LOCUS       NM_153332               4521 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens exoribonuclease 1 (ERI1), transcript variant 1, mRNA.
ACCESSION   NM_153332
VERSION     NM_153332.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4521)
  AUTHORS   Guo,L., Salian,S., Xue,J.Y., Rath,N., Rousseau,J., Kim,H.,
            Ehresmann,S., Moosa,S., Nakagawa,N., Kuroda,H., Clayton-Smith,J.,
            Wang,J., Wang,Z., Banka,S., Jackson,A., Zhang,Y.M., Wei,Z.J.,
            Huning,I., Brunet,T., Ohashi,H., Thomas,M.F., Bupp,C., Miyake,N.,
            Matsumoto,N., Mendoza-Londono,R., Costain,G., Hahn,G., Di
            Donato,N., Yigit,G., Yamada,T., Nishimura,G., Ansel,K.M.,
            Wollnik,B., Hrabe de Angelis,M., Megarbane,A., Rosenfeld,J.A.,
            Heissmeyer,V., Ikegawa,S. and Campeau,P.M.
  TITLE     Null and missense mutations of ERI1 cause a recessive phenotypic
            dichotomy in humans
  JOURNAL   Am J Hum Genet 110 (7), 1068-1085 (2023)
   PUBMED   37352860
  REMARK    GeneRIF: Null and missense mutations of ERI1 cause a recessive
            phenotypic dichotomy in humans.
REFERENCE   2  (bases 1 to 4521)
  AUTHORS   Declercq,M., Biquand,E., Karim,M., Pietrosemoli,N., Jacob,Y.,
            Demeret,C., Barbezange,C. and van der Werf,S.
  TITLE     Influenza A virus co-opts ERI1 exonuclease bound to histone mRNA to
            promote viral transcription
  JOURNAL   Nucleic Acids Res 48 (18), 10428-10440 (2020)
   PUBMED   32960265
  REMARK    GeneRIF: Influenza A virus co-opts ERI1 exonuclease bound to
            histone mRNA to promote viral transcription.
REFERENCE   3  (bases 1 to 4521)
  AUTHORS   Choucair,N., Rajab,M., Megarbane,A. and Chouery,E.
  TITLE     Homozygous microdeletion of the ERI1 and MFHAS1 genes in a patient
            with intellectual disability, limb abnormalities, and cardiac
            malformation
  JOURNAL   Am J Med Genet A 173 (7), 1955-1960 (2017)
   PUBMED   28488351
REFERENCE   4  (bases 1 to 4521)
  AUTHORS   Thomas,M.F., L'Etoile,N.D. and Ansel,K.M.
  TITLE     Eri1: a conserved enzyme at the crossroads of multiple
            RNA-processing pathways
  JOURNAL   Trends Genet 30 (7), 298-307 (2014)
   PUBMED   24929628
  REMARK    Review article
REFERENCE   5  (bases 1 to 4521)
  AUTHORS   von Moeller,H., Lerner,R., Ricciardi,A., Basquin,C., Marzluff,W.F.
            and Conti,E.
  TITLE     Structural and biochemical studies of SLIP1-SLBP identify DBP5 and
            eIF3g as SLIP1-binding proteins
  JOURNAL   Nucleic Acids Res 41 (16), 7960-7971 (2013)
   PUBMED   23804756
REFERENCE   6  (bases 1 to 4521)
  AUTHORS   Kupsco,J.M., Wu,M.J., Marzluff,W.F., Thapar,R. and Duronio,R.J.
  TITLE     Genetic and biochemical characterization of Drosophila Snipper: A
            promiscuous member of the metazoan 3'hExo/ERI-1 family of 3' to 5'
            exonucleases
  JOURNAL   RNA 12 (12), 2103-2117 (2006)
   PUBMED   17135487
REFERENCE   7  (bases 1 to 4521)
  AUTHORS   Yang,X.C., Purdy,M., Marzluff,W.F. and Dominski,Z.
  TITLE     Characterization of 3'hExo, a 3' exonuclease specifically
            interacting with the 3' end of histone mRNA
  JOURNAL   J Biol Chem 281 (41), 30447-30454 (2006)
   PUBMED   16912046
  REMARK    GeneRIF: 3'hExo is a 3' exonuclease specifically interacting with
            the 3' end of histone mRNA
REFERENCE   8  (bases 1 to 4521)
  AUTHORS   Cheng,Y. and Patel,D.J.
  TITLE     Crystallographic structure of the nuclease domain of 3'hExo, a
            DEDDh family member, bound to rAMP
  JOURNAL   J Mol Biol 343 (2), 305-312 (2004)
   PUBMED   15451662
  REMARK    GeneRIF: Data describe the structure of the nuclease domain of
            3'-5'-exoribonuclease (3'hExo) complexed with rAMP in the presence
            of magnesium at 1.6 A resolution.
REFERENCE   9  (bases 1 to 4521)
  AUTHORS   Kennedy,S., Wang,D. and Ruvkun,G.
  TITLE     A conserved siRNA-degrading RNase negatively regulates RNA
            interference in C. elegans
  JOURNAL   Nature 427 (6975), 645-649 (2004)
   PUBMED   14961122
  REMARK    GeneRIF: molecular cloning; degrades siRNAs in vitro[ERI-1]
REFERENCE   10 (bases 1 to 4521)
  AUTHORS   Dominski,Z., Yang,X.C., Kaygun,H., Dadlez,M. and Marzluff,W.F.
  TITLE     A 3' exonuclease that specifically interacts with the 3' end of
            histone mRNA
  JOURNAL   Mol Cell 12 (2), 295-305 (2003)
   PUBMED   14536070
  REMARK    GeneRIF: 3'hExo is a primary candidate for the exonuclease that
            initiates rapid decay of histone mRNA upon completion and/or
            inhibition of DNA replication
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AV709794.1, BC035279.1 and AC087579.17.
            
            On Jul 10, 2019 this sequence version replaced NM_153332.3.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK226180.1, SRR11853567.28426.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000250263.8/ ENSP00000250263.7
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-43                AV709794.1         94-136
            44-2162             BC035279.1         1-2119
            2163-4521           AC087579.17        101570-103928       c
FEATURES             Location/Qualifiers
     source          1..4521
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8p23.1"
     gene            1..4521
                     /gene="ERI1"
                     /gene_synonym="3'HEXO; HEXO; HXAL; SEMDGC; SEMDGS; THEX1"
                     /note="exoribonuclease 1"
                     /db_xref="GeneID:90459"
                     /db_xref="HGNC:HGNC:23994"
                     /db_xref="MIM:608739"
     exon            1..275
                     /gene="ERI1"
                     /gene_synonym="3'HEXO; HEXO; HXAL; SEMDGC; SEMDGS; THEX1"
                     /inference="alignment:Splign:2.1.0"
     CDS             168..1217
                     /gene="ERI1"
                     /gene_synonym="3'HEXO; HEXO; HXAL; SEMDGC; SEMDGS; THEX1"
                     /note="isoform 1 is encoded by transcript variant 1; three
                     prime histone mRNA exonuclease 1; three prime mRNA
                     exonuclease 1; enhanced RNAi three prime mRNA exonuclease
                     homolog 1; histone mRNA 3' end-specific exonuclease; 3'
                     exoribonuclease; 3'-5' exoribonuclease 1; 3'-5'
                     exonuclease ERI1; histone mRNA 3'-exonuclease 1; histone
                     mRNA 3'-end-specific exoribonuclease"
                     /codon_start=1
                     /product="3'-5' exoribonuclease 1 isoform 1"
                     /protein_id="NP_699163.2"
                     /db_xref="CCDS:CCDS5972.1"
                     /db_xref="GeneID:90459"
                     /db_xref="HGNC:HGNC:23994"
                     /db_xref="MIM:608739"
                     /translation="MEDPQSKEPAGEAVALALLESPRPEGGEEPPRPSPEETQQCKFD
                     GQETKGSKFITSSASDFSDPVYKEIAITNGCINRMSKEELRAKLSEFKLETRGVKDVL
                     KKRLKNYYKKQKLMLKESNFADSYYDYICIIDFEATCEEGNPPEFVHEIIEFPVVLLN
                     THTLEIEDTFQQYVRPEINTQLSDFCISLTGITQDQVDRADTFPQVLKKVIDWMKLKE
                     LGTKYKYSLLTDGSWDMSKFLNIQCQLSRLKYPPFAKKWINIRKSYGNFYKVPRSQTK
                     LTIMLEKLGMDYDGRPHCGLDDSKNIARIAVRMLQDGCELRINEKMHAGQLMSVSSSL
                     PIEGTPPPQMPHFRK"
     exon            276..454
                     /gene="ERI1"
                     /gene_synonym="3'HEXO; HEXO; HXAL; SEMDGC; SEMDGS; THEX1"
                     /inference="alignment:Splign:2.1.0"
     exon            455..665
                     /gene="ERI1"
                     /gene_synonym="3'HEXO; HEXO; HXAL; SEMDGC; SEMDGS; THEX1"
                     /inference="alignment:Splign:2.1.0"
     exon            666..749
                     /gene="ERI1"
                     /gene_synonym="3'HEXO; HEXO; HXAL; SEMDGC; SEMDGS; THEX1"
                     /inference="alignment:Splign:2.1.0"
     exon            750..859
                     /gene="ERI1"
                     /gene_synonym="3'HEXO; HEXO; HXAL; SEMDGC; SEMDGS; THEX1"
                     /inference="alignment:Splign:2.1.0"
     exon            860..974
                     /gene="ERI1"
                     /gene_synonym="3'HEXO; HEXO; HXAL; SEMDGC; SEMDGS; THEX1"
                     /inference="alignment:Splign:2.1.0"
     exon            975..4521
                     /gene="ERI1"
                     /gene_synonym="3'HEXO; HEXO; HXAL; SEMDGC; SEMDGS; THEX1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2065..2070
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ERI1"
                     /gene_synonym="3'HEXO; HEXO; HXAL; SEMDGC; SEMDGS; THEX1"
                     /note="hexamer: AATAAA"
     polyA_site      2089
                     /gene="ERI1"
                     /gene_synonym="3'HEXO; HEXO; HXAL; SEMDGC; SEMDGS; THEX1"
                     /note="major polyA site"
     regulatory      4503..4508
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ERI1"
                     /gene_synonym="3'HEXO; HEXO; HXAL; SEMDGC; SEMDGS; THEX1"
                     /note="hexamer: AATAAA"
     polyA_site      4518
                     /gene="ERI1"
                     /gene_synonym="3'HEXO; HEXO; HXAL; SEMDGC; SEMDGS; THEX1"
     polyA_site      4521
                     /gene="ERI1"
                     /gene_synonym="3'HEXO; HEXO; HXAL; SEMDGC; SEMDGS; THEX1"
                     /note="major polyA site"
ORIGIN      
        1 acacgctccc ggaagtggga ggtggccgct ggagtttgtg tggccgccgc cgcgggaacg
       61 cgagcccggt aatttttcaa cggagaaagg cgaggctttc gggctctgca gagtgagagt
      121 tagcaagtgt ccggctccag caactctcct ctggcgtgac agccggcatg gaggatccac
      181 agagtaaaga gcctgccggc gaggccgtgg ctctcgcgct gctggagtcg ccgcggccgg
      241 agggcgggga ggagccgccg cgtcccagtc ccgaggaaac tcaacagtgt aaatttgatg
      301 gccaggagac aaaaggatcc aagttcatta cctccagtgc gagtgacttc agtgacccgg
      361 tttacaaaga gattgccatt acgaatggct gtattaatag aatgagtaag gaagaactca
      421 gagctaagct ttcagaattc aagcttgaaa ctagaggagt aaaggatgtt ctaaagaaga
      481 gactgaaaaa ctattataag aagcagaagc tgatgctgaa agagagcaat tttgctgaca
      541 gttattatga ctacatttgt attattgact ttgaagccac ttgtgaagaa ggaaacccac
      601 ctgagtttgt acatgaaata attgaatttc cggttgtttt actgaatacg catactttag
      661 aaatagaaga cacgtttcag cagtatgtaa gaccagagat taacacacag ctgtctgatt
      721 tctgcatcag tctaactgga attactcagg atcaggtaga cagagctgat accttccctc
      781 aggtactaaa aaaagtaatt gactggatga aattgaagga attaggaaca aagtataaat
      841 actcactttt aacagatggt tcttgggata tgagtaagtt cttgaacatt cagtgtcaac
      901 tcagcaggct caaataccct ccttttgcga aaaagtggat caatattcgg aagtcatatg
      961 gaaattttta caaggttcct agaagccaaa ccaaactgac aataatgctt gaaaaattag
     1021 gaatggatta tgatgggcgg cctcactgtg gtcttgatga ctctaagaat atcgcccgaa
     1081 tagcagttcg aatgcttcag gatgggtgtg aactccgaat caacgagaaa atgcatgcag
     1141 gacagctaat gagtgtgtcc tcttccttac caatagaggg cactccacca ccacaaatgc
     1201 cacattttag aaagtaacaa cagttttgtg tgtggatcat tccaattgaa gttgctatga
     1261 agaggtagca gatgaatctc attgaattag tcctgtagtg caaactttaa gcaccttaaa
     1321 acatttaaaa tcttattaca ggtgatagag atagatacat gtatgtgaac agattttgta
     1381 ggaaggcata ctgaattctt tgtcaccagc acttttgata tgaacagtat tcgttacata
     1441 gtaacagttc ctgcttacaa ctgaatttta taatttaagg tgttcaagat atattctttt
     1501 tggttttaaa atgcaaaatc ttattggctg ttctgttgaa tgtcatatct tactggtgtt
     1561 taaatatgta atgtgtttct ttattaacat cactagatga aaccatatct taaaatgcag
     1621 aaatgattgg aaggtagatc ttatctagcc tttggatttc aagaatatca tagtcctttt
     1681 gattttcaaa gtttatatgt gaagttcacc atgtatgtgg tgaatttcgt aaggtacttg
     1741 gtatacatat ctgcctatgt ttcttttcaa ctcataattg gaagaattat gatggattat
     1801 agggtttggt taaaaatcca gttactgaag gaattaatga aaacgtagaa gaaagtacta
     1861 aaaggaatat cataagggct gtagctcaaa cttcataata cataaatcac tggggtcttt
     1921 ttggatttgg ttgtttgatt cgccttcctt ttttgacata tgtatgcctt aattcttaaa
     1981 tctgagggac catgctttga aatagactga aaattaaggg tcaccaccta attttacttt
     2041 gtattcagta tcgtaagtga ggttaataaa gtcaatactt tctaccatat attacgtttt
     2101 tgttattaaa aaacttcatt ggccactagt gaagttagtc aataaaagac ttgtttttct
     2161 gattttacat agtaaatggc tgctaagtat tgagtaattc ttaactaatt ctaaaaacta
     2221 aaatgtgcat ttcgacttga taaggtaaaa ctcttatcta gaggctaaac ccatgtattt
     2281 tcagaattga atttttctcc ttgtagcttt cagggaacaa tttcattgac attgcttgct
     2341 tcctgccttt taccttttaa taaaaattgt gatgctactt tattctaaag atttatattt
     2401 tataaccaga tgaatttcct caaaggtttc caaacctata tcatataggg tgaaaagcag
     2461 gaaagtagac atttttcttg gcgtgggaat tctctacata gggcagtaga tttcttaagc
     2521 caatgaattt ctgcttttca gcagtagtca tataatcagt atcataaaga ataatgtgta
     2581 aataacagaa ggcatatgag agtgtggtgt tcctagatga actgttacag attatagtaa
     2641 aataaggaaa tctaagtgct ttaagtttat acagttaact cttaggataa gagggatgta
     2701 tgctgagatg tttgtgcatc ccagatagca ctgtacaata acctgtaaag tattactgaa
     2761 tactgaatag ctgaaactgc aattggaaaa tctgatgatg acgaggaaat attacgtttc
     2821 cagttttttt agctctatct gctaatttct ttgcctgttt tcactttcgc caagtaccaa
     2881 caagctcatg ttgtatttct ttttaagaac ttcaacatta taagctctca gtaccctatt
     2941 ttgttgttgt tgttgtttga gacagagttt ttgctcgtct gccaggatgg agtgcagtgg
     3001 tgcgatcttg gctcactgca acctccgcct cctgggctca ggtgatcctc ttgcctcagc
     3061 ctcctgagta gctcagatta caggcgcgtg ccaccacacc cgcctaattt ttgtattttt
     3121 ggtagaggcg gggtttcacc atgttggtca ggctggtctt gaactcctga cctcaagtga
     3181 tttgcccacc ttgacctcct acagacgtga gccactgcgc tcagccatag attttactgt
     3241 cttaacccat tttaattcct ctgttgagtc tctgtcctcc cctccaattt gatttgggat
     3301 tttgctgatg agatgatact aaacattgag agtactgctt tttactctga cttttattgt
     3361 gttgtctttg aaagacaaat agtacaactt tttacaagga aacacgtaag agatggatgt
     3421 ccatgaaaac aatattagta tattctatta ttgtttctta ttaatagtta cttagtattt
     3481 acaaacaatt tattattagc tgtgttaact tttattctat gcttcatatg ctctgacatt
     3541 gacatagtgg atttctgctg atttttttca aatccgcaat ctttataacc aactgaagta
     3601 tataatagag cattacattt tatctttatt tgtgttctgt tggatcaagt atttaacatt
     3661 tgctctgaaa aaaatgtttt tgtgatgtgt ctttgttgcc ttgagataga tccatttatc
     3721 ctgcctccta gggagaagtt tctgcctgga ttgaaacaaa aaaacacagg cgtcacaagc
     3781 atgttaccta ttaagagaga gagggtatct ctgaagacta attaaaatgg taatttttaa
     3841 aaagatgtga ccagttgact tttagtatat catcccaagt attatcccca aaatgataat
     3901 gcaaaacaga ataatttgga gaccaggaga aaaactggta tgattactgg ggaggggaag
     3961 aagcacaggt ggtcaagata ataatgcatg tttggcctca gctgtagttg ccaaagaaac
     4021 tacctgcctc acagatgagc acgcacgggt gcattgtcaa agtctgagaa ggatgtattg
     4081 tactttgaag gaagactttc catttctaag ctaccatgga gaagtatatg ctcctcgaga
     4141 ccagagactg tgacttctgc atctttgatt ccagcgacat atgataaaat gttttgcaca
     4201 tagttgaatc cagcgttgat acatgaagga cagcattaca tcttttttct attatactta
     4261 gaaatttcct ctttgttctg caccaccaac ctgtatatca agcctccttg ccccacaaag
     4321 cttccaaagc ccgtaaattt gttaatctag agcaggggtc agcaaactac cacccatggg
     4381 ccaaatctgg ctgctgccta tttttgtatg gcctacaaac tatggttttt atattccctt
     4441 ttgttaatgg ctcaaaataa tattttgtat aatacgaaaa ttacgaaatt ttagtttctc
     4501 taaataaagt tttggaaaga a
//
