LOCUS       NM_001291832            2939 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens erythroferrone (ERFE), mRNA.
ACCESSION   NM_001291832
VERSION     NM_001291832.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2939)
  AUTHORS   Mast,J.F., Leach,E.A.E. and Thompson,T.B.
  TITLE     Characterization of erythroferrone oligomerization and its impact
            on BMP antagonism
  JOURNAL   J Biol Chem 300 (1), 105452 (2024)
   PUBMED   37949218
  REMARK    GeneRIF: Characterization of erythroferrone oligomerization and its
            impact on BMP antagonism.
REFERENCE   2  (bases 1 to 2939)
  AUTHORS   Srole,D.N., Jung,G., Waring,A.J., Nemeth,E. and Ganz,T.
  TITLE     Characterization of erythroferrone structural domains relevant to
            its iron-regulatory function
  JOURNAL   J Biol Chem 299 (12), 105374 (2023)
   PUBMED   37866631
  REMARK    GeneRIF: Characterization of erythroferrone structural domains
            relevant to its iron-regulatory function.
REFERENCE   3  (bases 1 to 2939)
  AUTHORS   Delaney,K.M., Barad,A., Castillo,L.F., Hasund,C.M., Guillet,R.,
            Pressman,E.K., Katzman,P.J., Ganz,T., Nemeth,E. and O'Brien,K.O.
  TITLE     Placental Erythroferrone and Erythropoietin mRNA Expression is not
            Associated with Maternal or Neonatal Iron Status in Adolescents
            Carrying Singletons and Adult Women Carrying Multiples
  JOURNAL   J Nutr 153 (7), 1950-1958 (2023)
   PUBMED   37253412
  REMARK    GeneRIF: Placental Erythroferrone and Erythropoietin mRNA
            Expression is not Associated with Maternal or Neonatal Iron Status
            in Adolescents Carrying Singletons and Adult Women Carrying
            Multiples.
REFERENCE   4  (bases 1 to 2939)
  AUTHORS   Xu,Q., Altrock,E., Schmitt,N., Streuer,A., Rapp,F., Nowak,V.,
            Oblander,J., Weimer,N., Palme,I., Gol,M., Hofmann,W.K., Nowak,D.
            and Riabov,V.
  TITLE     In Silico Pan-Cancer Analysis Reveals Prognostic Role of the
            Erythroferrone (ERFE) Gene in Human Malignancies
  JOURNAL   Int J Mol Sci 24 (2), 1725 (2023)
   PUBMED   36675239
  REMARK    GeneRIF: In Silico Pan-Cancer Analysis Reveals Prognostic Role of
            the Erythroferrone (ERFE) Gene in Human Malignancies.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2939)
  AUTHORS   Vatannejad,A., Fadaei,R., Salimi,F., Fouani,F.Z., Habibi,B.,
            Shapourizadeh,S., Eivazi,S., Eivazi,S., Sadeghi,A. and Moradi,N.
  TITLE     Plasma Complement C1q/tumor necrosis factor-related protein 15
            concentration is associated with polycystic ovary syndrome
  JOURNAL   PLoS One 17 (6), e0263658 (2022)
   PUBMED   35700181
  REMARK    GeneRIF: Plasma Complement C1q/tumor necrosis factor-related
            protein 15 concentration is associated with polycystic ovary
            syndrome.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2939)
  AUTHORS   Russo,R., Andolfo,I., Manna,F., De Rosa,G., De Falco,L.,
            Gambale,A., Bruno,M., Matte,A., Ricchi,P., Girelli,D., De
            Franceschi,L. and Iolascon,A.
  TITLE     Increased levels of ERFE-encoding FAM132B in patients with
            congenital dyserythropoietic anemia type II
  JOURNAL   Blood 128 (14), 1899-1902 (2016)
   PUBMED   27540014
  REMARK    GeneRIF: FAM132b expression is upregulated in Congenital
            Dyserythropoietic Anemia type II.
REFERENCE   7  (bases 1 to 2939)
  AUTHORS   Pasricha,S.R., McHugh,K. and Drakesmith,H.
  TITLE     Regulation of Hepcidin by Erythropoiesis: The Story So Far
  JOURNAL   Annu Rev Nutr 36, 417-434 (2016)
   PUBMED   27146013
  REMARK    GeneRIF: Data suggest hepcidin is the master regulator of systemic
            iron homeostasis; hepcidin levels are suppressed when
            erythropoiesis is stimulated; the erythroid-derived hormone
            erythroferrone appears to be a convincing candidate for link
            between increased erythropoiesis and hepcidin suppression. [REVIEW]
            Review article
REFERENCE   8  (bases 1 to 2939)
  AUTHORS   Honda,H., Kobayashi,Y., Onuma,S., Shibagaki,K., Yuza,T., Hirao,K.,
            Yamamoto,T., Tomosugi,N. and Shibata,T.
  TITLE     Associations among Erythroferrone and Biomarkers of Erythropoiesis
            and Iron Metabolism, and Treatment with Long-Term
            Erythropoiesis-Stimulating Agents in Patients on Hemodialysis
  JOURNAL   PLoS One 11 (3), e0151601 (2016)
   PUBMED   26978524
  REMARK    GeneRIF: In hemodialysis patients DA and CERA increased levels of
            ERFE that regulated hepcidin 25 and led to iron mobilization from
            body stores during erythropoiesis.
            Publication Status: Online-Only
REFERENCE   9  (bases 1 to 2939)
  AUTHORS   Lawen,A.
  TITLE     Is erythroferrone finally the long sought-after systemic erythroid
            regulator of iron?
  JOURNAL   World J Biol Chem 6 (3), 78-82 (2015)
   PUBMED   26322167
REFERENCE   10 (bases 1 to 2939)
  AUTHORS   Seldin,M.M., Peterson,J.M., Byerly,M.S., Wei,Z. and Wong,G.W.
  TITLE     Myonectin (CTRP15), a novel myokine that links skeletal muscle to
            systemic lipid homeostasis
  JOURNAL   J Biol Chem 287 (15), 11968-11980 (2012)
   PUBMED   22351773
  REMARK    GeneRIF: Myonectin links skeletal muscle to lipid homeostasis in
            liver and adipose tissue in response to alterations in energy
            state, revealing a novel myonectin-mediated metabolic circuit.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC016757.10, KF984314.1, BC047423.1, AI362696.1 and H05276.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001291832.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: KF984314.1, ERR3218372.148895.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1966682,
                                           SAMEA1968189 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000546354.6/ ENSP00000442304.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-38                AC016757.10        73189-73226
            39-1103             KF984314.1         1-1065
            1104-2606           BC047423.1         409-1911
            2607-2921           AI362696.1         1-315               c
            2922-2939           H05276.1           11-28               c
FEATURES             Location/Qualifiers
     source          1..2939
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q37.3"
     gene            1..2939
                     /gene="ERFE"
                     /gene_synonym="C1QTNF15; CTRP15; FAM132B"
                     /note="erythroferrone"
                     /db_xref="GeneID:151176"
                     /db_xref="HGNC:HGNC:26727"
                     /db_xref="MIM:615099"
     exon            1..236
                     /gene="ERFE"
                     /gene_synonym="C1QTNF15; CTRP15; FAM132B"
                     /inference="alignment:Splign:2.1.0"
     CDS             39..1103
                     /gene="ERFE"
                     /gene_synonym="C1QTNF15; CTRP15; FAM132B"
                     /note="protein FAM132B; myonectin; family with sequence
                     similarity 132, member B; complement C1q tumor necrosis
                     factor-related protein 15"
                     /codon_start=1
                     /product="erythroferrone precursor"
                     /protein_id="NP_001278761.1"
                     /db_xref="CCDS:CCDS77548.1"
                     /db_xref="GeneID:151176"
                     /db_xref="HGNC:HGNC:26727"
                     /db_xref="MIM:615099"
                     /translation="MAPARRPAGARLLLVYAGLLAAAAAGLGSPEPGAPSRSRARREP
                     PPGNELPRGPGESRAGPAARPPEPTAERAHSVDPRDAWMLFVRQSDKGVNGKKRSRGK
                     AKKLKFGLPGPPGPPGPQGPPGPIIPPEALLKEFQLLLKGAVRQRERAEPEPCTCGPA
                     GPVAASLAPVSATAGEDDDDVVGDVLALLAAPLAPGPRAPRVEAAFLCRLRRDALVER
                     RALHELGVYYLPDAEGAFRRGPGLNLTSGQYRAPVAGFYALAATLHVALGEPPRRGPP
                     RPRDHLRLLICIQSRCQRNASLEAIMGLESSSELFTISVNGVLYLQMGQWTSVFLDNA
                     SGCSLTVRSGSHFSAVLLGV"
     exon            237..359
                     /gene="ERFE"
                     /gene_synonym="C1QTNF15; CTRP15; FAM132B"
                     /inference="alignment:Splign:2.1.0"
     exon            360..462
                     /gene="ERFE"
                     /gene_synonym="C1QTNF15; CTRP15; FAM132B"
                     /inference="alignment:Splign:2.1.0"
     exon            463..725
                     /gene="ERFE"
                     /gene_synonym="C1QTNF15; CTRP15; FAM132B"
                     /inference="alignment:Splign:2.1.0"
     exon            726..834
                     /gene="ERFE"
                     /gene_synonym="C1QTNF15; CTRP15; FAM132B"
                     /inference="alignment:Splign:2.1.0"
     exon            835..925
                     /gene="ERFE"
                     /gene_synonym="C1QTNF15; CTRP15; FAM132B"
                     /inference="alignment:Splign:2.1.0"
     exon            926..1004
                     /gene="ERFE"
                     /gene_synonym="C1QTNF15; CTRP15; FAM132B"
                     /inference="alignment:Splign:2.1.0"
     exon            1005..2939
                     /gene="ERFE"
                     /gene_synonym="C1QTNF15; CTRP15; FAM132B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2919..2924
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ERFE"
                     /gene_synonym="C1QTNF15; CTRP15; FAM132B"
                     /note="hexamer: AATAAA"
     polyA_site      2924
                     /gene="ERFE"
                     /gene_synonym="C1QTNF15; CTRP15; FAM132B"
                     /note="major polyA site"
ORIGIN      
        1 gacgccgcgc tcggagccgc gagggaaccg ccgcccgcat ggccccggcc cgccgccccg
       61 ccggagcccg cctgctgctc gtctacgcgg gcctgctggc cgccgccgcc gcgggcctgg
      121 ggtccccgga gcctggggcg ccctcgagga gccgcgcccg cagggagccg ccgcccggga
      181 acgagctgcc ccggggcccc ggggagagcc gcgcggggcc ggccgctcgt ccgccggagc
      241 ccaccgctga gcgtgcacac agcgtcgacc cccgggacgc ctggatgctc ttcgtcaggc
      301 agagtgacaa gggtgtcaat ggcaagaaga ggagcagggg caaggccaag aagctgaagt
      361 tcggcttgcc agggccccct gggcctcccg gtccccaggg ccccccaggc cccatcatcc
      421 cacccgaggc gctgctgaag gagttccagc tgctgctgaa aggtgcggtg cggcagcggg
      481 agcgcgcgga gcccgaaccc tgtacgtgtg gccccgccgg gccggtcgct gcgagcctcg
      541 ccccggtctc ggccaccgcc ggggaggacg acgacgacgt ggtgggggac gtgctggcac
      601 tgctggccgc gcccctggcc ccggggccgc gggcgccgcg cgtggaggcc gctttcctct
      661 gccgcctgcg ccgggacgcg ttggtggagc ggcgcgcgct gcacgagctt ggcgtctact
      721 acctgcccga cgccgagggt gccttccgcc gcggcccggg cctgaacttg accagcggcc
      781 agtacagggc gcccgtggct ggcttctacg ctctcgccgc cacgctgcac gtggcgctcg
      841 gggagccgcc gaggaggggg ccgccgcgcc cccgggacca cctgcgcctg ctcatctgca
      901 tccagtcccg gtgccagcgc aacgcctccc tggaggccat catgggcctg gagagcagca
      961 gtgagctctt caccatctct gtgaatggcg tcctgtacct gcagatgggg cagtggacct
     1021 ccgtgttctt ggacaacgcc agcggctgct ccctcacagt gcgcagtggc tcccacttca
     1081 gtgctgtcct cctgggcgtg tgagcggcca ccacaggccc ttcctctcag gggcaaatgg
     1141 agcacagatc tagacaatgt gtggacagtg tcagagtagc agtggccaca tggaggagga
     1201 ggcccacccg gaactctgcc cacactggcc actgcagttc agcccacaga gccactgcag
     1261 gcaggcctac ggacgtgaca cgcacgctgg tggtcccgga gccagggttg attcaggaca
     1321 ccatcttggg ctcttatcca ggaaagaaag agtcggcgtg cctgggggca cctgctagtc
     1381 tccagctgca ggccgactct ttcctggcct gctcagcacc tgcccagatg gcctctgcgt
     1441 ctttcctgtg cccagcccca ccttttccac ctctcttcat gttctcatgg agtgcaaagt
     1501 gcaccagcca gggcccctac ctgggagagg gtcagctgac gcagggctga gggggctgcc
     1561 acagggacgt acgctgtgtg ttcttactgc ttagaaggga cggggtcact caccactccc
     1621 ctggtctcca tctgggctcc ttggtcttcc ctgcccctcc cctaaccgtg ttctacctgc
     1681 cagtggagct gagcactgcc tagcctgggc cagaggggca ctggacaagg gcctttgggg
     1741 gacagtaagt ctgggcccag cttctagttc taatgtgtgc aagattaact cacaaattca
     1801 cctcagaagg cctttccaaa tgggagctcc actcttcccc tcctctgcaa atcttcacag
     1861 ccaaggcccc ttccaccctc tccagaggtg gatgagatcc cttttcccct cccctctgag
     1921 gtgctgactc actggtagga gccacccacc agaggaaaga tctagaacgt ctttacagat
     1981 tggagacagc cgggcctgct gacccatcat ccgaatagct gaagcagagt cttccaccag
     2041 gggtgccagg gcctggctgg gtccagcggc tctgggatga gcctcccaag catctttccc
     2101 acttgggtgg ccatgcggcg ctgacattgg acaggtggtg gacgagagat ggtcccgaga
     2161 aagggtggtc ttgggagggc tggtcccaag cctgctgtgc tcctgtggca gtgatggggc
     2221 ctggggatgg ggacggcagc tctcatgagg acacacaggc tgtgagcccg cagcctcctc
     2281 aaatgtagcc tcccacattt tccccaaagt acaggactgt cccagagtag gtagtgaaga
     2341 ggacaaggcc ctcggcagcg acctccaggg cctcctacct gctgaggaag agttaaccca
     2401 ctgcctcccc acacaacagg ctacgaagaa cctggtgcct caggacctcc tgggagccaa
     2461 gctggtctgg caagggcgct caggcctggg agagaaggga gcaatggcca gtcaccttca
     2521 ccttctaact aactagcctc cggatgaggt ggctgccacc aggcccgaat gatccccagg
     2581 agcccagctt ccaaacccca acatcgaatc aaacatctcc atccccaagt gcagtaacac
     2641 acaaaaacca aacactctgc cctgggaaag gcctggtgcg attctcagta ggactcacac
     2701 ccaccctacc tagaagtact gggctggcct gggtactgca tccgtgtgtt ttgataaggg
     2761 ggtgatgtgg ccacgccctt atctagattt cactttgtat ccactgggca cagatattct
     2821 agagaactta tctttcactc ttgtaaaagc cacatatcca catctctttc atttttctca
     2881 gtgtgttatg cagcaattta ttaaagtatt tattgtctaa taaatactgc caagtggaa
//
