LOCUS       NM_007176               2320 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens ergosterol biosynthesis 28 homolog (ERG28), mRNA.
ACCESSION   NM_007176
VERSION     NM_007176.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2320)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 2320)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 2320)
  AUTHORS   Mialoundama,A.S., Jadid,N., Brunel,J., Di Pascoli,T., Heintz,D.,
            Erhardt,M., Mutterer,J., Bergdoll,M., Ayoub,D., Van Dorsselaer,A.,
            Rahier,A., Nkeng,P., Geoffroy,P., Miesch,M., Camara,B. and
            Bouvier,F.
  TITLE     Arabidopsis ERG28 tethers the sterol C4-demethylation complex to
            prevent accumulation of a biosynthetic intermediate that interferes
            with polar auxin transport
  JOURNAL   Plant Cell 25 (12), 4879-4893 (2013)
   PUBMED   24326590
REFERENCE   4  (bases 1 to 2320)
  AUTHORS   Passantino,R., Cascio,C., Deidda,I., Galizzi,G., Russo,D.,
            Spedale,G. and Guarneri,P.
  TITLE     Identifying protein partners of CLN8, an ER-resident protein
            involved in neuronal ceroid lipofuscinosis
  JOURNAL   Biochim Biophys Acta 1833 (3), 529-540 (2013)
   PUBMED   23142642
REFERENCE   5  (bases 1 to 2320)
  AUTHORS   Lee,C.N., Heidbrink,J.L., McKinnon,K., Bushman,V., Olsen,H.,
            FitzHugh,W., Li,A., Van Orden,K., He,T., Ruben,S.M. and Moore,P.A.
  TITLE     RNA interference characterization of proteins discovered by
            proteomic analysis of pancreatic cancer reveals function in cell
            growth and survival
  JOURNAL   Pancreas 41 (1), 84-94 (2012)
   PUBMED   21934552
  REMARK    GeneRIF: Data indicate that integrin beta6, CD46, tissue factor,
            and chromosome 14 open reading frame 1 (C14ORF1), were identified
            as overexpressed on pancreatic cancer cell lines.
REFERENCE   6  (bases 1 to 2320)
  AUTHORS   Gachotte,D., Eckstein,J., Barbuch,R., Hughes,T., Roberts,C. and
            Bard,M.
  TITLE     A novel gene conserved from yeast to humans is involved in sterol
            biosynthesis
  JOURNAL   J Lipid Res 42 (1), 150-154 (2001)
   PUBMED   11160377
REFERENCE   7  (bases 1 to 2320)
  AUTHORS   Simpson,J.C., Wellenreuther,R., Poustka,A., Pepperkok,R. and
            Wiemann,S.
  TITLE     Systematic subcellular localization of novel proteins identified by
            large-scale cDNA sequencing
  JOURNAL   EMBO Rep 1 (3), 287-292 (2000)
   PUBMED   11256614
REFERENCE   8  (bases 1 to 2320)
  AUTHORS   Ottolenghi,C., Daizadeh,I., Ju,A., Kossida,S., Renault,G.,
            Jacquet,M., Fellous,A., Gilbert,W. and Veitia,R.
  TITLE     The genomic structure of c14orf1 is conserved across eukarya
  JOURNAL   Mamm Genome 11 (9), 786-788 (2000)
   PUBMED   10967139
REFERENCE   9  (bases 1 to 2320)
  AUTHORS   Hu,R.M., Han,Z.G., Song,H.D., Peng,Y.D., Huang,Q.H., Ren,S.X.,
            Gu,Y.J., Huang,C.H., Li,Y.B., Jiang,C.L., Fu,G., Zhang,Q.H.,
            Gu,B.W., Dai,M., Mao,Y.F., Gao,G.F., Rong,R., Ye,M., Zhou,J.,
            Xu,S.H., Gu,J., Shi,J.X., Jin,W.R., Zhang,C.K., Wu,T.M.,
            Huang,G.Y., Chen,Z., Chen,M.D. and Chen,J.L.
  TITLE     Gene expression profiling in the human
            hypothalamus-pituitary-adrenal axis and full-length cDNA cloning
  JOURNAL   Proc Natl Acad Sci U S A 97 (17), 9543-9548 (2000)
   PUBMED   10931946
REFERENCE   10 (bases 1 to 2320)
  AUTHORS   Veitia,R.A., Ottolenghi,C., Bissery,M.C. and Fellous,A.
  TITLE     A novel human gene, encoding a potential membrane protein conserved
            from yeast to man, is strongly expressed in testis and cancer cell
            lines
  JOURNAL   Cytogenet Cell Genet 85 (3-4), 217-220 (1999)
   PUBMED   10449901
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BX248022.1, AF136971.1, AA709128.1 and AC007182.3.
            
            On May 17, 2019 this sequence version replaced NM_007176.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF134159.2, AF136971.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA2145544
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000256319.7/ ENSP00000256319.6
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-550               BX248022.1         314-863
            551-1218            AF136971.1         530-1197
            1219-1221           AA709128.1         37-39               c
            1222-2320           AC007182.3         162007-163105       c
FEATURES             Location/Qualifiers
     source          1..2320
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q24.3"
     gene            1..2320
                     /gene="ERG28"
                     /gene_synonym="C14orf1; NET51"
                     /note="ergosterol biosynthesis 28 homolog"
                     /db_xref="GeneID:11161"
                     /db_xref="HGNC:HGNC:1187"
                     /db_xref="MIM:604576"
     exon            1..102
                     /gene="ERG28"
                     /gene_synonym="C14orf1; NET51"
                     /inference="alignment:Splign:2.1.0"
     exon            103..266
                     /gene="ERG28"
                     /gene_synonym="C14orf1; NET51"
                     /inference="alignment:Splign:2.1.0"
     CDS             134..556
                     /gene="ERG28"
                     /gene_synonym="C14orf1; NET51"
                     /note="probable ergosterol biosynthetic protein 28"
                     /codon_start=1
                     /product="ergosterol biosynthetic protein 28 homolog"
                     /protein_id="NP_009107.1"
                     /db_xref="CCDS:CCDS9845.1"
                     /db_xref="GeneID:11161"
                     /db_xref="HGNC:HGNC:1187"
                     /db_xref="MIM:604576"
                     /translation="MSRFLNVLRSWLVMVSIIAMGNTLQSFRDHTFLYEKLYTGKPNL
                     VNGLQARTFGIWTLLSSVIRCLCAIDIHNKTLYHITLWTFLLALGHFLSELFVYGTAA
                     PTIGVLAPLMVASFSILGMLVGLRYLEVEPVSRQKKRN"
     exon            267..357
                     /gene="ERG28"
                     /gene_synonym="C14orf1; NET51"
                     /inference="alignment:Splign:2.1.0"
     exon            358..476
                     /gene="ERG28"
                     /gene_synonym="C14orf1; NET51"
                     /inference="alignment:Splign:2.1.0"
     exon            477..2320
                     /gene="ERG28"
                     /gene_synonym="C14orf1; NET51"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1192..1197
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ERG28"
                     /gene_synonym="C14orf1; NET51"
                     /note="hexamer: AATAAA"
     polyA_site      1218
                     /gene="ERG28"
                     /gene_synonym="C14orf1; NET51"
                     /note="major polyA site"
     regulatory      1816..1821
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ERG28"
                     /gene_synonym="C14orf1; NET51"
                     /note="hexamer: AATAAA"
     polyA_site      1849
                     /gene="ERG28"
                     /gene_synonym="C14orf1; NET51"
ORIGIN      
        1 gacaaatggc tcaggtggac tccgggctgg agctgtcctg ggggagcttg tttgcggcag
       61 cggctgctgc tgccactgct gtgctggggg cccggtcgcc aggcaaaaag ccctcccacg
      121 tttgagggga gtcatgagcc gtttcctgaa tgtgttaaga agttggctgg ttatggtgtc
      181 catcatagcc atggggaaca cgctgcagag cttccgagac cacacttttc tctatgaaaa
      241 gctctacact ggcaagccaa accttgtgaa tggcctccaa gctcggacct ttgggatctg
      301 gacgctgctc tcatcagtga ttcgctgcct ctgtgccatt gacattcaca acaagacgct
      361 ctatcacatc acactctgga ccttcctcct tgccctgggg catttcctct ctgagttgtt
      421 tgtctatgga actgcagctc ccacgattgg cgtcctggca cccctgatgg tggcaagttt
      481 ctccatcctg ggtatgctgg tcgggctccg gtatctagaa gtagaaccag tatccagaca
      541 gaagaagaga aactgaggcc agcattatca cctccaggac tttctcgttt tccaccttgg
      601 ccatcttctt ccttcgtcgt ctctcctctt taatttcttt tctattccat catctgccct
      661 tttattcact tttagcctct ttttttaatt tttaaaattt aaagatatgc atactgaaaa
      721 gtatataaca tgtacgtaca atttaaagaa taattttaaa gtgaatacta cgtaactcca
      781 tccaagtcaa gaaattgcca gcttctcgga agcccactgt gtctccttcc cctacctgca
      841 acctcttcca ggctcccttt tccagccttc ccctttttcc cttttatttt catgccttga
      901 tttgacttgt gtggtgggaa catgtgaact atgaaactta aacctgctgc ccacccagag
      961 cagctgtgac caagggctgc ctcaaggggt tgtccacgca ggttgggctc ctctctgctg
     1021 ctggacccaa gactctgaac cttccaaggg acaggcagtt cttctaagaa gggctcccct
     1081 gtgtgtgagc aagaccacag ctctccttct atctacagat gcatgagggt tggaagagtc
     1141 tgggctgttt ttagaccttc tggtcagctg tatttgtgta acaacttttg taataaatag
     1201 aaaaaccctc tgctctgatc agttcttgta ctttgacctc tgctaagaca agagcatggc
     1261 tgcctcctct gagccctagg agaatcacag ctttatgcct gattgaatac accatagtga
     1321 gtaggacagc tcatgacaca ggtcagcctg gctgcctccg gctccttact gtcatttgct
     1381 cattcctctt gtattcttga agtcaaatct tcttttttct caccttcaag agtctgcgtt
     1441 cacaactaaa cactaagtgc cctttcttat ttcctcctaa agaagaaaca gattcttgag
     1501 agagcagaga caaaaaaata gaactaggca gcatagatga aacaactgca tgacatggga
     1561 agaagacaac taaaccccga ggagaatgca ctggaatgga cagttgctct taaaccctac
     1621 ccagagggcc tcccccagct ggaccctcat acacagtgtg tgtatccaaa aggccattgc
     1681 tatttcagca aatatttgtt gagtacttct ccatgccgga cacttgggaa agagaaatga
     1741 acgacacagg caatgcccct gccctgtggg ccttatatta tagtcaaggt aacagaatca
     1801 acaagccaac acaaaaataa agaacttcaa atagggataa gaactctaac aaacacaagg
     1861 tattttggtc aagaaggaat gtggggtggg cagtggggaa cgtaacttaa attagatcat
     1921 cagaaagtcc tccctgagga gatgggattt ttttgttttt tagagacagg gtttcactct
     1981 gtcacccagg ctggagtgca gtggcacaat cacacctcac tgcagcctca acttcctggg
     2041 ctcaagtgat cctcctgcat cagcttccca agtagctggg actacaagtg tgtaccacca
     2101 catccagcta acatttttgg gggtgggaag agatggggtc ttactatgtt gtccaggcta
     2161 agaggtggga tttgagctga gacttgaatg cccaggagtt aaatgtctta agatatggag
     2221 caggccgtta gaaaggaggg agcagcaact ggaaggtaga atagtcttat tcaaggaata
     2281 agaactatgt aatcacagca tggtgaagag ttaggaagtg
//
