LOCUS       NM_182918               4904 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens ETS transcription factor ERG (ERG), transcript variant
            1, mRNA.
ACCESSION   NM_182918
VERSION     NM_182918.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4904)
  AUTHORS   Yamashita,T., Kaplan,U., Chakraborty,A., Marden,G., Gritli,S.,
            Roh,D., Bujor,A., Trojanowski,M., Ligresti,G., Browning,J.L. and
            Trojanowska,M.
  TITLE     ERG Regulates Lymphatic Vessel Specification Genes and Its
            Deficiency Impairs Wound Healing-Associated Lymphangiogenesis
  JOURNAL   Arthritis Rheumatol 76 (11), 1645-1657 (2024)
   PUBMED   38965683
  REMARK    GeneRIF: ERG Regulates Lymphatic Vessel Specification Genes and Its
            Deficiency Impairs Wound Healing-Associated Lymphangiogenesis.
REFERENCE   2  (bases 1 to 4904)
  AUTHORS   Wang,C., Hu,M., Yu,K., Liu,W., Hu,A., Kuang,Y., Huang,L.,
            Gajendran,B., Zacksenhaus,E., Xiao,X. and Ben-David,Y.
  TITLE     An intricate regulatory circuit between FLI1 and
            GATA1/GATA2/LDB1/ERG dictates erythroid vs. megakaryocytic
            differentiation
  JOURNAL   Mol Med Rep 29 (6) (2024)
   PUBMED   38695236
  REMARK    GeneRIF: An intricate regulatory circuit between FLI1 and
            GATA1/GATA2/LDB1/ERG dictates erythroid vs. megakaryocytic
            differentiation.
REFERENCE   3  (bases 1 to 4904)
  AUTHORS   Tao,T., Chen,H., Xu,Q., Li,Z., Chen,X., Zhou,X. and Luo,W.
  TITLE     NKX2-1-AS1 promotes the lymphangiogenesis of lung adenocarcinoma
            through regulation of ERG-mediated FABP4
  JOURNAL   Tissue Cell 87, 102314 (2024)
   PUBMED   38309204
  REMARK    GeneRIF: NKX2-1-AS1 promotes the lymphangiogenesis of lung
            adenocarcinoma through regulation of ERG-mediated FABP4.
REFERENCE   4  (bases 1 to 4904)
  AUTHORS   Behrens,K., Brajanovski,N., Xu,Z., Viney,E.M., DiRago,L.,
            Hediyeh-Zadeh,S., Davis,M.J., Pearson,R.B., Sanij,E.,
            Alexander,W.S. and Ng,A.P.
  TITLE     ERG and c-MYC regulate a critical gene network in BCR::ABL1-driven
            B cell acute lymphoblastic leukemia
  JOURNAL   Sci Adv 10 (10), eadj8803 (2024)
   PUBMED   38457494
  REMARK    GeneRIF: ERG and c-MYC regulate a critical gene network in
            BCR::ABL1-driven B cell acute lymphoblastic leukemia.
REFERENCE   5  (bases 1 to 4904)
  AUTHORS   Guo,L., Wu,D., Shen,J. and Gao,Y.
  TITLE     ERG mediates the inhibition of NK cell cytotoxicity through the
            HLX/STAT4/Perforin signaling pathway, thereby promoting the
            progression of myocardial infarction
  JOURNAL   J Physiol Biochem 80 (1), 219-233 (2024)
   PUBMED   38091230
  REMARK    GeneRIF: ERG mediates the inhibition of NK cell cytotoxicity
            through the HLX/STAT4/Perforin signaling pathway, thereby promoting
            the progression of myocardial infarction.
REFERENCE   6  (bases 1 to 4904)
  AUTHORS   Zammarchi,F., Boutsalis,G. and Cartegni,L.
  TITLE     5' UTR control of native ERG and of Tmprss2:ERG variants activity
            in prostate cancer
  JOURNAL   PLoS One 8 (3), e49721 (2013)
   PUBMED   23472063
  REMARK    GeneRIF: characterization of native ERG and Tmprss2:ERG variants
            reveals that their different oncogenic potential is affected by the
            status of the Ets domain and the configuration of the 5' UTR region
REFERENCE   7  (bases 1 to 4904)
  AUTHORS   Peterson,A., Patil,N., Robbins,C., Wang,L., Cox,D.R. and Myers,R.M.
  TITLE     A transcript map of the Down syndrome critical region on chromosome
            21
  JOURNAL   Hum Mol Genet 3 (10), 1735-1742 (1994)
   PUBMED   7849696
REFERENCE   8  (bases 1 to 4904)
  AUTHORS   Rao,V.N., Modi,W.S., Drabkin,H.D., Patterson,D., O'Brien,S.J.,
            Papas,T.S. and Reddy,E.S.
  TITLE     The human erg gene maps to chromosome 21, band q22: relationship to
            the 8; 21 translocation of acute myelogenous leukemia
  JOURNAL   Oncogene 3 (5), 497-500 (1988)
   PUBMED   3274086
REFERENCE   9  (bases 1 to 4904)
  AUTHORS   Reddy,E.S., Rao,V.N. and Papas,T.S.
  TITLE     The erg gene: a human gene related to the ets oncogene
  JOURNAL   Proc Natl Acad Sci U S A 84 (17), 6131-6135 (1987)
   PUBMED   3476934
REFERENCE   10 (bases 1 to 4904)
  AUTHORS   Rao,V.N., Papas,T.S. and Reddy,E.S.
  TITLE     erg, a human ets-related gene on chromosome 21: alternative
            splicing, polyadenylation, and translation
  JOURNAL   Science 237 (4815), 635-639 (1987)
   PUBMED   3299708
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA850637.1, AK300395.1,
            BC040168.1, AP001423.1, AP001422.1 and BF431907.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_182918.3.
            
            Summary: This gene encodes a member of the erythroblast
            transformation-specific (ETS) family of transcriptions factors. All
            members of this family are key regulators of embryonic development,
            cell proliferation, differentiation, angiogenesis, inflammation,
            and apoptosis. The protein encoded by this gene is mainly expressed
            in the nucleus. It contains an ETS DNA-binding domain and a PNT
            (pointed) domain which is implicated in the self-association of
            chimeric oncoproteins. This protein is required for platelet
            adhesion to the subendothelium, inducing vascular cell remodeling.
            It also regulates hematopoesis, and the differentiation and
            maturation of megakaryocytic cells. This gene is involved in
            chromosomal translocations, resulting in different fusion gene
            products, such as TMPSSR2-ERG and NDRG1-ERG in prostate cancer,
            EWS-ERG in Ewing's sarcoma and FUS-ERG in acute myeloid leukemia.
            More than two dozens of transcript variants generated from
            combinatorial usage of three alternative promoters and multiple
            alternative splicing events have been reported, but the full-length
            nature of many of these variants has not been determined. [provided
            by RefSeq, Apr 2014].
            
            Transcript Variant: This variant (1) contains a different segment
            for its 5' UTR and 5' coding region, compared to variant 3. The
            resulting protein (isoform 1) has a shorter and distinct N-terminus
            when it is compared to isoform 3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            transcript and genomic sequence to make the sequence consistent
            with the reference genome assembly. The genomic coordinates used
            for the transcript record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803612.109992.1, BC040168.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000288319.12/ ENSP00000288319.7
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-529               DA850637.1         7-535
            530-957             AK300395.1         547-974
            958-2000            BC040168.1         964-2006
            2001-2592           AP001423.1         1-592               c
            2593-4495           AP001422.1         80714-82616         c
            4496-4904           BF431907.1         17-425              c
FEATURES             Location/Qualifiers
     source          1..4904
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="21"
                     /map="21q22.2"
     gene            1..4904
                     /gene="ERG"
                     /gene_synonym="erg-3; LMPHM14; p55"
                     /note="ETS transcription factor ERG"
                     /db_xref="GeneID:2078"
                     /db_xref="HGNC:HGNC:3446"
                     /db_xref="MIM:165080"
     exon            1..115
                     /gene="ERG"
                     /gene_synonym="erg-3; LMPHM14; p55"
                     /inference="alignment:Splign:2.1.0"
     CDS             98..1537
                     /gene="ERG"
                     /gene_synonym="erg-3; LMPHM14; p55"
                     /note="isoform 1 is encoded by transcript variant 1; v-ets
                     avian erythroblastosis virus E26 oncogene related;
                     ets-related; ERG, ETS transcription factor; FUS/ERG fusion
                     protein; v-ets erythroblastosis virus E26 oncogene like;
                     transcriptional regulator ERG (transforming protein ERG);
                     TMPRSS2/ERG fusion; v-ets erythroblastosis virus E26
                     oncogene homolog; v-ets avian erythroblastosis virus E26
                     oncogene homolog"
                     /codon_start=1
                     /product="transcriptional regulator ERG isoform 1"
                     /protein_id="NP_891548.1"
                     /db_xref="CCDS:CCDS13658.1"
                     /db_xref="GeneID:2078"
                     /db_xref="HGNC:HGNC:3446"
                     /db_xref="MIM:165080"
                     /translation="MASTIKEALSVVSEDQSLFECAYGTPHLAKTEMTASSSSDYGQT
                     SKMSPRVPQQDWLSQPPARVTIKMECNPSQVNGSRNSPDECSVAKGGKMVGSPDTVGM
                     NYGSYMEEKHMPPPNMTTNERRVIVPADPTLWSTDHVRQWLEWAVKEYGLPDVNILLF
                     QNIDGKELCKMTKDDFQRLTPSYNADILLSHLHYLRETPLPHLTSDDVDKALQNSPRL
                     MHARNTGGAAFIFPNTSVYPEATQRITTRPDLPYEPPRRSAWTGHGHPTPQSKAAQPS
                     PSTVPKTEDQRPQLDPYQILGPTSSRLANPGSGQIQLWQFLLELLSDSSNSSCITWEG
                     TNGEFKMTDPDEVARRWGERKSKPNMNYDKLSRALRYYYDKNIMTKVHGKRYAYKFDF
                     HGIAQALQPHPPESSLYKYPSDLPYMGSYHAHPQKMNFVAPHPPALPVTSSSFFAAPN
                     PYWNSPTGGIYPNTRLPTSHMPSHLGTYY"
     exon            116..333
                     /gene="ERG"
                     /gene_synonym="erg-3; LMPHM14; p55"
                     /inference="alignment:Splign:2.1.0"
     exon            334..485
                     /gene="ERG"
                     /gene_synonym="erg-3; LMPHM14; p55"
                     /inference="alignment:Splign:2.1.0"
     exon            486..689
                     /gene="ERG"
                     /gene_synonym="erg-3; LMPHM14; p55"
                     /inference="alignment:Splign:2.1.0"
     exon            690..770
                     /gene="ERG"
                     /gene_synonym="erg-3; LMPHM14; p55"
                     /inference="alignment:Splign:2.1.0"
     exon            771..842
                     /gene="ERG"
                     /gene_synonym="erg-3; LMPHM14; p55"
                     /inference="alignment:Splign:2.1.0"
     exon            843..911
                     /gene="ERG"
                     /gene_synonym="erg-3; LMPHM14; p55"
                     /inference="alignment:Splign:2.1.0"
     exon            912..968
                     /gene="ERG"
                     /gene_synonym="erg-3; LMPHM14; p55"
                     /inference="alignment:Splign:2.1.0"
     exon            969..1016
                     /gene="ERG"
                     /gene_synonym="erg-3; LMPHM14; p55"
                     /inference="alignment:Splign:2.1.0"
     exon            1017..4904
                     /gene="ERG"
                     /gene_synonym="erg-3; LMPHM14; p55"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2883..2888
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ERG"
                     /gene_synonym="erg-3; LMPHM14; p55"
                     /note="hexamer: AATAAG"
     polyA_site      2916
                     /gene="ERG"
                     /gene_synonym="erg-3; LMPHM14; p55"
                     /note="major polyA site"
     regulatory      2949..2954
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ERG"
                     /gene_synonym="erg-3; LMPHM14; p55"
                     /note="hexamer: ACTAAA"
     polyA_site      2971
                     /gene="ERG"
                     /gene_synonym="erg-3; LMPHM14; p55"
     regulatory      4876..4881
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ERG"
                     /gene_synonym="erg-3; LMPHM14; p55"
                     /note="hexamer: AATAAA"
     polyA_site      4904
                     /gene="ERG"
                     /gene_synonym="erg-3; LMPHM14; p55"
ORIGIN      
        1 atccgctcta aacaacctca tcaaaactac tttctggtca gagagaagca ataattatta
       61 ttaacattta ttaacgatca ataaacttga tcgcattatg gccagcacta ttaaggaagc
      121 cttatcagtt gtgagtgagg accagtcgtt gtttgagtgt gcctacggaa cgccacacct
      181 ggctaagaca gagatgaccg cgtcctcctc cagcgactat ggacagactt ccaagatgag
      241 cccacgcgtc cctcagcagg attggctgtc tcaaccccca gccagggtca ccatcaaaat
      301 ggaatgtaac cctagccagg tgaatggctc aaggaactct cctgatgaat gcagtgtggc
      361 caaaggcggg aagatggtgg gcagcccaga caccgttggg atgaactacg gcagctacat
      421 ggaggagaag cacatgccac ccccaaacat gaccacgaac gagcgcagag ttatcgtgcc
      481 agcagatcct acgctatgga gtacagacca tgtgcggcag tggctggagt gggcggtgaa
      541 agaatatggc cttccagacg tcaacatctt gttattccag aacatcgatg ggaaggaact
      601 gtgcaagatg accaaggacg acttccagag gctcaccccc agctacaacg ccgacatcct
      661 tctctcacat ctccactacc tcagagagac tcctcttcca catttgactt cagatgatgt
      721 tgataaagcc ttacaaaact ctccacggtt aatgcatgct agaaacacag ggggtgcagc
      781 ttttattttc ccaaatactt cagtatatcc tgaagctacg caaagaatta caactaggcc
      841 agatttacca tatgagcccc ccaggagatc agcctggacc ggtcacggcc accccacgcc
      901 ccagtcgaaa gctgctcaac catctccttc cacagtgccc aaaactgaag accagcgtcc
      961 tcagttagat ccttatcaga ttcttggacc aacaagtagc cgccttgcaa atccaggcag
     1021 tggccagatc cagctttggc agttcctcct ggagctcctg tcggacagct ccaactccag
     1081 ctgcatcacc tgggaaggca ccaacgggga gttcaagatg acggatcccg acgaggtggc
     1141 ccggcgctgg ggagagcgga agagcaaacc caacatgaac tacgataagc tcagccgcgc
     1201 cctccgttac tactatgaca agaacatcat gaccaaggtc catgggaagc gctacgccta
     1261 caagttcgac ttccacggga tcgcccaggc cctccagccc caccccccgg agtcatctct
     1321 gtacaagtac ccctcagacc tcccgtacat gggctcctat cacgcccacc cacagaagat
     1381 gaactttgtg gcgccccacc ctccagccct ccccgtgaca tcttccagtt tttttgctgc
     1441 cccaaaccca tactggaatt caccaactgg gggtatatac cccaacacta ggctccccac
     1501 cagccatatg ccttctcatc tgggcactta ctactaaaga cctggcggag gcttttccca
     1561 tcagcgtgca ttcaccagcc catcgccaca aactctatcg gagaacatga atcaaaagtg
     1621 cctcaagagg aatgaaaaaa gctttactgg ggctggggaa ggaagccggg gaagagatcc
     1681 aaagactctt gggagggagt tactgaagtc ttactacaga aatgaggagg atgctaaaaa
     1741 tgtcacgaat atggacatat catctgtgga ctgaccttgt aaaagacagt gtatgtagaa
     1801 gcatgaagtc ttaaggacaa agtgccaaag aaagtggtct taagaaatgt ataaacttta
     1861 gagtagagtt tggaatccca ctaatgcaaa ctgggatgaa actaaagcaa tagaaacaac
     1921 acagttttga cctaacatac cgtttataat gccattttaa ggaaaactac ctgtatttaa
     1981 aaatagaaac atatcaaaaa caagagaaaa gacacgagag agactgtggc ccatcaacag
     2041 acgttgatat gcaactgcat ggcatgtgct gttttggttg aaatcaaata cattccgttt
     2101 gatggacagc tgtcagcttt ctcaaactgt gaagatgacc caaagtttcc aactccttta
     2161 cagtattacc gggactatga actaaaaggt gggactgagg atgtgtatag agtgagcgtg
     2221 tgattgtaga cagaggggtg aagaaggagg aggaagaggc agagaaggag gagaccaggg
     2281 ctgggaaaga aacttctcaa gcaatgaaga ctggactcag gacatttggg gactgtgtac
     2341 aatgagttat ggagactcga gggttcatgc agtcagtgtt ataccaaacc cagtgttagg
     2401 agaaaggaca cagcgtaatg gagaaagggg aagtagtaga attcagaaac aaaaatgcgc
     2461 atctctttct ttgtttgtca aatgaaaatt ttaactggaa ttgtctgata tttaagagaa
     2521 acattcagga cctcatcatt atgtgggggc tttgttctcc acagggtcag gtaagagatg
     2581 gccttcttgg ctgccacaat cagaaatcac gcaggcattt tgggtaggcg gcctccagtt
     2641 ttcctttgag tcgcgaacgc tgtgcgtttg tcagaatgaa gtatacaagt caatgttttt
     2701 cccccttttt atataataat tatataactt atgcatttat acactacgag ttgatctcgg
     2761 ccagccaaag acacacgaca aaagagacaa tcgatataat gtggccttga attttaactc
     2821 tgtatgctta atgtttacaa tatgaagtta ttagttctta gaatgcagaa tgtatgtaat
     2881 aaaataagct tggcctagca tggcaaatca gatttataca ggagtctgca tttgcacttt
     2941 ttttagtgac taaagttgct taatgaaaac atgtgctgaa tgttgtggat tttgtgttat
     3001 aatttacttt gtccaggaac ttgtgcaagg gagagccaag gaaataggat gtttggcacc
     3061 caaatggcgt cagcctctcc aggtccttct tgcctcccct cctgtctttt atttctagcc
     3121 ccttttggaa cagaaggacc ccgggtttca cattggagcc tccatattta tgcctggaat
     3181 ggaaagaggc ctatgaagct ggggttgtca ttgagaaatt ctagttcagc acctggtcac
     3241 aaatcaccct taattcctgc tatgattaaa atacatttgt tgaacagtga acaagctacc
     3301 actcgtaagg caaactgtat tattactggc aaataaagcg tcatggatag ctgcaatttc
     3361 tcactttaca gaaacaaggg ataacgtcta gatttgctgc ggggtttctc tttcaggagc
     3421 tctcactagg tagacagctt tagtcctgct acatcagagt tacctgggca ctgtggcttg
     3481 ggattcacta gccctgagcc tgatgttgct ggctatccct tgaagacaat gtttatttcc
     3541 ataatctaga gtcagtttcc ctgggcatct tttctttgaa tcacaaatgc tgccaacctt
     3601 ggtccaggtg aaggcaactc aaaaggtgaa aatacaaggt gaccgtgcga aggcgctagc
     3661 cgaaacatct tagctgaata ggtttctgaa ctggcccttt tcatagctgt ttcagggcct
     3721 gtttttttca cgttgcagtc cttttgctat gattatgtga agttgccaaa cctctgtgct
     3781 gtggatgttt tggcagtggg ctttgaagtc ggcaggacac gattaccaat gctcctgaca
     3841 ccccgtgtca tttggattag acggagccca accatccatc attttgcagc agcctgggaa
     3901 ggcccacaaa gtgcccgtat ctccttaggg aaaataaata aatacaatca tgaaagctgg
     3961 cagttaggct gacccaaact gtgctaatgg aaaagatcag tcatttttat tttggaatgc
     4021 aaagtcaaga cacacctaca ttcttcatag aaatacacat ttacttggat aatcactcag
     4081 ttctctcttc aagactgtct catgagcaag atcataaaaa caagacatga ttatcatatt
     4141 caattttaac agatgttttc cattagatcc ctcaaccctc cacccccagt ccaggttatt
     4201 agcaagtctt atgagcaact gggataattt tggataacat gataatactg agttccttca
     4261 aatacataat tcttaaattg tttcaaaatg gcattaactc tctgttactg ttgtaatcta
     4321 attccaaagc cccctccagg tcatattcat aattgcatga accttttctc tctgtttgtc
     4381 cctgtctctt ggcttgccct gatgtatact cagactcctg tacaatctta ctcctgctgg
     4441 caagagattt gtcttctttt cttgtcttca attggctttc gggccttgta tgtggtaaaa
     4501 tcaccaaatc acagtcaaga ctgtgttttt gttcctagtt tgatgccctt atgtcccgga
     4561 ggggttcaca aagtgctttg tcaggactgc tgcagttaga aggctcactg cttctcctaa
     4621 gccttctgca cagatgtggc acctgcaacc caggagcagg agccggagga gctgccctct
     4681 gacagcaggt gcagcagaga tggctacagc tcaggagctg ggaaggtgat ggggcacagg
     4741 gaaagcacag atgttctgca gcgccccaaa gtgacccatt gcctggagaa agagaagaaa
     4801 atatttttta aaaagctagt ttatttagct tctcattaat tcattcaaat aaagtcgtga
     4861 ggtgactaat tagagaataa aaattacttt ggactactca aaaa
//
