aaagaagcca aagatccagg ttcagatatt tctgccttta agttacctga acacaaatca
     1561 agtaccttca acagagttaa tgccaatatg tctcatcctt tagttttggg gaaacatcct
     1621 cttctttcag gtggtaccaa aaggaatcca tgcagtcccc aagctttccc accagcaaaa
     1681 aaacaaccct tcactattca tgaagaaaag cctacatcat ctgattgctc cccagtaaga
     1741 agttcttcct ggaggcgtct cccatctata ttaacttcta cagttaacct acaagagcca
     1801 tggaagagtg ggaaaatgac acctccatta tgcaagtgtg gtcggagatc taagagactt
     1861 gttgtttcta ataatggacc gaaccatgga aaagtcttct attgttgccc tatcgggaaa
     1921 taccaagaaa acagaaaatg ttgtggttat ttcaaatggg aacaaacact tcaaaaggaa
     1981 agagccaaca gcatggttcc atctcattcc acagggggac tcacttttag ttctccagaa
     2041 acaagccata tttgtgacag aaatttaagt atttccacca aaaattcttt gagactcagg
     2101 ccttcaatga ggaattgata acctttcatg tatgaatcct aattgttcct tgaatttcca
     2161 aacatgagta ttctgataac atcttacact attttatttt tattttatat attaatgttt
     2221 actgcattta ccatactttc ttcaggaacc acaagtgtaa tcttttgtaa acagtattta
     2281 ttagattaca tataataagc aacaatagta tatgatcctt cttttatagt tagaccttga
     2341 aacaagtcta aactattttt aaattatttg caaaaaatgt gactaataaa aatccctagt
     2401 ctattttcag gtagattctt gtactttgag attatcataa tcttctaact gatattttat
     2461 atttttctaa aaacttttat aagttcttta gttttatttc aggcttgaac attggttctg
     2521 atttgtatat caacatatca gaagaattag tcaactaaag tttgaaaacc tatgtagcag
     2581 agatctggtt cagaaactgc ttctatacta tacatttaaa aattaatcag caattgatgg
     2641 tattattttt atattaagaa atgataggaa cattgacact aatgtggagg aatttgccaa
     2701 atattttatt tcaaaattta gcctctgata tcataaccac aagatatttt aaatcaacag
     2761 tttctaagca tactaccaca gtttttatga cctctccatc atcttgtggt ttctagagat
     2821 tgacagatac tatgtttgtt ttatagatat ggtaattaat gaaacaactt taaattgtct
     2881 tccattcttt cttcctcagt tcatttcttt ttgtcttccc actgatagtc tttggcagct
     2941 cttgaataaa ttctacctgt tggcatcaag gggaagaaaa ttagcctgga aatttttatc
     3001 tttacataaa gccaattata tagcagtttg attatgaatt ctaggtggaa gaattagaat
     3061 agtctttgga atgggttttg ggtaacagcc aaaataggga aaagggtatt gttaggaaag
     3121 ttgtcttgat attaagtatt tactgtgagt ccagtaagcc aaaggaccaa acaaaatagg
     3181 ttcagggttt cattttaatc tcaaagattc tgattcttac ccatatgtca tcagttcagt
     3241 ttgggacatg tggtgcagca tgtgtgaaga aaatattcat taaaatgtaa aaataaacac
     3301 ttgaaattgt ccacaacact gagcaaatat tcgttataat taggatgcct acctttctgg
     3361 gatatttgta aggtgctgta gtttttttaa catgctcctg aatctccttt attagttgtt
     3421 cttgatcatg tgacttgtaa tcaggattta gaacgacaaa agcctttact acctaaaata
     3481 aatatttgaa acaccaggaa aa
//
