LOCUS       NM_004450                791 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens ERH mRNA splicing and mitosis factor (ERH), mRNA.
ACCESSION   NM_004450 XM_001130537
VERSION     NM_004450.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 791)
  AUTHORS   Tsai,Y.M., Wu,K.L., Huang,Y.C., Wu,Y.Y., Chang,C.Y., Chang,Y.Y.,
            Chiang,H.H., Liu,L.X. and Hung,J.Y.
  TITLE     Upregulated enhancer of rudimentary homolog promotes
            epithelial-mesenchymal transition and cancer cell migration in lung
            adenocarcinoma
  JOURNAL   Mol Med Rep 29 (1) (2024)
   PUBMED   37997813
  REMARK    GeneRIF: Upregulated enhancer of rudimentary homolog promotes
            epithelial-mesenchymal transition and cancer cell migration in lung
            adenocarcinoma.
REFERENCE   2  (bases 1 to 791)
  AUTHORS   Graille,M.
  TITLE     ERH: a plug-and-play protein important for gene silencing and cell
            cycle progression
  JOURNAL   FEBS J 290 (3), 688-691 (2023)
   PUBMED   36334004
  REMARK    GeneRIF: ERH: a plug-and-play protein important for gene silencing
            and cell cycle progression.
REFERENCE   3  (bases 1 to 791)
  AUTHORS   Wang,X., Xie,H., Zhu,Z., Zhang,J. and Xu,C.
  TITLE     Molecular basis for the recognition of CIZ1 by ERH
  JOURNAL   FEBS J 290 (3), 712-723 (2023)
   PUBMED   36047590
  REMARK    GeneRIF: Molecular basis for the recognition of CIZ1 by ERH.
REFERENCE   4  (bases 1 to 791)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 791)
  AUTHORS   Kwon,S.C., Jang,H., Shen,S., Baek,S.C., Kim,K., Yang,J., Kim,J.,
            Kim,J.S., Wang,S., Shi,Y., Li,F. and Kim,V.N.
  TITLE     ERH facilitates microRNA maturation through the interaction with
            the N-terminus of DGCR8
  JOURNAL   Nucleic Acids Res 48 (19), 11097-11112 (2020)
   PUBMED   33035348
  REMARK    GeneRIF: ERH facilitates microRNA maturation through the
            interaction with the N-terminus of DGCR8.
REFERENCE   6  (bases 1 to 791)
  AUTHORS   Amente,S., Napolitano,G., Licciardo,P., Monti,M., Pucci,P.,
            Lania,L. and Majello,B.
  TITLE     Identification of proteins interacting with the RNAPII FCP1
            phosphatase: FCP1 forms a complex with arginine methyltransferase
            PRMT5 and it is a substrate for PRMT5-mediated methylation
  JOURNAL   FEBS Lett 579 (3), 683-689 (2005)
   PUBMED   15670829
REFERENCE   7  (bases 1 to 791)
  AUTHORS   Andersen,J.S., Lam,Y.W., Leung,A.K., Ong,S.E., Lyon,C.E.,
            Lamond,A.I. and Mann,M.
  TITLE     Nucleolar proteome dynamics
  JOURNAL   Nature 433 (7021), 77-83 (2005)
   PUBMED   15635413
REFERENCE   8  (bases 1 to 791)
  AUTHORS   Skop,A.R., Liu,H., Yates,J. 3rd, Meyer,B.J. and Heald,R.
  TITLE     Dissection of the mammalian midbody proteome reveals conserved
            cytokinesis mechanisms
  JOURNAL   Science 305 (5680), 61-66 (2004)
   PUBMED   15166316
REFERENCE   9  (bases 1 to 791)
  AUTHORS   Gelsthorpe,M., Pulumati,M., McCallum,C., Dang-Vu,K. and
            Tsubota,S.I.
  TITLE     The putative cell cycle gene, enhancer of rudimentary, encodes a
            highly conserved protein found in plants and animals
  JOURNAL   Gene 186 (2), 189-195 (1997)
   PUBMED   9074495
REFERENCE   10 (bases 1 to 791)
  AUTHORS   Isomura,M., Okui,K., Fujiwara,T., Shin,S. and Nakamura,Y.
  TITLE     Cloning and mapping of a novel human cDNA homologous to DROER, the
            enhancer of the Drosophila melanogaster rudimentary gene
  JOURNAL   Genomics 32 (1), 125-127 (1996)
   PUBMED   8786099
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            U66871.1 and AK130850.1.
            
            On Nov 22, 2018 this sequence version replaced NM_004450.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163655.587541.1,
                                           SRR1163655.620782.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968832, SAMEA2142680
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000557016.6/ ENSP00000451080.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-9                 U66871.1           6-14
            10-791              AK130850.1         1-782
FEATURES             Location/Qualifiers
     source          1..791
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q24.1"
     gene            1..791
                     /gene="ERH"
                     /gene_synonym="DROER"
                     /note="ERH mRNA splicing and mitosis factor"
                     /db_xref="GeneID:2079"
                     /db_xref="HGNC:HGNC:3447"
                     /db_xref="MIM:601191"
     exon            1..69
                     /gene="ERH"
                     /gene_synonym="DROER"
                     /inference="alignment:Splign:2.1.0"
     CDS             67..381
                     /gene="ERH"
                     /gene_synonym="DROER"
                     /codon_start=1
                     /product="enhancer of rudimentary homolog"
                     /protein_id="NP_004441.1"
                     /db_xref="CCDS:CCDS9794.1"
                     /db_xref="GeneID:2079"
                     /db_xref="HGNC:HGNC:3447"
                     /db_xref="MIM:601191"
                     /translation="MSHTILLVQPTKRPEGRTYADYESVNECMEGVCKMYEEHLKRMN
                     PNSPSITYDISQLFDFIDDLADLSCLVYRADTQTYQPYNKDWIKEKIYVLLRRQAQQA
                     GK"
     exon            70..157
                     /gene="ERH"
                     /gene_synonym="DROER"
                     /inference="alignment:Splign:2.1.0"
     exon            158..278
                     /gene="ERH"
                     /gene_synonym="DROER"
                     /inference="alignment:Splign:2.1.0"
     exon            279..791
                     /gene="ERH"
                     /gene_synonym="DROER"
                     /inference="alignment:Splign:2.1.0"
     regulatory      771..776
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ERH"
                     /gene_synonym="DROER"
                     /note="hexamer: AATAAA"
     polyA_site      791
                     /gene="ERH"
                     /gene_synonym="DROER"
                     /note="major polyA site"
ORIGIN      
        1 gttgtagtta agctcgtgta acggcggcgg tgtcggcagc tgctgtagcg aagagagttt
       61 ggcgcgatgt ctcacaccat tttgctggta cagcctacca agaggccaga aggcagaact
      121 tatgctgact acgaatctgt gaatgaatgc atggaaggtg tttgtaaaat gtatgaagaa
      181 catctgaaaa gaatgaatcc caacagtccc tctatcacat atgacatcag tcagttgttt
      241 gatttcatcg atgatctggc agacctcagc tgcctggttt accgagctga tacccagaca
      301 taccagcctt ataacaaaga ctggattaaa gagaagatct acgtgctcct tcgtcggcag
      361 gcccaacagg ctgggaaata attgtgttgg aagcactggg ggggttgggg tgggcttgga
      421 acacaggtgt gtacagcgtg ctgtagtgga agttttgtat catagtaatc ctgtttccac
      481 tttgttatac tctagccaag attgactgta ttagatgaaa tgtgaggatc ttgttcaatc
      541 ggaaaccccc gttacctcct ctttttcttt ctctttcttt tttttttttt acttaaacat
      601 ttttatgatg atttagatgg aagttgttct tcgtcactta atgttggttc cagtccttca
      661 actgttcata tctactttat aacattcaca tactaaccct tcttcaagat ggggtggggg
      721 gtggaaatgc agtttagcca tgtcctcaag ataaagtctt ggtaaaaata aataaatgtc
      781 ctttagttat a
//
