LOCUS       NM_016570               5033 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens ERGIC and golgi 2 (ERGIC2), mRNA.
ACCESSION   NM_016570
VERSION     NM_016570.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5033)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 5033)
  AUTHORS   Yoo,W., Cho,E.B., Kim,S. and Yoon,J.B.
  TITLE     The E3 ubiquitin ligase MARCH2 regulates ERGIC3-dependent
            trafficking of secretory proteins
  JOURNAL   J Biol Chem 294 (28), 10900-10912 (2019)
   PUBMED   31142615
REFERENCE   3  (bases 1 to 5033)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   4  (bases 1 to 5033)
  AUTHORS   Yu,J., Chia,J., Canning,C.A., Jones,C.M., Bard,F.A. and
            Virshup,D.M.
  TITLE     WLS retrograde transport to the endoplasmic reticulum during Wnt
            secretion
  JOURNAL   Dev Cell 29 (3), 277-291 (2014)
   PUBMED   24768165
REFERENCE   5  (bases 1 to 5033)
  AUTHORS   Kwok,S.C., Kumar,S. and Dai,G.
  TITLE     Characterization of a variant of ERGIC2 transcript
  JOURNAL   DNA Cell Biol 33 (2), 73-78 (2014)
   PUBMED   24303950
  REMARK    GeneRIF: A variant of ERGIC2 with four coding bases deleted has an
            abrogated function as a transport shuttle, but does continue to
            upregulate the heme oxygenase 1 gene, suggesting that it may be
            involved in the oxidative stress pathway.
REFERENCE   6  (bases 1 to 5033)
  AUTHORS   Yang,Y.F., Chou,M.Y., Fan,C.Y., Chen,S.F., Lyu,P.C., Liu,C.C. and
            Tseng,T.L.
  TITLE     The possible interaction of CDA14 and protein elongation factor
            1alpha
  JOURNAL   Biochim Biophys Acta 1784 (2), 312-318 (2008)
   PUBMED   17980171
  REMARK    GeneRIF: CDA14 participated in the elongation factor 1alpha
            regulated mechanisms
REFERENCE   7  (bases 1 to 5033)
  AUTHORS   Kwok,S.C., Liu,X., Mangel,P. and Daskal,I.
  TITLE     PTX1(ERGIC2)-VP22 fusion protein upregulates interferon-beta in
            prostate cancer cell line PC-3
  JOURNAL   DNA Cell Biol 25 (9), 523-529 (2006)
   PUBMED   16989575
  REMARK    GeneRIF: Ectopic expression of a partial sequence of PTX1 (Met84 -
            Leu225) as a VP22-fusion protein in prostate cancer cell line,
            PC-3, induced cellular senescence.
REFERENCE   8  (bases 1 to 5033)
  AUTHORS   Breuza,L., Halbeisen,R., Jeno,P., Otte,S., Barlowe,C., Hong,W. and
            Hauri,H.P.
  TITLE     Proteomics of endoplasmic reticulum-Golgi intermediate compartment
            (ERGIC) membranes from brefeldin A-treated HepG2 cells identifies
            ERGIC-32, a new cycling protein that interacts with human Erv46
  JOURNAL   J Biol Chem 279 (45), 47242-47253 (2004)
   PUBMED   15308636
  REMARK    GeneRIF: ERGIC-32 functions as a modulator of the hErv41-hErv46
            complex by stabilizing hErv46
REFERENCE   9  (bases 1 to 5033)
  AUTHORS   Liu,X., Daskal,I. and Kwok,S.C.
  TITLE     Effects of PTX1 expression on growth and tumorigenicity of the
            prostate cancer cell line PC-3
  JOURNAL   DNA Cell Biol 22 (7), 469-474 (2003)
   PUBMED   12932305
  REMARK    GeneRIF: may play an important role in the growth and
            tumorigenicity of PC-3 prostate tumor cells
REFERENCE   10 (bases 1 to 5033)
  AUTHORS   Kwok,S.C., Liu,X. and Daskal,I.
  TITLE     Molecular cloning, expression, localization, and gene organization
            of PTX1, a human nuclear protein that is downregulated in prostate
            cancer
  JOURNAL   DNA Cell Biol 20 (6), 349-357 (2001)
   PUBMED   11445006
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BF681475.1, BC000887.1, AL834128.2, BU675240.1 and AC009318.11.
            
            On Nov 22, 2018 this sequence version replaced NM_016570.2.
            
            Summary: ERGIC2, or PTX1, is a ubiquitously expressed nuclear
            protein that is downregulated in prostate carcinoma (Kwok et al.,
            2001 [PubMed 11445006]).[supplied by OMIM, Aug 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803617.452088.1, AL834128.2
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000360150.9/ ENSP00000353270.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-11                BF681475.1         65-75
            12-1354             BC000887.1         3-1345
            1355-1704           AL834128.2         1334-1683
            1705-1739           BU675240.1         18-52               c
            1740-5033           AC009318.11        114934-118227       c
FEATURES             Location/Qualifiers
     source          1..5033
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12p11.22"
     gene            1..5033
                     /gene="ERGIC2"
                     /gene_synonym="cd002; CDA14; Erv41; PTX1"
                     /note="ERGIC and golgi 2"
                     /db_xref="GeneID:51290"
                     /db_xref="HGNC:HGNC:30208"
                     /db_xref="MIM:612236"
     exon            1..58
                     /gene="ERGIC2"
                     /gene_synonym="cd002; CDA14; Erv41; PTX1"
                     /inference="alignment:Splign:2.1.0"
     exon            59..201
                     /gene="ERGIC2"
                     /gene_synonym="cd002; CDA14; Erv41; PTX1"
                     /inference="alignment:Splign:2.1.0"
     CDS             96..1229
                     /gene="ERGIC2"
                     /gene_synonym="cd002; CDA14; Erv41; PTX1"
                     /note="CD14 protein"
                     /codon_start=1
                     /product="endoplasmic reticulum-Golgi intermediate
                     compartment protein 2"
                     /protein_id="NP_057654.2"
                     /db_xref="CCDS:CCDS41765.1"
                     /db_xref="GeneID:51290"
                     /db_xref="HGNC:HGNC:30208"
                     /db_xref="MIM:612236"
                     /translation="MRRLNRKKTLSLVKELDAFPKVPESYVETSASGGTVSLIAFTTM
                     ALLTIMEFSVYQDTWMKYEYEVDKDFSSKLRINIDITVAMKCQYVGADVLDLAETMVA
                     SADGLVYEPTVFDLSPQQKEWQRMLQLIQSRLQEEHSLQDVIFKSAFKSTSTALPPRE
                     DDSSQSPNACRIHGHLYVNKVAGNFHITVGKAIPHPRGHAHLAALVNHESYNFSHRID
                     HLSFGELVPAIINPLDGTEKIAIDHNQMFQYFITVVPTKLHTYKISADTHQFSVTERE
                     RIINHAAGSHGVSGIFMKYDLSSLMVTVTEEHMPFWQFFVRLCGIVGGIFSTTGMLHG
                     IGKFIVEIICCRFRLGSYKPVNSVPFEDGHTDNHLPLLENNTH"
     exon            202..310
                     /gene="ERGIC2"
                     /gene_synonym="cd002; CDA14; Erv41; PTX1"
                     /inference="alignment:Splign:2.1.0"
     exon            311..357
                     /gene="ERGIC2"
                     /gene_synonym="cd002; CDA14; Erv41; PTX1"
                     /inference="alignment:Splign:2.1.0"
     exon            358..428
                     /gene="ERGIC2"
                     /gene_synonym="cd002; CDA14; Erv41; PTX1"
                     /inference="alignment:Splign:2.1.0"
     exon            429..469
                     /gene="ERGIC2"
                     /gene_synonym="cd002; CDA14; Erv41; PTX1"
                     /inference="alignment:Splign:2.1.0"
     exon            470..571
                     /gene="ERGIC2"
                     /gene_synonym="cd002; CDA14; Erv41; PTX1"
                     /inference="alignment:Splign:2.1.0"
     exon            572..667
                     /gene="ERGIC2"
                     /gene_synonym="cd002; CDA14; Erv41; PTX1"
                     /inference="alignment:Splign:2.1.0"
     exon            668..723
                     /gene="ERGIC2"
                     /gene_synonym="cd002; CDA14; Erv41; PTX1"
                     /inference="alignment:Splign:2.1.0"
     exon            724..822
                     /gene="ERGIC2"
                     /gene_synonym="cd002; CDA14; Erv41; PTX1"
                     /inference="alignment:Splign:2.1.0"
     exon            823..920
                     /gene="ERGIC2"
                     /gene_synonym="cd002; CDA14; Erv41; PTX1"
                     /inference="alignment:Splign:2.1.0"
     exon            921..1083
                     /gene="ERGIC2"
                     /gene_synonym="cd002; CDA14; Erv41; PTX1"
                     /inference="alignment:Splign:2.1.0"
     exon            1084..1166
                     /gene="ERGIC2"
                     /gene_synonym="cd002; CDA14; Erv41; PTX1"
                     /inference="alignment:Splign:2.1.0"
     exon            1167..5033
                     /gene="ERGIC2"
                     /gene_synonym="cd002; CDA14; Erv41; PTX1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1650..1655
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ERGIC2"
                     /gene_synonym="cd002; CDA14; Erv41; PTX1"
                     /note="hexamer: AATAAA"
     polyA_site      1676
                     /gene="ERGIC2"
                     /gene_synonym="cd002; CDA14; Erv41; PTX1"
                     /note="major polyA site"
     regulatory      4107..4112
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ERGIC2"
                     /gene_synonym="cd002; CDA14; Erv41; PTX1"
                     /note="hexamer: ATTAAA"
     polyA_site      4128
                     /gene="ERGIC2"
                     /gene_synonym="cd002; CDA14; Erv41; PTX1"
     regulatory      5013..5018
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ERGIC2"
                     /gene_synonym="cd002; CDA14; Erv41; PTX1"
                     /note="hexamer: AATAAA"
     polyA_site      5033
                     /gene="ERGIC2"
                     /gene_synonym="cd002; CDA14; Erv41; PTX1"
ORIGIN      
        1 agccccggcg acccgggctt ctgtgaaaca tggcggtagg ctgggaccat aacacaagca
       61 tgactatatg aaggaagagg aaggttttcc tgaagatgag gcgactgaat cggaaaaaaa
      121 ctttaagttt ggtaaaagag ttggatgcct ttccgaaggt tcctgagagc tatgtagaga
      181 cttcagccag tggaggtaca gtttctctaa tagcatttac aactatggct ttattaacca
      241 taatggaatt ctcagtatat caagatacat ggatgaagta tgaatacgaa gtagacaagg
      301 atttttctag caaattaaga attaatatag atattactgt tgccatgaag tgtcaatatg
      361 ttggagcgga tgtattggat ttagcagaaa caatggttgc atctgcagat ggtttagttt
      421 atgaaccaac agtatttgat ctttcaccac agcagaaaga gtggcagagg atgctgcagc
      481 tgattcagag taggctacaa gaagagcatt cacttcaaga tgtgatattt aaaagtgctt
      541 ttaaaagtac atcaacagct cttccaccaa gagaagatga ttcatcacag tctccaaatg
      601 catgcagaat tcatggccat ctatatgtca ataaagtagc agggaatttt cacataacag
      661 tgggcaaggc aattccacat cctcgtggtc atgcacattt ggcagcactt gtcaaccatg
      721 aatcttacaa tttttctcat agaatagatc atttgtcttt tggagagctt gttccagcaa
      781 ttattaatcc tttagatgga actgaaaaaa ttgctataga tcacaaccag atgttccaat
      841 attttattac agttgtgcca acaaaactac atacatataa aatatcagca gacacccatc
      901 agttttctgt gacagaaagg gaacgtatca ttaaccatgc tgcaggcagc catggagtct
      961 ctgggatatt tatgaaatat gatctcagtt ctcttatggt gacagttact gaggagcaca
     1021 tgccattctg gcagtttttt gtaagactct gtggtattgt tggaggaatc ttttcaacaa
     1081 caggcatgtt acatggaatt ggaaaattta tagttgaaat aatttgctgt cgtttcagac
     1141 ttggatccta taaacctgtc aattctgttc cttttgagga tggccacaca gacaaccact
     1201 tacctctttt agaaaataat acacattaac acctcccgat tgaaggagaa aaactttttg
     1261 cctgagacat aaaacctttt tttaataata aaatattgtg caatatattc aaagaaaaga
     1321 aaacacaaat aagcagaaaa catacttatt ttaaaaaaga aaaaaaagga taaaaaaacc
     1381 caaactgaaa ttctatatac gttgtgtctg ttacaaatgt cgtagaagaa atcatgcagc
     1441 taaacgatga agaagcccaa ctggagtgtt gctttgaaga tgacgccttc ttatattttc
     1501 atagcaaatg ggtggtatca aaatcagaca ttgcttcttg ctgataaaaa gcctgaagga
     1561 aataagtgaa actacatcta tgggaaaaaa aaaaacattg agaagtgcaa atgttcgcat
     1621 ccttttgttt ttaaaagata tgatgtcaga ataaaatgtg gaaaacatac ggaaaactag
     1681 tctagacttt aaagaattgt gatcaggtca cattgttaat aaaaaaaaaa aacgggctag
     1741 tccctatgtt atagccatat taatgttaag ccatattgac aagaccagtt atccaataat
     1801 ttggtcttaa aaagtaacta cttttctttg aactctggtt attgacttat ctaactgttg
     1861 aagatagagt cttagaagac taaggtaaat tctcacaggg gcagatatgt aggtgttatg
     1921 taactagggt gtcattcaca aatggtatag tagaatctta tacacggaaa agaaagcaca
     1981 tttttttaaa aaagatgcca agttttttaa tctaatcatt atattattgg tgtattttgg
     2041 gcaacatagg gtgagttata aaaagatccg ctactgatag tgaaaattac cggtttgtaa
     2101 aacattaaga gaaaaaatag gatattttat acatgtggtg agtggagaac agggtaactt
     2161 taaatgaaag tgtaaggcaa attgtaagca ccacaagata tatcagattt gagaggtgcc
     2221 atgttaaaca ttgtccatta aactataaaa ctgtattatg aagtatttgc attcagggtg
     2281 tcctgaatat gattgattct gtattagatt gtgttctaac tttcttacta tttaaggatt
     2341 ggttctaaat cttcacatta taaaagatta aaaacagtga gagggagcta tcacacaggt
     2401 actattaaaa gctgtatttg gaatatgtgt accaatatca gttttccttt tgtagtactg
     2461 aatggcagta gaagaatcag cagccaatcc tcaaagttta aatcatttaa ggaaatgggg
     2521 aaacaaaatt ccaggtaaat aacaagactg aaaaactaga tttaaaatag tggttttaga
     2581 aaacaggata tcacaagtaa cagtttttca aatggatttt tttaaagata aatttatgaa
     2641 aacaggataa acaatataat ggagagaagg agaaatagtg atgggtctgt tttgcagtaa
     2701 agtttatgca gaatgacgtt ttgcagaaaa taacagaagc atcactttaa aaaatatatc
     2761 attaagagcc atgacgttaa ctgatgaaaa taagtgatat aacatacttt gaaagatttt
     2821 taaacagaaa attctgaatc gtgaatgagc cttctctagg ttttaatttt ttttcttcaa
     2881 attatttcca acaaagtttg gctataaact aacaccatct atccacagga attttaatag
     2941 gaaaggatta gaattgtaga ctgattgttg gtcctttaag tatgcttgga agaaaattca
     3001 atcgagtttc aaggcttttt ctaaatggga gggagaacaa tattgattta ggattatttt
     3061 ctttcattta ggattagaac agttaagtgc ctttaaaaag gactttaaaa attattttga
     3121 tacttatata tgatttttaa ttgttttcgt attttccaaa taccatatta aaattttaat
     3181 gaaatttatc tcctatgaaa ggaatttctt taaagcaaaa ttctgctttg cctttgattt
     3241 ccattttaaa agttaaaggc ttccatctga aactcctcaa atagagtcag atttttggca
     3301 atggaagtat taaaattccg atcagccctt tggacgatga agtttacctg catattagga
     3361 tttgttagga gtttttggcc tcaccaagtg attcttttct attgcagaga gcactttact
     3421 cacctacctg ttatgcaact ttccctatgc ctggaggtgc ctccagccag gataccctac
     3481 tttgttaccc aattctcctt tttgttttac aagagtattc ataatatcta tatgtttata
     3541 ttccagacta catatttaaa aatgagatct caaattatat gaaatggatt tttaaatact
     3601 gtgtttgcat acattgacct ataaagaaga ttaaatattt aggtgaataa ttccctgctg
     3661 cagtatttgt acacttcaga ctacctctta ggaaaagctt aacttagtat tgcaaaattc
     3721 cctttctctt ttttttttta agagatgggg tctcgcactg ttgcccaggc tgaagtgcag
     3781 tggcatgatt gtaactcact gcatcctcga actcctgggt tcaagcaatc ctcctgcttc
     3841 catctgctga gtaggtagga ctacagccat gcaccaacaa acctggctaa ttctttttca
     3901 tttatatagt tagtatcttg ctgtgttgtt caagctggac tccaactccc ggactcaagt
     3961 aatcctccca ccttagtctc ctgcattgct ggaattatag gcacgagcca ctgcacctgg
     4021 cacccaaatt acttctagtt ctcaagttag atgattaata tcacactttt ctcatgtatg
     4081 ttttatgata gcattgaatt tttataatta aaaatttact aatgcaaaca agatttacag
     4141 tctttaatac aatcttaatt ttggaattca tgaaggaatg actaagttct aatttttttt
     4201 tttttttttt tgaaactgag tctcgctctg tcgcctaggc tggagtgcag tggtgcaatc
     4261 tcagctcact gcaacctccg tctcccgggt tcaagtgatt ctcctgcctc agcctgttga
     4321 gtagctggga ctacaggtgc gtaccaccaa gcccagctaa tttttttata tttttagtag
     4381 agacggggtt tcactgtgtt agccaggatg gtctcaatct cctgacctca tgatccgccc
     4441 accttggcct cccaaagtgt tgggattaca ggcatgagcc actgcccctg gacagatcta
     4501 attttttaat agtgtaagag agatacactg tgcattccat ctatgtcctg agttagtaat
     4561 tcaagtacca aaaagtaatt taatatgaaa ctccttgaaa attcagagct tacacttgaa
     4621 ttcaaaatgc ctatttttga ttgtttaaaa gttacttaaa cctgagcttt aggaccttta
     4681 aaatctcagc atgcctttta agctagtact tttcctgttt tgagctctag caaaccttca
     4741 gcaagccaag gtggtagccc tttttcaaca caatcaaaat agagaggtca ccagttgttt
     4801 actaccttat ggtaaaatgc ccggatcaag atccatgtat cccccccata ttgtgatgat
     4861 gcaatcaaag catagttttt ttctactttc tgaaatatta ctgatgaaat cactttacat
     4921 ttaagaggag aaaacagact gccttggatt ttttttttgt cttgagagaa aaaacaaaat
     4981 atttagtatt gcaagcataa acatttggac tcaataaatg acaaattatg aaa
//
